Telomere-mediated effects on melanogenesis and skin aging

Journal of Investigative Dermatology Symposium Proceedings

Volumn 14, Issue 1, 2009, Pages 25-31

  Gilchrest, Barbara A ^a   Eller, Mark S ^a   Yaar, Mina ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANIN; OLIGONUCLEOTIDE;

CANCER PREVENTION; CONFERENCE PAPER; CUTANEOUS PARAMETERS; DNA DAMAGE; DNA REPAIR; GENOME; HUMAN; MELANOGENESIS; NONHUMAN; PHOTOAGING; PREMATURE AGING; TELOMERE; ULTRAVIOLET RADIATION;

ANIMALS; BASE SEQUENCE; CELL AGING; DNA DAMAGE; DNA REPAIR; HUMANS; MELANINS; MODELS, BIOLOGICAL; OLIGODEOXYRIBONUCLEOTIDES; SIGNAL TRANSDUCTION; SKIN AGING; SUNTAN; TELOMERE; ULTRAVIOLET RAYS;

EID: 68849094826     PISSN: 10870024     EISSN: 15291774     Source Type: Journal    
DOI: 10.1038/jidsymp.2009.9     Document Type: Conference Paper

References (83)

1. Agar N, Young AR (2005) Melanogenesis: a photoprotective response to DNA damage? Mutat Res 571:121-132
2. Aoki H, Iwado E, Eller MS, Kondo Y, Fujiwara K, Li GZ et al. (2007) Telomere 3′ overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells. FASEB J 21:2918-2930 (Pubitemid 47372758)
3. Arad S, Konnikov N, Goukassian DA, Gilchrest BA (2006) T-oligos augment UV-induced protective responses in human skin. FASEB J 20:1895-1897 (Pubitemid 44939740)
4. Arad S, Konnikov N, Goukassian DA, Gilchrest BA (2007) Quantification of inducible SOS-like photoprotective responses in human skin. J Invest Dermatol 127:2629-2636 (Pubitemid 47585058)
5. Arad S, Zattra E, Hebert J, Epstein EH Jr, Goukassian DA, Gilchrest BA (2008) Topical thymidine dinucleotide treatment reduces development of ultraviolet-induced basal cell carcinoma in Ptch-1+/- mice. Am J Pathol 172:1248-1255 (Pubitemid 351671538)
6. Bekaert S, De Meyer T, Van Oostveldt P (2005) Telomere attrition as ageing biomarker. Anticancer Res 25:3011-3021
7. Bertram C, Hass R (2008) Cellular responses to reactive oxygen species-induced DNA damage and aging. Biol Chem 389:211-220 (Pubitemid 351329029)
8. Beukers R, Eker AP, Lohman PH (2008) 50 years thymine dimer. DNA Repair 7:530-543
9. Blackburn EH (1991) Structure and function of telomeres. Nature 350:569-573
10. Blackburn EH (2001) Switching and signaling at the telomere. Cell 106:661-673
11. Bolognia JL (1995) Aging skin. Am J Med 98:S99-103
12. Bonilla CY, Melo JA, Toczyski DP (2008) Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell 30:267-276 (Pubitemid 351615321)
13. Campisi J (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120:513-522
14. Cui R, Widlund HR, Feige E, Lin JY, Wilensky DL, Igras VE et al. (2007) Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell 128:853-864 (Pubitemid 46341415)
15. Denchi EL, de Lange T (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448:1068-1071
16. Eller MS, Asarch A, Gilchrest BA (2008a) Photoprotection in human skin - a multifaceted SOS response. Photochem Photobiol 84:339-349
17. Eller MS, Backvall H, Reddy K, Opresko PL, Bohr VA, Gilchrest BA (2006a) WRN-mediated DNA damage responses localize to telomeres. J Invest Dermatol 126:81 (abstr.) (Pubitemid 44583166)
18. Eller MS, Li GZ, Firoozabadi R, Puri N, Gilchrest BA (2003) Induction of a p95/Nbs1-mediated S phase checkpoint by telomere 3′ overhang specific DNA. FASEB J 17:152-162 (Pubitemid 36164385)
19. Eller MS, Liao X, Liu S, Hanna K, Backvall H, Opresko PL et al. (2006b) A role for WRN in telomere-based DNA damage responses. Proc Natl Acad Sci USA 103:15073-15078 (Pubitemid 44583166)
20. Eller MS, Maeda T, Magnoni C, Atwal D, Gilchrest BA (1997) Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response. Proc Natl Acad Sci USA 94:12627-12632 (Pubitemid 27492579)
21. Eller MS, Ostrom K, Gilchrest BA (1996) DNA damage enhances melanogenesis. Proc Natl Acad Sci USA 93:1087-1092
22. Eller MS, Puri N, Hadshiew IM, Venna SS, Gilchrest BA (2002) Induction of apoptosis by telomere 3′ overhang-specific DNA. Exp Cell Res 276:185-193 (Pubitemid 34969312)
23. Eller MS, Shariftabrizi A, Gilchrest BA (2007) WRN-mediated telomere-associated DNA damage responses occur at sites of telomere replication and serve to protect genomic itegrity. J Invest Dermatol 127(Suppl. 1):S26 (abstr.)
24. Eller MS, Shariftabrizi A, Gilchrest BA (2008b) The response to replicative stress at telomeres is mediated by Werner protein and induced by T-oligos. J Invest Dermatol 128(Suppl. 1):S126 (abstr.)
