Ultrasound molecular imaging of atherosclerosis

Cardiovascular Research

Volumn 83, Issue 4, 2009, Pages 617-625

  Kaufmann, Beat A ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Atherosclerosis; Contrast; Molecular imaging; Ultrasound

Indexed keywords

VASCULAR CELL ADHESION MOLECULE 1;

ARTERY WALL; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; B SCAN; BIOMECHANICS; CONTRAST ENHANCEMENT; ECHOGRAPHY; HUMAN; IMAGE ANALYSIS; INTRAVASCULAR ULTRASOUND; MOLECULAR IMAGING; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; REVIEW; SCANNING ELECTRON MICROSCOPY;

ANIMALS; ARTERIES; ATHEROSCLEROSIS; BIOMECHANICS; CONTRAST MEDIA; HUMANS; MICROBUBBLES; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, FLUORESCENCE; NEOVASCULARIZATION, PATHOLOGIC;

EID: 68949097683     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp179     Document Type: Review

References (68)

1. Ford ES, Capewell S. Coronary heart disease mortality among young adults in the U.S. from 1980 through 2002: concealed leveling of mortality rates. J Am Coll Cardiol 2007;50:2128-2132.
2. Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K et al. Heart Disease and Stroke Statistics-2009 Update. A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009;119:480-486.
3. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002;288:1723-1727.
4. Ford ES, Giles WH, Mokdad AH. Increasing prevalence of the metabolic syndrome among US Adults. Diabetes Care 2004;27:2444-2449.
5. Jacobson TA, Griffiths GG, Varas C, Gause D, Sung JC, Ballantyne CM. Impact of evidence-based 'clinical judgment' on the number of American adults requiring lipid-lowering therapy based on updated NHANES III data. National Health and Nutrition Examination Survey. Arch Intern Med 2000; 160:1361-1369.
6. Stork S, van den Beld AW, von Schacky C, Angermann CE, Lamberts SW, Grobbee DE et al. Carotid artery plaque burden, stiffness, and mortality risk in elderly men: a prospective, population-based cohort study. Circulation 2004;110:344-348.
7. Chan SY, Mancini GB, Kuramoto L, Schulzer M, Frohlich J, Ignaszewski A. The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease. J Am Coll Cardiol 2003;42:1037-1043.
8. Chambless LE, Folsom AR, Davis V, Sharrett R, Heiss G, Sorlie P et al. Risk factors for progression of common carotid atherosclerosis: the Atherosclerosis Risk in Communities Study, 1987-1998. Am J Epidemiol 2002; 155:38-47.
9. Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities [ARIC] Study, 1987-1993. Am J Epidemiol 1997;146: 483-494.
10. Chambless LE, Folsom AR, Clegg LX, Sharrett AR, Shahar E, Nieto FJ et al. Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities [ARIC] study. Am J Epidemiol 2000;151: 478-487.
11. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999;340:14-22.
12. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997;96:1432-1437.
13. Taylor AJ, Kent SM, Flaherty PJ, Coyle LC, Markwood TT, Vernalis MN. ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness. Circulation 2002;106:2055-2060.
14. Taylor AJ, Sullenberger LE, Lee HJ, Lee JK, Grace KA. Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol [ARBITER] 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation 2004;110:3512-3517.
15. Hedblad B, Wikstrand J, Janzon L, Wedel H, Berglund G. Low-dose metoprolol CR/XL and fluvastatin slow progression of carotid intima-media thickness: main results from the Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS). Circulation 2001;103: 1721-1726.
16. Wiklund O, Hulthe J, Wikstrand J, Schmidt C, Olofsson SO, Bondjers G. Effect of controlled release/extended release metoprolol on carotid intima-media thickness in patients with hypercholesterolemia: a 3-year randomized study. Stroke 2002;33:572-577.
17. Pitt B, Byington RP, Furberg CD, Hunninghake DB, Mancini GB, Miller ME et al. Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. PREVENT Investigators. Circulation 2000;102:1503-1510.
18. Smilde TJ, van WS, Wollersheim H, Trip MD, Kastelein JJ, Stalenhoef AF. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet 2001;357:577-581.
19. Potkin BN, Bartorelli AL, Gessert JM, Neville RF, Almagor Y, Roberts WC et al. Coronary artery imaging with intravascular high-frequency ultrasound. Circulation 1990;81:1575-1585.
20. Nishimura RA, Edwards WD, Warnes CA, Reeder GS, Holmes DR, Tajik AJ et al. Intravascular ultrasound imaging: in vitro validation and pathologic correlation. J Am Coll Cardiol 1990;16:145-154.
21. Yamagishi M, Terashima M, Awano K, Kijima M, Nakatani S, Daikoku S et al. Morphology of vulnerable coronary plaque: insights from follow-up of patients examined by intravascular ultrasound before an acute coronary syndrome. J Am Coll Cardiol 2000;35:106-111.
