메뉴 건너뛰기




Volumn 4, Issue 6, 2002, Pages 464-470

Prevention of liver cancer

Author keywords

Acyclic Retinoid; Aflatoxin; Ebselen; Glycyrrhizin; Oltipraz

Indexed keywords

ANTIVIRUS AGENT; CARCINOGEN;

EID: 0036834810     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-002-0057-4     Document Type: Article
Times cited : (43)

References (68)
  • 1
    • 0035732841 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: an Asian perspective
    • PID: 11935085, COI: 1:STN:280:DC%2BD383gtF2mtg%3D%3D
    • Teo EK, Fock KM: Hepatocellular carcinoma: an Asian perspective. Dig Dis 2001, 19:263–268.
    • (2001) Dig Dis , vol.19 , pp. 263-268
    • Teo, E.K.1    Fock, K.M.2
  • 2
    • 0034142193 scopus 로고    scopus 로고
    • Predictive factors for intrahepatic recurrence after percutaneous ethanol injection therapy for small hepatocellular carcinoma
    • PID: 10649243, COI: 1:STN:280:DC%2BD3c7hsFemtg%3D%3D
    • Koda M, Murawaki Y, Mitsuda A, et al.: Predictive factors for intrahepatic recurrence after percutaneous ethanol injection therapy for small hepatocellular carcinoma. Cancer 2000, 88:529–537.
    • (2000) Cancer , vol.88 , pp. 529-537
    • Koda, M.1    Murawaki, Y.2    Mitsuda, A.3
  • 3
    • 0035014082 scopus 로고    scopus 로고
    • Underlying liver disease, not tumor factors, predicts long-term survival after resection of hepatocellular carcinoma
    • PID: 11343543, COI: 1:STN:280:DC%2BD3Mzht1Ogug%3D%3D
    • Bilimoria MM, Lauwers GY, Doherty DA, et al.: Underlying liver disease, not tumor factors, predicts long-term survival after resection of hepatocellular carcinoma. Arch Surg 2001, 136:528–535.
    • (2001) Arch Surg , vol.136 , pp. 528-535
    • Bilimoria, M.M.1    Lauwers, G.Y.2    Doherty, D.A.3
  • 4
    • 0036120412 scopus 로고    scopus 로고
    • Eight-year follow-up of the 90,000-person Haimen City cohort: I. Hepatocellular carcinoma mortality, risk factors, and gender differences
    • PID: 11927497, This prospective cohort study of 58,545 men and 25,340 women identified HBV infection as the primary risk factor for HCC mortality this Haimen City, China cohort
    • Evans AA, Chen G, Ross EA, et al.: Eight-year follow-up of the 90,000-person Haimen City cohort: I. Hepatocellular carcinoma mortality, risk factors, and gender differences. Cancer Epidemiol Biomarkers Prev 2002, 11:369–376. This prospective cohort study of 58,545 men and 25,340 women identified HBV infection as the primary risk factor for HCC mortality in this Haimen City, China cohort.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 369-376
    • Evans, A.A.1    Chen, G.2    Ross, E.A.3
  • 5
    • 0036293899 scopus 로고    scopus 로고
    • Hepatocellular carcinoma associated with hepatitis C virus infection in Japan: projection to other countries in the foreseeable future
    • PID: 11868791
    • Yoshizawa H: Hepatocellular carcinoma associated with hepatitis C virus infection in Japan: projection to other countries in the foreseeable future. Oncology 2002, 62(suppl 1):8–17.
    • (2002) Oncology , vol.62 , pp. 8-17
    • Yoshizawa, H.1
  • 6
    • 0034650148 scopus 로고    scopus 로고
    • Prospective study of hepatitis B and C viral infections, cigarette smoking, alcohol consumption, and other factors associated with hepatocellular carcinoma risk in Japan
    • PID: 10645815, COI: 1:STN:280:DC%2BD3c7gvVCisQ%3D%3D
    • Mori M, Hara M, Wada I, et al.: Prospective study of hepatitis B and C viral infections, cigarette smoking, alcohol consumption, and other factors associated with hepatocellular carcinoma risk in Japan. Am J Epidemiol 2000, 151:131–139.
    • (2000) Am J Epidemiol , vol.151 , pp. 131-139
    • Mori, M.1    Hara, M.2    Wada, I.3
  • 7
    • 0035731768 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in southern Germany: epidemiological and clinicopathological characteristics and risk factors
    • PID: 11935095, COI: 1:STN:280:DC%2BD383gtF2ltg%3D%3D
    • Hellerbrand C, Hartmann A, Richter G, et al.: Hepatocellular carcinoma in southern Germany: epidemiological and clinicopathological characteristics and risk factors. Dig Dis 2001, 19:345–351.
    • (2001) Dig Dis , vol.19 , pp. 345-351
    • Hellerbrand, C.1    Hartmann, A.2    Richter, G.3
  • 8
    • 0034793847 scopus 로고    scopus 로고
    • The epidemiology and prevention of hepatocellular carcinoma
    • PID: 11685737, COI: 1:STN:280:DC%2BD3MngvVOhtw%3D%3D
    • Monto A, Wright TL: The epidemiology and prevention of hepatocellular carcinoma. Semin Oncol 2001, 28:441–449.
