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Volumn 324, Issue 2, 2008, Pages 769-775

Chemokine receptor 2 blockade prevents asthma in a cynomolgus monkey model

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CHEMOKINE RECEPTOR 2; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG;

EID: 38749112167     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.128538     Document Type: Article
Times cited : (32)

References (39)
  • 2
    • 0025721109 scopus 로고
    • Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: Comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness
    • Bradley BL, Azzawi M, Jacobson M, Assoufi B, Collins JV, Irani AM, Schwartz LB, Durham SR, Jeffery PK, and Kay AB (1991) Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol 88:661-674.
    • (1991) J Allergy Clin Immunol , vol.88 , pp. 661-674
    • Bradley, B.L.1    Azzawi, M.2    Jacobson, M.3    Assoufi, B.4    Collins, J.V.5    Irani, A.M.6    Schwartz, L.B.7    Durham, S.R.8    Jeffery, P.K.9    Kay, A.B.10
  • 3
    • 0034716486 scopus 로고    scopus 로고
    • Therapeutic monoclonal antibodies
    • Breedveld F (2000) Therapeutic monoclonal antibodies. Lancet 355:735-740.
    • (2000) Lancet , vol.355 , pp. 735-740
    • Breedveld, F.1
  • 5
    • 0036014530 scopus 로고    scopus 로고
    • Distribution and degranulation of airway mast cell in normal and asthmatic subjects
    • Carroll NG, Mutavdzic S, and James AL (2002) Distribution and degranulation of airway mast cell in normal and asthmatic subjects. Eur Respir J 19:879-885.
    • (2002) Eur Respir J , vol.19 , pp. 879-885
    • Carroll, N.G.1    Mutavdzic, S.2    James, A.L.3
  • 7
    • 85047693849 scopus 로고    scopus 로고
    • Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
    • Flood-Page P, Menzies-Gow A, Phipps S, Ying S, Wangoo A, Ludwig M, Barnes N, Robinson D, and Kay A (2003) Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 112:1029-1036.
    • (2003) J Clin Invest , vol.112 , pp. 1029-1036
    • Flood-Page, P.1    Menzies-Gow, A.2    Phipps, S.3    Ying, S.4    Wangoo, A.5    Ludwig, M.6    Barnes, N.7    Robinson, D.8    Kay, A.9
  • 8
    • 0031296740 scopus 로고    scopus 로고
    • Characterization of the CCR2 chemokine receptor: Functional CCR2 receptor expression in B cells
    • Frade JM, Mellado M, del Real G, Gutierrez-Ramos JC, Lind P, and Martinez AC (1997) Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells. J Immunol 159:5576-5584.
    • (1997) J Immunol , vol.159 , pp. 5576-5584
    • Frade, J.M.1    Mellado, M.2    del Real, G.3    Gutierrez-Ramos, J.C.4    Lind, P.5    Martinez, A.C.6
  • 9
    • 0033855859 scopus 로고    scopus 로고
    • Clinical trials of antibody therapy
    • Glennie MJ and Johnson PW (2000) Clinical trials of antibody therapy. Immunol Today 121:403-410.
    • (2000) Immunol Today , vol.121 , pp. 403-410
    • Glennie, M.J.1    Johnson, P.W.2
  • 12
    • 0025277877 scopus 로고
    • Repeated antigen inhalation results in a prolonged airway eosinophilia and airway hyperresponsiveness in primates
    • Gundel RH, Gerritsen ME, Gleich GJ, and Wegner CD (1990) Repeated antigen inhalation results in a prolonged airway eosinophilia and airway hyperresponsiveness in primates. J Appl Physiol 68:779-786.
    • (1990) J Appl Physiol , vol.68 , pp. 779-786
    • Gundel, R.H.1    Gerritsen, M.E.2    Gleich, G.J.3    Wegner, C.D.4
  • 13
    • 0033647212 scopus 로고    scopus 로고
    • Non-redundant functional groups of chemokines operate in a coordinate manner during the inflammatory response in the lung
    • Gutierrez-Ramos JC, Lloyd C, Kapsenberg ML, Gonzalo JA, and Coyle AJ (2000) Non-redundant functional groups of chemokines operate in a coordinate manner during the inflammatory response in the lung. Immunol Rev 177:31-42.
    • (2000) Immunol Rev , vol.177 , pp. 31-42
    • Gutierrez-Ramos, J.C.1    Lloyd, C.2    Kapsenberg, M.L.3    Gonzalo, J.A.4    Coyle, A.J.5
  • 14
    • 0036379740 scopus 로고    scopus 로고
    • Preclinical efficacy and safety of pascolizumab (SB 240683): A humanized anti-interleukin-4 antibody with therapeutic potential in asthma
