Identification and characterization of the major Huperzine A metabolite in rat blood

Journal of Analytical Toxicology

Volumn 28, Issue 5, 2004, Pages 379-383

  Garcia, Gregory E ^a   Hicks, Rickey P ^a   Skanchy, David ^a   Moorad Doctor, Deborah R ^a   Doctor, Bhupendra P ^a   Ved, Haresh S ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; DRUG METABOLITE; HUPERZINE A;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CHEMICAL ANALYSIS; CHINESE MEDICINE; CHOLINESTERASE INHIBITION; EMBRYO; HUPERZIA; HUPERZIA SERRATA; INTOXICATION; MASS SPECTROMETRY; MEDICINAL PLANT; METABOLITE; NEUROLOGIC DISEASE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; TRADITIONAL MEDICINE;

ANIMALIA; HUPERZIA; HUPERZIA SERRATA;

EID: 3242687012     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/28.5.379     Document Type: Article

References (11)

1. A.P. Kozikowski and W. Tuckmantel. Chemistry, pharmacology, and clinical efficacy of the Chinese nootropic agent huperzine A. Acc. Chem. Res. 32: 641-650 (1999).
2. M. McKinney, J.H. Miller, F. Yamnada, W. Tuckmantel, and A.P. Kozikowski. Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase. Eur. J. Pharmacol. 203: 303-305 (1991).
3. Y. Ashani, J.O. Peggins, and B.P. Doctor. Mechanism of inhibition of cholinesterases by huperzine A. Biochem. Biophys. Res. Comm. 184: 719-726 (1992).
4. M.L. Raves, M. Harel, Y.P. Pang, I. Silman, A.P. Kozikowski, and J.L. Sussman. Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. Nat. Struct. Biol. 4: 57-63 (1997).
5. A.P. Kozikowski, Y. Xia, E.R. Reddy, W. Tuckmantel, I. Hanin, and X.C. Tang. Synthesis of huperzine A and its analogs and their anticholinesterase activity. J. Org. Chem. 56: 4633-4645 (1991).
6. H.S. Ved, M.L. Koenig, J.R. Dave, and B.P. Doctor. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport 8: 963-968 (1997).
7. R.K. Gordon, S.V. Nigam, J.A. Weitz, J.R. Dave, B.P. Doctor, and H.S. Ved. The NMDA receptor ion channel: a site for binding of huperzine A. J. Appl. Toxicol. 21: S47-S51 (2001).
8. X.Q. Xiao, H.Y. Zhang, and X.C. Tang. Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation. J. Neuosci. Res. 67: 30-39 (2001).
9. 15N HSQC experiments optimized to retain full sensitivity. J. Magn. Reson. Series A 102: 241-245 (1993).
10. G. Eich, G. Bodenhausen, and R.R. Ernst. Exploring nuclear spin systems by relayed magnetization transfer. J. Am. Chem. Soc. 104: 3731-3732 (1982).
11. D.J. States, R.A. Haberkorn, and D.J. Rubin. A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants. J. Magn. Reson. 48: 286-292 (1982).