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Volumn , Issue , 2007, Pages 369-409

Introduction to NMR and Its Application in Metabolite Structure Determination

Author keywords

Chemically nonequivalent nuclei; Multiple bond heteronuclear coupling constants; Solvent suppression techniques

Indexed keywords


EID: 69249105418     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470191699.ch12     Document Type: Chapter
Times cited : (11)

References (61)
  • 1
    • 0029010536 scopus 로고
    • Online use of NMR detection in separation chemistry
    • Albert K. Online use of NMR detection in separation chemistry. J Chromatogr A 1995;703:123-147.
    • (1995) J Chromatogr A , vol.703 , pp. 123-147
    • Albert, K.1
  • 2
    • 29544447413 scopus 로고    scopus 로고
    • The design of a multidimensional LC-SPE-NMR system (LC2-SPE-NMR) for complex mixture analysis
    • Alexander AJ, Xu F, Bernard C. The design of a multidimensional LC-SPE-NMR system (LC2-SPE-NMR) for complex mixture analysis. Magn Reson Chem 2006;44(1):1-6.
    • (2006) Magn Reson Chem , vol.44 , Issue.1 , pp. 1-6
    • Alexander, A.J.1    Xu, F.2    Bernard, C.3
  • 3
    • 0025572601 scopus 로고
    • Use of 1H NMR in the identification of a metabolite of a catecholic cephalosporin excreted in rat bile
    • Basker MJ, Finch SC, Tyler JW. Use of 1H NMR in the identification of a metabolite of a catecholic cephalosporin excreted in rat bile. J Pharm Biomed Anal 1990;8:573-576.
    • (1990) J Pharm Biomed Anal , vol.8 , pp. 573-576
    • Basker, M.J.1    Finch, S.C.2    Tyler, J.W.3
  • 4
    • 14644396847 scopus 로고    scopus 로고
    • 200 and More NMR Experiments
    • second ed. John Wiley & Sons
    • Berger S, Braun S. 200 and More NMR Experiments. second ed. John Wiley & Sons; 2004.
    • (2004)
    • Berger, S.1    Braun, S.2
  • 5
    • 33744538803 scopus 로고    scopus 로고
    • Biomolecular NMR: a chaperone to drug discovery
    • Betz M, Saxena K, Schwalbe H. Biomolecular NMR: a chaperone to drug discovery. Curr Opin Chem Biol 2006;10(3):219-225.
    • (2006) Curr Opin Chem Biol , vol.10 , Issue.3 , pp. 219-225
    • Betz, M.1    Saxena, K.2    Schwalbe, H.3
  • 6
    • 33645560263 scopus 로고    scopus 로고
    • Identification of isomeric tropane alkaloids from Schizanthus grahamii by HPLC-NMR with loop storage and HPLC-UV-MS/SPE-NMR using a cryogenic flowprobe
    • Bieri S, Varesio E, Veuthey JL, Muñoz O, Tseng LH, Braumann U, Spraul M, Christen P. Identification of isomeric tropane alkaloids from Schizanthus grahamii by HPLC-NMR with loop storage and HPLC-UV-MS/SPE-NMR using a cryogenic flowprobe. Phytochem Anal 2006;17(2):78-86.
    • (2006) Phytochem Anal , vol.17 , Issue.2 , pp. 78-86
    • Bieri, S.1    Varesio, E.2    Veuthey, J.L.3    Muñoz, O.4    Tseng, L.H.5    Braumann, U.6    Spraul, M.7    Christen, P.8
  • 7
    • 0038434517 scopus 로고    scopus 로고
    • Verapamil: identification of novel metabolites in cultures of primary human hepatocytes and human urine by LC-MS(n) and LC-NMR
    • Borlak J, Walles M, Elend M, Thum T, Preiss A, Levsen K. Verapamil: identification of novel metabolites in cultures of primary human hepatocytes and human urine by LC-MS(n) and LC-NMR. Xenobiotica 2003;33(6):655-676.
