Combined HPLC, NMR spectroscopy, and ion-trap mass spectrometry with application to the detection and characterization of xenobiotic and endogenous metabolites in human urine

Analytical Chemistry

Volumn 68, Issue 24, 1996, Pages 4431-4435

  Shockcor, John P ^a   Unger, Steve E ^a   Wilson, Ian D ^b   Foxall, Peta J D ^c   Nicholson, Jeremy K ^c   Lindon, John C ^c  

^a GLAXOSMITHKLINE   (United States)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; PARACETAMOL; PHENYLACETYLGLUTAMINE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MASS SPECTROMETRY; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE; ORAL DRUG ADMINISTRATION; TECHNIQUE; ULTRAVIOLET SPECTROPHOTOMETRY; URINALYSIS;

ACETAMINOPHEN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUTAMINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; XENOBIOTICS;

CHARACTERIZATION; CHEMICAL ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC COMPOUNDS;

ACETAMINOPHEN GLUCURONIDES; AUTOMATED ANALYSIS; ENDOGENOUS METABOLITES; HUMAN URINE; ION-TRAP MASS SPECTROMETRY; SULFATE METABOLITES; XENOBIOTIC METABOLITES;

BODY FLUIDS;

EID: 0030300931     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac9606463     Document Type: Article

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