Design, synthesis, and structure-activity relationship of novel CCR2 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 6, 2009, Pages 1830-1834

  Kothandaraman, Shankaran ^a   Donnely, Karla L ^a   Butora, Gabor ^a   Jiao, Richard ^a   Pasternak, Alexander ^a   Morriello, Gregori J ^a   Goble, Stephen D ^a   Zhou, Changyou ^a   Mills, Sander G ^a   MacCoss, Malcolm ^a   Vicario, Pasquale P ^a   Ayala, Julia M ^a   DeMartino, Julie A ^a   Struthers, Mary ^a   Cascieri, Margaret A ^a   Yang, Lihu ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aminocyclopentane carboxamide; CCR2 Antagonist; Chemotaxis; Reductive aminations

Indexed keywords

1 AMINOCYCLOPENTYL 3 CARBOXYAMIDE DERIVATIVE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR2; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CHEMOTAXIS; CONTROLLED STUDY; CYCLOPROPANATION; DOG; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHEMOTAXIS; DOGS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MACACA MULATTA; MODELS, CHEMICAL; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CCR2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 61449261080     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.050     Document Type: Article

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