Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides

Molecular Immunology

Volumn 46, Issue 15, 2009, Pages 3163-3170

  Brownlie, Robert ^a   Zhu, Jianzhong ^b   Allan, Brenda ^a   Mutwiri, George K ^a   Babiuk, Lorne A ^c   Potter, Andrew ^a   Griebel, Philip ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Chicken; CpG oligodeoxynucleotide; HD11; TLR21; TLR9; Toll like receptor

Indexed keywords

BAFILOMYCIN; BAFILOMYCIN A; CPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; LEUCINE; N ACETYL BETA GLUCOSAMINIDASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 15; TOLL LIKE RECEPTOR 21; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CELL STRAIN HEK293; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOSOME; GENE ACTIVATION; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG PARENCHYMA; MACROPHAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MOTIF; RNA INTERFERENCE; SEQUENCE HOMOLOGY; SKIN; SMALL INTESTINE; SPLEEN; SYNOVIAL BURSA; TISSUE SPECIFICITY; UPREGULATION;

ADJUVANTS, IMMUNOLOGIC; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHICKENS; HUMANS; MACROPHAGES; MOLECULAR SEQUENCE DATA; NF-KAPPA B; OLIGODEOXYRIBONUCLEOTIDES; RNA INTERFERENCE; SEQUENCE ALIGNMENT; TOLL-LIKE RECEPTOR 9;

AVES; GALLUS GALLUS; MAMMALIA;

EID: 68749108013     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.06.002     Document Type: Article

References (42)

1. Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
2. al Yacoub N., Romanowska M., Haritonova N., and Foerster J. Optimized production and concentration of lentiviral vectors containing large inserts. J. Gene Med. 9 (2007) 579-584
3. Carrington A.C., and Secombes C.J. A review of CpGs and their relevance to aquaculture. Vet. Immunol. Immunopathol. 112 (2006) 87-101
4. Dar A., Nichani A.K., Benjamin P., Lai K., Soita H., Krieg A.M., Potter A., Babiuk L.A., and Mutwiri G.K. Attenuated cytokine responses in porcine lymph node cells stimulated with CpG DNA are associated with low frequency of IFNalpha-producing cells and TLR9 mRNA expression. Vet. Immunol. Immunopathol. 123 (2008) 324-336
5. Dardalhon V., Herpers B., Noraz N., Pflumio F., Guetard D., Leveau C., Dubart-Kupperschmitt A., Charneau P., and Taylor N. Lentivirus-mediated gene transfer in primary T cells is enhanced by a central DNA flap. Gene Ther. 8 (2001) 190-198
6. Gomis S., Babiuk L., Allan B., Willson P., Waters E., Ambrose N., Hecker R., and Potter A. Protection of neonatal chicks against a lethal challenge of Escherichia coli using DNA containing cytosine-phosphodiester-guanine motifs. Avian Dis. 48 (2004) 813-822
7. Gomis S., Babiuk L., Allan B., Willson P., Waters E., Hecker R., and Potter A. Protection of chickens against a lethal challenge of Escherichia coli by a vaccine containing CpG oligodeoxynucleotides as an adjuvant. Avian Dis. 51 (2007) 78-83
8. Gomis S., Babiuk L., Godson D.L., Allan B., Thrush T., Townsend H., Willson P., Waters E., Hecker R., and Potter A. Protection of chickens against Escherichia coli infections by DNA containing CpG motifs. Infect Immun. 71 (2003) 857-863
9. Gupta K., and Cooper C. A review of the role of CpG oligodeoxynucleotides as toll-like receptor 9 agonists in prophylactic and therapeutic vaccine development in infectious diseases. Drugs R D 9 (2008) 137-145
10. He H., Crippen T.L., Farnell M.B., and Kogut M.H. Identification of CpG oligodeoxynucleotide motifs that stimulate nitric oxide and cytokine production in avian macrophage and peripheral blood mononuclear cells. Dev. Comp. Immunol. 27 (2003) 621-627
11. He H., Genovese K.J., Lowry V.K., Nisbet D.J., and Kogut M.H. Response of nitric oxide production to CpG oligodeoxynucleotides in turkey and chicken peripheral blood monocytes. FEMS Immunol. Med. Microbiol. 48 (2006) 99-106
12. He H., Genovese K.J., Nisbet D.J., and Kogut M.H. Synergy of CpG oligodeoxynucleotide and double-stranded RNA (poly I:C) on nitric oxide induction in chicken peripheral blood monocytes. Mol. Immunol. 44 (2007) 3234-3242
13. He H., Genovese K.J., Swaggerty C.L., Nisbet D.J., and Kogut M.H. In vivo priming heterophil innate immune functions and increasing resistance to Salmonella enteritidis infection in neonatal chickens by immune stimulatory CpG oligodeoxynucleotides. Vet. Immunol. Immunopathol. 117 (2007) 275-283
14. He H., and Kogut M.H. CpG-ODN-induced nitric oxide production is mediated through clathrin-dependent endocytosis, endosomal maturation, and activation of PKC, MEK1/2 and p38 MAPK, and NF-kappaB pathways in avian macrophage cells (HD11). Cell Signal. 15 (2003) 911-917
15. He H., Lowry V.K., Ferro P.J., and Kogut M.H. CpG-oligodeoxynucleotide-stimulated chicken heterophil degranulation is serum cofactor and cell surface receptor dependent. Dev. Comp. Immunol. 29 (2005) 255-264
16. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., and Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
17. Higgs R., Cormican P., Cahalane S., Allan B., Lloyd A.T., Meade K., James T., Lynn D.J., Babiuk L.A., and O'Farrelly C. Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection. Infect Immun. 74 (2006) 1692-1698
18. Jurk M., Schulte B., Kritzler A., Noll B., Uhlmann E., Wader T., Schetter C., Krieg A.M., and Vollmer J. C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level. Immunobiology 209 (2004) 141-154
19. Klinman D.M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4 (2004) 249-258
20. Krieg A.M. Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug Discov. 5 (2006) 471-484
21. Kumagai Y., Takeuchi O., and Akira S. TLR9 as a key receptor for the recognition of DNA. Adv. Drug Deliv. Rev. 60 (2008) 795-804
22. Lahiri A., Das P., and Chakravortty D. Engagement of TLR signaling as adjuvant: towards smarter vaccine and beyond. Vaccine 26 (2008) 6777-6783
23. Latz E., Verma A., Visintin A., Gong M., Sirois C.M., Klein D.C., Monks B.G., McKnight C.J., Lamphier M.S., Duprex W.P., Espevik T., and Golenbock D.T. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol 8 (2007) 772-779
24. Leulier F., and Lemaitre B. Toll-like receptors-taking an evolutionary approach. Nat. Rev. Genet. 9 (2008) 165-178
25. Li M.J., and Rossi J.J. Lentiviral vector delivery of recombinant small interfering RNA expression cassettes. Methods Enzymol. 392 (2005) 218-226
26. Matsushima N., Tanaka T., Enkhbayar P., Mikami T., Taga M., Yamada K., and Kuroki Y. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics 8 (2007) 124
27. Nichani A.K., Mena A., Popowych Y., Dent D., Townsend H.G., Mutwiri G.K., Hecker R., Babiuk L.A., and Griebel P.J. In vivo immunostimulatory effects of CpG oligodeoxynucleotide in cattle and sheep. Vet. Immunol. Immunopathol. 98 (2004) 17-29
28. Paddison P.J., Cleary M., Silva J.M., Chang K., Sheth N., Sachidanandam R., and Hannon G.J. Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat. Methods 1 (2004) 163-167
29. Patel B.A., Gomis S., Dar A., Willson P.J., Babiuk L.A., Potter A., Mutwiri G., and Tikoo S.K. Oligodeoxynucleotides containing CpG motifs (CpG-ODN) predominantly induce Th1-type immune response in neonatal chicks. Dev. Comp. Immunol. 32 (2008) 1041-1049
30. Philbin V.J., Iqbal M., Boyd Y., Goodchild M.J., Beal R.K., Bumstead N., Young J., and Smith A.L. Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens. Immunology 114 (2005) 507-521
31. Rankin R., Pontarollo R., Ioannou X., Krieg A.M., Hecker R., Babiuk L.A., and van Drunen Littel-van den Hurk S. CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved. Antisense Nucleic Acid Drug Dev. 11 (2001) 333-340
32. Rutz M., Metzger J., Gellert T., Luppa P., Lipford G.B., Wagner H., and Bauer S. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur. J. Immunol. 34 (2004) 2541-2550
33. Schwarz H., Schneider K., Ohnemus A., Lavric M., Kothlow S., Bauer S., Kaspers B., and Staeheli P. Chicken toll-like receptor 3 recognizes its cognate ligand when ectopically expressed in human cells. J. Interferon Cytokine Res. 27 (2007) 97-101
34. Smith J., Speed D., Law A.S., Glass E.J., and Burt D.W. In-silico identification of chicken immune-related genes. Immunogenetics 56 (2004) 122-133
35. Taghavi A., Allan B., Mutwiri G., Van Kessel A., Willson P., Babiuk L., Potter A., and Gomis S. Protection of neonatal broiler chicks against Salmonella Typhimurium septicemia by DNA containing CpG motifs. Avian Dis. 52 (2008) 398-406
36. Temperley N.D., Berlin S., Paton I.R., Griffin D.K., and Burt D.W. Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss. BMC Genomics 9 (2008) 62
37. Vollmer J., and Krieg A.M. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv Drug Deliv Rev (2009)
38. Wang Y., Shan C., Ming S., Liu Y., Du Y., and Jiang G. Immunoadjuvant effects of bacterial genomic DNA and CpG oligodeoxynucleotides on avian influenza virus subtype H5N1 inactivated oil emulsion vaccine in chicken. Res. Vet. Sci. (2008)
39. West A.P., Koblansky A.A., and Ghosh S. Recognition and signaling by toll-like receptors. Annu. Rev. Cell Dev. Biol. 22 (2006) 409-437
40. Xie H., Raybourne R.B., Babu U.S., Lillehoj H.S., and Heckert R.A. CpG-induced immunomodulation and intracellular bacterial killing in a chicken macrophage cell line. Dev. Comp. Immunol. 27 (2003) 823-834
41. Zarember K.A., and Godowski P.J. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. 168 (2002) 554-561
42. Zhu J., Lai K., Brownile R., Babiuk L.A., and Mutwiri G.K. Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod. Mol. Immunol. 45 (2008) 3238-3243