22. Schoenhagen P, Stone GW, Nissen SE, Grines CL, Griffin J, Clemson BS et al. Coronary plaque morphology and frequency of ulceration distant from culprit lesions in patients with unstable and stable presentation. Arterioscler Thromb Vasc Biol 2003;23:1895-1900.
23. Kawasaki M, Takatsu H, Noda T, Sano K, Ito Y, Hayakawa K et al. In vivo quantitative tissue characterization of human coronary arterial plaques by use of integrated backscatter intravascular ultrasound and comparison with angioscopic findings. Circulation 2002;105:2487-2492.
24. Nair A, Kuban BD, Obuchowski N, Vince DG. Assessing spectral algorithms to predict atherosclerotic plaque composition with normalized and raw intravascular ultrasound data. Ultrasound Med Biol 2001;27:1319- 1331.
25. Nair A, Kuban BD, Tuzcu EM, Schoenhagen P, Nissen SE, Vince DG. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation 2002;106:2200-2206.
26. Nasu K, Tsuchikane E, Katoh O, Vince DG, Virmani R, Surmely JF et al. Accuracy of in vivo coronary plaque morphology assessment: a validation study of in vivo virtual histology compared with in vitro histopathology. J Am Coll Cardiol 2006;47:2405-2412.
27. Granada JF, Wallace-Bradley D, Win HK, Alviar CL, Builes A, Lev EI et al. In vivo plaque characterization using intravascular ultrasound-virtual histology in a porcine model of complex coronary lesions. Arterioscler Thromb Vasc Biol 2007;27:387-393.
28. Lee RT, Grodzinsky AJ, Frank EH, Kamm RD, Schoen FJ. Structure-dependent dynamic mechanical behavior of fibrous caps from human atherosclerotic plaques. Circulation 1991;83:1764-1770.
29. Hunziker PR, Imsand C, Keller D, Hess N, Barbosa V, Nietlisbach F et al. Bedside quantification of atherosclerosis severity for cardiovascular risk stratification: a prospective cohort study. J Am Coll Cardiol 2002;39: 702-709.
30. de Korte CL, van der Steen AF, Cespedes EI, Pasterkamp G. Intravascular ultrasound elastography in human arteries: initial experience in vitro. Ultrasound Med Biol 1998;24:401-408.
31. Schaar JA, de Korte CL, Mastik F, Strijder C, Pasterkamp G, Boersma E et al. Characterizing vulnerable plaque features with intravascular elastography. Circulation 2003;108:2636-2641.
32. Schaar JA, Regar E, Mastik F, McFadden EP, Saia F, Disco C et al. Incidence of high-strain patterns in human coronary arteries: assessment with three-dimensional intravascular palpography and correlation with clinical presentation. Circulation 2004;109:2716-2719.
33. Schaar JA, van der Steen AF, Mastik F, Baldewsing RA, Serruys PW. Intravascular palpography for vulnerable plaque assessment. J Am Coll Cardiol 2006;47:C86-C91.
34. Maurice RL, Soulez G, Giroux MF, Cloutier G. Noninvasive vascular elastography for carotid artery characterization on subjects without previous history of atherosclerosis. Med Phys 2008;35:3436-3443.
35. Schmitt C, Soulez G, Maurice RL, Giroux MF, Cloutier G. Noninvasive vascular elastography: toward a complementary characterization tool of atherosclerosis in carotid arteries. Ultrasound Med Biol 2007;33: 1841-1858.
36. Moreno PR, Purushothaman KR, Fuster V, Echeverri D, Truszczynska H, Sharma SK et al. Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability. Circulation 2004;110:2032-2038.
37. Vicenzini E, Giannoni MF, Puccinelli F, Ricciardi MC, Altieri M, DiPiero V et al. Detection of carotid adventitial vasa vasorum and plaque vascularization with ultrasound cadence contrast pulse sequencing technique and echo-contrast agent. Stroke 2007;38:2841-2843.
38. Coli S, Magnoni M, Sangiorgi G, Morrocco-Trischitta MM, Melisurgo G, Mauriello A et al. Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity. J Am Coll Cardiol 2008;52:223-230.
39. Goertz DE, Frijlink ME, Tempel D, van Damme LC, Krams R, Schaar JA et al. Contrast harmonic intravascular ultrasound: a feasibility study for vasa vasorum imaging. Invest Radiol 2006;41:631-638.
40. Christiansen JP, Leong-Poi H, Klibanov AL, Kaul S, Lindner JR. Noninvasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography. Circulation 2002;105:1764-1767.
41. Lindner JR, Song J, Christiansen J, Klibanov AL, Xu F, Ley K. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation 2001;104:2107-2112.
42. Lankford M, Behm CZ, Yeh J, Klibanov AL, Robinson P, Lindner JR. Effect of microbubble ligation to cells on ultrasound signal enhancement: implications for targeted imaging. Invest Radiol 2006;41:721-728.
43. Jayaweera AR, Edwards N, Glasheen WP, Villanueva FS, Abbott RD, Kaul S. In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography. Comparison with radio-labeled red blood cells. Circ Res 1994;74:1157-1165.
44. Hamilton AJ, Huang SL, Warnick D, Rabbat M, Kane B, Nagaraj A et al. Intravascular ultrasound molecular imaging of atheroma components in vivo. J Am Coll Cardiol 2004;43:453-460.
