Changes in expression of cell-cycle-related genes in PC-3 prostate cancer cells caused by ovine uterine serpin

Journal of Cellular Biochemistry

Volumn 107, Issue 6, 2009, Pages 1182-1188

  Padua, Maria B ^a   Hansen, Peter J ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Cell cycle arrest; P21; PC 3 prostate cancer cells; PCR array; Proliferation; Serpina14; Uterine serpin; UTMP

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; OVINE UTERINE SERPIN; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CELL CYCLE; CELL LINE, TUMOR; DOWN-REGULATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; PROSTATIC NEOPLASMS; SERINE PROTEINASE INHIBITORS; SERPINS; SHEEP; UP-REGULATION; UTERUS;

OVIS;

EID: 68049107159     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22222     Document Type: Article

References (50)

1. Aylon Y, Liefshitz B, Kupiec M. 2004. The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO J 23:4868-4875. (Pubitemid 40069716)
2. Baker DJ, Dawlaty MM, Galardy P, van Deursen JM. 2007. Mitotic regulation of the anaphase-promoting complex. Cell Mol Life Sci 64:589-600.
3. Bates S, Rowan S, Vousden KH. 1996. Characterization of human cyclin G1 and G2: DNA damage inducible genes. Oncogene 13:1103-1109.
4. Bennin DA, Don ASA, Brake T, McKenzie L, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC. 2002. Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B′ subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. J Biol Chem 277:27449-27467. (Pubitemid 34951766)
5. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 78:248-254.
6. Branzei D, Foiani M. 2008. Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol 9:297-308.
7. 2 arrest after DNA damage. Science 282:1497-1501.
8. Cayrol C, Knibiehler M, Ducommun B. 1998. p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. Oncogene 16:311-320. (Pubitemid 28052285)
9. Croucher D, Saunders DN, Lobov S, Ranson M. 2008. Revisiting the biological roles of PAI2 (SERPINB2) in cancer. Nat Rev Cancer 8:535-545. (Pubitemid 351881848)
10. Gartel AL, Tyner AL. 2002. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 1:639-649.
11. Gatz SA, Wiesmüller L. 2006. p53 in recombination and repair. Cell Death Differ 13:1003-1016.
12. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H. 1984. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710-1715. (Pubitemid 14035254)
13. Hansen PJ. 1998. Regulation of uterine immune function by progesterone-lessons from the sheep. J Reprod Immunol 40:63-79. (Pubitemid 29049010)
14. Hansen PJ, Ing NH, Moffatt J, Baumbach GA, Saunders PTK, Bazer FW, Roberts RM. 1987a. Biochemical characterization of biosynthesis of the uterine milk proteins of the pregnant sheep uterus. Biol Reprod 36:405-418.
15. Hansen PJ, Segerson EC, Bazer FW. 1987b. Characterization of immunosuppressive substances in the basic protein fraction of uterine secretions of pregnant ewes. Biol Reprod 36:393-403.
16. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. 1993. The p21 Cdk-interacting protein Cipl is a potent inhibitor of Gl cyclin-dependent kinases. Cell 75:805-816. (Pubitemid 223003113)
17. Horne MC, Donaldson KL, Goolsby GL, Tran D, Mulheisen M, Hell WJ, Wahl AF. 1997. Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest. J Biol Chem 272:12650-12661. (Pubitemid 27203362)
18. Ing NH, Roberts RM. 1989. The major progesterone-induced proteins secreted into the sheep uterus are members of the serpin superfamily of protease inhibitors. J Biol Chem 264:3372-3379.
19. Irving JA, Pike RN, Lesk AM, Whisstock JC. 2000. Phylogeny of the serpin superfamily: Implications of patterns of amino acid conservation for structure and function. Genome Res 10:1845-1864.
20. Irving JA, Shushanov SS, Pike RN, Popova EY, Bromme D, Coetzer THT, Bottomley SP, Boulynko IA, Grigoryev SA, Whisstock JC. 2002. Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation. J Biol Chem 277:13192-13201. (Pubitemid 34952690)
21. Isaacs WB, Carter BS, Erwing CM. 1991. Wild-type p53 suppresses growth oh human prostate cancer cells containing mutant p53 alleles. Cancer Res 51:4716-4720.
22. Kaldis P. 1999. The cdk-activating kinase (CAK): From yeast to mammals. Cell Mol Life Sci 55:284-296. (Pubitemid 29118894)
23. Krug U, Ganser A, Koeffler HP. 2002. Tumor suppressor genes in normal and malignant hematopoiesis. Oncogene 21:3475-3495. (Pubitemid 34587717)
24. Le XF, Arachchige-DonAS, Mao W, Horne MC, Bast RC, Jr. 2007. Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells. Mol Cancer Ther 6:2847-2857.
