Molecular design, chemical synthesis, and biological evaluation of '4-1' pentacyclic aryl/heteroaryl-imidazonaphthalimides

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 15, 2007, Pages 5114-5121

  Li, Feng ^a   Cui, Jingnan ^a   Guo, Lianying ^b   Qian, Xuhong ^a,c   Ren, Weimin ^a   Wang, Kewei ^a   Liu, Fengyu ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

'4 1' Pentacyclic DNA intercalating agents; Aryl heteroaryl imidazonaphthalimides

Indexed keywords

5 [2 (DIMETHYLAMINO)ETHYL] 9 (2 FURYL) 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 (2 PYRIDINYL) 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 (2 PYRROLYL) 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 (2 THIENYL) 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 (3 FURYL) 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 (3 METHOXY 4 HYDROXYLPHENYL) 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 (3 THIENYL) 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 (4 CHLOROPHENYL) 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 (4 METHOXYLPHENYL) 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 (4 PYRIDINYL) 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 (N METHYL 2 PYRROLYL) 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 [3,4 (DIMETHOXYL)PHENYL] 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 [4 (DIMETHYLAMINO)PHENYL] 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 [4 (ETHOXYL)PHENYL] 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 [4 (HYDROXYL)PHENYL] 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 [4 (METHYL)PHENYL] 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 [4 (TRIFLUOROMETHYL)PHENYL] 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; 5 [2 (DIMETHYLAMINO)ETHYL] 9 PHENYL 5,8 DIHYDROBENZ[DE]IMIDAZO[4,5 G]ISOQUINOLINE 4,6 DIONE; AMONAFIDE; IMIDAZOLE; INTERCALATING AGENT; NAPHTHALENE DERIVATIVE; PHTHALIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA; HUMANS; MICE; MOLECULAR STRUCTURE; NAPHTHALIMIDES; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSITION TEMPERATURE;

EID: 34249939072     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.032     Document Type: Article

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