Rabbit models of heart disease

Drug Discovery Today: Disease Models

Volumn 5, Issue 3, 2008, Pages 185-193

  Pogwizd, Steven M ^a   Bers, Donald M ^b  

^a Biophysics and Bioengineering   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CHANNEL L TYPE; CALCIUM ION; CONNEXIN 43; DELAYED RECTIFIER POTASSIUM CHANNEL; FIBROBLAST GROWTH FACTOR 2; G PROTEIN COUPLED RECEPTOR KINASE 2; NORADRENALIN TRANSPORTER; PHOSPHOLAMBAN; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KCNE1; PROTEIN BCL 2; PROTEIN P35; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN; SUPEROXIDE DISMUTASE;

ATRIOVENTRICULAR BLOCK; AUTOLOGOUS STEM CELL TRANSPLANTATION; CALCIUM TRANSPORT; CARDIAC RESYNCHRONIZATION THERAPY; DEFIBRILLATION; DISEASE MODEL; DRUG MECHANISM; GENE EXPRESSION; HEART ARRHYTHMIA; HEART DISEASE; HEART FAILURE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART PACING; HEART VENTRICLE OVERLOAD; HUMAN; INFECTION; MYOCARDITIS; NONHUMAN; PROTEIN EXPRESSION; RABBIT; RADIOFREQUENCY ABLATION; REVIEW; SPECIES DIFFERENCE; TRANSGENICS; VIRAL GENE THERAPY;

EID: 67651241292     PISSN: 17406757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmod.2009.02.001     Document Type: Review

References (105)