    • Hart T, Blackburn M, Brigham-Burke M, Dede K, Al-Mahdi N, Zia-Amirhosseini P, and Cook R (2002) Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma. Clin Exp Immunol 130:93-100.
    • (2002) Clin Exp Immunol , vol.130 , pp. 93-100
    • Hart, T.1    Blackburn, M.2    Brigham-Burke, M.3    Dede, K.4    Al-Mahdi, N.5    Zia-Amirhosseini, P.6    Cook, R.7
  • 15
    • 0035911254 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein 1 in mice leads to decreases local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis
    • Huang D, Wang J, Kivisakk P, Rollins BJ, and Ransohoff RM (2001) Absence of monocyte chemoattractant protein 1 in mice leads to decreases local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J Exp Med 193:713-725.
    • (2001) J Exp Med , vol.193 , pp. 713-725
    • Huang, D.1    Wang, J.2    Kivisakk, P.3    Rollins, B.J.4    Ransohoff, R.M.5
  • 16
  • 17
    • 0035253654 scopus 로고    scopus 로고
    • Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice
    • Kawasaki S, Takizawa H, Yoneyama H, Nakayama T, Fujisawa R, Izumizaki M, Imai T, Yoshie O, Homma I, Yamamoto K, et al. (2001) Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice. J Immunol 166:2055-2062.
    • (2001) J Immunol , vol.166 , pp. 2055-2062
    • Kawasaki, S.1    Takizawa, H.2    Yoneyama, H.3    Nakayama, T.4    Fujisawa, R.5    Izumizaki, M.6    Imai, T.7    Yoshie, O.8    Homma, I.9    Yamamoto, K.10
  • 18
    • 17044371904 scopus 로고    scopus 로고
    • The role of eosinophils in the pathogenesis of asthma
    • Kay AB (2005) The role of eosinophils in the pathogenesis of asthma. Trends Mol Med 11:148-152.
    • (2005) Trends Mol Med , vol.11 , pp. 148-152
    • Kay, A.B.1
  • 19
    • 0035871633 scopus 로고    scopus 로고
    • Enhanced airway Th2 response after challenge in mice deficient in CC chemokine receptor-2 (CCR2)
    • Kim Y, Sung SJ, Kuziel WA, Feldman S, Fu SM, and Rose CE Jr (2001) Enhanced airway Th2 response after challenge in mice deficient in CC chemokine receptor-2 (CCR2). J Immunol 166:5183-5192.
    • (2001) J Immunol , vol.166 , pp. 5183-5192
    • Kim, Y.1    Sung, S.J.2    Kuziel, W.A.3    Feldman, S.4    Fu, S.M.5    Rose Jr, C.E.6
  • 20
    • 0036419905 scopus 로고    scopus 로고
    • What's in the pipeline? Prospects for monoclonal antibodies (mAbs) as therapies for lung diseases
    • Li L, Das AM, Torphy TJ, and Griswold DE (2002) What's in the pipeline? Prospects for monoclonal antibodies (mAbs) as therapies for lung diseases. Pulm Pharmacol Ther 15:409-416.
    • (2002) Pulm Pharmacol Ther , vol.15 , pp. 409-416
    • Li, L.1    Das, A.M.2    Torphy, T.J.3    Griswold, D.E.4
  • 21
    • 0034677038 scopus 로고    scopus 로고
    • CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/ monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo
    • Lloyd CM, Delaney T, Nguyen T, Tian J, Martinez-A C, Coyle AJ, and Gutierrez-Ramos JC (2000) CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/ monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J Exp Med 191:265-274.
    • (2000) J Exp Med , vol.191 , pp. 265-274
    • Lloyd, C.M.1    Delaney, T.2    Nguyen, T.3    Tian, J.4    Martinez-A, C.5    Coyle, A.J.6    Gutierrez-Ramos, J.C.7
  • 22
    • 0038545569 scopus 로고    scopus 로고
    • Chemokine receptors in asthma: Searching for the correct immune targets
    • Lukacs NW, Miller AL, and Hogaboam CM (2003) Chemokine receptors in asthma: searching for the correct immune targets. J Immunol 171:11-15.
    • (2003) J Immunol , vol.171 , pp. 11-15
    • Lukacs, N.W.1    Miller, A.L.2    Hogaboam, C.M.3
  • 23
    • 11144248234 scopus 로고    scopus 로고
    • Mast cells and basophils: Friends as well as foes in bronchial asthma?
    • Marone G, Triggiani M, and de Paulis A (2005) Mast cells and basophils: friends as well as foes in bronchial asthma? Trends Immunol 26:25-33.
    • (2005) Trends Immunol , vol.26 , pp. 25-33
    • Marone, G.1    Triggiani, M.2    de Paulis, A.3
  • 25
    • 33750507499 scopus 로고    scopus 로고
    • Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a
    • Munitz A, Bachelet I, and Levi-Schaffer F (2006) Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a. J Allergy Clin Immunol 118:1082-1089.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 1082-1089
    • Munitz, A.1    Bachelet, I.2    Levi-Schaffer, F.3
  • 27
    • 34447581076 scopus 로고    scopus 로고
    • Chemokines and their receptors as potential targets for the treatment of asthma
    • Palmqvist C, Wardlaw AJ, and Bradding P (2007) Chemokines and their receptors as potential targets for the treatment of asthma. Br J Pharmacol 151:725-736.
    • (2007) Br J Pharmacol , vol.151 , pp. 725-736
    • Palmqvist, C.1    Wardlaw, A.J.2    Bradding, P.3
  • 28
    • 24644520068 scopus 로고    scopus 로고
    • Airway remodeling contributes to the progressive loss of lung function in asthma: An overview
    • Pascual RM and Peters SP (2005) Airway remodeling contributes to the progressive loss of lung function in asthma: an overview. J Allergy Clin Immunol 116:477-486.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 477-486
    • Pascual, R.M.1    Peters, S.P.2
  • 29
    • 33644883892 scopus 로고    scopus 로고
    • Asthma, allergy and chemokines
    • Pease JE (2006) Asthma, allergy and chemokines. Curr Drug Targets 7:3-12.
    • (2006) Curr Drug Targets , vol.7 , pp. 3-12
    • Pease, J.E.1
  • 30
    • 0031028633 scopus 로고    scopus 로고
    • Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia
    • Rothenberg ME, MacLean JA, Pearlman E, Luster AD, and Leder P (1997) Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med 185:785-790.
    • (1997) J Exp Med , vol.185 , pp. 785-790
    • Rothenberg, M.E.1    MacLean, J.A.2    Pearlman, E.3    Luster, A.D.4    Leder, P.5
  • 31
    • 0035376544 scopus 로고    scopus 로고
    • Monoclonal antibodies as a strategy for pulmonary diseases
    • Torphy T, Li L, and Griswold DE (2001) Monoclonal antibodies as a strategy for pulmonary diseases. Curr Op Pharmacol 1:265-271.
    • (2001) Curr Op Pharmacol , vol.1 , pp. 265-271
    • Torphy, T.1    Li, L.2    Griswold, D.E.3
  • 32
    • 0028231180 scopus 로고
    • Effects of rolipram on responses to acute and chronic antigen exposure in monkeys
    • Turner CR, Andresen CJ, Smith WB, and Watson JW (1994) Effects of rolipram on responses to acute and chronic antigen exposure in monkeys. Am J Respir Crit Care 149:1153-1159.
    • (1994) Am J Respir Crit Care , vol.149 , pp. 1153-1159
    • Turner, C.R.1    Andresen, C.J.2    Smith, W.B.3    Watson, J.W.4
  • 33
    • 0030001459 scopus 로고    scopus 로고
    • Characterization of a primate model of asthma using anti-allergy/anti-asthma agents
    • Turner CR, Andresen CJ, Smith WB, and Watson JW (1996) Characterization of a primate model of asthma using anti-allergy/anti-asthma agents. Inflamm Res 45:239-245.
    • (1996) Inflamm Res , vol.45 , pp. 239-245
    • Turner, C.R.1    Andresen, C.J.2    Smith, W.B.3    Watson, J.W.4
  • 34
    • 0344256483 scopus 로고    scopus 로고
    • Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease
    • Ulbrich H, Eriksson EE, and Lindbom L (2003) Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease. Trends Pharmacol Sci 24:640-647.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 640-647
    • Ulbrich, H.1    Eriksson, E.E.2    Lindbom, L.3
  • 35
    • 33746373909 scopus 로고    scopus 로고
    • The regulation of allergy and asthma
    • Umetsu DT and DeKruyff RH (2006) The regulation of allergy and asthma. Immunol Rev 212:238-255.
    • (2006) Immunol Rev , vol.212 , pp. 238-255
    • Umetsu, D.T.1    DeKruyff, R.H.2
  • 36
    • 0041735102 scopus 로고    scopus 로고
    • Regulatory T cells control the development of allergic disease and asthma
    • Umetsu DT, Akbari O, and Dekruyff RH (2003) Regulatory T cells control the development of allergic disease and asthma. J Allergy Clin Immunol 112:480-487.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 480-487
    • Umetsu, D.T.1    Akbari, O.2    Dekruyff, R.H.3


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