Direct observation of hierarchical folding in single riboswitch aptamers

Science

Volumn 319, Issue 5863, 2008, Pages 630-633

  Greenleaf, William J ^a   Frieda, Kirsten L ^a   Foster, Daniel A N ^b   Woodside, Michael T ^b,c   Block, Steven M ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; APTAMER; RNA POLYMERASE; TRANSCRIPTION FACTOR;

BIOASSAY; BIOENERGETICS; ENZYME ACTIVITY; GENE EXPRESSION; LIGAND; PEPTIDE; REACTION KINETICS; RNA;

ARTICLE; ENERGY TRANSFER; GENE CONTROL; GENE STRUCTURE; KINETICS; LIGAND BINDING; MOLECULE; PRIORITY JOURNAL; RIBOSWITCH;

ADENINE; APTAMERS, NUCLEOTIDE; BASE PAIRING; DNA-DIRECTED RNA POLYMERASES; LIGANDS; NUCLEIC ACID CONFORMATION; OPTICAL TWEEZERS; RNA, MESSENGER; THERMODYNAMICS;

EID: 38849204944     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1151298     Document Type: Article

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30. We thank R. Landick for providing purified RNAP, K. Herbert for providing the plasmid used to make the transcription template, M. Larson and O. Dudko for helpful advice, and members of the Block lab and Program Project grant GM066275 for useful discussions. Our research was supported by grants from the National Institute of General Medical Sciences (GM057035) and the National Institute for Nanotechnology.