    • (2003) Xenobiotica , vol.33 , Issue.6 , pp. 655-676
    • Borlak, J.1    Walles, M.2    Elend, M.3    Thum, T.4    Preiss, A.5    Levsen, K.6
  • 8
    • 0003505017 scopus 로고    scopus 로고
    • Structure Elucidation by NMR in Organic Chemistry: A Practical Guide
    • Third ed. John Wiley & Sons
    • Breitmaier E. Structure Elucidation by NMR in Organic Chemistry: A Practical Guide. Third ed. John Wiley & Sons; 2002.
    • (2002)
    • Breitmaier, E.1
  • 9
    • 0013307458 scopus 로고    scopus 로고
    • Bruker BioSpin announces novel capillary LC-NMR system
    • Bruker Biospin GmbH, Forthcoming
    • Bruker Biospin GmbH. Bruker BioSpin announces novel capillary LC-NMR system 2002. Forthcoming.
    • (2002)
  • 10
    • 0013276569 scopus 로고    scopus 로고
    • Bruker BioSpin introduces the CryoFlowProbe, the world's first cryogenic flow-injection NMR probe
    • Buker Biospin GmbH, Forthcoming, Available at
    • Buker Biospin GmbH. Bruker BioSpin introduces the CryoFlowProbe, the world's first cryogenic flow-injection NMR probe 2002. Forthcoming, Available at http://www.bruker-biospin.com/nmr/news/pdf_files/cryoflowprb.pdf.
    • (2002)
  • 12
    • 0036130782 scopus 로고    scopus 로고
    • Delineating novel metabolic pathways of DPC 963, a nonnucleoside reverse transcriptase inhibitor, in rats. Characterization of glutathione conjugates of postulated oxirene and benzoquinone imine intermediates by LC-MS and LC-NMR
    • Chen H, Shockcor J, Chen W, Espina R, Gan LS,Mutlib AE. Delineating novel metabolic pathways of DPC 963, a nonnucleoside reverse transcriptase inhibitor, in rats. Characterization of glutathione conjugates of postulated oxirene and benzoquinone imine intermediates by LC-MS and LC-NMR. Chem Res Toxicol 2002;15:388-399.
    • (2002) Chem Res Toxicol , vol.15 , pp. 388-399
    • Chen, H.1    Shockcor, J.2    Chen, W.3    Espina, R.4    Gan, L.S.5    Mutlib, A.E.6
  • 13
    • 0038012572 scopus 로고    scopus 로고
    • LC-NMR-MS in drug discovery
    • Corcoran O, Spraul M. LC-NMR-MS in drug discovery. Drug Discov Today 2003;8(14):624-631.
    • (2003) Drug Discov Today , vol.8 , Issue.14 , pp. 624-631
    • Corcoran, O.1    Spraul, M.2
  • 16
    • 0242653709 scopus 로고    scopus 로고
    • LC-UV-solid-phase extraction-NMR-MS combined with a cryogenic flow probe and its application to the identification of compounds present in Greek oregano
    • Exarchou V, Godejohann M, van Beek TA, Gerothanassis IP, Vervoort J. LC-UV-solid-phase extraction-NMR-MS combined with a cryogenic flow probe and its application to the identification of compounds present in Greek oregano. Anal Chem 2003;75(22):6288-6294.
    • (2003) Anal Chem , vol.75 , Issue.22 , pp. 6288-6294
    • Exarchou, V.1    Godejohann, M.2    van Beek, T.A.3    Gerothanassis, I.P.4    Vervoort, J.5
  • 18
    • 0003504249 scopus 로고    scopus 로고
    • A Handbook of Nuclear Magnetic Resonance.. second ed
    • Longman Publishing Group
    • Freeman R, A Handbook of Nuclear Magnetic Resonance. second ed. Longman Publishing Group; 1997.
