Metabolism of N-hydroxyguanidines (N-hydroxydebrisoquine) in human and porcine hepatocytes: Reduction and formation of glucuronides

Drug Metabolism and Disposition

Volumn 33, Issue 10, 2005, Pages 1532-1537

  Froehlich, Anja Kristina ^a   Girreser, Ulrich ^a   Clement, Bernd ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEBRISOQUINE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; GUANIDINE DERIVATIVE; N HYDROXYDEBRISOQUINE; N HYDROXYDEBRISOQUINE GLUCURONIDE; RECOMBINANT ENZYME; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CULTURE MEDIUM; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG TRANSFORMATION; ELECTROSPRAY; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER CELL CULTURE; LIVER MICROSOME METABOLISM; MASS SPECTROMETRY; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; SWINE;

ANIMALS; CELLS, CULTURED; DEBRISOQUIN; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; HYDROXYLATION; ISOENZYMES; OXIDATION-REDUCTION; RECOMBINANT PROTEINS;

SUIDAE; SUS SCROFA;

EID: 24944473872     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.004572     Document Type: Article

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