Mutations at a glycine loop in aminolevulinate synthase affect pyridoxal phosphate cofactor binding and catalysis

Biochemistry

Volumn 35, Issue 45, 1996, Pages 14109-14117

  Gong, Jian ^a,b   Kay, Christopher J ^a   Barber, Michael J ^a   Ferreira, Gloria C ^a,b,c  

^a Inst for Biomolecular Science   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c AMERICAN HEART ASSOCIATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; PYRIDOXAL 5 PHOSPHATE;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME STABILITY; GENE MUTATION; PRIORITY JOURNAL; THERMOSTABILITY;

5-AMINOLEVULINATE SYNTHETASE; AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; CIRCULAR DICHROISM; COMPUTER SIMULATION; GLYCINE; HEAT; KINETICS; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY; PYRIDOXAL PHOSPHATE; STRUCTURE-ACTIVITY RELATIONSHIP; ULTRAVIOLET RAYS;

ANIMALIA; FUNGI;

EID: 0029843559     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961296h     Document Type: Article

References (38)

1. Alexander, F. W., Sandmeier, E., Mehta, P. K., & Christen, P. (1994) Eur. J. Biochem. 219, 953-960.
2. Antson, A. A., Demidkina, T. V., Gollnick, P., Dauter, Z., Von Tersch, R. L., Long, J., Berezhnoy, S. N., Phillips, R. S., Harutyunyan, E. H., & Wilson, K. S. (1993) Biochemistry 32, 4195-4206.
3. Barford, D., & Johnson, L. N. (1989) Nature 340, 609-616.
4. Bossemeyer, D. (1994) Trends Biochem. Sci. 19, 201-205.
5. Branden, C., & Tooze, J. (1991) in Introduction to Protein Structure (Branden, C., & Tooze, J., Eds.) pp 141-159, Garland, New York.
6. Chen, G. C., & Yang, J. T. (1977) Anal Lett. 10, 1195-1207.
7. Datta, P., GOSS, T. J., Omnaas, J. R., & Patil, R. V. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 393-397.
8. Dunathan, H. C. (1971) Adv. Enzymol. 35, 79-134.
9. Ferreira, G. C., & Dailey, H. A. (1993) J. Biol. Chem. 268, 584-590.
10. Ferreira, G. C., & Gong, J. (1995) J. Bioenerg. Biomembr. 27, 151-159.
11. Ferreira, G. C., Neame, P. J., & Dailey, H. A. (1993) Protein Sci. 2, 1959-1965.
12. Ferreira, G. C., Vajapey, U., Hafez, O., Hunter, G. A., & Barber, M. J. (1995) Protein Sci. 4, 1001-1006.
13. Gong, J., & Ferreira, G. C. (1995) Biochemistry 34, 1678-1685.
14. Grishin, N. V., Phillips, M. A., & Goldsmith, E. J. (1995) Protein Sci. 4, 1291-1304.
15. Hayashi, H., Mizuguchi, H., & Kagamiyama, H. (1993) Biochem- istry 32, 812-818.
16. Hunter, G. A., & Ferreira, G. C. (1995) Anal. Biochem. 226, 221- 224.
17. Hyde, C. C., Ahmed, S. A., Padlan, E. A., Miles, E. W., & Davies, D. R. (1988) J. Biol. Chem. 263, 17857-17871.
18. Iwamoto, R., Imanaga, Y., & Soda, K. (1984) J. Biochem. 95, 1318.
19. John, R. A. (1995) Biochim. Biophys. Acta 1248, 81-96.
20. Jordan, P. M. (1991) in Biosynthesis of Tetrapyrroles (Jordan, P. M., Ed.) pp 1-66, Elsevier, Amsterdam.
21. Kirsch, J. F., Eichele, G., Ford, G. C., Vincent, M. G., & Jansonius, J. N. (1984) J. Mol. Biol. 174, 497-525.
22. Laemmli, U. K. (1970) Nature 227, 680-685.
23. Lu, Z., Nagata, S., McPhie, P., & Miles, E. W. (1993) J. Biol. Chem. 268, 8727-8734.
24. Marceau, M., Lewis, S. D., Kojiro, C. L., Mountjoy, K., & Shafer. J. A. (1990) J. Biol. Chem. 265, 20421-20429.
25. McLaughlin, P. J., Stuart, D. I., Klein, H. W., Oikonomakos, N. G., & Johnson, L. N. (1984) Biochemistry 23, 5862-5873.
26. Momany, C., Ghosh, R., & Hackert, M. L. (1995) Protein Sci. 4, 849-854.
27. Oikonomakos, N. G., Johnson, L. N., Acharya, K. R., Stuart, D. I., Barford, D., Hajdu, J., Varvill, K. M., Melpidou, A. E., Papageorgiou, T., Graves, D. J., & Palm, D. (1987) Biochemistry 26, 8381-8389.
28. Riddle, R. D., Yamamoto, M., & Engel, J. D. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 792-796.
29. Sanger, F., Nicklen, S., & Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 5463-5467.
30. Saraste, M., Sibbald, P. R., & Wittinghofer, A. (1990) Trends Biochem. Sci. 15, 430-434.
31. Swindells, M. B. (1993) Protein Sci. 2, 2146-2153.
32. Tan, D., & Ferreira, G. C. (1996) Biochemistry 35, 8934-8941.
33. Toney, M. D., Hohenester, E., Keller, J. W., & Jansonius, J. N. (1995) J. Mol. Biol. 245, 151-179.
34. Weber, I. T., Johnson, L. N., Wilson, K. S., Yeates, D. G. R., Wild, D. L., & Jenkins, J. A. (1978) Nature 274, 433-437.
35. Wierenga, R. K., Drenth, J., & Schulz, G. E. (1983) J. Mol. Biol. 167, 725-739.
36. Yano, T., Kuramitsu, S., Tanase, S., Morino, Y., & Kagamiyama, H. (1992) Biochemistry 31, 5878-5887.
37. Yonaha, K., Misono, H., Yamamoto, T., & Soda, K. (1975) J. Biol. Chem. 250, 6983-6989.
38. Yonaha, K., Toyama, S., & Kagamiyama, H. (1983) J. Biol. Chem. 258, 2260-2265.