UV-induced tyrosine phosphorylation of PKCδ and promotion of apoptosis in the HaCaT cell line

Biochemical and Biophysical Research Communications

Volumn 289, Issue 2, 2001, Pages 573-579

  Fukunaga, Mizuho ^a,b   Oka, Masahiro ^b   Ichihashi, Masamitsu ^b   Yamamoto, Toshiyoshi ^a   Matsuzaki, Hidenori ^a   Kikkawa, Ushio ^a  

^a KOBE UNIVERSITY   (Japan)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Bisindolylmaleimide I; H2O2; HaCaT; Keratinocyte; N acetyl L cysteine; Protein kinase C; Tyrosine phosphorylation; Ultraviolet radiation

Indexed keywords

ACETYLCYSTEINE; BISINDOLYLMALEIMIDE; GENISTEIN; HYDROGEN PEROXIDE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; THREONINE; TYROSINE;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; ULTRAVIOLET RADIATION;

EID: 0035976741     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6025     Document Type: Article

References (36)

1. Molecular and cellular effects of ultraviolet light-induced genotoxicity
2. Protein kinase C and lipid signaling for sustained cellular responses
3. Protein kinase C δ
4. Role of oncogenes and tumor suppressor genes in multistage carcinogenesis
5. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells
6. The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis
7. Proteolytic activation of PKN by caspase-3 or related protease during apoptosis
8. 2-induced apoptosis in CHO cells
9. Protein kinase Cδ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes
10. Protein kinase C δ is essential for etoposide-induced apoptosis in salivary gland acinar cells
11. PKC-δ is an apoptotic lamin kinase
12. 2
13. 2-treated cells and its activation by tyrosine kinase in vitro
14. Multiple pathways control protein kinase C phosphorylation
15. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
16. 2 for platelet-derived growth factor signal transduction
17. Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-Acetyl-cysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade
18. Genistein, a specific inhibitor of tyrosine-specific protein kinases
19. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
20. Oxygen radicals and signaling
21. Redox signaling: Hydrogen peroxide as intracellular messenger
22. 2-induced tyrosine phosphorylation of protein kinase Cδ by a mechanism independent of inhibition of protein-tyrosine phosphatase in CHO and COS-7 cells
23. lck in T cells
24. Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394
25. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases
26. 2-induced T cell signal transduction
27. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway
28. Distinctive functions of Syk and Lyn in mediating osmotic stress- and ultraviolet C irradiation-induced apoptosis in chicken B cells
29. Multiple signaling pathways for the activation of JNK in mast cells: Involvement of Bruton's tyrosine kinase, protein kinase C, and JNK kinases, SEK1 and MKK7
30. Involvement of growth factor receptors in the mammalian UVC response
31. Ultraviolet radiation induces phosphorylation of the epidermal growth factor receptor
32. UV activation of receptor tyrosine kinase activity
33. Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases
34. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
35. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
36. Phosphorylation of protein kinase Cδ (PKCδ) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCδ and an alanine 505 mutant in bacteria in a functional form