-
1
-
-
0035732841
-
Hepatocellular carcinoma: an Asian perspective
-
PID: 11935085, COI: 1:STN:280:DC%2BD383gtF2mtg%3D%3D
-
Teo EK, Fock KM: Hepatocellular carcinoma: an Asian perspective. Dig Dis 2001, 19:263–268.
-
(2001)
Dig Dis
, vol.19
, pp. 263-268
-
-
Teo, E.K.1
Fock, K.M.2
-
2
-
-
0034142193
-
Predictive factors for intrahepatic recurrence after percutaneous ethanol injection therapy for small hepatocellular carcinoma
-
PID: 10649243, COI: 1:STN:280:DC%2BD3c7hsFemtg%3D%3D
-
Koda M, Murawaki Y, Mitsuda A, et al.: Predictive factors for intrahepatic recurrence after percutaneous ethanol injection therapy for small hepatocellular carcinoma. Cancer 2000, 88:529–537.
-
(2000)
Cancer
, vol.88
, pp. 529-537
-
-
Koda, M.1
Murawaki, Y.2
Mitsuda, A.3
-
3
-
-
0035014082
-
Underlying liver disease, not tumor factors, predicts long-term survival after resection of hepatocellular carcinoma
-
PID: 11343543, COI: 1:STN:280:DC%2BD3Mzht1Ogug%3D%3D
-
Bilimoria MM, Lauwers GY, Doherty DA, et al.: Underlying liver disease, not tumor factors, predicts long-term survival after resection of hepatocellular carcinoma. Arch Surg 2001, 136:528–535.
-
(2001)
Arch Surg
, vol.136
, pp. 528-535
-
-
Bilimoria, M.M.1
Lauwers, G.Y.2
Doherty, D.A.3
-
4
-
-
0036120412
-
Eight-year follow-up of the 90,000-person Haimen City cohort: I. Hepatocellular carcinoma mortality, risk factors, and gender differences
-
PID: 11927497, This prospective cohort study of 58,545 men and 25,340 women identified HBV infection as the primary risk factor for HCC mortality this Haimen City, China cohort
-
Evans AA, Chen G, Ross EA, et al.: Eight-year follow-up of the 90,000-person Haimen City cohort: I. Hepatocellular carcinoma mortality, risk factors, and gender differences. Cancer Epidemiol Biomarkers Prev 2002, 11:369–376. This prospective cohort study of 58,545 men and 25,340 women identified HBV infection as the primary risk factor for HCC mortality in this Haimen City, China cohort.
-
(2002)
Cancer Epidemiol Biomarkers Prev
, vol.11
, pp. 369-376
-
-
Evans, A.A.1
Chen, G.2
Ross, E.A.3
-
5
-
-
0036293899
-
Hepatocellular carcinoma associated with hepatitis C virus infection in Japan: projection to other countries in the foreseeable future
-
PID: 11868791
-
Yoshizawa H: Hepatocellular carcinoma associated with hepatitis C virus infection in Japan: projection to other countries in the foreseeable future. Oncology 2002, 62(suppl 1):8–17.
-
(2002)
Oncology
, vol.62
, pp. 8-17
-
-
Yoshizawa, H.1
-
6
-
-
0034650148
-
Prospective study of hepatitis B and C viral infections, cigarette smoking, alcohol consumption, and other factors associated with hepatocellular carcinoma risk in Japan
-
PID: 10645815, COI: 1:STN:280:DC%2BD3c7gvVCisQ%3D%3D
-
Mori M, Hara M, Wada I, et al.: Prospective study of hepatitis B and C viral infections, cigarette smoking, alcohol consumption, and other factors associated with hepatocellular carcinoma risk in Japan. Am J Epidemiol 2000, 151:131–139.
-
(2000)
Am J Epidemiol
, vol.151
, pp. 131-139
-
-
Mori, M.1
Hara, M.2
Wada, I.3
-
7
-
-
0035731768
-
Hepatocellular carcinoma in southern Germany: epidemiological and clinicopathological characteristics and risk factors
-
PID: 11935095, COI: 1:STN:280:DC%2BD383gtF2ltg%3D%3D
-
Hellerbrand C, Hartmann A, Richter G, et al.: Hepatocellular carcinoma in southern Germany: epidemiological and clinicopathological characteristics and risk factors. Dig Dis 2001, 19:345–351.
-
(2001)
Dig Dis
, vol.19
, pp. 345-351
-
-
Hellerbrand, C.1
Hartmann, A.2
Richter, G.3
-
8
-
-
0034793847
-
The epidemiology and prevention of hepatocellular carcinoma
-
PID: 11685737, COI: 1:STN:280:DC%2BD3MngvVOhtw%3D%3D
-
Monto A, Wright TL: The epidemiology and prevention of hepatocellular carcinoma. Semin Oncol 2001, 28:441–449.
-
(2001)
Semin Oncol
, vol.28
, pp. 441-449
-
-
Monto, A.1
Wright, T.L.2
-
9
-
-
0037137875
-
Recent updates in hepatitis vaccination and the prevention of hepatocellular carcinoma
-
PID: 11774275, COI: 1:CAS:528:DC%2BD38XhvVWmuw%3D%3D
-
Kao JH, Chen DS: Recent updates in hepatitis vaccination and the prevention of hepatocellular carcinoma. Int J Cancer 2002, 97:269–271.
