Metabolic interaction between ethanol, high-dose alprazolam and its two main metabolites using human liver microsomes in vitro

Journal of Forensic and Legal Medicine

Volumn 14, Issue 6, 2007, Pages 348-351

  Tanaka, Einosuke ^a   Nakamura, Takako ^a   Terada, Masaru ^b   Shinozuka, Tatsuo ^c   Honda, Katsuya ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TOHO UNIVERSITY   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

Alprazolam; Cytochrome P450; Drug interaction; Ethanol; In vitro

Indexed keywords

ALCOHOL; ALPRAZOLAM; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; DRUG METABOLITE;

ARTICLE; CONTROLLED STUDY; DRUG ALCOHOL INTERACTION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; LIVER MICROSOME; OXIDATION; ULTRAVIOLET SPECTROSCOPY;

ALPRAZOLAM; ANTI-ANXIETY AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ETHANOL; FORENSIC TOXICOLOGY; HUMANS; MICROSOMES, LIVER;

EID: 34447254521     PISSN: 1752928X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jflm.2006.11.004     Document Type: Article

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