25. Leslie MV, Hansen PJ, Newton GR. 1990. Uterine secretions of the cow contain proteins that are immunochemically related to the major progesterone-induced proteins of the sheep uterus. Domest Anim Endocrinol 7:517-526.
26. Li R, Waga S, Hannon GJ, Beach D, Stillman B. 1994. Differential effects by the p21 CDK inhibitor on PCNA-dependent replication and repair. Nature 371:534-537. (Pubitemid 24306614)
27. Liu WJ, Hansen PJ. 1995. Progesterone-induced secretion of dipeptidyl peptidase-IV (cell differentiation antigen 26) by the uterine endometrium of the ewe and cow that costimulates lymphocyte proliferation. Endocrinology 136:779-787.
28. Liu WJ, Peltier MR, Hansen PJ. 1999. Binding of ovine uterine serpin to lymphocytes. Am J Reprod Immunol 41:428-432.
29. Lühr K, Müritz C, Contente A, Dobbelstein M. 2003. p21/CDKN1A mediates negative regulation of transcription by p53. J Biol Chem 278:32507-32516. (Pubitemid 37055688)
30. Lu H, Guo X, Meng X, Liu J, Allen C, Wray J, Nickoloff JA, Shen Z. 2005. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Mol Cell Biol 25:1949-1957. (Pubitemid 40280157)
31. Malathy PV, Imakawa K, Simmen RC, Roberts RM. 1990. Molecular cloning of the uteroferrin-associated protein, a major progesterone-induced serpin secreted by the porcine uterus, and expression of its mRNA during pregnancy. Mol Endocrinol 4:428-440. (Pubitemid 20121513)
32. Martinsson-Ahlzén H, Liberal V, Grünenfelder B, Chaves SR, Spruck CH, Reed SI. 2008. Cyclin-dependent kinase-associated proteins cks1 and cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells. Mol Cell Biol 28:5698-5709.
33. Mathialagan N, Hansen TR. 1996. Pepsin-inhibitory activity of uterine serpins. Proc Natl Acad Sci 93:13653-13658.
34. Moffatt J, Bazer FW, Hansen PJ, Chun PW, Roberts RM. 1987. Purification, secretion and immunocytochemical localization of the uterine milk proteins, major progesterone-induced proteins in uterine secretion of the sheep. Biol Reprod 36:419-430. (Pubitemid 17062216)
35. Morgan L, Broughton Pipkin F, Kalsheker N. 1996. Angiotensinogen: Molecular biology, biochemistry and physiology. Int J Biochem Cell Biol 28:1211-1222. (Pubitemid 27033137)
36. Nagata K. 1998. Expression and function of heat shock protein 47: A collagen-specific molecular chaperone in the endoplasmic reticulum. Matrix Biol 16:379-386. (Pubitemid 28069864)
37. Padua MB, Hansen PJ. 2008. Regulation of DNA synthesis and the cell cycle in human prostate cancer cells and lymphocytes by ovine uterine serpin. BMC Cell Biol 9:5.
38. Peltier MR, Liu WJ, Hansen PJ. 1999. Regulation of lymphocyte proliferation by uterine serpin: Interleukin-2 mRNA production, CD25 expression and responsiveness to interleukin-2. Proc Soc Exp Biol Med 223:75-81.
39. Pemberton PA, Stein PE, Pepys MB, Potter JM, Carrell RW. 1998. Hormone binding globulins undergo serpin conformational change in inflammation. Nature 336:257-258.
40. Sancar A, Lindsey-Boltz LA, Unsal-Kamaz K, Linn S. 2004. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73:39-85. (Pubitemid 39050363)
41. Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP. 2007. Human CtIP promotes DNA end resection. Nature 450:509-514. (Pubitemid 350190253)
42. Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PGW, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC. 2001. The serpins are an expanding superfamily of structurally similar but functional diverse proteins. J Biol Chem 276:33293-33296.
43. Skopets B, Hansen PJ. 1993. Identification of the predominant proteins in uterine fluids of unilaterally pregnant ewes that inhibit lymphocyte proliferation. Biol Reprod 49:997-1007. (Pubitemid 23313824)
44. Tekin Ş, Padua MB, Brad AM, Hansen PJ. 2005a. Antiproliferative actions of ovine uterine serpin. Am J Reprod Immunol 53:136-143. (Pubitemid 40352723)
45. Tekin Ş, Padua MB, Brad AM, Rhodes ML, Hansen PJ. 2006. Expression and properties of recombinant ovine uterine serpin. Exp Biol Med (Maywood) 231:1313-1322. (Pubitemid 44330567)
46. Tekin Ş, Padua MB, Newton GR, Hansen PJ. 2005b. Identification and cloning of caprine uterine serpin. Mol Reprod Dev 70:262-270. (Pubitemid 40170694)
47. Teng SC, Wu KJ, Tseng SF, Wong CW, Kao L. 2003. Importin KPNA2, NBS1, DNA repair and tumorigenesis. J Mol Hist 37:293-299. (Pubitemid 44795632)
48. Waga S, Hannon GJ, Beach D, Stillman B. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369:574-578. (Pubitemid 24192528)
49. waf1 overexpression in HepG2 hepatocellular carcinoma cells. J Huazhong Univ Sci Technol Med Sci 28:308-313.
50. Zhang B, Lu Y, Campbell-Thompson M, Specer T, Wasserfall C, Atkinson M, Song S. 2007. α1-antitrypsin protects β-cells from apoptosis. Diabetes 56:1316-1323.