Free and bound state structures of 6-O-methyl homoerythromycins and epitope mapping of their interactions with ribosomes

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 16, 2009, Pages 5857-5867

  Novak, Predrag ^a   Barber, Jill ^b   Čikoš, Ana ^c   Arsic, Biljana ^b   Plavec, Janez ^d   Lazarevski, Gorjana ^c   Tepeš, Predrag ^e   Košutić Hulita, Nada ^f  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

^d NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^e UNIVERSITY OF ZAGREB   (Croatia)

^f PLIVA CROATIA LTD   (Croatia)

Author keywords

Binding epitopes; Free and ribosome bound structures; Homoerythromycins; NMR and molecular modeling

Indexed keywords

6 O METHYLHOMOERYTHROMYCIN DERIVATIVE; ANTIINFECTIVE AGENT; AZITHROMYCIN; ERYTHROMYCIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG BINDING; DRUG CONFORMATION; DRUG MECHANISM; EPITOPE MAPPING; ESCHERICHIA COLI; IC 50; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; RIBOSOME; SATURATION TRANSFER DIFFERENCE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLID STATE; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BINDING SITES; CLARITHROMYCIN; CRYSTALLOGRAPHY, X-RAY; EPITOPE MAPPING; ESCHERICHIA COLI; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR CONFORMATION; RIBOSOMES;

ESCHERICHIA COLI;

EID: 68149131329     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.013     Document Type: Article

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