Caffeine augments Alprazolam induced cytotoxicity in human cell lines

Toxicology in Vitro

Volumn 23, Issue 6, 2009, Pages 1100-1109

  Saha, Biswarup ^a   Mukherjee, Ananda ^a   Samanta, Saheli ^a   Saha, Piyali ^a   Ghosh, Anup Kumar ^a   Santra, Chitta Ranjan ^b   Karmakar, Parimal ^a  

^a JADAVPUR UNIVERSITY   (India)

^b Netaji Nagar Day College   (India)

Author keywords

Calpain; Alprazolam; Caffeine; Cathepsin B; Cell death; Lysosomes; Necrosis

Indexed keywords

ALPRAZOLAM; CAFFEINE; CALCIUM; CALPAIN 1; CASPASE 3; CATHEPSIN B; GLUTATHIONE; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE;

ANISOTROPY; ARTICLE; CELL DEATH; CELL LINE; CELL MEMBRANE; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME RELEASE; HELA CELL; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; TOXICITY TESTING;

ALPRAZOLAM; ANTI-ANXIETY AGENTS; APOPTOSIS; CAFFEINE; CELL LINE, TUMOR; CENTRAL NERVOUS SYSTEM STIMULANTS; DRUG SYNERGISM; GLUTATHIONE; HELA CELLS; HUMANS; L-LACTATE DEHYDROGENASE; NECROSIS; REACTIVE OXYGEN SPECIES;

EID: 68049084588     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.05.018     Document Type: Article

References (59)