    • (1997)
    • Freeman, R.1
  • 19
    • 0003660535 scopus 로고    scopus 로고
    • Basic One-and Two-Dimensional NMR Spectroscopy. fourth ed
    • John Wiley & Sons
    • Friebolin H, Basic One-and Two-Dimensional NMR Spectroscopy. fourth ed. John Wiley & Sons; 2005.
    • (2005)
    • Friebolin, H.1
  • 20
    • 24944473872 scopus 로고    scopus 로고
    • Metabolism of N-hydroxyguanidines (N-hydroxydebrisoquine) in human and porcine hepatocytes: reduction and formation of glucuronides
    • Froehlich AK, Girreser D, Clement B. Metabolism of N-hydroxyguanidines (N-hydroxydebrisoquine) in human and porcine hepatocytes: reduction and formation of glucuronides. Drug Metabo Dispos 2005;33:1532-1537.
    • (2005) Drug Metabo Dispos , vol.33 , pp. 1532-1537
    • Froehlich, A.K.1    Girreser, D.2    Clement, B.3
  • 21
    • 84985822349 scopus 로고
    • Methods of single-and double-selective excitation: theory and applications
    • Gaggelli E, Valensin G. Methods of single-and double-selective excitation: theory and applications. Part II. Conc Magn Reson 1993;5(1):19-42.
    • (1993) Part II. Conc Magn Reson , vol.5 , Issue.1 , pp. 19-42
    • Gaggelli, E.1    Valensin, G.2
  • 23
  • 24
    • 8444252479 scopus 로고    scopus 로고
    • Characterization of a paracetamol metabolite using on-line LC-SPE-NMR-MS and a cryogenic NMR probe
    • Godejohann M, Tseng LH, Braumann U, Fuchser J, Spraul M. Characterization of a paracetamol metabolite using on-line LC-SPE-NMR-MS and a cryogenic NMR probe. J Chromatogr A 2004;1058(1-2):191-196.
    • (2004) J Chromatogr A , vol.1058 , Issue.1-2 , pp. 191-196
    • Godejohann, M.1    Tseng, L.H.2    Braumann, U.3    Fuchser, J.4    Spraul, M.5
  • 25
    • 33749659675 scopus 로고    scopus 로고
    • SAR by NMR: putting the pieces together
    • Hajduk PJ. SAR by NMR: putting the pieces together. Mol Interv 2006;6(5):266-272.
    • (2006) Mol Interv , vol.6 , Issue.5 , pp. 266-272
    • Hajduk, P.J.1
  • 26
    • 0004001607 scopus 로고    scopus 로고
    • A Dictionary of Concepts in NMR
    • Second ed. Oxford University Press
    • Homans SW. A Dictionary of Concepts in NMR. Second ed. Oxford University Press; 2005.
    • (2005)
    • Homans, S.W.1
  • 27
    • 79960698472 scopus 로고
    • Water suppression that works. Excitation sculpting using arbitrary wave-forms and pulsed-field gradients
    • Hwang TL, Shaka AJ. Water suppression that works. Excitation sculpting using arbitrary wave-forms and pulsed-field gradients. J Magn Reson Series A 1995;112(2):275-279.
    • (1995) J Magn Reson Series A , vol.112 , Issue.2 , pp. 275-279
    • Hwang, T.L.1    Shaka, A.J.2
  • 28
    • 0344442310 scopus 로고    scopus 로고
    • LC-NMR and LC-MS analysis of 2,3,10,11-oxygenated protoberberine metabolites in Corydalis cell cultures
    • Iwasa K, Kuribayashi A, Sugiura M, Moriyasu M, Lee DU, Wiegrebe W. LC-NMR and LC-MS analysis of 2,3,10,11-oxygenated protoberberine metabolites in Corydalis cell cultures. Phytochemistry 2003;64(7):1229-1238.
