Cellular ELF signals as a possible tool in informative medicine

Electromagnetic Biology and Medicine

Volumn 28, Issue 1, 2009, Pages 71-79

  Foletti, Alberto ^a   Lisi, Antonella ^b   Ledda, Mario ^b   De Carlo, Flavia ^b   Grimaldi, Settimio ^b  

^a BITitalia   (Italy)

^b CNR   (Italy)

Author keywords

Differentiation; ICR; Resonance

Indexed keywords

AQUEOUS SOLUTIONS; BIOLOGICAL MECHANISMS; BIOLOGICAL TARGETS; BIOLOGICAL TISSUES; CALCIUM IONS; CDS; CHARGED MOLECULE; CLINICAL FEASIBILITY; COHERENT COMPONENTS; DIFFERENTIATION; DYNAMICAL THEORY; EXTREMELY LOW FREQUENCIES; GLUTAMIC ACID; HIGH VOLTAGE; HUMAN EPITHELIAL CELLS; ICR; ION CURRENTS; ION CYCLOTRON RESONANCE; ION CYCLOTRONS; LIQUID WATER; LOW FREQUENCY; ORDERED STRUCTURES; PARALLEL MAGNETIC FIELD; PURE WATER; TWO-COMPONENT; WATER MOLECULE; WEAK MAGNETIC FIELDS;

CALCIUM; CELL MEMBRANES; CYCLOTRONS; ELECTRIC FIELDS; ELECTRIC POTENTIAL; ELECTROMAGNETIC FIELD EFFECTS; ELECTROMAGNETIC FIELDS; ELECTRON RESONANCE; IONS; MAGNETIC FIELDS; MAGNETIC MATERIALS; MOLECULES; PLASMAS;

MAGNETIC DOMAINS;

ION; WATER;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOPHYSICS; BONE REMODELING; CHEMISTRY; CYCLOTRON; ELECTROCHEMISTRY; ELECTROMAGNETIC FIELD; EQUIPMENT DESIGN; HUMAN; MEDICAL INFORMATICS; METHODOLOGY;

ANIMALS; BIOPHYSICS; BONE REMODELING; CYCLOTRONS; ELECTROCHEMISTRY; ELECTROMAGNETIC FIELDS; EQUIPMENT DESIGN; HUMANS; IONS; MEDICAL INFORMATICS; MODELS, BIOLOGICAL; WATER;

EID: 67749090950     PISSN: 15368378     EISSN: 15368386     Source Type: Journal    
DOI: 10.1080/15368370802708801     Document Type: Article

References (91)

