A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage

Journal of Biological Chemistry

Volumn 284, Issue 29, 2009, Pages 19280-19289

  Yan, Jun ^a   Menendez, Daniel ^a   Yang, Xiao Ping ^a   Resnick, Michael A ^a   Jetten, Anton M ^a  

^a Department of Health and Human Services   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; DNA DAMAGE RESPONSE; DNA DAMAGES; GENOME STABILITY; MASTER REGULATORS; ONCOGENESIS; REGULATORY NETWORK; RESPONSE ELEMENTS; SMALL INTERFERING RNA; TARGET GENES; TRANSACTIVATION; TRANSCRIPTIONAL LEVELS; UBIQUITIN INTERACTION MOTIFS; UBIQUITIN LIGASE; UBIQUITINATION;

CELL DEATH; DNA; ENZYMES; LAWS AND LEGISLATION; NUCLEIC ACIDS; PROTEINS; RNA; TRANSCRIPTION;

GENES;

BINDING PROTEIN; DNA; PROTEIN MDM2; PROTEIN P53; RECEPTOR ASSOCIATED PROTEIN 80; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOREGULATION; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; UBIQUITINATION;

APOPTOSIS; BASE SEQUENCE; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DNA DAMAGE; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MDM2; REGULATORY SEQUENCES, NUCLEIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 67749131153     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.013102     Document Type: Article

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