1. Bers D.M. Excitation-Contraction Coupling and Cardiac Contractile Force (2001), Kluwer Academic Publishers, Dordrecht, Netherlands p. 427
2. Bers D.M. Altered cardiac myocyte Ca regulation in heart failure. Physiology (Bethesda) 21 (2006) 380-387 (PM:17119150)
3. Pogwizd S.M., and Bers D.M. Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc. Med. 14 (2004) 61-66 (PM:15030791)
4. Pogwizd S.M., et al. Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ. Res. 85 (1999) 1009-1019 (PM:10571531)
5. Pogwizd S.M., et al. Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ. Res. 88 (2001) 1159-1167 (PM:11397782)
6. Piacentino III V., et al. Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ. Res. 92 (2003) 651-658 (PM:12600875)
7. Gupta M.P. Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure. J. Mol. Cell. Cardiol. 43 (2007) 388-403 (PM:17720186)
8. Sugawara H., et al. Differential alteration of cardiotonic effects of EMD 57033 and beta-adrenoceptor agonists in volume-overload rabbit ventricular myocytes. J. Card. Fail. 6 (2000) 338-349 (PM:11145759)
9. Magid N.M., et al. Heart failure due to chronic experimental aortic regurgitation. Am. J. Physiol. 267 (1994) H556-H562 (PM:8067410)
10. Borer J.S., et al. Myocardial fibrosis in chronic aortic regurgitation: molecular and cellular responses to volume overload. Circulation 105 (2002) 1837-1842 (PM:11956128)
11. Oros A., et al. The canine model with chronic, complete atrio-ventricular block. Pharmacol. Ther. 119 (2008) 168-178 (PM:18514320)
12. Tsuji Y., et al. Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes. Circulation 113 (2006) 345-355 (PM:16432066)
13. Mohammadi K., et al. Protein kinase C activity and expression in rabbit left ventricular hypertrophy. J. Mol. Cell. Cardiol. 29 (1997) 1687-1694 (PM:9220354)
14. Friehs I., et al. Impaired glucose transporter activity in pressure-overload hypertrophy is an early indicator of progression to failure. Circulation 100 (1999) II187-II193 (PM:10567302)
15. Stamm C., et al. Inhibition of tumor necrosis factor-alpha improves postischemic recovery of hypertrophied hearts. Circulation 104 (2001) I350-I355 (PM:11568081)
16. Signolet I., et al. Echocardiography in conscious 1K,1C Goldblatt rabbits reveals typical features of human hypertensive ventricular diastolic dysfunction. Int. J. Cardiol. 132 (2009) 135-137 (PM:18045708)
17. Lorell B.H., et al. Influence of hypertension with minimal hypertrophy on diastolic function during demand ischemia. Hypertension 13 (1989) 361-370 (PM:2522416)
18. Burke S.L., et al. Renal sympathetic neuroeffector function in renovascular and angiotensin II-dependent hypertension in rabbits. Hypertension 49 (2007) 932-938 (PM:17309940)
19. Hamrell B.B., and Alpert N.R. The mechanical characteristics of hypertrophied rabbit cardiac muscle in the absence of congestive heart failure: the contractile and series elastic elements. Circ. Res. 40 (1977) 20-25 (PM:137085)
20. Gibbs C.L., et al. Mechanical, energetic, and biochemical changes in long-term pressure overload of rabbit heart. Am. J. Physiol. 259 (1990) H849-H859 (PM:2144403)
21. Gunaydin S., et al. The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine. Cardiovasc. Surg. 10 (2002) 138-145 (PM:11888743)
22. Coker S.J. Anesthetized rabbit as a model for ischemia- and reperfusion-induced arrhythmias: effects of quinidine and bretylium. J. Pharmacol. Methods 21 (1989) 263-279 (PM:2755145)
23. 2+ transients recorded from the epicardial surface of isolated hearts from rabbits with heart failure. Cardiovasc. Res. 37 (1998) 489-502 (PM:9614503)
24. Chatterjee S., et al. Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure. Circulation 106 (2002) I212-I217 (PM:12354736)
25. Maurice J.P., et al. Molecular beta-adrenergic signaling abnormalities in failing rabbit hearts after infarction. Am. J. Physiol. 276 (1999) H1853-H1860 (PM:10362663)
26. Litwin S.E., et al. Dyssynchronous Ca(2+) sparks in myocytes from infarcted hearts. Circ. Res. 87 (2000) 1040-1047 (PM:11090550)
27. Minatoguchi S., et al. Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment. Circulation 109 (2004) 2572-2580 (PM:15123535)