1. Adey, W. R. (1981). Tissue interaction with non-ionizing electromagnetic field. Physiol. Rev. 61:435-514.
2. Adey, W. R. (1993). Biological effects of electromagnetic fields. J. Cell. Biochem. 51(4):410-416.
3. Anversa, P., Kajstura, J. (1998). Ventricular myocytes are not terminally differentiated in the adult mammalian heart. Circ. Res. 83:1-14.
4. Armstrong, M. T., Lee, D. Y., Armstrong, P. B. (2000). Regulation of proliferation of the fetal myocardium. Dev. Dyn. 219:226-236.
5. Barnes, P. S. (1996). Effect of electromagnetic field on the rate of chemical reactions. Biophysics 41:801-808.
6. Basset, C. A. L. (1993). Beneficial effects of electromagnetic fields. J. Cell. Biochem. 51:387-393.
7. Bates, R. C., Edwards, N. S., Yates, J. D. (2000). Spheroids and cell survival. Crit. Rev. Oncol. Hematol. 36:61-74.
8. Batta, K., Rugg, E. L., et al. (2000). A keratin 14 'knockout' mutation in recessive epidermolysis bullosa simplex resulting in less severe disease. Br. J. Dermatol. 143(3):621-627.
9. Bauréus Koch, C. L. M., Sommarin, M., et al. (2003). Interaction between weak low frequency magnetic fields and cell membranes. Bioelectromagnetics 24:395-402.
10. Bearzi, C., Cascapera, S., et al. (2005). Characterization and growth of human cardiac stem cells. Late-breaking developments in stem cell biology and cardiac growth regulation. Circulation 11(13):1720.
11. Beltrami, A. P., Barlucchi, L., et al. (2003). Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114(6):763-776.
12. Beltrami, A. P., Urbanek, K., et al. (2001). Evidence that human cardiac myocytes divide after myocardial infarction. N. Engl. J. Med. 344:1750-1757.
13. Bertani, F. R. (2001/2002). Effetti indotti da campi elettromagneici a bassa frequenza su una linea cellulare in vitro. Tesi di laurea in Fisica, La Sapienza, Roma.
14. Blackman, C. F., Benane, S. G., et al. (1985). Effects of ELF (1-120 Hz) and modulated (50 Hz) RF fields on the efflux of calcium ions from brain tissue in vitro. Bioelectromagnetics 6:1-11.
15. Blau, H. M., Brazelton, T. R., Weimann, J. M. (2001). The evolving concept of a stem cell: Entity or function? Cell 105(7):829-841.
16. Boukamp, P., Petrussevska, R. T., et al. (1988). Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106:761-771.
17. Brockes, J. P. (1997). Amphibian limb regeneration: rebuilding a complex structure. Science 276(5309):81-87.
18. Breitkreutz, D., Schoop, V. M., et al. (1998). Epidermal differentiation and basement membrane formation by HaCaT cells in surface transplants. Eur. J. Cell Biol. 75:273-286.
19. Cai, C. L., Liang, X., et al. (2003). Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev. Cell. 5:877-989.
20. Cai, J., Weiss, M. L., Rao, M. S. (2004). In search of "stemness." Exp. Hematol. 32(7):585-598.
21. Canigiani, S., Volpini, M. (2003). Infarto acuto del miocardio: Biochimica del danno cellulare e marcatori di lesione. Caleidoscopio 172, Medical Systems S.p.A. Genova.
22. Ceci, M., Ross, J. Jr., Condorelli, G. (2004). Molecular determinants of the physiological adaptation to stress in the cardiomyocyte: A focus on AKT. J. Mol. Cell. Cardiol. 37(5):905-912.
23. Chen, S., Zhang, Q., et al. (2004). Dedifferentiation of lineage-committed cells by a small molecule. J. Amer. Chem. Soc. 126:410-411.
24. Dawn, B., Stein, A. B., et al. (2005). Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function. Proc. Natl. Acad. Sci. USA 102(10):3766-3771.
25. Dimmeler, S., Zeiher, A. M., Schneider, M. D. (2005). Unchain my heart: The scientific foundations of cardiac repair. J. Clin. Invest. 115:572-583.
26. Doevendans, P. A., Kubalak, S. W., et al. (2000). Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes. J. Mol. Cell. Cardiol. 32:839-851.
27. Dominey, A. M., Wang, X. J., et al. (1993). Targeted over expression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas. Cell Growth Differ. 4:1071-1082.
28. Engel, F. B., Schebesta, M., et al. (2005). p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev. 19(10):1175-1187.
29. Frey, A. H. (1993). Electromagnetic field interactions with biological systems. FASEB 7:272-281.
30. Fukunaga, M., Oka, M., et al. (2001). UV-induced tyrosine phosphorylation of PKC delta and promotion of apoptosis in the HaCaT cell line. Biochem. Biophys. Res. Commun. 30:289(2):573-579.
31. Glaser, R. (1992). Current concepts of the interaction of weak electromagnetic fields with cells. Bioelectrochem. Bioenerg. 27:255-268.