    • (2001) Semin Oncol , vol.28 , pp. 441-449
    • Monto, A.1    Wright, T.L.2
  • 9
    • 0037137875 scopus 로고    scopus 로고
    • Recent updates in hepatitis vaccination and the prevention of hepatocellular carcinoma
    • PID: 11774275, COI: 1:CAS:528:DC%2BD38XhvVWmuw%3D%3D
    • Kao JH, Chen DS: Recent updates in hepatitis vaccination and the prevention of hepatocellular carcinoma. Int J Cancer 2002, 97:269–271.
    • (2002) Int J Cancer , vol.97 , pp. 269-271
    • Kao, J.H.1    Chen, D.S.2
  • 10
    • 0034772438 scopus 로고    scopus 로고
    • Immunoprophylaxis of hepatitis C virus infection
    • PID: 11685797, COI: 1:STN:280:DC%2BD3MnhtFyitg%3D%3D
    • Prince AM, Shata MT: Immunoprophylaxis of hepatitis C virus infection. Clin Liver Dis 2001, 5:1091–1103.
    • (2001) Clin Liver Dis , vol.5 , pp. 1091-1103
    • Prince, A.M.1    Shata, M.T.2
  • 11
    • 0034821605 scopus 로고    scopus 로고
    • Universal hepatitis B vaccination and the decreased mortality from fulminant hepatitis in infants in Taiwan
    • PID: 11562612, COI: 1:STN:280:DC%2BD3MrjvFKlsA%3D%3D
    • Kao JH, Hsu HM, Shau WY, et al.: Universal hepatitis B vaccination and the decreased mortality from fulminant hepatitis in infants in Taiwan. J Pediatr 2001, 139:349–352.
    • (2001) J Pediatr , vol.139 , pp. 349-352
    • Kao, J.H.1    Hsu, H.M.2    Shau, W.Y.3
  • 12
    • 0034694947 scopus 로고    scopus 로고
    • Hepatitis B vaccination and hepatocellular carcinoma rates in boys and girls
    • PID: 11122592, COI: 1:STN:280:DC%2BD3M%2FotVKisQ%3D%3D
    • Chang MH, Shau WY, Chen CJ, et al.: Hepatitis B vaccination and hepatocellular carcinoma rates in boys and girls. JAMA 2000, 284:3040–3042.
    • (2000) JAMA , vol.284 , pp. 3040-3042
    • Chang, M.H.1    Shau, W.Y.2    Chen, C.J.3
  • 13
    • 0034993211 scopus 로고    scopus 로고
    • Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after 3 years of therapy
    • PID: 11391543, COI: 1:CAS:528:DC%2BD3MXktlygtLc%3D
    • Leung NW, Lai CL, Chang TT, et al.: Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after 3 years of therapy. Hepatology 2001, 33:1527–1532.
    • (2001) Hepatology , vol.33 , pp. 1527-1532
    • Leung, N.W.1    Lai, C.L.2    Chang, T.T.3
  • 14
    • 0037181625 scopus 로고    scopus 로고
    • Vertical transmission of hepatitis B virus despite maternal lamivudine therapy
    • PID: 11988251
    • Kazim SN, Wakil SM, Khan LA, et al.: Vertical transmission of hepatitis B virus despite maternal lamivudine therapy. Lancet 2002, 359:1488–1489.
    • (2002) Lancet , vol.359 , pp. 1488-1489
    • Kazim, S.N.1    Wakil, S.M.2    Khan, L.A.3
  • 15
    • 0035139830 scopus 로고    scopus 로고
    • Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers
    • PID: 11164188, COI: 1:CAS:528:DC%2BD3MXnsVKntg%3D%3D
    • Cheng YC: Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers. Cancer Lett 2001, 162(suppl):S33-S37.
    • (2001) Cancer Lett , vol.162 , pp. S33-S37
    • Cheng, Y.C.1
  • 16
    • 0035084728 scopus 로고    scopus 로고
    • Antiviral activity of beta-L-2′,3′-dideoxy-2′,3′-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus
    • PID: 11257017
    • Le Guerhier F, Pichoud C, Jamard C, et al.: Antiviral activity of beta-L-2′,3′-dideoxy-2′,3′-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus. Antimicrob Agents Chemother 2001, 45:1065–1077.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 1065-1077
    • Le Guerhier, F.1    Pichoud, C.2    Jamard, C.3
  • 17
    • 0035915622 scopus 로고    scopus 로고
    • Prevention of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrhosis
    • PID: 11213099, COI: 1:STN:280:DC%2BD3M7kvFCitQ%3D%3D, This prospective, randomized, controlled study of 90 chronic HCV patients found a protective effect of interferon α on HCC development and death (risk ratios vs symptomatic treatment, 0.256 and 0.135, respectively) after 8.7 years of follow-up
    • Nishiguchi S, Shiomi S, Nakatani S, et al.: Prevention of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrhosis. Lancet 2001, 357:196–197. This prospective, randomized, controlled study of 90 chronic HCV patients found a protective effect of interferon α on HCC development and death (risk ratios vs symptomatic treatment, 0.256 and 0.135, respectively) after 8.7 years of follow-up.
    • (2001) Lancet , vol.357 , pp. 196-197
    • Nishiguchi, S.1    Shiomi, S.2    Nakatani, S.3
  • 18
    • 0035042901 scopus 로고    scopus 로고
    • Long-term interferon therapy for 1 year or longer reduces the hepatocellular carcinogenesis rate in patients with liver cirrhosis caused by hepatitis C virus: a pilot study
    • PID: 11354279, COI: 1:CAS:528:DC%2BD3MXktVOiu7c%3D
    • Ikeda K, Saitoh S, Kobayashi M, et al.: Long-term interferon therapy for 1 year or longer reduces the hepatocellular carcinogenesis rate in patients with liver cirrhosis caused by hepatitis C virus: a pilot study. J Gastroenterol Hepatol 2001, 16:406–415.