25. Eller MS, Yaar M, Gilchrest BA (1994) DNA damage and melanogenesis. Nature 372:413-414
26. Foster PL (2007) Stress-induced mutagenesis in bacteria. Crit Rev Biochem Mol Biol 42:373-397
27. Freeman SE, Hacham H, Gange RW, Maytum DJ, Sutherland JC, Sutherland BM (1989) Wavelength dependence of pyrimidine dimer formation in DNA of human skin irradiated in situ with ultraviolet light. Proc Natl Acad Sci USA 86:5605-5609 (Pubitemid 19185593)
28. Gilchrest BA (2004) Using DNA damage responses to prevent and treat skin cancers. J Dermatol 31:862-877
29. Gilchrest BA, Eller MS (1999) DNA photodamage stimulates melanogenesis and other photoprotective responses. J Investig Dermatol Symp Proc 4:35-40
30. Gilchrest BA, Eller MS (2001) Evidence in man for an evolutionarily conserved protective adaption to DNA damage. Comm Theor Biol 6:483-501
31. Gilchrest BA, Eller MS (2005) The tale of the telomere: implications for prevention and treatment of skin cancers. J Investig Dermatol Symp Proc 10:124-130
32. Gilchrest BA, Zhai S, Eller MS, Yarosh DB, Yaar M (1993) Treatment of human melanocytes and S91 melanoma cells with the DNA repair enzyme T4 endonuclease V enhances melanogenesis after ultraviolet irradiation. J Invest Dermatol 101:666-672 (Pubitemid 23322021)
33. Goukassian DA, Eller MS, Yaar M, Gilchrest BA (1999) Thymidine dinucleotide mimics the effect of solar simulated irradiation on p53 and p53-regulated proteins. J Invest Dermatol 112:25-31 (Pubitemid 29024701)
34. Goukassian DA, Helms E, Van Steeg H, Van Oostrom C, Bhawan J, Gilchrest BA (2004) Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice. Proc Natl Acad Sci USA 101:3933-3938 (Pubitemid 38381080)
35. Gray MD, Shen JC, Kamath-Loeb AS, Blank A, Sopher BL,Martin GMet al. (1997) The Werner syndrome protein is a DNA helicase. Nat Genet 17:100-103
36. Greider CW (1996) Telomere length regulation. Annu Rev Biochem 65:337-365
37. Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H et al. (1999) Mammalian telomeres end in a large duplex loop. Cell 97:503-514 (Pubitemid 29231173)
38. Guney I, Sedivy JM (2006) Cellular senescence, epigenetic switches and c-Myc. Cell Cycle (Georgetown, Tex) 5:2319-2323 (Pubitemid 44801376)
39. Halachmi S, Yaar M, Gilchrest BA (2005) [Advances in skin aging/photoaging: theoretical and practical implications]. Annales de Dermatologie et de Venereologie 132:362-367
40. Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460 (Pubitemid 20178256)
41. Harrington L, Robinson MO (2002) Telomere dysfunction: multiple paths to the same end. Oncogene 21:592-597 (Pubitemid 34146259)
42. Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37:614-636
43. Hayflick L (1977) The cellular basis of biological aging. In: Handbook of the Biology of Aging (FCHL, ed), Van Nostrand Reinhold: New York, 159-179
44. Hayflick L, Moorhead PS (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25:585-621
45. Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14:501-513
46. Ishibashi T, Lippard SJ (1998) Telomere loss in cells treated with cisplatin. Proc Natl Acad Sci USA 95:4219-4223 (Pubitemid 28207892)
47. Ishikawa F (2000) Aging clock: the watchmaker's masterpiece. Cell Mol Life Sci 57:698-704
48. Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T (1999) p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283:1321-1325 (Pubitemid 129507217)
49. Khlgatian MK, Hadshiew IM, Asawanonda P, Yaar M, Eller MS, Fujita M et al. (2002) Tyrosinase gene expression is regulated by p53. J Invest Dermatol 118:126-132 (Pubitemid 34107433)
50. Khlgatian MK, Hadshiew IM, Eller MS, Giese H, Vijg J, Gilchrest BA (1999) Thymidine dinucleotide pre-treatment reduces DNA mutation frequency. J Invest Dermatol 112:557 (abstr.)
51. Kosmadaki MG, Gilchrest BA (2004) The role of telomeres in skin aging/photoaging. Micron 35:155-159
52. Krtolica A, Campisi J (2002) Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol 34:1401-1414 (Pubitemid 35251811)
53. Kvam E, Tyrrell RM (1997) Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation. Carcinogenesis 18:2379-2384 (Pubitemid 28134653)
54. Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB (1992) Telomere end-replication problem and cell aging. J Mol Biol 225:951-960
55. Li GZ, Eller MS, Firoozabadi R, Gilchrest BA (2003) Evidence that exposure of the telomere 30 overhang sequence induces senescence. Proc Natl Acad Sci USA 100:527-531 (Pubitemid 36126085)
