On the importance of ribose orientation in the substrate activation of the coenzyme B12-dependent mutases

Chemistry - A European Journal

Volumn 15, Issue 34, 2009, Pages 8578-8585

  Durbeej, Bo ^a,b   Sandala, Gregory M ^a   Bucher, Denis ^a   Smith, David M ^c   Radom, Leo ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UPPSALA UNIVERSITY   (Sweden)

^c RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

Density functional calculations; Enzymes; Molecular moldeling; Radicals; Reaction mechanisms

Indexed keywords

CATALYZED REACTIONS; DEGREE OF STABILIZATION; DENSITY FUNCTIONAL CALCULATIONS; FAVORABLE INTERACTIONS; GLUTAMATE MUTASE; MOLECULAR MOLDELING; OH GROUP; RADICALS; REACTION MECHANISMS; RIBOSE MOIETY; SUBSTRATE ACTIVATION; TRANSITION STRUCTURES;

CATALYSTS; CRYSTAL ORIENTATION; ENZYMES; GRANULAR MATERIALS; HYDROGEN; HYDROGEN BONDS; STABILIZATION;

DENSITY FUNCTIONAL THEORY;

COBALT; COBAMAMIDE; LIGAND; MUTASE; RIBOSE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; ENZYME ACTIVATION; HYDROGEN BOND; METABOLISM; PROTEIN BINDING; X RAY CRYSTALLOGRAPHY;

CATALYSIS; COBALT; COBAMIDES; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HYDROGEN BONDING; INTRAMOLECULAR TRANSFERASES; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; RIBOSE;

EID: 69249086558     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200901002     Document Type: Article

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