    • (2001) J Gastroenterol Hepatol , vol.16 , pp. 406-415
    • Ikeda, K.1    Saitoh, S.2    Kobayashi, M.3
  • 19
    • 17944383158 scopus 로고    scopus 로고
    • Effect of the dose and duration of interferon-alpha therapy on the incidence of hepatocellular carcinoma in noncirrhotic patients with a nonsustained response to interferon for chronic hepatitis C
    • PID: 11528252, COI: 1:CAS:528:DC%2BD3MXntFKjtL8%3D
    • Toyoda H, Kumada T, Nakano S, et al.: Effect of the dose and duration of interferon-alpha therapy on the incidence of hepatocellular carcinoma in noncirrhotic patients with a nonsustained response to interferon for chronic hepatitis C. Oncology 2001, 61:134–142.
    • (2001) Oncology , vol.61 , pp. 134-142
    • Toyoda, H.1    Kumada, T.2    Nakano, S.3
  • 20
    • 0035037997 scopus 로고    scopus 로고
    • Effect of interferon therapy on the development of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis: a meta-analysis
    • PID: 11328263, COI: 1:CAS:528:DC%2BD3MXjslCjsLY%3D, This high-quality meta-analysis, which considered 11 studies with 2178 HCV patients, found a significant protective effect of interferon α on HCC development. Although the effect was most pronounced for sustained responders, a reduced HCC incidence nonresponders was also found
    • Papatheodoridis GV, Papadimitropoulos VC, Hadziyannis SJ: Effect of interferon therapy on the development of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis: a meta-analysis. Aliment Pharmacol Ther 2001, 15:689–698. This high-quality meta-analysis, which considered 11 studies with 2178 HCV patients, found a significant protective effect of interferon α on HCC development. Although the effect was most pronounced for sustained responders, a reduced HCC incidence in nonresponders was also found.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 689-698
    • Papatheodoridis, G.V.1    Papadimitropoulos, V.C.2    Hadziyannis, S.J.3
  • 21
    • 0036147150 scopus 로고    scopus 로고
    • Interferon inhibits progression of liver fibrosis and reduces the risk of hepatocarcinogenesis in patients with chronic hepatitis C: a retrospective multicenter analysis of 652 patients
    • PID: 11837720, COI: 1:CAS:528:DC%2BD38XhsVGmsLc%3D
    • Takimoto M, Ohkoshi S, Ichida T, et al.: Interferon inhibits progression of liver fibrosis and reduces the risk of hepatocarcinogenesis in patients with chronic hepatitis C: a retrospective multicenter analysis of 652 patients. Dig Dis Sci 2002, 47:170–176.
    • (2002) Dig Dis Sci , vol.47 , pp. 170-176
    • Takimoto, M.1    Ohkoshi, S.2    Ichida, T.3
  • 22
    • 0035061788 scopus 로고    scopus 로고
    • Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: an evidence-based approach
    • PID: 11394661, COI: 1:CAS:528:DC%2BD3MXjvVerur4%3D, This excellent meta-analysis considered three randomized and 15 nonrandomized controlled trials including 4614 patients and comparing interferon α treatment with no treatment. A protective effect of interferon α HCV was identified, but the magnitude was low and related to response to interferon α. Interferon α did not affect HCC development HBV-related cirrhosis
    • Camma C, Giunta M, Andreone P, Craxi A: Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: an evidence-based approach. J Hepatol 2001, 34:593–602. This excellent meta-analysis considered three randomized and 15 nonrandomized controlled trials including 4614 patients and comparing interferon α treatment with no treatment. A protective effect of interferon α in HCV was identified, but the magnitude was low and related to response to interferon α. Interferon α did not affect HCC development in HBV-related cirrhosis.
    • (2001) J Hepatol , vol.34 , pp. 593-602
    • Camma, C.1    Giunta, M.2    Andreone, P.3    Craxi, A.4
  • 23
    • 0034962643 scopus 로고    scopus 로고
    • Long-term follow-up of interferon alfa treatment in Chinese patients with chronic hepatitis B infection: the effect on hepatitis B e antigen seroconversion and the development of cirrhosis-related complications
    • PID: 11431745, COI: 1:CAS:528:DC%2BD3MXltlKjsL4%3D
    • Yuen MF, Hui CK, Cheng CC, et al.: Long-term follow-up of interferon alfa treatment in Chinese patients with chronic hepatitis B infection: the effect on hepatitis B e antigen seroconversion and the development of cirrhosis-related complications. Hepatology 2001, 34:139–145.
    • (2001) Hepatology , vol.34 , pp. 139-145
    • Yuen, M.F.1    Hui, C.K.2    Cheng, C.C.3
  • 24
    • 0036289062 scopus 로고    scopus 로고
    • Long-term treatment of chronic hepatitis C with glycyrrhizin (stronger neo-minophagen C [SNMC]) for preventing liver cirrhosis and hepatocellular carcinoma
    • PID: 11868794, COI: 1:CAS:528:DC%2BD38Xot1SntA%3D%3D
    • Kumada H: Long-term treatment of chronic hepatitis C with glycyrrhizin (stronger neo-minophagen C [SNMC]) for preventing liver cirrhosis and hepatocellular carcinoma. Oncology 2002, 62(suppl 1):94–100.