1. Aldridge A., Parsons W.D., and Neims A.H. Stimulation of caffeine metabolism in the rat by 3-methylcholanthrene. Life Sciences 21 (1977) 967-974
2. 2+ sink in PC12 cells. The Biochemical Journal 300 (1994) 589-597
3. Boulares A.H., Yakovlev A.G., Ivanova V., Stoica B.A., Wang G., Iyer S., and Smulson M. Role of poly(ADP-ribose) polymerase (PARP) cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis. The Journal of Biological Chemistry 275 (1999) 9043-9046
4. Boulenger J.P., Uhde T.W., Wolff III E.A., and Post R.M. Increased sensitivity to caffeine in patients with panic disorders. Preliminary evidence. Archives of General Psychiatry 41 (1984) 1067-1071
5. Capiod T., Shuba Y., Skryma R., and Prevarskaya N. Calcium signaling and cancer cell growth. Sub-cellular Biochemistry 45 (2007) 405-427
6. Chaitanya G.V., and Babu P.P. Activation of calpain, cathepsin-b and caspase-3 during transient focal cerebral ischemia in rat model. Neurochemical Research 33 (2008) 2178-2186
7. Charney D.S., and Heninger G.R. Noradrenergic function and the mechanism of action of antianxiety treatment. I. The effect of long-term alprazolam treatment. Archives of General Psychiatry 42 (1985) 458-467
8. Chen Y., McMillan-Ward E., Kong J., Israels S.J., and Gibson S.B. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death and Differentiation 15 (2008) 171-182
9. Cheung N.S., Peng Z.F., Chen M.J., Moore P.K., and Whiteman M. Hydrogen sulfide induced neuronal death occurs via glutamate receptor and is associated with calpain activation and lysosomal rupture in mouse primary cortical neurons. Neuropharmacology 53 (2007) 505-514
10. D'Ambrosio S.M. Evaluation of the genotoxicity data on caffeine. Regulatory Toxicology and Pharmacology: RTP 19 (1994) 243-281
11. Fukasawa T., Suzuki A., and Otani K. Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines. Journal of Clinical Pharmacy and Therapeutics 32 (2007) 333-341
12. Galluzzi L., and Kroemer G. Necroptosis: a specialized pathway of programmed necrosis. Cell 135 (2008) 1161-1163
13. Garbarino J.A., Cardile V., Lombardo L., Chamy M.C., Piovano M., and Russo A. Demalonyl thyrsiflorin A, a semisynthetic labdane-derived diterpenoid, induces apoptosis and necrosis in human epithelial cancer cells. Chemico-biological Interactions 169 (2007) 198-206
14. Goll D.E., Thompson V.F., Li H., Wei W., and Cong J. The calpain system. Physiological Reviews 83 (2003) 731-801
15. Golstein P., and Kroemer G. Cell death by necrosis: towards a molecular definition. Trends in Biochemical Sciences 32 (2006) 37-43
16. Greenblatt D.J., and Wright C.E. Clinical pharmacokinetics of alprazolam. Therapeutic implications. Clinical Pharmacokinetics 24 (1993) 453-471
17. 2+ indicators with greatly improved fluorescence properties. The Journal of Biological Chemistry 260 (1985) 3440-3450
18. Haefely W. Benzodiazepine interactions with GABA receptors. Neuroscience Letters 47 (1984) 201-206
19. Hans G., Wislet-Gendebien S., Lallemend F., Robe P., Rogister B., Belachew S., Nguyen L., Malgrange B., Moonen G., and Rigo J.M. Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression. Biochemical Pharmacology 69 (2005) 819-830
20. Hughes M.C., O'Neill E.E., McSweeney P.L.H., and Healy A. Proteolysis of bovine F-actin by cathepsin B. Food Chemistry 64 (1999) 525-530
21. Hunakova L., Bodo J., Chovancova J., Sulikova G., Pastorekova S., and Sedlak J. Expression of new prognostic markers, peripheral-type benzodiazepine receptor and carbonic anhydrase IX, in human breast and ovarian carcinoma cell lines. Neoplasma 54 (2007) 541-548
22. Jo M., Kim T.H., Seol D.W., Esplen J.E., Dorko K., Billiar T.R., and Strom S.C. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nature Medicine 6 (2000) 564-567
23. Kletsas D., Li W., Han Z., and Papadopoulos V. Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways. Biochemical Pharmacology 67 (2004) 1927-1932
24. Kroemer G., Galluzzi L., Vandenabeele P., Abrams J., Alnemri E.S., Baehrecke E.H., Blagosklonny M.V., El-Deiry W.S., Golstein P., Green D.R., Hengartner M., Knight R.A., Kumar S., Lipton S.A., Malorni W., Nuñez G., Peter M.E., Tschopp J., Yuan J., Piacentini M., Zhivotovsky B., and Melino G. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death and Differentiation 16 (2009) 3-11
25. Kulkarni A.C., Kuppusamy P., and Parinandi N. Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy. Antioxidants & Redox Signaling 9 (2007) 1717-1730
26. Leung A.M., Redlak M.J., and Miller T.A. Oxygen radical induced gastric mucosal cell death: apoptosis or necrosis?. Digestive Diseases and Sciences 53 (2008) 2429-2435
27. Li W., Hardwick M.J., Rosenthal D., Culty M., and Papadopoulos V. Peripheral-type benzodiazepine receptor overexpression and knockdown in human breast cancer cells indicate its prominent role in tumor cell proliferation. Biochemical Pharmacology 73 (2007) 491-503
28. Liu L., Xie Y., and Lou L. Cyclic AMP inhibition of proliferation of hepatocellular carcinoma cells is mediated by Akt. Cancer Biology & Therapy 4 (2005) 1240-1247
29. Maaser K., Sutter A.P., Krahn A., Höpfner M., Grabowski P., and Scherübl H. Cell cycle-related signaling pathways modulated by peripheral benzodiazepine receptor ligands in colorectal cancer cells. Biochemical and Biophysical Research Communications 324 (2004) 878-886
30. Maaser K., Sutter A.P., and Scherübl H. Mechanisms of mitochondrial apoptosis induced by peripheral benzodiazepine receptor ligands in human colorectal cancer cells. Biochemical and Biophysical Research Communications 332 (2005) 646-652