-
(2002)
Int J Cancer
, vol.97
, pp. 269-271
-
-
Kao, J.H.1
Chen, D.S.2
-
10
-
-
0034772438
-
Immunoprophylaxis of hepatitis C virus infection
-
PID: 11685797, COI: 1:STN:280:DC%2BD3MnhtFyitg%3D%3D
-
Prince AM, Shata MT: Immunoprophylaxis of hepatitis C virus infection. Clin Liver Dis 2001, 5:1091–1103.
-
(2001)
Clin Liver Dis
, vol.5
, pp. 1091-1103
-
-
Prince, A.M.1
Shata, M.T.2
-
11
-
-
0034821605
-
Universal hepatitis B vaccination and the decreased mortality from fulminant hepatitis in infants in Taiwan
-
PID: 11562612, COI: 1:STN:280:DC%2BD3MrjvFKlsA%3D%3D
-
Kao JH, Hsu HM, Shau WY, et al.: Universal hepatitis B vaccination and the decreased mortality from fulminant hepatitis in infants in Taiwan. J Pediatr 2001, 139:349–352.
-
(2001)
J Pediatr
, vol.139
, pp. 349-352
-
-
Kao, J.H.1
Hsu, H.M.2
Shau, W.Y.3
-
12
-
-
0034694947
-
Hepatitis B vaccination and hepatocellular carcinoma rates in boys and girls
-
PID: 11122592, COI: 1:STN:280:DC%2BD3M%2FotVKisQ%3D%3D
-
Chang MH, Shau WY, Chen CJ, et al.: Hepatitis B vaccination and hepatocellular carcinoma rates in boys and girls. JAMA 2000, 284:3040–3042.
-
(2000)
JAMA
, vol.284
, pp. 3040-3042
-
-
Chang, M.H.1
Shau, W.Y.2
Chen, C.J.3
-
13
-
-
0034993211
-
Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after 3 years of therapy
-
PID: 11391543, COI: 1:CAS:528:DC%2BD3MXktlygtLc%3D
-
Leung NW, Lai CL, Chang TT, et al.: Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after 3 years of therapy. Hepatology 2001, 33:1527–1532.
-
(2001)
Hepatology
, vol.33
, pp. 1527-1532
-
-
Leung, N.W.1
Lai, C.L.2
Chang, T.T.3
-
14
-
-
0037181625
-
Vertical transmission of hepatitis B virus despite maternal lamivudine therapy
-
PID: 11988251
-
Kazim SN, Wakil SM, Khan LA, et al.: Vertical transmission of hepatitis B virus despite maternal lamivudine therapy. Lancet 2002, 359:1488–1489.
-
(2002)
Lancet
, vol.359
, pp. 1488-1489
-
-
Kazim, S.N.1
Wakil, S.M.2
Khan, L.A.3
-
15
-
-
0035139830
-
Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers
-
PID: 11164188, COI: 1:CAS:528:DC%2BD3MXnsVKntg%3D%3D
-
Cheng YC: Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers. Cancer Lett 2001, 162(suppl):S33-S37.
-
(2001)
Cancer Lett
, vol.162
, pp. S33-S37
-
-
Cheng, Y.C.1
-
16
-
-
0035084728
-
Antiviral activity of beta-L-2′,3′-dideoxy-2′,3′-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus
-
PID: 11257017
-
Le Guerhier F, Pichoud C, Jamard C, et al.: Antiviral activity of beta-L-2′,3′-dideoxy-2′,3′-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus. Antimicrob Agents Chemother 2001, 45:1065–1077.
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 1065-1077
-
-
Le Guerhier, F.1
Pichoud, C.2
Jamard, C.3
-
17
-
-
0035915622
-
Prevention of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrhosis
-
PID: 11213099, COI: 1:STN:280:DC%2BD3M7kvFCitQ%3D%3D, This prospective, randomized, controlled study of 90 chronic HCV patients found a protective effect of interferon α on HCC development and death (risk ratios vs symptomatic treatment, 0.256 and 0.135, respectively) after 8.7 years of follow-up
-
Nishiguchi S, Shiomi S, Nakatani S, et al.: Prevention of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrhosis. Lancet 2001, 357:196–197. This prospective, randomized, controlled study of 90 chronic HCV patients found a protective effect of interferon α on HCC development and death (risk ratios vs symptomatic treatment, 0.256 and 0.135, respectively) after 8.7 years of follow-up.
-
(2001)
Lancet
, vol.357
, pp. 196-197
-
-
Nishiguchi, S.1
Shiomi, S.2
Nakatani, S.3
-
18
-
-
0035042901
-
Long-term interferon therapy for 1 year or longer reduces the hepatocellular carcinogenesis rate in patients with liver cirrhosis caused by hepatitis C virus: a pilot study
-
PID: 11354279, COI: 1:CAS:528:DC%2BD3MXktVOiu7c%3D
-
Ikeda K, Saitoh S, Kobayashi M, et al.: Long-term interferon therapy for 1 year or longer reduces the hepatocellular carcinogenesis rate in patients with liver cirrhosis caused by hepatitis C virus: a pilot study. J Gastroenterol Hepatol 2001, 16:406–415.