    • (2002) Oncology , vol.62 , pp. 94-100
    • Kumada, H.1
  • 25
    • 0035654420 scopus 로고    scopus 로고
    • Study on chemoprevention of hepatocellular carcinoma by ginseng: an introduction to the protocol
    • The Ginseng-HCC Chemopreventive Study Osaka Group: Study on chemoprevention of hepatocellular carcinoma by ginseng: an introduction to the protocol. J Korean Med Sci 2001, 16(suppl):S70-S74.
    • (2001) J Korean Med Sci , vol.16 , pp. S70-S74
  • 26
    • 0034572785 scopus 로고    scopus 로고
    • Clinical and pharmacological studies on liver diseases treated with Kampo herbal medicine
    • PID: 11154048, COI: 1:STN:280:DC%2BD3M3kt1KrtA%3D%3D
    • Cyong JC, Ki SM, Iijima K, et al.: Clinical and pharmacological studies on liver diseases treated with Kampo herbal medicine. Am J Chin Med 2000, 28:351–360.
    • (2000) Am J Chin Med , vol.28 , pp. 351-360
    • Cyong, J.C.1    Ki, S.M.2    Iijima, K.3
  • 27
    • 0035702637 scopus 로고    scopus 로고
    • Chemoprevention of hepatocellular carcinoma: concept, progress and perspectives
    • PID: 11851828, COI: 1:CAS:528:DC%2BD38XhtlWjtrs%3D
    • Okuno M, Kojima S, Moriwaki H: Chemoprevention of hepatocellular carcinoma: concept, progress and perspectives. J Gastroenterol Hepatol 2001, 16:1329–1335.
    • (2001) J Gastroenterol Hepatol , vol.16 , pp. 1329-1335
    • Okuno, M.1    Kojima, S.2    Moriwaki, H.3
  • 28
    • 0035011152 scopus 로고    scopus 로고
    • In vivo inhibition of human CYP1A2 activity by oltipraz
    • PID: 11459203, COI: 1:CAS:528:DC%2BD3MXkt1aktb8%3D
    • Sofowora GG, Choo EF, Mayo G, et al.: In vivo inhibition of human CYP1A2 activity by oltipraz. Cancer Chemother Pharmacol 2001, 47:505–510.
    • (2001) Cancer Chemother Pharmacol , vol.47 , pp. 505-510
    • Sofowora, G.G.1    Choo, E.F.2    Mayo, G.3
  • 29
    • 0035798606 scopus 로고    scopus 로고
    • Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase: a new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase
    • PID: 11524419, COI: 1:CAS:528:DC%2BD3MXosVKhurc%3D, This study demonstrated a novel catalytic activity of NAD(P)H-dependent alkenal/one oxidoreductase (leukotriene B412-hydroxydehydrogenase): reduction of the α,β-carbon=carbon double bond of α,β-unsaturated aldehydes and ketones such as 4-hydroxy-2-nonenal. addition, forced overexpression of the enzyme protected cells from the toxicity of 4-hydroxy-2-nonenal, a major product of lipid peroxidation
    • Dick RA, Kwak MK, Sutter TR, Kensler TW: Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase: a new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase. J Biol Chem 2001, 276:40803–40810. This study demonstrated a novel catalytic activity of NAD(P)H-dependent alkenal/one oxidoreductase (leukotriene B412-hydroxydehydrogenase): reduction of the α,β-carbon=carbon double bond of α,β-unsaturated aldehydes and ketones such as 4-hydroxy-2-nonenal. In addition, forced overexpression of the enzyme protected cells from the toxicity of 4-hydroxy-2-nonenal, a major product of lipid peroxidation.
    • (2001) J Biol Chem , vol.276 , pp. 40803-40810
    • Dick, R.A.1    Kwak, M.K.2    Sutter, T.R.3    Kensler, T.W.4
  • 30
    • 0035260034 scopus 로고    scopus 로고
    • Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione
    • PID: 11471548, COI: 1:CAS:528:DC%2BD3MXitlKms7g%3D, This investigation characterized the expression patterns of over a dozen genes inducible by 3H-1,2-dithiole-3-thione both wild-type and nrf2-disrupted mice. Nrf2 was found to play a central regulatory role the constitutive and dithiolthione-inducible expression of multiple phase 2 and antioxidative enzymes
    • Kwak MK, Itoh K, Yamamoto M, et al.: Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione. Mol Med 2001, 7:135–145. This investigation characterized the expression patterns of over a dozen genes inducible by 3H-1,2-dithiole-3-thione in both wild-type and nrf2-disrupted mice. Nrf2 was found to play a central regulatory role in the constitutive and dithiolthione-inducible expression of multiple phase 2 and antioxidative enzymes.
    • (2001) Mol Med , vol.7 , pp. 135-145
    • Kwak, M.K.1    Itoh, K.2    Yamamoto, M.3
  • 31
    • 0035807837 scopus 로고    scopus 로고
    • Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer
    • PID: 11724948, COI: 1:CAS:528:DC%2BD3MXptFCksL0%3D, This double-blind, placebo-controlled study of chlorophyllin (100 mg three times a day for 4 months) 180 residents of Qidong, People’s Republic of China, demonstrated a 55% reduction urinary aflatoxin-DNA adducts (P=0.036
    • Egner PA, Wang JB, Zhu YR, et al.: Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Proc Natl Acad Sci U S A 2001, 98:14601–14606. This double-blind, placebo-controlled study of chlorophyllin (100 mg three times a day for 4 months) in 180 residents of Qidong, People’s Republic of China, demonstrated a 55% reduction in urinary aflatoxin-DNA adducts (P=0.036).
