-
1
-
-
3042777392
-
Systemic treatment and liver transplantation for hepatocellular carcinoma: Two ends of the therapeutic spectrum
-
Burroughs A, Hochhauser D, Meyer T. Systemic treatment and liver transplantation for hepatocellular carcinoma: Two ends of the therapeutic spectrum. Lancet Oncol 2004; 5:409-18.
-
(2004)
Lancet Oncol
, vol.5
, pp. 409-418
-
-
Burroughs, A.1
Hochhauser, D.2
Meyer, T.3
-
3
-
-
4644370487
-
Current treatment for hepatocellular carcinoma
-
Cahill BA, Braccia D. Current treatment for hepatocellular carcinoma. Clin J Oncol Nurs 2004; 8:393-9.
-
(2004)
Clin J Oncol Nurs
, vol.8
, pp. 393-399
-
-
Cahill, B.A.1
Braccia, D.2
-
5
-
-
0031892108
-
Upregulation of the cyclic AMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas
-
Chen TC, Hinton DR, Zidovetzki R, Hofman FM. Upregulation of the cyclic AMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab Invest 1998; 78:165-74.
-
(1998)
Lab Invest
, vol.78
, pp. 165-174
-
-
Chen, T.C.1
Hinton, D.R.2
Zidovetzki, R.3
Hofman, F.M.4
-
6
-
-
0037306635
-
cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression
-
Grader-Beck T, van Puijenbroek AAFL, Nadler LM, Boussioris VA. cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression. Blood 2003; 101:998-1006.
-
(2003)
Blood
, vol.101
, pp. 998-1006
-
-
Grader-Beck, T.1
Van Puijenbroek, A.A.F.L.2
Nadler, L.M.3
Boussioris, V.A.4
-
7
-
-
0034256966
-
Inhibition of platelet-derived growth factor- induced mitogenesis by phosphodiesterase 3 inhibitors: Role of provein kinase A in vascular smooth muscle cell mitogenesis
-
Osinski MT, Schror K. Inhibition of platelet-derived growth factor- induced mitogenesis by phosphodiesterase 3 inhibitors: Role of provein kinase A in vascular smooth muscle cell mitogenesis. Biochem Pharmacol 2000; 60:381-7.
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 381-387
-
-
Osinski, M.T.1
Schror, K.2
-
8
-
-
0034996666
-
Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1
-
Schmitt JM, Stork PJS. Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1. Mol Cell Biol 2001; 21:3671-83.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3671-3683
-
-
Schmitt, J.M.1
Stork, P.J.S.2
-
10
-
-
0030921717
-
Cyclin D1 expression is a major target of the cyclic AMP-induced inhibition of cell cycle entry in fibroblasts
-
L'Allemain G, Lavoie JN, Rivard N, Baldin V, Pouyssegur J. Cyclin D1 expression is a major target of the cyclic AMP-induced inhibition of cell cycle entry in fibroblasts. Oncogene 1997; 14:1981-90.
-
(1997)
Oncogene
, vol.14
, pp. 1981-1990
-
-
L'Allemain, G.1
Lavoie, J.N.2
Rivard, N.3
Baldin, V.4
Pouyssegur, J.5
-
12
-
-
0032954089
-
Cyclic AMP induces inhibition of cyclin A expression and growth arrest in human hepatoma cells
-
Lee J, Choi YH, Nguyen P, Kim JS, Lee SJ, Trepel JB. Cyclic AMP induces inhibition of cyclin A expression and growth arrest in human hepatoma cells. Biochim Biophys Acta 1999; 1449:261-8.
-
(1999)
Biochim Biophys Acta
, vol.1449
, pp. 261-268
-
-
Lee, J.1
Choi, Y.H.2
Nguyen, P.3
Kim, J.S.4
Lee, S.J.5
Trepel, J.B.6
-
13
-
-
0033405063
-
The role of cyclic AMP-p42/44MAPK signaling in the regulation of human hepatocellular carcinoma growth
-
Schmidt CM, Mckillop IH, Cahill PA, Sitzmann JV. The role of cyclic AMP-p42/44MAPK signaling in the regulation of human hepatocellular carcinoma growth. Eur J Gastroenterol Hepatol 1999; 11:1393-9.
-
(1999)
Eur J Gastroenterol Hepatol
, vol.11
, pp. 1393-1399
-
-
Schmidt, C.M.1
Mckillop, I.H.2
Cahill, P.A.3
Sitzmann, J.V.4
-
14
-
-
0035949699
-
Akt plays a central role in tumorigenesis
-
USA
-
Joseph RT, Alfonso B. Akt plays a central role in tumorigenesis. Proc Natl Acad Sci USA 2001; 98:10983-5.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 10983-10985
-
-
Joseph, R.T.1
Alfonso, B.2
-
15
-
-
0036185848
-
The protein kinase B/Akt signaling pathway in human malignancy
-
Nicholson KM, Anderson NG. The protein kinase B/Akt signaling pathway in human malignancy. Cell Signal 2002; 14:381-95.