-
(2001)
J Gastroenterol Hepatol
, vol.16
, pp. 406-415
-
-
Ikeda, K.1
Saitoh, S.2
Kobayashi, M.3
-
19
-
-
17944383158
-
Effect of the dose and duration of interferon-alpha therapy on the incidence of hepatocellular carcinoma in noncirrhotic patients with a nonsustained response to interferon for chronic hepatitis C
-
PID: 11528252, COI: 1:CAS:528:DC%2BD3MXntFKjtL8%3D
-
Toyoda H, Kumada T, Nakano S, et al.: Effect of the dose and duration of interferon-alpha therapy on the incidence of hepatocellular carcinoma in noncirrhotic patients with a nonsustained response to interferon for chronic hepatitis C. Oncology 2001, 61:134–142.
-
(2001)
Oncology
, vol.61
, pp. 134-142
-
-
Toyoda, H.1
Kumada, T.2
Nakano, S.3
-
20
-
-
0035037997
-
Effect of interferon therapy on the development of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis: a meta-analysis
-
PID: 11328263, COI: 1:CAS:528:DC%2BD3MXjslCjsLY%3D, This high-quality meta-analysis, which considered 11 studies with 2178 HCV patients, found a significant protective effect of interferon α on HCC development. Although the effect was most pronounced for sustained responders, a reduced HCC incidence nonresponders was also found
-
Papatheodoridis GV, Papadimitropoulos VC, Hadziyannis SJ: Effect of interferon therapy on the development of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis: a meta-analysis. Aliment Pharmacol Ther 2001, 15:689–698. This high-quality meta-analysis, which considered 11 studies with 2178 HCV patients, found a significant protective effect of interferon α on HCC development. Although the effect was most pronounced for sustained responders, a reduced HCC incidence in nonresponders was also found.
-
(2001)
Aliment Pharmacol Ther
, vol.15
, pp. 689-698
-
-
Papatheodoridis, G.V.1
Papadimitropoulos, V.C.2
Hadziyannis, S.J.3
-
21
-
-
0036147150
-
Interferon inhibits progression of liver fibrosis and reduces the risk of hepatocarcinogenesis in patients with chronic hepatitis C: a retrospective multicenter analysis of 652 patients
-
PID: 11837720, COI: 1:CAS:528:DC%2BD38XhsVGmsLc%3D
-
Takimoto M, Ohkoshi S, Ichida T, et al.: Interferon inhibits progression of liver fibrosis and reduces the risk of hepatocarcinogenesis in patients with chronic hepatitis C: a retrospective multicenter analysis of 652 patients. Dig Dis Sci 2002, 47:170–176.
-
(2002)
Dig Dis Sci
, vol.47
, pp. 170-176
-
-
Takimoto, M.1
Ohkoshi, S.2
Ichida, T.3
-
22
-
-
0035061788
-
Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: an evidence-based approach
-
PID: 11394661, COI: 1:CAS:528:DC%2BD3MXjvVerur4%3D, This excellent meta-analysis considered three randomized and 15 nonrandomized controlled trials including 4614 patients and comparing interferon α treatment with no treatment. A protective effect of interferon α HCV was identified, but the magnitude was low and related to response to interferon α. Interferon α did not affect HCC development HBV-related cirrhosis
-
Camma C, Giunta M, Andreone P, Craxi A: Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: an evidence-based approach. J Hepatol 2001, 34:593–602. This excellent meta-analysis considered three randomized and 15 nonrandomized controlled trials including 4614 patients and comparing interferon α treatment with no treatment. A protective effect of interferon α in HCV was identified, but the magnitude was low and related to response to interferon α. Interferon α did not affect HCC development in HBV-related cirrhosis.
-
(2001)
J Hepatol
, vol.34
, pp. 593-602
-
-
Camma, C.1
Giunta, M.2
Andreone, P.3
Craxi, A.4
-
23
-
-
0034962643
-
Long-term follow-up of interferon alfa treatment in Chinese patients with chronic hepatitis B infection: the effect on hepatitis B e antigen seroconversion and the development of cirrhosis-related complications
-
PID: 11431745, COI: 1:CAS:528:DC%2BD3MXltlKjsL4%3D
-
Yuen MF, Hui CK, Cheng CC, et al.: Long-term follow-up of interferon alfa treatment in Chinese patients with chronic hepatitis B infection: the effect on hepatitis B e antigen seroconversion and the development of cirrhosis-related complications. Hepatology 2001, 34:139–145.
-
(2001)
Hepatology
, vol.34
, pp. 139-145
-
-
Yuen, M.F.1
Hui, C.K.2
Cheng, C.C.3
-
24
-
-
0036289062
-
Long-term treatment of chronic hepatitis C with glycyrrhizin (stronger neo-minophagen C [SNMC]) for preventing liver cirrhosis and hepatocellular carcinoma
-
PID: 11868794, COI: 1:CAS:528:DC%2BD38Xot1SntA%3D%3D
-
Kumada H: Long-term treatment of chronic hepatitis C with glycyrrhizin (stronger neo-minophagen C [SNMC]) for preventing liver cirrhosis and hepatocellular carcinoma. Oncology 2002, 62(suppl 1):94–100.