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14601-14606
    • Egner, P.A.1    Wang, J.B.2    Zhu, Y.R.3
  • 32
    • 0034940451 scopus 로고    scopus 로고
    • Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats
    • PID: 11453740, COI: 1:CAS:528:DC%2BD3MXks1Sgtrk%3D
    • Walton M, Egner P, Scholl PF, et al.: Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats. Chem Res Toxicol 2001, 14:919–926.
    • (2001) Chem Res Toxicol , vol.14 , pp. 919-926
    • Walton, M.1    Egner, P.2    Scholl, P.F.3
  • 33
    • 0035122919 scopus 로고    scopus 로고
    • Suppression of chemical carcinogenesis by water-soluble organosulfur compounds
    • PID: 11238814, COI: 1:CAS:528:DC%2BD3MXhvVOiu7o%3D
    • Fukushima S, Takada N, Wanibuchi H, et al.: Suppression of chemical carcinogenesis by water-soluble organosulfur compounds. J Nutr 2001, 131:1049S-1053S.
    • (2001) J Nutr , vol.131 , pp. 1049S-1053S
    • Fukushima, S.1    Takada, N.2    Wanibuchi, H.3
  • 34
    • 0034524417 scopus 로고    scopus 로고
    • Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats
    • PID: 11133813, COI: 1:CAS:528:DC%2BD3MXmsFykug%3D%3D
    • Yang CF, Liu J, Wasser S, et al.: Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis 2000, 21:2237–2243.
    • (2000) Carcinogenesis , vol.21 , pp. 2237-2243
    • Yang, C.F.1    Liu, J.2    Wasser, S.3
  • 35
    • 0034929422 scopus 로고    scopus 로고
    • Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats
    • PID: 11429047, COI: 1:CAS:528:DC%2BD3MXlslOitr0%3D
    • Watanabe T, Sugie S, Okamoto K, et al.: Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. Jpn J Cancer Res 2001, 92:603–609.
    • (2001) Jpn J Cancer Res , vol.92 , pp. 603-609
    • Watanabe, T.1    Sugie, S.2    Okamoto, K.3
  • 36
    • 0034465205 scopus 로고    scopus 로고
    • Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv
    • PID: 11277323, COI: 1:CAS:528:DC%2BD3MXhsFGkt7c%3D
    • Rajeshkumar NV, Kuttan R: Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv. J Exp Clin Cancer Res 2000, 19:459–465.
    • (2000) J Exp Clin Cancer Res , vol.19 , pp. 459-465
    • Rajeshkumar, N.V.1    Kuttan, R.2
  • 37
    • 0035099029 scopus 로고    scopus 로고
    • Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats
    • PID: 11259848, COI: 1:CAS:528:DC%2BD3MXhvFKisr8%3D
    • Ahmed S, Rahman A, Mathur M, et al.: Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats. Food Chem Toxicol 2001, 39:19–28.
    • (2001) Food Chem Toxicol , vol.39 , pp. 19-28
    • Ahmed, S.1    Rahman, A.2    Mathur, M.3
  • 38
    • 0035827136 scopus 로고    scopus 로고
    • Protection of salvia miltiorrhiza against aflatoxin-B1-induced hepatocarcinogenesis in Fischer 344 rats dual mechanisms involved
    • PID: 11441922, COI: 1:CAS:528:DC%2BD3MXktlOku7c%3D
    • Liu J, Yang CF, Wasser S, et al.: Protection of salvia miltiorrhiza against aflatoxin-B1-induced hepatocarcinogenesis in Fischer 344 rats dual mechanisms involved. Life Sci 2001, 69:309–326.
    • (2001) Life Sci , vol.69 , pp. 309-326
    • Liu, J.1    Yang, C.F.2    Wasser, S.3
  • 39
    • 0034778038 scopus 로고    scopus 로고
    • Preventive effect of FK143, a 5alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats
    • PID: 11448929, COI: 1:CAS:528:DC%2BD3MXlslalu7c%3D
    • Maruyama S, Nagasue N, Dhar DK, et al.: Preventive effect of FK143, a 5alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats. Clin Cancer Res 2001, 7:2096–2104.
    • (2001) Clin Cancer Res , vol.7 , pp. 2096-2104
    • Maruyama, S.1    Nagasue, N.2    Dhar, D.K.3
  • 40
    • 0034351134 scopus 로고    scopus 로고
    • Chemoprevention of aflatoxin B1-initiated and carbon tetrachloride-promoted hepatocarcinogenesis in the rat by green tea
    • PID: 11525600, COI: 1:CAS:528:DC%2BD3MXmsF2hs7c%3D
    • Qin G, Ning Y, Lotlikar PD: Chemoprevention of aflatoxin B1-initiated and carbon tetrachloride-promoted hepatocarcinogenesis in the rat by green tea. Nutr Cancer 2000, 38:215–222.
    • (2000) Nutr Cancer , vol.38 , pp. 215-222
    • Qin, G.1    Ning, Y.2    Lotlikar, P.D.3
  • 41
    • 0035002593 scopus 로고    scopus 로고
    • Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene
    • PID: 11346485, COI: 1:CAS:528:DC%2BD3MXjtleqsLY%3D
    • Hosaka S, Kawa S, Aoki Y, et al.: Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene. Food Chem Toxicol 2001, 39:557–561.