    • (2003) Phytochemistry , vol.64 , Issue.7 , pp. 1229-1238
    • Iwasa, K.1    Kuribayashi, A.2    Sugiura, M.3    Moriyasu, M.4    Lee, D.U.5    Wiegrebe, W.6
  • 29
    • 0036917659 scopus 로고    scopus 로고
    • Comparative biotransformation of morphine, codeine and pholcodine in rat hepatocytes: identification of a novel metabolite of pholcodine
    • Jairaj M, Watson DG, Grant MH, Gray AI, Skellern GG. Comparative biotransformation of morphine, codeine and pholcodine in rat hepatocytes: identification of a novel metabolite of pholcodine. Xenobiotica 2002;32:1093-1107.
    • (2002) Xenobiotica , vol.32 , pp. 1093-1107
    • Jairaj, M.1    Watson, D.G.2    Grant, M.H.3    Gray, A.I.4    Skellern, G.G.5
  • 30
    • 33645948818 scopus 로고    scopus 로고
    • Understanding NMR Spectroscopy
    • first ed. UK: John Wiley and Sons
    • Keeler J. Understanding NMR Spectroscopy. first ed. UK: John Wiley and Sons; 2005.
    • (2005)
    • Keeler, J.1
  • 32
    • 84889341490 scopus 로고    scopus 로고
    • On-line LC-NMR and Related Techniques
    • first ed. E-Book
    • Klaus A. On-line LC-NMR and Related Techniques, first ed. E-Book;2003.
    • (2003)
    • Klaus, A.1
  • 33
    • 0035524596 scopus 로고    scopus 로고
    • NMR at 900 MHz
    • Kupee E. NMR at 900 MHz. Chem Heter Comp 2001;37(11):1429-1438.
    • (2001) Chem Heter Comp , vol.37 , Issue.11 , pp. 1429-1438
    • Kupee, E.1
  • 34
    • 4344711355 scopus 로고    scopus 로고
    • Theory and applications of NMR-based screening in pharmaceutical research
    • Lepre CA, Moore JM, Peng JW. Theory and applications of NMR-based screening in pharmaceutical research. Chem Rev 2004:104(8):3641-76
    • (2004) Chem Rev , vol.104 , Issue.8 , pp. 3641-3676
    • Lepre, C.A.1    Moore, J.M.2    Peng, J.W.3
  • 35
    • 0029687420 scopus 로고    scopus 로고
    • The development and application of coupled HPLC-NMR spectroscopy
    • Lindon JC, Nicholson JK, Wilson ID. The development and application of coupled HPLC-NMR spectroscopy. Adv Chromatogr 1996;36:315-382.
    • (1996) Adv Chromatogr , vol.36 , pp. 315-382
    • Lindon, J.C.1    Nicholson, J.K.2    Wilson, I.D.3
  • 36
    • 33845926648 scopus 로고    scopus 로고
    • An anomalous course of the reduction of 2-(3-oxo-3,4-dihydroquinoxalin-2-yl)benzene diazonium salt: a reinvestigation
    • Lyčka A, Fryšová I, Slouka J. An anomalous course of the reduction of 2-(3-oxo-3,4-dihydroquinoxalin-2-yl)benzene diazonium salt: a reinvestigation. Magn Reson Chem 2007;45(1):46-50.
    • (2007) Magn Reson Chem , vol.45 , Issue.1 , pp. 46-50
    • Lyčka, A.1    Fryšová, I.2    Slouka, J.3
  • 37
    • 0003677243 scopus 로고    scopus 로고
    • Two-Dimensional NMR Methods for Establishing Molecular Connectivity
    • First ed. VCH; New York
    • Martin G, Zektzer A, Two-Dimensional NMR Methods for Establishing Molecular Connectivity. First ed. VCH; New York: 1998.
    • (1998)
    • Martin, G.1    Zektzer, A.2
  • 39
    • 84989060076 scopus 로고
    • NMR conformational studies of fenamate non-steroidal antiinflammatory drugs
    • Munro SLA, Craik DJ. NMR conformational studies of fenamate non-steroidal antiinflammatory drugs. Magn Reson Chem 1994;32(6):335-342.