32. Hierlihy, A. M., Seale, P., et al. (2002). The post-natal heart contains a myocardial stem cell population. FEBS Lett. 530(1-3):239-243.
33. Hinsenkamp, M., Jercinovic, A., et al. (1997). Effects of low frequency pulsed electromagnetical current on keratinocytes in vitro. Bioelectromagnetics 18:250-254.
34. Hsu, M., Andl, T., et al. (2000). Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression. J. Cell Sci. 113(pt 9):1535-1542.
35. John, C. F., Morris, K., et al. (2001). Ultraviolet-B exposure leads to up-regulation of senescence-associated genes in Arabidopsis thaliana. J. Exp. Bot. 52(359):1367-1373.
36. Jost, M., Kari, C., Rodeck, U. (2000). The EGF receptor-an essential regulator of multiple epidermal functions. Eur. J. Dematol. 10:505-510.
37. Kaiser, F. (1988). Theory of non-linear excitation. In: Frolich, H., et al., eds. Biological Coherence and Response to External Stimuli. Springer: Heidelberg, pp. 25-48.
38. Karabakhtsian, R., Bronde, N., et al. (1994). Calcium is necessary in the cell response to EM fields. FEBS Lett. 301:53-59.
39. Korff, T., Augustin, H. G. (1998). Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation. J. Cell Biol. 143:1341-1352.
40. La Thangue, N. B. (1996). E2F and the molecular mechanisms of early cell-cycle control. Biochem. Soc. Trans. 24(1):54-59.
41. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head bacteriophage T4. Nature 227:680-685.
42. Laugwitz, K. L., Moretti, A., et al. (2005). Postnatal isl1 + cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 433(7026):647-653.
43. Leszczynski, D., Pitsillides, C. M., et al. (2001). Laser-beam-triggered microcavitation: A novel method for selective celldestruction. Radiat. Res. 156(4):399-407.
44. Liboff, A. R. (1985). Cyclotron resonance in membrane transport. In: Chiabrera, A., Nicolini, C., Schwan, H. P., eds. Interaction between Electromagnetic Fields and Cells. London: Plenum Press, pp. 281-296.
45. Liboff, A. R. (1997). Electric-field ion cyclotrone resonance. Bioelectromagnetics 18:85-87.
46. Liboff, A. R. (2004). Toward an electromagnetic paradigm for biology and medicine. J. Altern. Complement. Med. 10:41-47.
47. Liboff, A. R., Smith, S. D., McLeod, B. R. (1987). Experimental evidence for ion cyclotron resonance mediation of membrane transport. In: Blank, M., Findl, E., eds. Mechanistic Approaches to Interaction of Electric and Electromagnetic Fields with Living Systems. New York: Plenum Press, pp. 109-132.
48. Liburdy, R. P. (1992). Calcium signalling in lymphocytes and ELF fields: Evidence for an electromagnetic field metric and a site of interaction involving calcium ion channels. FEBS Lett. 301(1):53-59.
49. Lisi, A., Foletti, A., et al. (2006). Extremely low frequency 7 Hz 100 microT electromagnetic radiation promotes differentiation in the human epithelial cell line HaCaT. Electromagn. Biol. Med. 25(4):269-280.
50. Lo, D. C., Allen, F., Brockes, J. P. (1993). Reversal of muscle differentiation during urodele limb regeneration. Proc. Natl. Acad. Sci. USA. August 1 90(15):7230-7234.
51. Maden, M. (2003). Regeneration: every clot has a thrombin lining. Curr. Biol. 13(13):R517-R518.
52. Majno, G., Joris, I. (2000). Cellule, Tessuti e Malattia. Milan, Italy: Casa Editrice Ambrosiana.
53. Martin, C. M., Meeson, A. P., et al. (2004). Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart. Dev. Biol. 265(1):262-275.
54. Mathur, A., Martin, J. F. (2004). Stem cells and repair of the heart. Lancet 364(9429):183-192.
55. Matsuura, K., Nagai, T., et al. (2004). Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J. Biol. Chem. 279:11384-11391.
56. McGann, C. J., Odelberg, S. J., Keating, M. T. (2001). Mammalian myotube dedifferentiation induced by newt regeneration extract. Proc. Natl. Acad. Sci. USA 98:13699-13704.
57. Medema, J. P., Sark, M. W., et al. (1994). Calcium inhibits epidermal growth factor-induced activation of p21ras in human primary keratinocytes. Mol. Cell. Biol. 14(11):7078-7085.
58. Medvinnsky, A., Smith, A. (2003). Fusion brings down barriers. Nature 422:823-825.
59. Messina, E., De Angelis, L., et al. (2004). Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ. Res. 95(9):911-921. Epub October 7, 2004.
60. Murphy, E., Mild, K. H. (1997). EMF science review symposium: theoretical mechanisms and in vitro research findings. NIHS & EMF RAPID; see http://www.niehs.nih.gov/ emfrapid/html/Symposium1/3.htm.
61. Nadal-Ginard, B., Kajstura, J., et al. (2003). Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ. Res. 92:139-150.