-
(2002)
Oncology
, vol.62
, pp. 94-100
-
-
Kumada, H.1
-
25
-
-
0035654420
-
Study on chemoprevention of hepatocellular carcinoma by ginseng: an introduction to the protocol
-
The Ginseng-HCC Chemopreventive Study Osaka Group: Study on chemoprevention of hepatocellular carcinoma by ginseng: an introduction to the protocol. J Korean Med Sci 2001, 16(suppl):S70-S74.
-
(2001)
J Korean Med Sci
, vol.16
, pp. S70-S74
-
-
-
26
-
-
0034572785
-
Clinical and pharmacological studies on liver diseases treated with Kampo herbal medicine
-
PID: 11154048, COI: 1:STN:280:DC%2BD3M3kt1KrtA%3D%3D
-
Cyong JC, Ki SM, Iijima K, et al.: Clinical and pharmacological studies on liver diseases treated with Kampo herbal medicine. Am J Chin Med 2000, 28:351–360.
-
(2000)
Am J Chin Med
, vol.28
, pp. 351-360
-
-
Cyong, J.C.1
Ki, S.M.2
Iijima, K.3
-
27
-
-
0035702637
-
Chemoprevention of hepatocellular carcinoma: concept, progress and perspectives
-
PID: 11851828, COI: 1:CAS:528:DC%2BD38XhtlWjtrs%3D
-
Okuno M, Kojima S, Moriwaki H: Chemoprevention of hepatocellular carcinoma: concept, progress and perspectives. J Gastroenterol Hepatol 2001, 16:1329–1335.
-
(2001)
J Gastroenterol Hepatol
, vol.16
, pp. 1329-1335
-
-
Okuno, M.1
Kojima, S.2
Moriwaki, H.3
-
28
-
-
0035011152
-
In vivo inhibition of human CYP1A2 activity by oltipraz
-
PID: 11459203, COI: 1:CAS:528:DC%2BD3MXkt1aktb8%3D
-
Sofowora GG, Choo EF, Mayo G, et al.: In vivo inhibition of human CYP1A2 activity by oltipraz. Cancer Chemother Pharmacol 2001, 47:505–510.
-
(2001)
Cancer Chemother Pharmacol
, vol.47
, pp. 505-510
-
-
Sofowora, G.G.1
Choo, E.F.2
Mayo, G.3
-
29
-
-
0035798606
-
Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase: a new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase
-
PID: 11524419, COI: 1:CAS:528:DC%2BD3MXosVKhurc%3D, This study demonstrated a novel catalytic activity of NAD(P)H-dependent alkenal/one oxidoreductase (leukotriene B412-hydroxydehydrogenase): reduction of the α,β-carbon=carbon double bond of α,β-unsaturated aldehydes and ketones such as 4-hydroxy-2-nonenal. addition, forced overexpression of the enzyme protected cells from the toxicity of 4-hydroxy-2-nonenal, a major product of lipid peroxidation
-
Dick RA, Kwak MK, Sutter TR, Kensler TW: Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase: a new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase. J Biol Chem 2001, 276:40803–40810. This study demonstrated a novel catalytic activity of NAD(P)H-dependent alkenal/one oxidoreductase (leukotriene B412-hydroxydehydrogenase): reduction of the α,β-carbon=carbon double bond of α,β-unsaturated aldehydes and ketones such as 4-hydroxy-2-nonenal. In addition, forced overexpression of the enzyme protected cells from the toxicity of 4-hydroxy-2-nonenal, a major product of lipid peroxidation.
-
(2001)
J Biol Chem
, vol.276
, pp. 40803-40810
-
-
Dick, R.A.1
Kwak, M.K.2
Sutter, T.R.3
Kensler, T.W.4
-
30
-
-
0035260034
-
Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione
-
PID: 11471548, COI: 1:CAS:528:DC%2BD3MXitlKms7g%3D, This investigation characterized the expression patterns of over a dozen genes inducible by 3H-1,2-dithiole-3-thione both wild-type and nrf2-disrupted mice. Nrf2 was found to play a central regulatory role the constitutive and dithiolthione-inducible expression of multiple phase 2 and antioxidative enzymes
-
Kwak MK, Itoh K, Yamamoto M, et al.: Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione. Mol Med 2001, 7:135–145. This investigation characterized the expression patterns of over a dozen genes inducible by 3H-1,2-dithiole-3-thione in both wild-type and nrf2-disrupted mice. Nrf2 was found to play a central regulatory role in the constitutive and dithiolthione-inducible expression of multiple phase 2 and antioxidative enzymes.
-
(2001)
Mol Med
, vol.7
, pp. 135-145
-
-
Kwak, M.K.1
Itoh, K.2
Yamamoto, M.3
-
31
-
-
0035807837
-
Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer
-
PID: 11724948, COI: 1:CAS:528:DC%2BD3MXptFCksL0%3D, This double-blind, placebo-controlled study of chlorophyllin (100 mg three times a day for 4 months) 180 residents of Qidong, People’s Republic of China, demonstrated a 55% reduction urinary aflatoxin-DNA adducts (P=0.036
-
Egner PA, Wang JB, Zhu YR, et al.: Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Proc Natl Acad Sci U S A 2001, 98:14601–14606. This double-blind, placebo-controlled study of chlorophyllin (100 mg three times a day for 4 months) in 180 residents of Qidong, People’s Republic of China, demonstrated a 55% reduction in urinary aflatoxin-DNA adducts (P=0.036).