    • (1994) Magn Reson Chem , vol.32 , Issue.6 , pp. 335-342
    • Munro, S.L.A.1    Craik, D.J.2
  • 40
    • 84889479444 scopus 로고    scopus 로고
    • Varian Inc
    • NMR probes, Palo Alto, CA, USA, Available at
    • NMR probes. Varian Inc, Palo Alto, CA, USA;2002. Available at http://www.varianinc.com/cgi-bin/nav?varinc/docs/nmr/products/probes.
    • (2002)
  • 41
    • 33645377497 scopus 로고    scopus 로고
    • Structure-based development of target-specific compound libraries
    • Orry AJ, Abagyan RA, Cavasotto CN. Structure-based development of target-specific compound libraries. Drug Discov Today 2006;11(5-6):261-266.
    • (2006) Drug Discov Today , vol.11 , Issue.5-6 , pp. 261-266
    • Orry, A.J.1    Abagyan, R.A.2    Cavasotto, C.N.3
  • 42
    • 25144456011 scopus 로고    scopus 로고
    • Solution nuclear magnetic resonance spectroscopy techniques for probing intermolecular interactions
    • Pellecchia M. Solution nuclear magnetic resonance spectroscopy techniques for probing intermolecular interactions. Chem Biol 2005;12(9):961-971.
    • (2005) Chem Biol , vol.12 , Issue.9 , pp. 961-971
    • Pellecchia, M.1
  • 44
    • 84986769180 scopus 로고
    • Regio-and stereoselective alkylation of a pyrrolidinic system: structural and conformational studies by high field NMR techniques
    • Schaefer M, Faller P, Nicole D. Regio-and stereoselective alkylation of a pyrrolidinic system: structural and conformational studies by high field NMR techniques. Org Magn Reson 1982;19(2):108-111.
    • (1982) Org Magn Reson , vol.19 , Issue.2 , pp. 108-111
    • Schaefer, M.1    Faller, P.2    Nicole, D.3
  • 45
    • 0036713604 scopus 로고    scopus 로고
    • Highresolution capillary tube NMR. A miniaturized 5 mL high-sensitivity TXI probe for mass-limited samples, off-line LC NMR, and HT NMR
    • Schlotterbeck G, Ross A, Hochstrasser R, Senn H, Kuhn T, Marek D, Schett O. Highresolution capillary tube NMR. A miniaturized 5 mL high-sensitivity TXI probe for mass-limited samples, off-line LC NMR, and HT NMR. Anal Chem 2002;74:4464-4471.
    • (2002) Anal Chem , vol.74 , pp. 4464-4471
    • Schlotterbeck, G.1    Ross, A.2    Hochstrasser, R.3    Senn, H.4    Kuhn, T.5    Marek, D.6    Schett, O.7
  • 46
    • 17644388120 scopus 로고    scopus 로고
    • Intermediates and transition states in thiamin diphosphate-dependent decarboxylases. A kinetic and NMR study on wild-type indolepyruvate decarboxylase and variants using indolepyruvate, benzoylformate, and pyruvate as substrates
    • Schutz A, Golbik R, Konig S, Hubner G, Tittmann K. Intermediates and transition states in thiamin diphosphate-dependent decarboxylases. A kinetic and NMR study on wild-type indolepyruvate decarboxylase and variants using indolepyruvate, benzoylformate, and pyruvate as substrates. Biochemistry 2005;26:44916):6164-79.
    • (2005) Biochemistry , vol.26
    • Schutz, A.1    Golbik, R.2    Konig, S.3    Hubner, G.4    Tittmann, K.5
  • 47
    • 33750959927 scopus 로고    scopus 로고
    • Reaction product analysis by high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance Application to the absolute configuration determination of naturally occurring polyyne alcohols
    • Seger C, Godejohann M, Spraul M, Stuppner H, Hadacek F. Reaction product analysis by high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance Application to the absolute configuration determination of naturally occurring polyyne alcohols. J Chromatogr A 2006;1136(1):82-88.
