MD simulations of ligand-bound and ligand-free aptamer: Molecular level insights into the binding and switching mechanism of the add A-riboswitch

RNA

Volumn 15, Issue 9, 2009, Pages 1673-1692

  Sharma, Monika ^a   Bulusu, Gopalakrishnan ^a,b   Mitra, Abhijit ^a  

^a INTERNATIONAL INSTITUTE OF INFORMATION TECHNOLOGY   (India)

^b TATA CONSULTANCY SERVICES   (India)

Author keywords

Aptamer; Dynamic cross correlation; Ligand discrimination; Molecular dynamics; Molecular mechanism; Purine riboswitch

Indexed keywords

ADENINE; APTAMER; GUANINE; LIGAND; MAGNESIUM ION; NUCLEOTIDE; PURINE;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENERGY TRANSFER; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; RIBOSWITCH; SIMULATION;

ADENINE; APTAMERS, NUCLEOTIDE; BINDING SITES; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; LIGANDS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, CATALYTIC;

EID: 69049086655     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.1675809     Document Type: Article

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