    • (2001) Food Chem Toxicol , vol.39 , pp. 557-561
    • Hosaka, S.1    Kawa, S.2    Aoki, Y.3
  • 42
    • 0035427196 scopus 로고    scopus 로고
    • Inhibition by d-limonene of experimental hepatocarcinogenesis in Sprague-Dawley rats does not involve p21(ras) plasma membrane association
    • PID: 11433412, COI: 1:CAS:528:DC%2BD3MXlt12gsbc%3D
    • Kaji I, Tatsuta M, Iishi H, et al.: Inhibition by d-limonene of experimental hepatocarcinogenesis in Sprague-Dawley rats does not involve p21(ras) plasma membrane association. Int J Cancer 2001, 93:441–444.
    • (2001) Int J Cancer , vol.93 , pp. 441-444
    • Kaji, I.1    Tatsuta, M.2    Iishi, H.3
  • 43
    • 0034760007 scopus 로고    scopus 로고
    • Effect of alphatocopherol on hepatocarcinogenesis in transforming growth factor-alpha (TGF-alpha) transgenic mice treated with diethylnitrosamine
    • PID: 11725690, COI: 1:CAS:528:DC%2BD3MXptFKrs7g%3D
    • Kakizaki S, Takagi H, Fukusato T, et al.: Effect of alphatocopherol on hepatocarcinogenesis in transforming growth factor-alpha (TGF-alpha) transgenic mice treated with diethylnitrosamine. Int J Vitam Nutr Res 2001, 71:261–267.
    • (2001) Int J Vitam Nutr Res , vol.71 , pp. 261-267
    • Kakizaki, S.1    Takagi, H.2    Fukusato, T.3
  • 44
    • 0035047448 scopus 로고    scopus 로고
    • 1 alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesis
    • PID: 11241675, COI: 1:CAS:528:DC%2BD3MXivVKgsbc%3D
    • Basak R, Bhattacharya R, Chatterjee M: 1 alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesis. J Cell Biochem 2001, 81:357–367.
    • (2001) J Cell Biochem , vol.81 , pp. 357-367
    • Basak, R.1    Bhattacharya, R.2    Chatterjee, M.3
  • 45
    • 0035237561 scopus 로고    scopus 로고
    • Vitamin A and alltrans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats
    • PID: 11759288, COI: 1:CAS:528:DC%2BD3MXpt1WhtL8%3D
    • Silveira ER, Naves MM, Vannucchi H, et al.: Vitamin A and alltrans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats. Nutr Cancer 2001, 39:244–251.
    • (2001) Nutr Cancer , vol.39 , pp. 244-251
    • Silveira, E.R.1    Naves, M.M.2    Vannucchi, H.3
  • 46
    • 0035137702 scopus 로고    scopus 로고
    • Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry
    • PID: 11196182, COI: 1:CAS:528:DC%2BD3MXlsl2nug%3D%3D
    • Jackson PE, Qian GS, Friesen MD, et al.: Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry. Cancer Res 2001, 61:33–35.
    • (2001) Cancer Res , vol.61 , pp. 33-35
    • Jackson, P.E.1    Qian, G.S.2    Friesen, M.D.3
  • 47
    • 0035950534 scopus 로고    scopus 로고
    • INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas
    • PID: 11704835, COI: 1:CAS:528:DC%2BD3MXotlCgu78%3D
    • Tannapfel A, Busse C, Weinans L, et al.: INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas. Oncogene 2001, 20:7104–7109.
    • (2001) Oncogene , vol.20 , pp. 7104-7109
    • Tannapfel, A.1    Busse, C.2    Weinans, L.3
  • 48
    • 17844387825 scopus 로고    scopus 로고
    • Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas
    • PID: 11408803, COI: 1:CAS:528:DC%2BD3MXlsFShtb0%3D
    • Azechi H, Nishida N, Fukuda Y, et al.: Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas. Oncology 2001, 60:346–354.
    • (2001) Oncology , vol.60 , pp. 346-354
    • Azechi, H.1    Nishida, N.2    Fukuda, Y.3
  • 49
    • 0035056507 scopus 로고    scopus 로고
    • Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus
    • PID: 11171828, COI: 1:CAS:528:DC%2BD3MXitlCjur0%3D
    • Kaneto H, Sasaki S, Yamamoto H, et al.: Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus. Gut 2001, 48:372–377.
    • (2001) Gut , vol.48 , pp. 372-377
    • Kaneto, H.1    Sasaki, S.2    Yamamoto, H.3
  • 50
    • 0035159977 scopus 로고    scopus 로고
    • The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility
    • PID: 11698349, COI: 1:CAS:528:DC%2BD3MXosV2msbs%3D
    • Bugni JM, Poole TM, Drinkwater NR: The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility. Carcinogenesis 2001, 22:1853–1862.
    • (2001) Carcinogenesis , vol.22 , pp. 1853-1862
    • Bugni, J.M.1    Poole, T.M.2    Drinkwater, N.R.3
  • 51
    • 0035375014 scopus 로고    scopus 로고
    • Lack of p53 accelerates hepatocarcinogenesis in transgenic mice constitutively overexpressing c-myc in the liver
    • PID: 11387238, COI: 1:CAS:528:DC%2BD3MXlvVersrc%3D
    • Klocke R, Bartels T, Jennings G, et al.: Lack of p53 accelerates hepatocarcinogenesis in transgenic mice constitutively overexpressing c-myc in the liver. FASEB J 2001, 15:1404–1406.