28. Iwatate M., et al. Effects of in vivo gene transfer of fibroblast growth factor-2 on cardiac function and collateral vessel formation in the microembolized rabbit heart. Jpn. Circ. J. 65 (2001) 226-231 (PM:11266199)
29. Sabbah H.N., et al. A canine model of chronic heart failure produced by multiple sequential coronary microembolizations. Am. J. Physiol. 260 (1991) H1379-H1384 (PM:1826414)
30. Arnolda L., et al. Systemic and regional effects of vasopressin and angiotensin in acute left ventricular failure. Am. J. Physiol. 260 (1991) H499-H506 (PM:1825456)
31. Driesen R.B., et al. Structural remodelling of cardiomyocytes in the border zone of infarcted rabbit heart. Mol. Cell. Biochem. 302 (2007) 225-232 (PM:17387581)
32. Dispersyn G.D., et al. Adult rabbit cardiomyocytes undergo hibernation-like dedifferentiation when co-cultured with cardiac fibroblasts. Cardiovasc. Res. 51 (2001) 230-240 (PM:11470462)
33. Smith H.J., and Nuttall A. Experimental models of heart failure. Cardiovasc. Res. 19 (1985) 181-186 (PM:3159477)
34. Arnolda L.F., et al. Animal models of heart failure. Aust. N. Z. J. Med. 29 (1999) 403-409 (PM:10868512)
35. Monnet E., and Chachques J.C. Animal models of heart failure: what is new?. Ann. Thorac. Surg. 79 (2005) 1445-1453 (PM:15797108)
36. Rhoden W., et al. Anthracyclines and the heart. Br. Heart J. 70 (1993) 499-502 (PM:8280512)
37. Arnolda L., et al. Adriamycin cardiomyopathy in the rabbit: an animal model of low output cardiac failure with activation of vasoconstrictor mechanisms. Cardiovasc. Res. 19 (1985) 378-382 (PM:4016815)
38. Wanless R.B., et al. An experimental model of chronic cardiac failure using adriamycin in the rabbit: central haemodynamics and regional blood flow. Cardiovasc. Res. 21 (1987) 7-13 (PM:3664539)
39. Pye M.P., and Cobbe S.M. Arrhythmogenesis in experimental models of heart failure: the role of increased load. Cardiovasc. Res. 32 (1996) 248-257 (PM:8796111)
40. Woodcock E.A., et al. Ventricular beta-adrenoceptors in adriamycin-induced cardiomyopathy in the rabbit. J. Mol. Cell. Cardiol. 20 (1988) 771-777 (PM:2906708)
41. Gille L., and Nohl H. Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity. Free Radic. Biol. Med. 23 (1997) 775-782 (PM:9296455)
42. Muders F., et al. Hemodynamic changes and neurohumoral regulation during development of congestive heart failure in a model of epinephrine-induced cardiomyopathy in conscious rabbits. J. Card. Fail. 5 (1999) 109-116 (PM:10404350)
43. Shinbane J.S., et al. Tachycardia-induced cardiomyopathy: a review of animal models and clinical studies. J. Am. Coll. Cardiol. 29 (1997) 709-715 (PM:9091514)
44. Eble D.M., et al. Myosin heavy chain synthesis is increased in a rabbit model of heart failure. Am. J. Physiol. 272 (1997) H969-H978 (PM:9124461)
45. 2+ homeostasis in rabbits with pacing-induced heart failure. Am. J. Physiol. 275 (1998) H1441-H1448 (PM:9746495)
46. Kawai H., et al. Alterations in cardiac adrenergic terminal function and beta-adrenoceptor density in pacing-induced heart failure. Am. J. Physiol. Heart Circ. Physiol. 278 (2000) H1708-H1716 (PM:10775152)
47. Spinale F.G., et al. Left ventricular and myocyte structure and function following chronic ventricular tachycardia in rabbits. Basic Res. Cardiol. 89 (1994) 456-467 (PM:7702537)
48. Hobai I.A., and O'Rourke B. Enhanced Ca(2+)-activated Na(+)-Ca(2+) exchange activity in canine pacing-induced heart failure. Circ. Res. 87 (2000) 690-698 (PM:11029405)
49. Rose J., et al. Molecular correlates of altered expression of potassium currents in failing rabbit myocardium. Am. J. Physiol. Heart Circ. Physiol. 288 (2005) H2077-H2087 (PM:15637125)
50. 2+ uptake and release mechanisms. Am. J. Physiol. Heart Circ. Physiol. 292 (2007) H1607-H1618 (PM:17122195)
51. Gao L., et al. Exercise training normalizes sympathetic outflow by central antioxidant mechanisms in rabbits with pacing-induced chronic heart failure. Circulation 115 (2007) 3095-3102 (PM:17548725)
52. Leclercq J.F., et al. Experimental cardiac hypertrophy in rabbits after aortic stenosis or incompetence or both. Biomedicine 28 (1978) 180-184 (PM:151562)
53. Desantiago J., et al. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ. Res. 102 (2008) 1389-1397 (PM:18467626)