    • (2006) J Chromatogr A , vol.1136 , Issue.1 , pp. 82-88
    • Seger, C.1    Godejohann, M.2    Spraul, M.3    Stuppner, H.4    Hadacek, F.5
  • 48
    • 0034918529 scopus 로고    scopus 로고
    • NMR in the acceleration of drug discovery
    • Sem DS, Pellecchia M. NMR in the acceleration of drug discovery. Curr Opin Drug Discov Devel 2001;4(4):479-492.
    • (2001) Curr Opin Drug Discov Devel , vol.4 , Issue.4 , pp. 479-492
    • Sem, D.S.1    Pellecchia, M.2
  • 49
    • 0030300931 scopus 로고    scopus 로고
    • Combined hyphenation of HPLC, NMR spectroscopy and ion trap mass spectrometry (LC-NMR-MS) with application to the detection and characterization of xenobiotic and endogenous metabolites in human urine
    • Shockcor PJ, Unger SH, Wilson ID, Foxall PJD, Nicholson JK, Lindon JC. Combined hyphenation of HPLC, NMR spectroscopy and ion trap mass spectrometry (LC-NMR-MS) with application to the detection and characterization of xenobiotic and endogenous metabolites in human urine. Anal Chem 1996;68:4431-4435.
    • (1996) Anal Chem , vol.68 , pp. 4431-4435
    • Shockcor, P.J.1    Unger, S.H.2    Wilson, I.D.3    Foxall, P.J.D.4    Nicholson, J.K.5    Lindon, J.C.6
  • 50
    • 58149365344 scopus 로고
    • WET solvent suppression and its applications to LC-NMR and high-resolution NMR spectroscopy
    • Smallcombe SH, Patt SL. WET solvent suppression and its applications to LC-NMR and high-resolution NMR spectroscopy. J Magn Reson Series A 1995;117(2):295-303.
    • (1995) J Magn Reson Series A , vol.117 , Issue.2 , pp. 295-303
    • Smallcombe, S.H.1    Patt, S.L.2
  • 51
    • 0028535256 scopus 로고
    • Evaluation of liquid-chromatography coupled with high-field 1H NMR spectroscopy for drug metabolite detection and characterization: the identification of paracetamol metabolites in urine and bile
    • Spraul M, Hofmann M, Lindon JC, Farrant RD, Seddon MJ, Nicholson JK, Wilson ID. Evaluation of liquid-chromatography coupled with high-field 1H NMR spectroscopy for drug metabolite detection and characterization: the identification of paracetamol metabolites in urine and bile. NMR Biomed 1994;7:295-303.
    • (1994) NMR Biomed , vol.7 , pp. 295-303
    • Spraul, M.1    Hofmann, M.2    Lindon, J.C.3    Farrant, R.D.4    Seddon, M.J.5    Nicholson, J.K.6    Wilson, I.D.7
  • 52
    • 0027394931 scopus 로고
    • High-performance liquid chromatography coupled to high-field proton nuclear magnetic resonance spectroscopy: application to the urinary metabolites of ibuprofen
    • Spraul M, Hofmann M, Dvortsak P, Nicholson JK, Wilson ID. High-performance liquid chromatography coupled to high-field proton nuclear magnetic resonance spectroscopy: application to the urinary metabolites of ibuprofen. Anal Chem 1993;65:327-330.
    • (1993) Anal Chem , vol.65 , pp. 327-330
    • Spraul, M.1    Hofmann, M.2    Dvortsak, P.3    Nicholson, J.K.4    Wilson, I.D.5
  • 53
    • 0037444518 scopus 로고    scopus 로고
    • Advancing NMR sensitivity for LC-NMR-MS using a cryoflow probe: application to the analysis of acetaminophen metabolites in urine
    • Spraul M, Freund AS, Nast RE, Withers RS, Maas WE, Corcoran O. Advancing NMR sensitivity for LC-NMR-MS using a cryoflow probe: application to the analysis of acetaminophen metabolites in urine. Anal Chem 2003;75(6):1536-1541.
