Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2

Circulation Research

Volumn 102, Issue 9, 2008, Pages

  Sims, Carl ^a,b   Reisenweber, Steven ^a   Viswanathan, Prakash C ^a   Choi, Bum Rak ^a,c   Walker, William H ^a   Salama, Guy ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b YOUNGSTOWN STATE UNIVERSITY   (United States)

^c RHODE ISLAND HOSPITAL   (United States)

Author keywords

Cardiac voltage gated calcium current; ICa,L, sex differences; Ion channel expression; QT interval; Torsade de Pointes

Indexed keywords

CALCIUM CHANNEL L TYPE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DEPOLARIZATION; EPICARDIUM; FEMALE; HEART ARRHYTHMIA; MALE; MATURITY; MUSCLE CELL; NONHUMAN; PHENOTYPE; PREPUBERTY; PRIORITY JOURNAL; QT PROLONGATION; RABBIT; REPOLARIZATION; SEX DIFFERENCE; SIMULATION; TORSADE DES POINTES; WESTERN BLOTTING;

ACTION POTENTIALS; AGE FACTORS; ANIMALS; CALCIUM CHANNELS, L-TYPE; COMPUTER SIMULATION; FEMALE; HEART VENTRICLES; ION CHANNEL GATING; LONG QT SYNDROME; MALE; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PERICARDIUM; PHENOTYPE; POTASSIUM CHANNEL BLOCKERS; PYRROLIDINES; RABBITS; RESEARCH DESIGN; RISK FACTORS; RNA, MESSENGER; SEX FACTORS; SODIUM-CALCIUM EXCHANGER; TIME FACTORS; TORSADES DE POINTES;

EID: 43449088837     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.173740     Document Type: Article

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