Synthesis and structure-activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6468-6470

  Xia, Mingde ^a   Hou, Cuifen ^a   DeMong, Duane ^a   Pollack, Scott ^a   Pan, Meng ^a   Singer, Monica ^a   Matheis, Michele ^a   Murray, William ^a   Cavender, Druie ^a   Wachter, Michael ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

CCR2 antagonist; Chemokines; MCP 1

Indexed keywords

CHEMOKINE RECEPTOR 2 ANTAGONIST; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR2; CYTOCHROME P450; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IC 50; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ALCOHOLS; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; CHEMOKINE CCL2; DRUG DESIGN; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PIPERIDINES; RECEPTORS, CCR2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56249128217     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.061     Document Type: Article

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