-
(2002)
Cell Signal
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
16
-
-
0032189381
-
Protien kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
-
Coffer PJ, Jin J, Woodgett JR. Protien kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J 1998; 335:1-13.
-
(1998)
Biochem J
, vol.335
, pp. 1-13
-
-
Coffer, P.J.1
Jin, J.2
Woodgett, J.R.3
-
17
-
-
0034653608
-
The PI3K-PDK-1 connection: More than just a road to PKB
-
Vanhaesebroeck B, Alessi DR. The PI3K-PDK-1 connection: More than just a road to PKB. Biochem J 2000; 346:561-76.
-
(2000)
Biochem J
, vol.346
, pp. 561-576
-
-
Vanhaesebroeck, B.1
Alessi, D.R.2
-
18
-
-
0035658389
-
Akt protects mouse hepatocytes from TNF-α- and Fas-mediated apoptosis through NK-κB activation
-
Hatano E, Brenner DA. Akt protects mouse hepatocytes from TNF-α- and Fas-mediated apoptosis through NK-κB activation. Am J Physiol Gastrointest Liver Physiol 2001; 281:1357-68.
-
(2001)
Am J Physiol Gastrointest Liver Physiol
, vol.281
, pp. 1357-1368
-
-
Hatano, E.1
Brenner, D.A.2
-
19
-
-
0141891442
-
Inhibition of nuclear factor kappa B and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice
-
Imose M, Nagaki M, Naiki T, Osawa V, Brenner DA, Asano T, Hayashi H, Kato T, Moriwaki H. Inhibition of nuclear factor kappa B and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Liver Int 2003; 23:386-96.
-
(2003)
Liver Int
, vol.23
, pp. 386-396
-
-
Imose, M.1
Nagaki, M.2
Naiki, T.3
Osawa, V.4
Brenner, D.A.5
Asano, T.6
Hayashi, H.7
Kato, T.8
Moriwaki, H.9
-
20
-
-
0346037347
-
Cyclic AMP induces transactivation of the receptors of epidermal growth factor and nerve growth factor, thereby modulating activation ot MAP kinase, Akt, and neurite outgrowth in PC12 cells
-
Piiper A, Dikic I, Lutz MP, Leser J, Kronenberger B, Elez R, Cramer H, Müller-Esterl W, Zeuzem S. Cyclic AMP induces transactivation of the receptors of epidermal growth factor and nerve growth factor, thereby modulating activation ot MAP kinase, Akt, and neurite outgrowth in PC12 cells. J Biol Chem 2002; 277:43623-30.
-
(2002)
J Biol Chem
, vol.277
, pp. 43623-43630
-
-
Piiper, A.1
Dikic, I.2
Lutz, M.P.3
Leser, J.4
Kronenberger, B.5
Elez, R.6
Cramer, H.7
Müller-Esterl, W.8
Zeuzem, S.9
-
21
-
-
0032997270
-
Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase
-
Filippa N, Sable CL, Filloux C, Hemmings B, Van Obberghen E. Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase. Mol Cell Biol 1999; 19:4989-5000.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4989-5000
-
-
Filippa, N.1
Sable, C.L.2
Filloux, C.3
Hemmings, B.4
Van Obberghen, E.5
-
22
-
-
0035918149
-
Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK-1
-
Kim SH, Jee KG, Kim DH, Koh HJ, Cluing JK. Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK-1. J Biol Chem 2001; 276:12864-70.
-
(2001)
J Biol Chem
, vol.276
, pp. 12864-12870
-
-
Kim, S.H.1
Jee, K.G.2
Kim, D.H.3
Koh, H.J.4
Cluing, J.K.5
-
23
-
-
0037059834
-
Induction of cyclic AMP-response element-binding protein activity decreases protein kinase B/Akt expression in 3T3-L1 adipocytes and induces apoptosis
-
Reusch JEB, Klemm DJ. Induction of cyclic AMP-response element-binding protein activity decreases protein kinase B/Akt expression in 3T3-L1 adipocytes and induces apoptosis. J Biol Chem 2002; 277:1426-32,
-
(2002)
J Biol Chem
, vol.277
, pp. 1426-1432
-
-
Reusch, J.E.B.1
Klemm, D.J.2
-
24
-
-
0035813228
-
Cyclic AMP inhibits extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways by inhibiting Rap1
-
Wang L, Liu F, Adamo ML. Cyclic AMP inhibits extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways by inhibiting Rap1. J Biol Chem 2001; 276:37242-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 37242-37249
-
-
Wang, L.1
Liu, F.2
Adamo, M.L.3
-
25
-
-
0037031872
-
Cyclic AMP inhibition of Akt is mediated by activated and phosphorylated Rap1b
-
Lou LG, Urbani J, Ribeiro-Neto F, Altschuler DL. Cyclic AMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. J Biol Chem 2002; 277:32799-806.