    • (2001) FASEB J , vol.15 , pp. 1404-1406
    • Klocke, R.1    Bartels, T.2    Jennings, G.3
  • 52
    • 0034852454 scopus 로고    scopus 로고
    • p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3
    • PID: 11514734, COI: 1:CAS:528:DC%2BD3MXmslSktbY%3D
    • Kwun HJ, Jung EY, Ahn JY, et al.: p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3. J Gen Virol 2001, 82:2235–2241.
    • (2001) J Gen Virol , vol.82 , pp. 2235-2241
    • Kwun, H.J.1    Jung, E.Y.2    Ahn, J.Y.3
  • 53
    • 0035674620 scopus 로고    scopus 로고
    • Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats
    • PID: 11749691, COI: 1:CAS:528:DC%2BD38XhtV2jt7s%3D
    • Hatanaka Y, Nakae D, Mutai M, et al.: Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats. Jpn J Cancer Res 2001, 92:1270–1277.
    • (2001) Jpn J Cancer Res , vol.92 , pp. 1270-1277
    • Hatanaka, Y.1    Nakae, D.2    Mutai, M.3
  • 54
    • 0034891659 scopus 로고    scopus 로고
    • Transfer of bcl-xs plasmid is effective in preventing and inhibiting rat hepatocellular carcinoma induced by N-nitrosomorpholine
    • PID: 11509945, COI: 1:CAS:528:DC%2BD3MXlvVSlsb0%3D
    • Baba M, Iishi H, Tatsuta M: Transfer of bcl-xs plasmid is effective in preventing and inhibiting rat hepatocellular carcinoma induced by N-nitrosomorpholine. Gene Ther 2001, 8:1149–1156.
    • (2001) Gene Ther , vol.8 , pp. 1149-1156
    • Baba, M.1    Iishi, H.2    Tatsuta, M.3
  • 55
    • 0034765595 scopus 로고    scopus 로고
    • Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene
    • PID: 11677206, COI: 1:CAS:528:DC%2BD3MXpt1Srsb8%3D, This German case-control study involved 59 cancer patients and 70 control subjects. The uridine 5′-diphosphate-glucuroyltransferase allele UGT1A7*3, which encodes a protein with low carcinogen detoxification activity, was significantly associated with HCC
    • Vogel A, Kneip S, Barut A, et al.: Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene. Gastroenterology 2001, 121:1136–1144. This German case-control study involved 59 cancer patients and 70 control subjects. The uridine 5′-diphosphate-glucuronosyltransferase allele UGT1A7*3, which encodes a protein with low carcinogen detoxification activity, was significantly associated with HCC.
    • (2001) Gastroenterology , vol.121 , pp. 1136-1144
    • Vogel, A.1    Kneip, S.2    Barut, A.3
  • 56
    • 0034897931 scopus 로고    scopus 로고
    • Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan
    • PID: 11470760, COI: 1:CAS:528:DC%2BD3MXlvVSqu7o%3D, This Taiwanese case-control study of chronic HBV carriers involved 79 HCC patients and 149 control subjects. A statistically significant correlation between HCC risk and serum AFB1-albumin adducts was found. addition, the effect of aflatoxin exposure on HCC risk was more pronounced among HBV carriers with the GSTT1 null genotype (P=0.03
    • Sun CA, Wang LY, Chen CJ, et al.: Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan. Carcinogenesis 2001, 22:1289–1294. This Taiwanese case-control study of chronic HBV carriers involved 79 HCC patients and 149 control subjects. A statistically significant correlation between HCC risk and serum AFB1-albumin adducts was found. In addition, the effect of aflatoxin exposure on HCC risk was more pronounced among HBV carriers with the GSTT1 null genotype (P=0.03).
    • (2001) Carcinogenesis , vol.22 , pp. 1289-1294
    • Sun, C.A.1    Wang, L.Y.2    Chen, C.J.3
  • 57
    • 0034793092 scopus 로고    scopus 로고
    • Increased hepatic oxidative DNA damage in patients with hepatocellular carcinoma
    • PID: 11680593, COI: 1:CAS:528:DC%2BD3MXot1Kls7Y%3D
    • Schwarz KB, Kew M, Klein A, et al.: Increased hepatic oxidative DNA damage in patients with hepatocellular carcinoma. Dig Dis Sci 2001, 46:2173–2178.
    • (2001) Dig Dis Sci , vol.46 , pp. 2173-2178
    • Schwarz, K.B.1    Kew, M.2    Klein, A.3
  • 58
    • 0035175467 scopus 로고    scopus 로고
    • In situ detection of oxidative DNA damage, 8-hydroxydeoxyguanosine, in chronic human liver disease
    • PID: 11690707, COI: 1:CAS:528:DC%2BD38XktFWi
    • Kitada T, Seki S, Iwai S, et al.: In situ detection of oxidative DNA damage, 8-hydroxydeoxyguanosine, in chronic human liver disease. J Hepatol 2001, 35:613–618.
    • (2001) J Hepatol , vol.35 , pp. 613-618
    • Kitada, T.1    Seki, S.2    Iwai, S.3
  • 59
    • 0035360859 scopus 로고    scopus 로고
    • Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis
    • PID: 11389061, COI: 1:CAS:528:DC%2BD3MXktlSqu7o%3D
    • Moriya K, Nakagawa K, Santa T, et al.: Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res 2001, 61:4365–4370.