56. Li GZ, Eller MS, Hanna K, Gilchrest BA (2004) Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotides. Exp Cell Res 301:189-200 (Pubitemid 39504972)
57. Li S, Crothers J, Haqq CM, Blackburn EH (2005) Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J Biol Chem 280:23709-23717 (Pubitemid 40884853)
58. Lisby M, Rothstein R (2004) DNA damage checkpoint and repair centers. Curr Opin Cell Biol 16:328-334 (Pubitemid 38610415)
59. Maor-Shoshani A, Reuven NB, Tomer G, Livneh Z (2000) Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis. Proc Natl Acad Sci USA 97:565-570 (Pubitemid 30070349)
60. Morin GB (1989) The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59:521-529
61. Moriwaki S, Takahashi Y (2008) Photoaging and DNA repair. J Dermatol Sci 50:169-176
62. Nishigori C (2006) Cellular aspects of photocarcinogenesis. Photochem Photobiol Sci 5:208-214
63. Ohashi N, Yaar M, Eller MS, Truzzi F, Gilchrest BA (2007) Features that determine telomere homolog oligonucleotide-induced therapeutic DNA damage-like responses in cancer cells. J Cell Physiol 210:582-595 (Pubitemid 46185027)
64. Oikawa S, Kawanishi S (1999) Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening. FEBS Lett 453:365-368 (Pubitemid 29326680)
65. Parrish JA, Jaenicke KF, Anderson RR (1982) Erythema and melanogenesis action spectra of normal human skin. Photochem Photobiol 36:187-191
66. Puri N, Eller MS, Byers HR, Dykstra S, Kubera J, Gilchrest BA (2004) Telomere-based DNA damage responses: a new approach to melanoma. FASEB J 18:1373-1381 (Pubitemid 39150352)
67. Radman M (1975) SOS repair hypothesis: phenomenology of an inducible DNA repair which is accompanied by mutagenesis. In: Molecular Mechanisms for Repair of DNA, Part A (Hanawalt P, Stewlow RB, eds), Plenum: New York, 355-367
68. Rajagopalan M, Lu C, Woodgate R, O'Donnell M, Goodman MF, Echols H (1992) Activity of the purified mutagenesis proteins UmuC, UmuD′, and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III. Proc Natl Acad Sci USA 89:10777-10781
69. Rao L, Bierbach U (2007) Kinetically favored platination of adenine in the g-rich human telomeric repeat. J Am Chem Soc 129:15764-15765
70. Redon S, Bombard S, Elizondo-Riojas MA, Chottard JC (2003) Platinum crosslinking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutions. Nucleic Acids Res 31:1605-1613
71. Ruenger TM, Rees A, Dunn J, Potter M, Eller MS, Gilchrest BA (2007) Role of the Fanconi anemia/BRCA pathway in mediation of telomere loop opening and closing. J Invest Dermatol 127(Suppl. 1):S97 (abstr.)
72. Setlow RB, Carrier WL (1966) Pyrimidine dimers in ultraviolet-irradiated DNA's. J Mol Biol 17:237-254
73. Soutoglou E, Misteli T (2008) Activation of the cellular DNA damage response in the absence of DNA lesions. Science 320:1507-1510 (Pubitemid 351929432)
74. Stewart SA, Ben-Porath I, Carey VJ, O'Connor BF, Hahn WC, Weinberg RA (2003) Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet 33:492-496 (Pubitemid 36390011)
75. Takai H, Smogorzewska A, de Lange T (2003) DNA damage foci at dysfunctional telomeres. Curr Biol 13:1549-1556 (Pubitemid 37078413)
76. Tang M, Shen X, Frank EG, O'Donnell M, Woodgate R, Goodman MF (1999) UmuD′(2)C is an error-prone DNA polymerase, Escherichia coli pol V. Proc Natl Acad Sci USA 96:8919-8924
77. Toussaint O, Medrano EE, von Zglinicki T (2000) Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 35:927-945 (Pubitemid 30838466)
78. van Steensel B, Smogorzewska A, de Lange T (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413 (Pubitemid 28093017)
79. Walker GC (1984) Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. Microbiol Rev 48:60-80
80. Yaar M, Eller MS, Panova I, Kubera J, Wee LH, Cowan KH et al. (2007) Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells. Breast Cancer Res 9:R13, doi:10.1186/bcr1646 (Pubitemid 350215148)
81. Yaar M, Gilchrest BA (1998) Aging versus photoaging: postulated mechanisms and effectors. J Investig Dermatol Symp Proc 3:47-51 (Pubitemid 28532824)
82. Zhang P, Dilley C, Mattson MP (2007) DNA damage responses in neural cells: Focus on the telomere. Neuroscience 145:1439-1448 (Pubitemid 46602741)
83. Zhu J, Woods D, McMahon M, Bishop JM (1998) Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 12:2997-3007 (Pubitemid 28469302)