31. Maitra S., Saha B., Santra C.R., Mukherjee A., Goswami S., Chanda P.K., and Karmakar P. Alprazolam induced conformational change in hemoglobin. International Journal of Biological Macromolecules 41 (2007) 23-29
32. 2+ in monolayers and suspensions of various types of animal cells. The Journal of Cell Biology 105 (1987) 2145-2155
33. Merighi S., Benini A., Mirandola P., Gessi S., Varani K., Simioni C., Leung E., Maclennan S., Baraldi P.G., and Borea P.A. Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1 alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells. Molecular Pharmacology 72 (2007) 395-406
34. O'Beirne G.B., Woods M.J., and Williams D.C. Two subcellular locations for peripheral-type benzodiazepine acceptors in rat liver. European Journal of Biochemistry 188 (1990) 131-138
35. Okano J., Nagahara T., Matsumoto K., and Murawaki Y. Caffeine inhibits the proliferation of liver cancer cells and activates the MEK/ERK/EGFR signalling pathway. Basic & Clinical Pharmacology & Toxicology 102 (2008) 543-551
36. Orrenius S. Reactive oxygen species in mitochondria-mediated cell death. Drug Metabolism Reviews 39 (2007) 443-455
37. Orrenius S., McCabe Jr. M.J., and Nicotera P. Ca(2+)-dependent mechanisms of cytotoxicity and programmed cell death. Toxicology Letters 64-65 (1992) 357-364
38. Peng X.H., Karna P., O'Regan R.M., Liu X.J., Naithani R., Moriarty R.M., Wood W.C., Lee H.Y., and Yang L. Down-regulation of inhibitor proteins by deguelin selectively induces apoptosis in breast cancer cells. Molecular Pharmacology 71 (2007) 101-111
39. Reinke A., Chen J.C., Aronova S., and Powers T. Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p. The Journal of Biological Chemistry 281 (2006) 31616-31626
40. Robbins E., and Marcus P.I. Dynamics of acridine orange-cell interaction. I. Interrelationships of acridine orange particles and cytoplasmic reddening. The Journal of Cell Biology 18 (1963) 237-250
41. Roca D.J., Schiller G.D., and Farb D.H. Chronic caffeine or theophylline exposure reduces gamma-aminobutyric acid/benzodiazepine receptor site interactions. Molecular Pharmacology 33 (1988) 481-485
42. Russo A., Piovano M., Lombardo L., Vanella L., Cardile V., and Garbarino J. Pannarin inhibits cell growth and induces cell death in human prostate carcinoma DU-145 cells. Anti-cancer Drugs 17 (2006) 1163-1169
43. Saha B., Mukherjee A., Santra C.R., Chattopadhyay A., Ghosh A.N., Choudhuri U., and Karmakar P. Alprazolam intercalates into DNA. Journal of Biomolecular Structure & Dynamics 26 (2009) 421-429
44. Sarkaria J.N., Busby E.C., Tibbetts R.S., Roos P., Taya Y., Karnitz L.M., and Abraham R.T. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Research 59 (1999) 4375-4382
45. Shamsi F.A., and Boulton M. Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin. Investigative Ophthalmology & Visual Science 42 (2001) 3041-3046
46. Shinitzky M., and Barenholz Y. Dynamics of the hydrocarbon layer in liposomes of lecithin and sphingomyelin containing dicetylphosphate. The Journal of Biological Chemistry 249 (1974) 2652-2657
47. Sutter A.P., Maaser K., Höpfner M., Barthel B., Grabowski P., Faiss S., Carayon P., Zeitz M., and Scherübl H. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells. International Journal of Cancer 102 (2002) 318-327
48. Sutter A.P., Maaser K., Grabowski P., Bradacs G., Vormbrock K., Höpfner M., Krahn A., Heine B., Stein H., Somasundaram R., Schuppan D., Zeitz M., and Scherübl H. Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1. Journal of Hepatology 41 (2004) 799-807
49. Tanaka E., Nakamura T., Terada M., Shinozuka T., and Honda K. Metabolic interaction between ethanol, high-dose alprazolam and its two main metabolites using human liver microsomes in vitro. Journal of Forensic and Legal Medicine 14 (2007) 348-351
50. Unal-Cevik I., Kilinç M., Can A., Gürsoy-Ozdemir Y., and Dalkara T. Apoptotic and necrotic death mechanisms are concomitantly activated in the same cell after cerebral ischemia. Stroke 35 (2004) 2189-2194
51. Vassault S.A. Lactate dehydrogenase. In: Bergemeyer H. (Ed). Methods of Enzyme Analysis (1983), Verlag Chemie, Weinheim 118-126
52. von Moltke L.L., Greenblatt D.J., Harmatz J.S., and Shader R.I. Alprazolam metabolism in vitro: studies of human, monkey, mouse, and rat liver microsomes. Pharmacology 47 (1993) 268-276
53. Weir R.L., and Hruska R.E. Interaction between methylxanthines and the benzodiazepine receptor. Archives Internationales de Pharmacodynamie et de Thérapie 265 (1983) 42-48
54. Woo R.A., Jack M.T., Xu Y., Burma S., Chen D.J., and Lee P.W. DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53. The EMBO Journal 21 (2002) 3000-3008
55. 2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates. Cell Calcium 36 (2004) 285-293
56. Yang Y.W., Wu C.A., and Morrow W.J. The apoptotic and necrotic effects of tomatine adjuvant. Vaccine 22 (2004) 2316-2327
57. Zdolsek J.M., Olsson G.M., and Brunk U.T. Photooxidative damage to lysosomes of cultured macrophages by acridine orange. Photochemistry and Photobiology 51 (1990) 67-76
58. Zhu L.P., Yu X.D., Ling S., Brown R.A., and Kuo T.H. Mitochondrial Ca(2+)homeostasis in the regulation of apoptotic and necrotic cell deaths. Cell Calcium 28 (2000) 107-117
59. Zong W.X., and Thompson C.B. Necrotic death as a cell fate. Genes & Development 20 (2006) 1-15