-
(2002)
J Biol Chem
, vol.277
, pp. 32799-32806
-
-
Lou, L.G.1
Urbani, J.2
Ribeiro-Neto, F.3
Altschuler, D.L.4
-
26
-
-
0033369266
-
Role of the P13K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp
-
Webster CRL, Anwer MS. Role of the P13K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp. Am J Physiol Gastrointest Liver Physiol 1999; 277:1165-72.
-
(1999)
Am J Physiol Gastrointest Liver Physiol
, vol.277
, pp. 1165-1172
-
-
Webster, C.R.L.1
Anwer, M.S.2
-
27
-
-
0021828496
-
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
-
Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature 1985; 315:239-42.
-
(1985)
Nature
, vol.315
, pp. 239-242
-
-
Whitman, M.1
Kaplan, D.R.2
Schaffhausen, B.3
Cantley, L.4
Roberts, T.M.5
-
29
-
-
0032807749
-
Protein kinase A-dependent and independent signaling pathways contribute to cyclic AMP-stimulated proliferation
-
Cass LA, Summers SA, Prendergast GV, Backer JM, Birnbaum MJ, Meinkoth JL. Protein kinase A-dependent and independent signaling pathways contribute to cyclic AMP-stimulated proliferation. Mol Cell Biol 1999; 19:5882-91.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5882-5891
-
-
Cass, L.A.1
Summers, S.A.2
Prendergast, G.V.3
Backer, J.M.4
Birnbaum, M.J.5
Meinkoth, J.L.6
-
30
-
-
0032545328
-
A family of cyclic AMP-binding proteins that directly activate Rap1
-
Kawasaki H, Springen GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM. A family of cyclic AMP-binding proteins that directly activate Rap1. Science 1998; 282:2275-9.
-
(1998)
Science
, vol.282
, pp. 2275-2279
-
-
Kawasaki, H.1
Springen, G.M.2
Mochizuki, N.3
Toki, S.4
Nakaya, M.5
Matsuda, M.6
Housman, D.E.7
Graybiel, A.M.8
-
31
-
-
0032480888
-
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
-
Derooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, BOS JL. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 1998; 396:474-7.
-
(1998)
Nature
, vol.396
, pp. 474-477
-
-
Derooij, J.1
Zwartkruis, F.J.2
Verheijen, M.H.3
Cool, R.H.4
Nijman, S.M.5
Wittinghofer, A.6
Bos, J.L.7
-
32
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Ba
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Ba. Curr Biol 1997; 7:261-9.
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
33
-
-
0032482374
-
Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B
-
Anderson KE, Coadwell J, Stephens LR, Hawkins PT. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol 1998; 8:684-91.
-
(1998)
Curr Biol
, vol.8
, pp. 684-691
-
-
Anderson, K.E.1
Coadwell, J.2
Stephens, L.R.3
Hawkins, P.T.4
-
34
-
-
0030980892
-
Proliferation of adult rat hepatocytes in primary culture induced by insulin is potentiated by cAMP-elevating agents
-
Kimura M, Ogihara M. Proliferation of adult rat hepatocytes in primary culture induced by insulin is potentiated by cAMP-elevating agents. Eur J Pharmacol 1997; 327:87-95.
-
(1997)
Eur J Pharmacol
, vol.327
, pp. 87-95
-
-
Kimura, M.1
Ogihara, M.2
-
37
-
-
0347717892
-
Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes
-
Raucci A, Laplantine E, Mansukhani A, Basilico C. Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes. J Biol Chem 2004; 279:1747-56.
-
(2004)
J Biol Chem
, vol.279
, pp. 1747-1756
-
-
Raucci, A.1
Laplantine, E.2
Mansukhani, A.3
Basilico, C.4
-
38
-
-
0027394488
-
Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: Contrast with phorbol 12-myristate 13-acetate
-
Casillas AM, Amaral K, Chegini-Farahani S, Nel AE. Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: Contrast with phorbol 12-myristate 13-acetate. Biochem J 1993; 290:545-50.
-
(1993)
Biochem J
, vol.290
, pp. 545-550
-
-
Casillas, A.M.1
Amaral, K.2
Chegini-Farahani, S.3
Nel, A.E.4
-
39
-
-
12344289067
-
Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma
-
Nakanishi K, Sakamoto M, Yamasaki S, Todo S, Hirohashi S. Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma. Cancer 2005; 103:307-12.
-
(2005)
Cancer
, vol.103
, pp. 307-312
-
-
Nakanishi, K.1
Sakamoto, M.2
Yamasaki, S.3
Todo, S.4
Hirohashi, S.5
-
41
-
-
0034637524
-
Kip1 expression
-
Kip1 expression. J Biol Chem 2000; 275:24500-5.
-
(2000)
J Biol Chem
, vol.275
, pp. 24500-24505
-
-
Graff, J.R.1
Konicek, B.W.2
McNulty, A.M.3
Wang, Z.J.4
Houck, K.5
Allen, S.6
Paul, J.D.7
Hbaiu, A.8
Goode, R.G.9
Sandusky, G.E.10
Vessella, R.L.11
Neubauer, B.L.12
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