Functional characterisation of homomeric ionotropic glutamate receptors GluR1-GluR6 in a fluorescence-based high throughput screening assay

Combinatorial Chemistry and High Throughput Screening

Volumn 9, Issue 2, 2006, Pages 147-158

  Strange, Mette ^a   Bräuner Osborne, Hans ^a   Jensen, Anders A ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

AMPA; Fluo 4; Glutamate; High throughput screening; HTS; Ion channel; Ionotropic; Kainate

Indexed keywords

2 AMINO 3 (3 CARBOXY 5 METHYL 4 ISOXAZOYL)PROPIONATE; 2 AMINO 3 (3 HYDROXY 7,8 DIHYDRO 6H CYCLOHEPTAL[D]ISOXAZOL 4 YL)PROPIONATE; 2 AMINO 3 (5 TERT BUTYL 3 PHOSPHONOMETHOXY 4 ISOXAZOLYL)PROPIONATE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ALPHA AMINO 5 TERT BUTYL 3 HYDROXY 4 ISOXAZOLEPROPIONIC ACID; BUFFER; CALCIUM; CONCANAVALIN A; CYCLOTHIAZIDE; FLUO 4; FLUORESCENT DYE; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 3; GLUTAMATE RECEPTOR 4; GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR 6; GLUTAMIC ACID; IONOTROPIC RECEPTOR; KAINIC ACID; PROPIONIC ACID; QUISQUALIC ACID; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; EMBRYO; FLUORESCENCE; HEART FUNCTION TEST; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOPUS;

ANILINE COMPOUNDS; BENZOTHIADIAZINES; CALCIUM; CELL LINE; COMBINATORIAL CHEMISTRY TECHNIQUES; CONCANAVALIN A; DRUG EVALUATION, PRECLINICAL; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FLUORESCENCE; GLUTAMIC ACID; HUMANS; KAINIC ACID; QUINOXALINES; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE; SIGNAL TRANSDUCTION; XANTHENES;

MAMMALIA;

EID: 33645790297     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620706775541918     Document Type: Article

References (39)