    • (2003) Anal Chem , vol.75 , Issue.6 , pp. 1536-1541
    • Spraul, M.1    Freund, A.S.2    Nast, R.E.3    Withers, R.S.4    Maas, W.E.5    Corcoran, O.6
  • 54
    • 20544461955 scopus 로고    scopus 로고
    • NMR investigation of hydrogen bonding and 1,3-tautomerism in 2-(2-hydroxy-5-substituted-aryl) benzimidazoles
    • Sridharan V, Saravanan S, Muthusubramanian S, Sivasubramanian S. NMR investigation of hydrogen bonding and 1,3-tautomerism in 2-(2-hydroxy-5-substituted-aryl) benzimidazoles. Magn Reson Chem 2005;43(7):551-556.
    • (2005) Magn Reson Chem , vol.43 , Issue.7 , pp. 551-556
    • Sridharan, V.1    Saravanan, S.2    Muthusubramanian, S.3    Sivasubramanian, S.4
  • 55
    • 33845287229 scopus 로고    scopus 로고
    • Implications of protein conformational diversity for binding and development of new biological active compounds
    • Valente AP, Miyamoto CA, Almeida FC. Implications of protein conformational diversity for binding and development of new biological active compounds. Curr Med Chem 2006;13(30):3697-3703.
    • (2006) Curr Med Chem , vol.13 , Issue.30 , pp. 3697-3703
    • Valente, A.P.1    Miyamoto, C.A.2    Almeida, F.C.3
  • 57
    • 23644435617 scopus 로고    scopus 로고
    • The design of an on-line semipreparative LC-SPE-NMR system for trace analysis
    • Xu F, Alexander AJ. The design of an on-line semipreparative LC-SPE-NMR system for trace analysis. Magn Reson Chem 2005;43(9):776-782.
    • (2005) Magn Reson Chem , vol.43 , Issue.9 , pp. 776-782
    • Xu, F.1    Alexander, A.J.2
  • 58
    • 32444441286 scopus 로고    scopus 로고
    • Online hyphenated liquid chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry for drug metabolite and nature product analysis
    • Yang Z. Online hyphenated liquid chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry for drug metabolite and nature product analysis. J Pharm Biomed Anal 2006;40(3):516-527.
    • (2006) J Pharm Biomed Anal , vol.40 , Issue.3 , pp. 516-527
    • Yang, Z.1
  • 59
    • 33750538244 scopus 로고    scopus 로고
    • Protein NMR-based screening in drug discovery
    • Zartler ER, Shapiro MJ. Protein NMR-based screening in drug discovery. Curr Pharm Des 2006;12(31):3963-3972.
    • (2006) Curr Pharm Des , vol.12 , Issue.31 , pp. 3963-3972
    • Zartler, E.R.1    Shapiro, M.J.2
  • 60
    • 2042474751 scopus 로고    scopus 로고
    • Amide Nglucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans
    • Zhang D, Zhao W, Roongta VR, Mitroka JG, Klunk LJ, Zhu M. Amide Nglucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans. Drug Metab Dispos 2004;32:545-551.
    • (2004) Drug Metab Dispos , vol.32 , pp. 545-551
    • Zhang, D.1    Zhao, W.2    Roongta, V.R.3    Mitroka, J.G.4    Klunk, L.J.5    Zhu, M.6
  • 61
    • 33846625532 scopus 로고    scopus 로고
    • The keto-enol tautomerization of ethyl butylryl acetate studied by LC-NMR
    • Zhou CC, Hill DR. The keto-enol tautomerization of ethyl butylryl acetate studied by LC-NMR. Magn Reson Chem 2006;45(2):128-132.
    • (2006) Magn Reson Chem , vol.45 , Issue.2 , pp. 128-132
    • Zhou, C.C.1    Hill, D.R.2


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