Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6

Journal of Clinical Investigation

Volumn 107, Issue 7, 2001, Pages 861-869

  Sitaraman, Shanthi V ^a,b   Merlin, Didier ^a   Wang, Lixin ^a   Wong, Michelle ^a   Gewirtz, Andrew T ^a   Si Tahar, Mustapha ^a,c   Madara, James L ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Institut Pasteur ^*  (United States)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; CALCIUM; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOKINE RELEASE; DEGRANULATION; ENTERITIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; LEUKOCYTE ACTIVATION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION;

EID: 0035057564     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11783     Document Type: Article

References (39)

1. In vitro model of intestinal crypt abscess: A novel neutrophil-derived secretagogue (NDS) activity
2. Adenosine receptors
3. Emerging roles of purinergic signalling in gastrointestinal epithelial secretion and hepatobiliary function
4. Receptors for purines and pyrimidines
5. Formation and release of purine catabolites during hypoperfusion, anoxia, and ischemia
6. Adenosine A2B receptors
7. The structure and function of A1 and A2B adenosine receptors
8. Ligand-activation of adenosine A2a receptors inhibits IL-12 production by human monocytes
9. Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma
10. 5′ AMP is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial monolayers
11. Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia
12. The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia
13. Immune-related intestinal chloride secretion. II. Effect of adenosine on T84 cell line
14. Polarity of A2b adenosine receptor expression determines characteristics of receptor desensitization
15. Molecular and cellular biology of interleukin-6 and its receptor
16. Interleukin-6: Structure-function relationships
17. Interleukin-6 and its receptor are expressed in human intestinal epithelial cells
18. Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease
19. Clinical relevance of serum interleukin-6 in Crohn's disease: Single point measurements, therapy monitoring, and prediction of clinical relapse
20. A high serum concentration of interleukin-6 is predictive of relapse in quiescent Crohn's disease
21. Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent
22. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in crohn disease and experimental colitis in vivo
23. IL-6 is required for the development of Th1 cell-mediated murine colitis
24. Hypoxia-induced modulation of endothelial cell properties: Regulation of barrier function and expression of interleukin-6
25. Interleukin-1beta induces complement component C3 and IL-6 production at the basolateral and apical membranes in a human intestinal epithelial cell line
26. Transforming growth Factor-beta and IL-1 beta act in synergy to enhance IL-6 secretion by the intestinal epithelial cell line, IEC-6
27. Evidence for an acute phase response in human intestinal epithelial cells
28. Salmonella typhi stimulation of human intestinal epithelial cells induces secretion of epithelial cell-derived interleukin-6
29. Interferon alpha synergistically enhances induction of interleukin-6 by double stranded RNA in HeLa cells
30. Salmonella typhimurium induces epithelial IL-8 expression via Ca(2+)-mediated activation of the NF-kappaB pathway
31. Adenosine and its nucleotides activate wild-type and R117H CFTR through an A2B receptor-coupled pathway
32. Constitutive and regulated secretion of secretory leukocyte proteinase inhibitor by human intestinal epithelial cells
33. Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6
34. CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals
35. What is a cAMP response unit?
36. Adenosine: Cyclic AMP pathways and cytokine expression
37. Clinical relevance of serum interleukin-6 in Crohn's disease: Single point measurements, therapy monitoring, and prediction of clinical relapse
38. Interleukin-6 stimulates neutrophil production of platelet-activating factor
39. Effect of proinflammatory interleukins on jejunal nutrient transport