    • (2001) Cancer Res , vol.61 , pp. 4365-4370
    • Moriya, K.1    Nakagawa, K.2    Santa, T.3
  • 60
    • 0035940493 scopus 로고    scopus 로고
    • Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6-methylguanine-DNA methyltransferase
    • PID: 11606727, COI: 1:CAS:528:DC%2BD3MXotFaiur4%3D
    • Zhou ZQ, Manguino D, Kewitt K, et al.: Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6-methylguanine-DNA methyltransferase. Proc Natl Acad Sci U S A 2001, 98:12566–12571.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 12566-12571
    • Zhou, Z.Q.1    Manguino, D.2    Kewitt, K.3
  • 61
    • 0035035637 scopus 로고    scopus 로고
    • Health span and life span in transgenic mice with modulated DNA repair
    • PID: 11795504, COI: 1:STN:280:DC%2BD38%2FntVSjsg%3D%3D
    • Walter CA, Zhou ZQ, Manguino D, et al.: Health span and life span in transgenic mice with modulated DNA repair. Ann NY Acad Sci 2001, 928:132–140.
    • (2001) Ann NY Acad Sci , vol.928 , pp. 132-140
    • Walter, C.A.1    Zhou, Z.Q.2    Manguino, D.3
  • 62
    • 0036256927 scopus 로고    scopus 로고
    • Enhanced spontaneous and aflatoxin-induced liver tumorigenesis in xeroderma pigmentosum group A gene-deficient mice
    • PID: 11960916, COI: 1:CAS:528:DC%2BD38XjvVGrur8%3D
    • Takahashi Y, Nakatsuru Y, Zhang S, et al.: Enhanced spontaneous and aflatoxin-induced liver tumorigenesis in xeroderma pigmentosum group A gene-deficient mice. Carcinogenesis 2002, 23:627–633.
    • (2002) Carcinogenesis , vol.23 , pp. 627-633
    • Takahashi, Y.1    Nakatsuru, Y.2    Zhang, S.3
  • 63
    • 0035886844 scopus 로고    scopus 로고
    • Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma
    • PID: 11606411, COI: 1:CAS:528:DC%2BD3MXnvFSht7o%3D, surgically resected HCC and HuH17 human HCC-derived cells, RXR-α was phosphorylated at serine 260 by MAPK. Phosphorylated RXR-α lost its transactivation activity, was resistant to degradation, and was associated with increased proliferation
    • Matsushima-Nishiwaki R, Okuno M, Adachi S, et al.: Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma. Cancer Res 2001, 61:7675–7682. In surgically resected HCC and in HuH17 human HCC-derived cells, RXR-α was phosphorylated at serine 260 by MAPK. Phosphorylated RXR-α lost its transactivation activity, was resistant to degradation, and was associated with increased proliferation.
    • (2001) Cancer Res , vol.61 , pp. 7675-7682
    • Matsushima-Nishiwaki, R.1    Okuno, M.2    Adachi, S.3
  • 64
    • 0034797845 scopus 로고    scopus 로고
    • Apoptosis induction by acyclic retinoid: a molecular basis of ‘clonal deletion’ therapy for hepatocellular carcinoma
    • PID: 11574627, COI: 1:STN:280:DC%2BD3MrivVGitA%3D%3D
    • Okuno M, Sano T, Matsushima-Nishiwaki R, et al.: Apoptosis induction by acyclic retinoid: a molecular basis of ‘clonal deletion’ therapy for hepatocellular carcinoma. Jpn J Clin Oncol 2001, 31:359–362.
    • (2001) Jpn J Clin Oncol , vol.31 , pp. 359-362
    • Okuno, M.1    Sano, T.2    Matsushima-Nishiwaki, R.3
  • 65
    • 0035113393 scopus 로고    scopus 로고
    • Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance
    • PID: 11819729, COI: 1:CAS:528:DC%2BD3MXhsFGjtL8%3D
    • Feng DY, Zheng H, Tan Y, Cheng RX: Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance. World J Gastroenterol 2001, 7:33–36.
    • (2001) World J Gastroenterol , vol.7 , pp. 33-36
    • Feng, D.Y.1    Zheng, H.2    Tan, Y.3    Cheng, R.X.4
  • 66
    • 0035860752 scopus 로고    scopus 로고
    • Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes
    • PID: 11461911, COI: 1:CAS:528:DC%2BD3MXmvFCltLw%3D
    • Tarn C, Lee S, Hu Y, et al.: Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes. J Biol Chem 2001, 276:34671–34680.
    • (2001) J Biol Chem , vol.276 , pp. 34671-34680
    • Tarn, C.1    Lee, S.2    Hu, Y.3
  • 67
    • 0035821645 scopus 로고    scopus 로고
    • The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner
    • PID: 11423982, COI: 1:CAS:528:DC%2BD3MXltVSqsbs%3D
    • Lara-Pezzi E, Roche S, Andrisani OM, et al.: The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner. Oncogene 2001, 20:3323–3331.
    • (2001) Oncogene , vol.20 , pp. 3323-3331
    • Lara-Pezzi, E.1    Roche, S.2    Andrisani, O.M.3
  • 68
    • 0035502957 scopus 로고    scopus 로고
    • Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues
    • PID: 11691796, COI: 1:CAS:528:DC%2BD3MXotlakurk%3D
    • Tu H, Bonura C, Giannini C, et al.: Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Res 2001, 61:7803–7810.
    • (2001) Cancer Res , vol.61 , pp. 7803-7810
    • Tu, H.1    Bonura, C.2    Giannini, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.