Effect of microbubble ligation to cells on ultrasound signal enhancement: Implications for targeted imaging

Investigative Radiology

Volumn 41, Issue 10, 2006, Pages 721-728

  Lankford, Miles ^a   Behm, Carolyn Z ^a   Yeh, James ^b   Klibanov, Alexander L ^a   Robinson, Peter ^a   Lindner, Jonathan R ^c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Contrast ultrasound; Microbubbles; Molecular imaging

Indexed keywords

METHACRYLIC ACID; STREPTAVIDIN; VASCULAR CELL ADHESION MOLECULE 1;

ACOUSTICS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; CELL SURFACE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DENSITY; ECHOGRAPHY; ENDOTHELIUM CELL; IMAGE ENHANCEMENT; IMAGING; IN VITRO STUDY; MICROBUBBLE; MOLECULAR IMAGING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLID; ULTRASOUND;

EID: 33748743436     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.rli.0000236825.72344.a9     Document Type: Article

References (20)

1. Lindner JR. Molecular imaging with contrast ultrasound and targeted microbubbles. J Nucl Cardiol. 2004;11:215-221.
2. Lindner JR, Song J, Christiansen J, et al. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation. 2001;104:2107-2112.
3. Lindner JR, Dayton PA, Coggins MP, et al. Non-invasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles. Circulation. 2000;102:531-538.
4. Dayton PA, Chomas JE, Lum A, et al. Optical and acoustical dynamics of microbubble contrast agents inside neutrophils. Biophys J. 2001;80:1547-1556.
5. Dayton PA, Pearson D, Clark J, et al. Ultrasonic analysis of peptide- and antibody-targeted microbubble contrast agents for molecular imaging of αvβ3-expressing cells. Mol Imag. 2004;3:125-134.
6. Lindner JR, Song J, Xu F, et al. Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation. 2000;102:2745-2750.
7. Simpson DH, Burns PN. Pulse inversion Doppler: a new method for detecting non-linear echos from microbubble contrast agents. Proc IEEE Ultrason Symp. 1997;1597-1600.
8. Dawson D, Vincent MA, Clarke A, et al. Assessment of capillary recruitment in skeletal muscle using contrast-enhanced ultrasound. Am J Physiol. 2002;282:E714-E720.
9. Vincent MA, Clerk LH, Barrett EJ, et al. Microvascular responses to acute insulin are abnormal in type-2 diabetes and are reversed by ACE-inhibitor therapy: assessment of capillary recruitment by contrast ultrasound. J Am Soc Echocardiogr. 2005;18:500.
10. Morgan KE, Allen JS, Dayton PA, et al. Experimental and theoretical evaluation of microbubble behavior: effect of transmitted phase and bubble size. IEEE Trans Ultrason Ferroelect Freq Contr. 2000;47:1491-1504.
11. Chapman RB, Plesset MS. Thermal effects in the free oscillation of gas bubbles. ASME J Basic Eng. 1971;93:373-376.
12. Sarkar K, Shi WT, Chatterjee D, et al. Characterization of ultrasound contrast microbubbles using in vitro experiments and viscous and viscoelastic interface models for encapsulation. J Acoust Soc Am. 2005;118:539-550.
13. Church CC. The effects of an elastic solid surface layer on the radial pulsations of gas bubbles. J Acoust Soc Am. 1995;97:1510.
14. Khismatullin DB, Nadim A. Radial oscillations of encapsulated microbubbles in viscoelastic liquids. Phys Fluids. 2002;14:3534-3557.
15. van Wamel A, Bouakaz A, Versluis M, et al. Micromanipulation of endothelial cells: ultrasound-microbubble-cell interaction. Ultrasound Med Biol. 2004;30:1255-1258.
16. Epstein PS, Plesset MS. On the stability of gas bubbles in liquid-gas solutions. J Chem Phys. 1950;18:1505-1509.
17. Weinberg MC, Onorato PIK, Ulmann DR. Behavior of bubbles in glassmelts: I, dissolution of stationary bubble containing a single gas. J Am Ceram Soc. 1980;63:175-180.
18. Jaffer FA, Libby P, Weissleder R. Molecular and cellular imaging of atherosclerosis. J Am Coll Cardiol. 2006;47:1328-1338.
19. Hamilton AJ, Huang SL, Warnick D, et al. Intravascular ultrasound molecular imaging of atheroma components in vivo. J Am Coll Cardiol. 2004;43:453-460.
20. Davis C, Christiansen JP, Klibanov AL, et al. Microbubbles targeted to endothelial VCAM-1 adhere to atherosclerotic plaques at physiologic shear rates. Circulation. 2003;108(suppl):IV-624.