45. Lanza GM, Abendschein DR, Hall CS, Marsh JN, Scott MJ, Scherrer DE et al. Molecular imaging of stretch-induced tissue factor expression in carotid arteries with intravascular ultrasound. Invest Radiol 2000;35: 227-234.
46. Yang J, Hirata T, Croce K, Merrill-Skoloff G, Tchernychev B, Williams E et al. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 [PSGL-1] is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration. J Exp Med 1999; 190:1769-1782.
47. Shimizu M, Kohara S, Yamamoto M, Ando Y, Haida M, Shinohara Y. Significant relationship between platelet activation and intra-media thickness of the carotid artery in patients with ischemic cerebrovascular disease. Thromb Res 2006;117:647-652.
48. Ramos CL, Huo Y, Jung U, Ghosh S, Manka DR, Sarembock IJ et al. Direct demonstration of P-Selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein e-deficient mice. Circ Res 1999;84:1237-1244.
49. Dansky HM, Barlow CB, Lominska C, Sikes JL, Kao C, Weinsaft J et al. Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage. Arterioscler Thromb Vasc Biol 2001;21:1662-1667.
50. Walpola PL, Gotlieb AI, Cybulsky MI, Langille BL. Expression of ICAM-1 and VCAM-1 and monocyte adherence in arteries exposed to altered shear stress. Arterioscler Thromb Vasc Biol 1995;15:2-10.
51. Iiyama K, Hajra L, Iiyama M, Li H, DiChiara M, Medoff BD et al. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res 1999;85:199-207.
52. Nakashima Y, Raines EW, Plump AS, Breslow JL, Ross R. Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler Thromb Vasc Biol 1998;18: 842-851.
53. Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, Iiyama M et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001; 107:1255-1262.
54. Steffel J, Luscher TF, Tanner FC. Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications. Circulation 2006;113: 722-731.
55. Marmur JD, Thiruvikraman SV, Fyfe BS, Guha A, Sharma SK, Ambrose JA et al. Identification of active tissue factor in human coronary atheroma. Circulation 1996;94:1226-1232.
56. Leong-Poi H, Christiansen J, Heppner P, Lewis CW, Klibanov AL, Kaul S et al. Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Circulation 2005;111:3248-3254.
57. Behm CZ, Kaufmann BA, Carr C, Lankford M, Sanders JM, Rose CE et al. Molecular imaging of endothelial vascular cell adhesion molecule-1 expression and inflammatory cell recruitment during vasculogenesis and ischemia-mediated arteriogenesis. Circulation 2008;117: 2902-2911.
58. Willmann JK, Paulmurugan R, Chen K, Gheysens O, Rodriguez-Porcel M, Lutz AM et al. US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. Radiology 2008;246:508-518.
59. Kaufmann BA, Lewis C, Xie A, Mirza-Mohd A, Lindner JR. Detection of recent myocardial ischaemia by molecular imaging of P-selectin with targeted contrast echocardiography. Eur Heart J 2007;28:2011-2017.
60. Eriksson EE, Werr J, Guo Y, Thoren P, Lindbom L. Direct observations in vivo on the role of endothelial selectins and alpha[4] integrin in cytokine-induced leukocyte-endothelium interactions in the mouse aorta. Circ Res 2000;86:526-533.
61. Greve JM, Les AS, Tang BT, Draney Blomme MT, Wilson NM, Dalman RL et al. Allometric scaling of wall shear stress from mice to humans: quantification using cine phase-contrast MRI and computational fluid dynamics. Am J Physiol Heart Circ Physiol 2006;291:H1700-H1708.
62. Takalkar AM, Klibanov AL, Rychak JJ, Lindner JR, Ley K. Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow. J Control Release 2004;96:473-482.
63. Kaufmann BA, Sanders JM, Davis C, Xie A, Aldred P, Sarembock IJ et al. Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1. Circulation 2007; 116:276-284.
64. Lindner JR, Coggins MP, Kaul S, Klibanov AL, Brandenburger GH, Ley K. Microbubble persistence in the microcirculation during ischemia/ reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes. Circulation 2000;101: 668-675.
65. Tsutsui JM, Xie F, Cano M, Chomas J, Philipps P, Radio SJ et al. Detection of retained microbubbles in carotid arteries with real-time low mechanical index imaging in the setting of endothelial dysfunction. J Am Coll Cardiol 2004;44:1036-1046.
66. Anderson DR, Tsutsui JM, Xie F, Radio SJ, Porter TR. The role of complement in the adherence of microbubbles to dysfunctional arterial endothelium and atherosclerotic plaque. Cardiovasc Res 2007;73: 597-606.
67. Villanueva FS, Jankowski RJ, Klibanov S, Pina ML, Alber SM, Watkins SC et al. Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation 1998;98:1-5.
68. Nasu K, Tsuchikane E, Katoh O, Fujita H, Surmely JF, Ehara M et al. Plaque characterisation by virtual histology intravascular ultrasound analysis in patients with type 2 diabetes. Heart 2008;94:429-433.