1. Dingledine, R.; McBain, C.J. In: Basic Neurochemistry; (Ed.^(Eds. Siegel GJ, Agranoff BW, Albers RW, Fisher SK and Uhler MD), Lippencott-Raven, Philadelphia New York,1999; pp. 315.
2. Meldrum, B.S. Prog. Brain Res., 1998, 116, 441.
3. Bräuner-Osborne, H.; Egebjerg, J.; Nielsen, E.Ø.; Madsen, U.; Krogsgaard-Larsen, P. J. Med. Chem., 2000, 43, 2609.
4. Dingledine, R.; Borges, K.; Bowie, D.; Traynelis, S.F. Pharmacol. Rev., 1999, 51, 7.
5. Lees, G.J. Drugs, 2000, 59, 33.
6. Jensen, A.A. In: Molecular Neuropharmacology. Strategies and Methods; (Ed.^(Eds. Schousboe A and Bräuner-Osborne H), Humana Press, 2004; pp. 47.
7. Hollmann, M.; Heinemann, S. Annu. Rev. Neurosci., 1994, 17, 31.
8. Lerma, J.; Paternain, A.V.; Rodriguez-Moreno, A.; Lopez-Garcia, J.C. Physiol. Rev., 2001, 81, 971.
9. Sommer, B.; Keinanen, K.; Verdoorn, T.A.; Wisden, W.; Burnashev, N.; Herb, A.; Kohler, M.; Takagi, T.; Sakmann, B.; Seeburg, P.H. Science, 1990, 249, 1580.
10. Seeburg, P.H. Trends Pharmacol. Sci., 1993, 14, 297.
11. Sommer, B.; Kohler, M.; Sprengel, R.; Seeburg, P.H. Cell, 1991, 67, 11.
12. Egebjerg, J.; Heinemann, S.F. Proc. Natl. Acad. Sci. U.S.A., 1993, 90, 755.
13. Seeburg, P.H. J. Neurochem., 1996, 66, 1.
14. Lomeli, H.; Mosbacher, J.; Melcher, T.; Hoger, T.; Geiger, J.R.; Kuner, T.; Monyer, H.; Higuchi, M.; Bach, A.; Seeburg, P.H. Science, 1994, 266, 1709.
15. Köhler, M.; Burnashev, N.; Sakmann, B.; Seeburg, P.H. Neuron, 1993, 10, 491.
16. Varney, M.A.; Rao, S.P.; Jachec, C.; Deal, C.; Hess, S.D.; Daggett, L.P.; Lin, F.; Johnson, E.C.; Velicelebi, G. J. Pharmacol. Exp. Ther., 1998, 285, 358.
17. Alt, A.; Weiss, B.; Ogden, A.M.; Knauss, J.L.; Oler, J.; Ho, K.; Large, T.H.; Bleakman, D. Neuropharmacology, 2004, 46, 793.
18. Bednar, B.; Cunningham, M.E.; Kiss, L.; Cheng, G.; McCauley, J.A.; Liverton, N.J.; Koblan, K.S. J. Neurosci. Methods, 2004, 137, 247.
19. Fitch, R.W.; Xiao, Y.; Kellar, K.J.; Daly, J.W. Proc. Natl. Acad. Sci. U.S.A., 2003, 100, 4909.
20. Jensen, A.A.; Kristiansen, U. Biochem. Pharmacol., 2004, 67, 1789.
21. Adkins, C.E.; Pillai, G.V.; Kerby, J.; Bonnert, T.P.; Haldon, C.; McKernan, R.M.; Gonzalez, J.E.; Oades, K.; Whiting, P.J.; Simpson, P.B. J. Biol. Chem., 2001, 276, 38934.
22. Sommer, B.; Burnashev, N.; Verdoorn, T.A.; Keinanen, K.; Sakmann, B.; Seeburg, P.H. EMBO J., 1992, 11, 1651.
23. Craig, D.A. Trends Pharmacol. Sci., 1993, 14, 89.
24. Desai, M.A.; Burnett, J.P.; Ornstein, P.L.; Schoepp, D.D. J. Pharmacol. Exp. Ther., 1995, 272, 38.
25. Everts, I.; Petroski, R.; Kiselsztein, P.; Teichberg, V.I.; Heinemann, S.F.; Hollmann, M. J. Neurosci., 1999, 19, 916.
26. Banke, T.G.; Schousboe, A.; Pickering, D.S. J. Neurosci. Res., 1997, 49, 176.
27. Fletcher, E.J.; Nutt, S.L.; Hoo, K.H.; Elliott, C.E.; Korczak, B.; McWhinnie, E.A.; Kamboj, R.K. Receptors Channels, 1995, 3, 21.
28. Hoo, K.H.; Nutt, S.L.; Fletcher, E.J.; Elliott, C.E.; Korczak, B.; Deverill, R.M.; Rampersad, V.; Fantaske, R.P.; Kamboj, R.K. Receptors Channels, 1994, 2, 327.
29. Egebjerg, J.; Bettler, B.; Hermans-Borgmeyer, I.; Heinemann, S. Nature, 1991, 351, 745.
30. Brehm, L.; Greenwood, J.R.; Hansen, K.B.; Nielsen, B.; Egebjerg, J.; Stensbøl, T.B.; Bräuner-Osborne, H.; Sløk, F.A.; Kronborg, T.T.; Krogsgaard-Larsen, P. J. Med. Chem., 2003, 46, 1350.
31. Stensbøl, T.B.; Borre, L.; Johansen, T.N.; Egebjerg, J.; Madsen, U.; Ebert, B.; Krogsgaard-Larsen, P. Eur. J. Pharmacol., 1999, 380, 153.
32. Brehm, L.; Greenwood, J.R.; Sløk, F.A.; Holm, M.M.; Nielsen, B.; Geneser, U.; Stensbøl, T.B.; Bräuner-Osborne, H.; Begtrup, M.; Egebjerg, J.; Krogsgaard-Larsen, P. Chirality, 2004, 16, 452.
33. Møller, E.H.; Egebjerg, J.; Brehm, L.; Stensbøl, T.B.; Johansen, T.N.; Madsen, U.; Krogsgaard-Larsen, P. Chirality, 1999, 11, 752.
34. Nielsen, B.S.; Banke, T.G.; Schousboe, A.; Pickering, D.S. Eur. J. Pharmacol., 1998, 360, 227.
35. Andersen, P.H.; Tygesen, C.K.; Rasmussen, J.S.; Søgaard-Nielsen, L.; Hansen, A.; Hansen, K.; Kiemer, A.; Stidsen, C.E. Eur. J. Pharmacol., 1996, 311, 95.
36. Korczak, B.; Nutt, S.L.; Fletcher, E.J.; Hoo, K.H.; Elliott, C.E.; Rampersad, V.; McWhinnie, E.A.; Kamboj, R.K. Receptors Channels, 1995, 3, 41.
37. Lomeli, H.; Wisden, W.; Kohler, M.; Keinanen, K.; Sommer, B.; Seeburg, P.H. FEBS Lett., 1992, 307, 139.
38. Tygesen, C.K.; Rasmussen, J.S.; Jones, S.V.; Hansen, A.; Hansen, K.; Andersen, P.H. Proc. Natl. Acad. Sci. U.S.A., 1994, 91, 13018.
39. Tygesen, C.K.; Jørgensen, M.; Andersen, P.H. FEBS Lett., 1995, 363, 184.