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 14601-14606
-
-
Egner, P.A.1
Wang, J.B.2
Zhu, Y.R.3
-
32
-
-
0034940451
-
Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats
-
PID: 11453740, COI: 1:CAS:528:DC%2BD3MXks1Sgtrk%3D
-
Walton M, Egner P, Scholl PF, et al.: Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats. Chem Res Toxicol 2001, 14:919–926.
-
(2001)
Chem Res Toxicol
, vol.14
, pp. 919-926
-
-
Walton, M.1
Egner, P.2
Scholl, P.F.3
-
33
-
-
0035122919
-
Suppression of chemical carcinogenesis by water-soluble organosulfur compounds
-
PID: 11238814, COI: 1:CAS:528:DC%2BD3MXhvVOiu7o%3D
-
Fukushima S, Takada N, Wanibuchi H, et al.: Suppression of chemical carcinogenesis by water-soluble organosulfur compounds. J Nutr 2001, 131:1049S-1053S.
-
(2001)
J Nutr
, vol.131
, pp. 1049S-1053S
-
-
Fukushima, S.1
Takada, N.2
Wanibuchi, H.3
-
34
-
-
0034524417
-
Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats
-
PID: 11133813, COI: 1:CAS:528:DC%2BD3MXmsFykug%3D%3D
-
Yang CF, Liu J, Wasser S, et al.: Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis 2000, 21:2237–2243.
-
(2000)
Carcinogenesis
, vol.21
, pp. 2237-2243
-
-
Yang, C.F.1
Liu, J.2
Wasser, S.3
-
35
-
-
0034929422
-
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats
-
PID: 11429047, COI: 1:CAS:528:DC%2BD3MXlslOitr0%3D
-
Watanabe T, Sugie S, Okamoto K, et al.: Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. Jpn J Cancer Res 2001, 92:603–609.
-
(2001)
Jpn J Cancer Res
, vol.92
, pp. 603-609
-
-
Watanabe, T.1
Sugie, S.2
Okamoto, K.3
-
36
-
-
0034465205
-
Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv
-
PID: 11277323, COI: 1:CAS:528:DC%2BD3MXhsFGkt7c%3D
-
Rajeshkumar NV, Kuttan R: Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv. J Exp Clin Cancer Res 2000, 19:459–465.
-
(2000)
J Exp Clin Cancer Res
, vol.19
, pp. 459-465
-
-
Rajeshkumar, N.V.1
Kuttan, R.2
-
37
-
-
0035099029
-
Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats
-
PID: 11259848, COI: 1:CAS:528:DC%2BD3MXhvFKisr8%3D
-
Ahmed S, Rahman A, Mathur M, et al.: Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats. Food Chem Toxicol 2001, 39:19–28.
-
(2001)
Food Chem Toxicol
, vol.39
, pp. 19-28
-
-
Ahmed, S.1
Rahman, A.2
Mathur, M.3
-
38
-
-
0035827136
-
Protection of salvia miltiorrhiza against aflatoxin-B1-induced hepatocarcinogenesis in Fischer 344 rats dual mechanisms involved
-
PID: 11441922, COI: 1:CAS:528:DC%2BD3MXktlOku7c%3D
-
Liu J, Yang CF, Wasser S, et al.: Protection of salvia miltiorrhiza against aflatoxin-B1-induced hepatocarcinogenesis in Fischer 344 rats dual mechanisms involved. Life Sci 2001, 69:309–326.
-
(2001)
Life Sci
, vol.69
, pp. 309-326
-
-
Liu, J.1
Yang, C.F.2
Wasser, S.3
-
39
-
-
0034778038
-
Preventive effect of FK143, a 5alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats
-
PID: 11448929, COI: 1:CAS:528:DC%2BD3MXlslalu7c%3D
-
Maruyama S, Nagasue N, Dhar DK, et al.: Preventive effect of FK143, a 5alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats. Clin Cancer Res 2001, 7:2096–2104.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2096-2104
-
-
Maruyama, S.1
Nagasue, N.2
Dhar, D.K.3
-
40
-
-
0034351134
-
Chemoprevention of aflatoxin B1-initiated and carbon tetrachloride-promoted hepatocarcinogenesis in the rat by green tea
-
PID: 11525600, COI: 1:CAS:528:DC%2BD3MXmsF2hs7c%3D
-
Qin G, Ning Y, Lotlikar PD: Chemoprevention of aflatoxin B1-initiated and carbon tetrachloride-promoted hepatocarcinogenesis in the rat by green tea. Nutr Cancer 2000, 38:215–222.
-
(2000)
Nutr Cancer
, vol.38
, pp. 215-222
-
-
Qin, G.1
Ning, Y.2
Lotlikar, P.D.3
-
41
-
-
0035002593
-
Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene
-
PID: 11346485, COI: 1:CAS:528:DC%2BD3MXjtleqsLY%3D
-
Hosaka S, Kawa S, Aoki Y, et al.: Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene. Food Chem Toxicol 2001, 39:557–561.