62. Odelberg, S. J., Kollhoff, A., Keating, M. T. (2000). Dedifferentiation of mammalian myotubes induced by msx1. Cell 103:1099-1109.
63. Oh, H., Bradfute, S. B., et al. (2003). Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction. Proc. Natl. Acad. Sci. USA 100(21):12313-12318.
64. Pazur, A. (2004). Characterization of weak magnetic field effects in an acqueous glutamic acid solution by nonlinear dielectric spectroscopy and voltammetry. Biomagn. Res. Technol. 2:8.
65. Peus, D., Hamacher, L., Pittelkow, M. R. (1997). EGF-receptor tyrosine kinase inhibition induces keratinocytes growth arrest and terminal differentiation. J. Invest. Derm. 109:751-756.
66. Phillips, J. L., Haggren, W., et al. (1992). Magnetic field-induced changes in specific gene transcription. Biochimica Biophysica Acta 1132:140-144.
67. Pilla, A. A., Markov, M. S. (1992). Bioeffects of weak electromagnetic fields. Rev. Environ. Health 10(3-4):155-169.
68. Pletnev, S. D. (2000). The use of millimeter band electromagnetic waves in clinical oncology. Crit. Rev. Biomed. Eng. 28(3-4):573-587.
69. Preston, S. L., Alison, M. R., et al. (2003). The new stem cell biology: something for everyone. Mol. Pathol. 56(2):86-96.
70. Quaini, F., Urbanek, K., et al. (2002). Chimerism of the transplanted heart. N. Engl. J. Med. 346:5-1.
71. Rusovan, A., Kanje, M. (1992). Magnetic fields stimulate peripheral nerve regeneration hypophyctiomia rats. Neuroreport 3(12):1039-1041.
72. Santoro, N., Lisi, A., et al. (1997). Effect of extremely low frequency (ELF) magnetic field exposure on morphological and biophysical properties of human lymphoid cell line (Raji). Biochimica Biophyica. Acta 1357:281-290.
73. Savitz, D. A., Pearce, N., Poole, C. (1987). Update on methodological issues in the epidemiology of electromagnetic fields and cancer. Epidemiol. Rev. 15:558-566.
74. Schwan, A., Chiabrera, C., Nicolini, C., Schwan, H. P. (eds.). (1985). Interactions Between Electromagnetic Fields and Cells. New York: Plenum Press.
75. Serway, R. A. (1998). Principi di fisica. Philadelphia: Saunders College Publishing.
76. Smith, R. R., Abraham, M. R., et al. (2005). 5001 electrophysiology of human and porcine adult cardiac stem cells isolated from endomyocardial biopsies. Late-breaking developments in stem cell biology and cardiac growth regulation. Circulation 111(13):1720.
77. Smits, A. M., van Vliet, P., et al. (2005). The role of stem cells in cardiac regeneration. J. Cell Mol. Med. 9(1):25-36.
78. Spradling, A., Drummond-Barbosa, D., Kai, T. (2001). Stem cells find their niche. Nature 414(6859):98-104.
79. Sussman, M. A., Anversa, P. (2004). Myocardial aging and senescence: Where have the stem cells gone? Ann. Rev. Physiol. 66:29-48.
80. Szabo, I., Rojavin, M. A., et al. (2001). Reactions of keratinocytes to in vitro millimeter wave exposure. Bioelectromagnetics 22:358-364.
81. Tanaka, E. M. (2003). Regeneration: If they can do it, why can't we? Cell 113(5):559-562.
82. Tanaka, E. M., Drechsel, D. N., Brockes, J. P. (1999). Thrombin regulates S-phase re-entry by cultured newt myotubes. Curr. Biol. 9(15):792-799.
83. Tenforde, T. S. (1995). Interaction of extremely low frequency electromagnetic and magnetic fields with humans. In: Polk, C., Postow, E., eds. Handbook of Biological Effects of Electromagnetic Fields, 2nd ed. Boca Raton, FL: CRC Press, pp. 185-230.
84. Vasioukhin, V., Bauer, C., et al. (2001). Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell 104(4):605-617.
85. Ventura, C., Maioli, M., et al. (2005). Turning on stem cell cardiogenesis with extremely low frequency magnetic fields. FASEB J. 19(1):155-157.
86. Vescovi, A. L., Gritti, A., Galli, R. (2001). Le risorse delle cellule staminali somatiche. Le scienze 392:42-47.
87. Walleczeck, J. (1992). Electromagnetic field effect on cells of the immune system: The role of calcium signalling. Faseb. J. 6:3177-3185.
88. Weaver, J. C., Astumian, R. D. (1990). The response of living cells on very weak electromagnetic fiels: The thermal noise limit. Science 247:459-462.
89. Wojakowski, W., Tendera, M., et al. (2004). Mobilization of CD34/CXCR4+, CD34/CD117+, c-met + stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myocardial infarction. Circulation 110:3213-3220.
90. Wurmser, A. E., Gage, F. H. (2002). Stem cells: Cell fusion causes confusion. Nature 416(6880):485-487.
91. Zhadin, M. N. (2001). Review of russian literature on biological action of DC and low-frequency AC magnetic fields. Bioelectromagnetics 22(1):27-45.