Models of torsades de pointes: Effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts

Journal of Pharmacological and Toxicological Methods

Volumn 60, Issue 2, 2009, Pages 174-184

  Cheng, Hsien C ^a   Incardona, Josephine ^a  

^a SANOFI   (France)

Author keywords

Chromanol 293B; Dofetilide; DPI201106; FPL64176; IKs; Langendorff; QTc; Short term variability; Torsades

Indexed keywords

4 (2 BENZYLBENZOYL) 2,5 DIMETHYL 1H PYRROLE 3 CARBOXYLIC ACID METHYL ESTER; 4 [3 (4 BENZHYDRYL 1 PIPERAZINYL) 2 HYDROXYPROPOXY] 1H INDOLE 2 CARBONITRILE; CHROMANOL 293B; DOFETILIDE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RESEARCH; DRUG SAFETY; ELECTROCARDIOGRAM; FEMALE; GUINEA PIG; HEART ARRHYTHMIA; HEART PERFUSION; HEART RATE; HEART RATE VARIABILITY; HEART REPOLARIZATION; IN VITRO STUDY; ISOLATED HEART; MALE; NONHUMAN; QT INTERVAL; QT PROLONGATION; RABBIT; TORSADE DES POINTES;

ANIMALS; CALCIUM CHANNEL AGONISTS; CHROMANS; DATA INTERPRETATION, STATISTICAL; ELECTROCARDIOGRAPHY; FEMALE; GUINEA PIGS; HEART RATE; LONG QT SYNDROME; MALE; PHENETHYLAMINES; PIPERAZINES; POTASSIUM CHANNEL BLOCKERS; PYRROLES; RABBITS; SODIUM CHANNEL BLOCKERS; SULFONAMIDES; TIME FACTORS; TORSADES DE POINTES;

CAVIA; ORYCTOLAGUS CUNICULUS;

EID: 68549088717     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2009.05.010     Document Type: Article

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