-
(2001)
Food Chem Toxicol
, vol.39
, pp. 557-561
-
-
Hosaka, S.1
Kawa, S.2
Aoki, Y.3
-
42
-
-
0035427196
-
Inhibition by d-limonene of experimental hepatocarcinogenesis in Sprague-Dawley rats does not involve p21(ras) plasma membrane association
-
PID: 11433412, COI: 1:CAS:528:DC%2BD3MXlt12gsbc%3D
-
Kaji I, Tatsuta M, Iishi H, et al.: Inhibition by d-limonene of experimental hepatocarcinogenesis in Sprague-Dawley rats does not involve p21(ras) plasma membrane association. Int J Cancer 2001, 93:441–444.
-
(2001)
Int J Cancer
, vol.93
, pp. 441-444
-
-
Kaji, I.1
Tatsuta, M.2
Iishi, H.3
-
43
-
-
0034760007
-
Effect of alphatocopherol on hepatocarcinogenesis in transforming growth factor-alpha (TGF-alpha) transgenic mice treated with diethylnitrosamine
-
PID: 11725690, COI: 1:CAS:528:DC%2BD3MXptFKrs7g%3D
-
Kakizaki S, Takagi H, Fukusato T, et al.: Effect of alphatocopherol on hepatocarcinogenesis in transforming growth factor-alpha (TGF-alpha) transgenic mice treated with diethylnitrosamine. Int J Vitam Nutr Res 2001, 71:261–267.
-
(2001)
Int J Vitam Nutr Res
, vol.71
, pp. 261-267
-
-
Kakizaki, S.1
Takagi, H.2
Fukusato, T.3
-
44
-
-
0035047448
-
1 alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesis
-
PID: 11241675, COI: 1:CAS:528:DC%2BD3MXivVKgsbc%3D
-
Basak R, Bhattacharya R, Chatterjee M: 1 alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesis. J Cell Biochem 2001, 81:357–367.
-
(2001)
J Cell Biochem
, vol.81
, pp. 357-367
-
-
Basak, R.1
Bhattacharya, R.2
Chatterjee, M.3
-
45
-
-
0035237561
-
Vitamin A and alltrans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats
-
PID: 11759288, COI: 1:CAS:528:DC%2BD3MXpt1WhtL8%3D
-
Silveira ER, Naves MM, Vannucchi H, et al.: Vitamin A and alltrans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats. Nutr Cancer 2001, 39:244–251.
-
(2001)
Nutr Cancer
, vol.39
, pp. 244-251
-
-
Silveira, E.R.1
Naves, M.M.2
Vannucchi, H.3
-
46
-
-
0035137702
-
Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry
-
PID: 11196182, COI: 1:CAS:528:DC%2BD3MXlsl2nug%3D%3D
-
Jackson PE, Qian GS, Friesen MD, et al.: Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry. Cancer Res 2001, 61:33–35.
-
(2001)
Cancer Res
, vol.61
, pp. 33-35
-
-
Jackson, P.E.1
Qian, G.S.2
Friesen, M.D.3
-
47
-
-
0035950534
-
INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas
-
PID: 11704835, COI: 1:CAS:528:DC%2BD3MXotlCgu78%3D
-
Tannapfel A, Busse C, Weinans L, et al.: INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas. Oncogene 2001, 20:7104–7109.
-
(2001)
Oncogene
, vol.20
, pp. 7104-7109
-
-
Tannapfel, A.1
Busse, C.2
Weinans, L.3
-
48
-
-
17844387825
-
Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas
-
PID: 11408803, COI: 1:CAS:528:DC%2BD3MXlsFShtb0%3D
-
Azechi H, Nishida N, Fukuda Y, et al.: Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas. Oncology 2001, 60:346–354.
-
(2001)
Oncology
, vol.60
, pp. 346-354
-
-
Azechi, H.1
Nishida, N.2
Fukuda, Y.3
-
49
-
-
0035056507
-
Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus
-
PID: 11171828, COI: 1:CAS:528:DC%2BD3MXitlCjur0%3D
-
Kaneto H, Sasaki S, Yamamoto H, et al.: Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus. Gut 2001, 48:372–377.
-
(2001)
Gut
, vol.48
, pp. 372-377
-
-
Kaneto, H.1
Sasaki, S.2
Yamamoto, H.3
-
50
-
-
0035159977
-
The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility
-
PID: 11698349, COI: 1:CAS:528:DC%2BD3MXosV2msbs%3D
-
Bugni JM, Poole TM, Drinkwater NR: The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility. Carcinogenesis 2001, 22:1853–1862.
-
(2001)
Carcinogenesis
, vol.22
, pp. 1853-1862
-
-
Bugni, J.M.1
Poole, T.M.2
Drinkwater, N.R.3
-
51
-
-
0035375014
-
Lack of p53 accelerates hepatocarcinogenesis in transgenic mice constitutively overexpressing c-myc in the liver
-
PID: 11387238, COI: 1:CAS:528:DC%2BD3MXlvVersrc%3D
-
Klocke R, Bartels T, Jennings G, et al.: Lack of p53 accelerates hepatocarcinogenesis in transgenic mice constitutively overexpressing c-myc in the liver. FASEB J 2001, 15:1404–1406.
-
(2001)
FASEB J
, vol.15
, pp. 1404-1406
-
-
Klocke, R.1
Bartels, T.2
Jennings, G.3
-
52
-
-
0034852454
-
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3
-
PID: 11514734, COI: 1:CAS:528:DC%2BD3MXmslSktbY%3D
-
Kwun HJ, Jung EY, Ahn JY, et al.: p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3. J Gen Virol 2001, 82:2235–2241.
-
(2001)
J Gen Virol
, vol.82
, pp. 2235-2241
-
-
Kwun, H.J.1
Jung, E.Y.2
Ahn, J.Y.3
-
53
-
-
0035674620
-
Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats
-
PID: 11749691, COI: 1:CAS:528:DC%2BD38XhtV2jt7s%3D
-
Hatanaka Y, Nakae D, Mutai M, et al.: Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats. Jpn J Cancer Res 2001, 92:1270–1277.
-
(2001)
Jpn J Cancer Res
, vol.92
, pp. 1270-1277
-
-
Hatanaka, Y.1
Nakae, D.2
Mutai, M.3
-
54
-
-
0034891659
-
Transfer of bcl-xs plasmid is effective in preventing and inhibiting rat hepatocellular carcinoma induced by N-nitrosomorpholine
-
PID: 11509945, COI: 1:CAS:528:DC%2BD3MXlvVSlsb0%3D
-
Baba M, Iishi H, Tatsuta M: Transfer of bcl-xs plasmid is effective in preventing and inhibiting rat hepatocellular carcinoma induced by N-nitrosomorpholine. Gene Ther 2001, 8:1149–1156.
-
(2001)
Gene Ther
, vol.8
, pp. 1149-1156
-
-
Baba, M.1
Iishi, H.2
Tatsuta, M.3
-
55
-
-
0034765595
-
Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene
-
PID: 11677206, COI: 1:CAS:528:DC%2BD3MXpt1Srsb8%3D, This German case-control study involved 59 cancer patients and 70 control subjects. The uridine 5′-diphosphate-glucuroyltransferase allele UGT1A7*3, which encodes a protein with low carcinogen detoxification activity, was significantly associated with HCC
-
Vogel A, Kneip S, Barut A, et al.: Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene. Gastroenterology 2001, 121:1136–1144. This German case-control study involved 59 cancer patients and 70 control subjects. The uridine 5′-diphosphate-glucuronosyltransferase allele UGT1A7*3, which encodes a protein with low carcinogen detoxification activity, was significantly associated with HCC.
-
(2001)
Gastroenterology
, vol.121
, pp. 1136-1144
-
-
Vogel, A.1
Kneip, S.2
Barut, A.3
-
56
-
-
0034897931
-
Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan
-
PID: 11470760, COI: 1:CAS:528:DC%2BD3MXlvVSqu7o%3D, This Taiwanese case-control study of chronic HBV carriers involved 79 HCC patients and 149 control subjects. A statistically significant correlation between HCC risk and serum AFB1-albumin adducts was found. addition, the effect of aflatoxin exposure on HCC risk was more pronounced among HBV carriers with the GSTT1 null genotype (P=0.03
-
Sun CA, Wang LY, Chen CJ, et al.: Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan. Carcinogenesis 2001, 22:1289–1294. This Taiwanese case-control study of chronic HBV carriers involved 79 HCC patients and 149 control subjects. A statistically significant correlation between HCC risk and serum AFB1-albumin adducts was found. In addition, the effect of aflatoxin exposure on HCC risk was more pronounced among HBV carriers with the GSTT1 null genotype (P=0.03).
-
(2001)
Carcinogenesis
, vol.22
, pp. 1289-1294
-
-
Sun, C.A.1
Wang, L.Y.2
Chen, C.J.3
-
57
-
-
0034793092
-
Increased hepatic oxidative DNA damage in patients with hepatocellular carcinoma
-
PID: 11680593, COI: 1:CAS:528:DC%2BD3MXot1Kls7Y%3D
-
Schwarz KB, Kew M, Klein A, et al.: Increased hepatic oxidative DNA damage in patients with hepatocellular carcinoma. Dig Dis Sci 2001, 46:2173–2178.
-
(2001)
Dig Dis Sci
, vol.46
, pp. 2173-2178
-
-
Schwarz, K.B.1
Kew, M.2
Klein, A.3
-
58
-
-
0035175467
-
In situ detection of oxidative DNA damage, 8-hydroxydeoxyguanosine, in chronic human liver disease
-
PID: 11690707, COI: 1:CAS:528:DC%2BD38XktFWi
-
Kitada T, Seki S, Iwai S, et al.: In situ detection of oxidative DNA damage, 8-hydroxydeoxyguanosine, in chronic human liver disease. J Hepatol 2001, 35:613–618.
-
(2001)
J Hepatol
, vol.35
, pp. 613-618
-
-
Kitada, T.1
Seki, S.2
Iwai, S.3
-
59
-
-
0035360859
-
Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis
-
PID: 11389061, COI: 1:CAS:528:DC%2BD3MXktlSqu7o%3D
-
Moriya K, Nakagawa K, Santa T, et al.: Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res 2001, 61:4365–4370.
-
(2001)
Cancer Res
, vol.61
, pp. 4365-4370
-
-
Moriya, K.1
Nakagawa, K.2
Santa, T.3
-
60
-
-
0035940493
-
Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6-methylguanine-DNA methyltransferase
-
PID: 11606727, COI: 1:CAS:528:DC%2BD3MXotFaiur4%3D
-
Zhou ZQ, Manguino D, Kewitt K, et al.: Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6-methylguanine-DNA methyltransferase. Proc Natl Acad Sci U S A 2001, 98:12566–12571.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12566-12571
-
-
Zhou, Z.Q.1
Manguino, D.2
Kewitt, K.3
-
61
-
-
0035035637
-
Health span and life span in transgenic mice with modulated DNA repair
-
PID: 11795504, COI: 1:STN:280:DC%2BD38%2FntVSjsg%3D%3D
-
Walter CA, Zhou ZQ, Manguino D, et al.: Health span and life span in transgenic mice with modulated DNA repair. Ann NY Acad Sci 2001, 928:132–140.
-
(2001)
Ann NY Acad Sci
, vol.928
, pp. 132-140
-
-
Walter, C.A.1
Zhou, Z.Q.2
Manguino, D.3
-
62
-
-
0036256927
-
Enhanced spontaneous and aflatoxin-induced liver tumorigenesis in xeroderma pigmentosum group A gene-deficient mice
-
PID: 11960916, COI: 1:CAS:528:DC%2BD38XjvVGrur8%3D
-
Takahashi Y, Nakatsuru Y, Zhang S, et al.: Enhanced spontaneous and aflatoxin-induced liver tumorigenesis in xeroderma pigmentosum group A gene-deficient mice. Carcinogenesis 2002, 23:627–633.
-
(2002)
Carcinogenesis
, vol.23
, pp. 627-633
-
-
Takahashi, Y.1
Nakatsuru, Y.2
Zhang, S.3
-
63
-
-
0035886844
-
Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma
-
PID: 11606411, COI: 1:CAS:528:DC%2BD3MXnvFSht7o%3D, surgically resected HCC and HuH17 human HCC-derived cells, RXR-α was phosphorylated at serine 260 by MAPK. Phosphorylated RXR-α lost its transactivation activity, was resistant to degradation, and was associated with increased proliferation
-
Matsushima-Nishiwaki R, Okuno M, Adachi S, et al.: Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma. Cancer Res 2001, 61:7675–7682. In surgically resected HCC and in HuH17 human HCC-derived cells, RXR-α was phosphorylated at serine 260 by MAPK. Phosphorylated RXR-α lost its transactivation activity, was resistant to degradation, and was associated with increased proliferation.
-
(2001)
Cancer Res
, vol.61
, pp. 7675-7682
-
-
Matsushima-Nishiwaki, R.1
Okuno, M.2
Adachi, S.3
-
64
-
-
0034797845
-
Apoptosis induction by acyclic retinoid: a molecular basis of ‘clonal deletion’ therapy for hepatocellular carcinoma
-
PID: 11574627, COI: 1:STN:280:DC%2BD3MrivVGitA%3D%3D
-
Okuno M, Sano T, Matsushima-Nishiwaki R, et al.: Apoptosis induction by acyclic retinoid: a molecular basis of ‘clonal deletion’ therapy for hepatocellular carcinoma. Jpn J Clin Oncol 2001, 31:359–362.
-
(2001)
Jpn J Clin Oncol
, vol.31
, pp. 359-362
-
-
Okuno, M.1
Sano, T.2
Matsushima-Nishiwaki, R.3
-
65
-
-
0035113393
-
Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance
-
PID: 11819729, COI: 1:CAS:528:DC%2BD3MXhsFGjtL8%3D
-
Feng DY, Zheng H, Tan Y, Cheng RX: Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance. World J Gastroenterol 2001, 7:33–36.
-
(2001)
World J Gastroenterol
, vol.7
, pp. 33-36
-
-
Feng, D.Y.1
Zheng, H.2
Tan, Y.3
Cheng, R.X.4
-
66
-
-
0035860752
-
Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes
-
PID: 11461911, COI: 1:CAS:528:DC%2BD3MXmvFCltLw%3D
-
Tarn C, Lee S, Hu Y, et al.: Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes. J Biol Chem 2001, 276:34671–34680.
-
(2001)
J Biol Chem
, vol.276
, pp. 34671-34680
-
-
Tarn, C.1
Lee, S.2
Hu, Y.3
-
67
-
-
0035821645
-
The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner
-
PID: 11423982, COI: 1:CAS:528:DC%2BD3MXltVSqsbs%3D
-
Lara-Pezzi E, Roche S, Andrisani OM, et al.: The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner. Oncogene 2001, 20:3323–3331.
-
(2001)
Oncogene
, vol.20
, pp. 3323-3331
-
-
Lara-Pezzi, E.1
Roche, S.2
Andrisani, O.M.3
-
68
-
-
0035502957
-
Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues
-
PID: 11691796, COI: 1:CAS:528:DC%2BD3MXotlakurk%3D
-
Tu H, Bonura C, Giannini C, et al.: Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Res 2001, 61:7803–7810.
-
(2001)
Cancer Res
, vol.61
, pp. 7803-7810
-
-
Tu, H.1
Bonura, C.2
Giannini, C.3
|