54. Pogwizd S.M. Nonreentrant mechanisms underlying spontaneous ventricular arrhythmias in a model of nonischemic heart failure in rabbits. Circulation 92 (1995) 1034-1048 (PM:7543829)
55. Ai X., and Pogwizd S.M. Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A. Circ. Res. 96 (2005) 54-63 (PM:15576650)
56. 2+ leak in heart failure. Circ. Res. 97 (2005) 1314-1322 (PM:16269653)
57. Pogwizd S.M., et al. Mechanisms underlying spontaneous and induced ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy. Circulation 98 (1998) 2404-2414 (PM:9832485)
58. 2+ exchanger in end-stage human heart failure. Circ. Res. 75 (1994) 443-453 (PM:8062418)
59. Janse M.J., et al. Arrhythmogenesis in heart failure. J. Cardiovasc. Electrophysiol. 12 (2001) 496-499 (PM:11332576)
60. Opthof T., et al. Changes in sinus node function in a rabbit model of heart failure with ventricular arrhythmias and sudden death. Circulation 101 (2000) 2975-2980 (PM:10869272)
61. Vermeulen J.T., et al. Electrophysiologic and extracellular ionic changes during acute ischemia in failing and normal rabbit myocardium. J. Mol. Cell. Cardiol. 28 (1996) 123-131 (PM:8745220)
62. Carlsson L., et al. QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions. J. Cardiovasc. Pharmacol. 16 (1990) 276-285 (PM:1697384)
63. Mazur A., et al. Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits. Circulation 100 (1999) 2437-2442 (PM:10595957)
64. Farkas A., et al. Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model. Br. J. Pharmacol. 154 (2008) 958-970 (PM:18587444)
65. Gbadebo T.D., et al. Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes. Circulation 105 (2002) 770-774 (PM:11839636)
66. Hamlin R.L., and Kijtawornrat A. Use of the rabbit with a failing heart to test for torsadogenicity. Pharmacol. Ther. 119 (2008) 179-185 (PM:18691764)
67. Allessie M.A., et al. Circus movement in rabbit atrial muscle as a mechanism of tachycardia. III. The "leading circle" concept: a new model of circus movement in cardiac tissue without the involvement of an anatomical obstacle. Circ. Res. 41 (1977) 9-18 (PM:862147)
68. Nattel S., et al. Mechanisms of atrial fibrillation: lessons from animal models. Prog. Cardiovasc. Dis. 48 (2005) 9-28 (PM:16194689)
69. Ravelli F., and Allessie M. Effects of atrial dilatation on refractory period and vulnerability to atrial fibrillation in the isolated Langendorff-perfused rabbit heart. Circulation 96 (1997) 1686-1695 (PM:9315565)
70. Hirose M., et al. Mechanism for atrial tachyarrhythmia in chronic volume overload-induced dilated atria. J. Cardiovasc. Electrophysiol. 16 (2005) 760-769 (PM:16050835)
71. Shimano M., et al. Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure. Heart Rhythm. 5 (2008) 451-459 (PM:18313605)
72. Brunner M., et al. Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome. J. Clin. Invest. 118 (2008) 2246-2259 (PM:18464931)
73. Marian A.J., et al. A transgenic rabbit model for human hypertrophic cardiomyopathy. J. Clin. Invest. 104 (1999) 1683-1692 (PM:10606622)
74. Sanbe A., et al. Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy. Circulation 111 (2005) 2330-2338 (PM:15867176)
75. Nishizawa T., et al. Overexpressed cardiac Gs alpha in rabbits. J. Mol. Cell. Cardiol. 41 (2006) 44-50 (PM:16678849)
76. Pattison J.S., et al. Phospholamban overexpression in transgenic rabbits. Transgenic Res. 17 (2008) 157-170 (PM:17882530)
77. Edwards S., et al. An experimental model for myocarditis and congestive heart failure after rabbit coronavirus infection. J. Infect. Dis. 165 (1992) 134-140 (PM:1309370)
78. Kishimoto C., et al. Role of MIP-2 in coxsackie virus B3 myocarditis. J. Mol. Cell. Cardiol. 32 (2000) 631-638 (PM:10756119)
79. Nagai T., and Kawai C. Experimental cryptococcal-induced myocarditis. Jpn. Circ. J. 45 (1981) 539-546 (PM:7014958)
80. Henry L., et al. Experimental toxoplasmic myocarditis in rabbits. J. Pathol. 101 (1970) xxi (PM:5504757)
81. Burova L.A., et al. Induction of myocarditis in rabbits injected with group A streptococci. Indian J. Med. Res. 119 Suppl. (2004) 183-185 (PM:15232191)
82. Zabejinski M.M., et al. New animal model of diphtheritic myocarditis. Exp. Toxicol. Pathol. 52 (2000) 67-70 (PM:10779154)
83. Figueiredo F., et al. The evolution of experimental Trypanosoma cruzi cardiomyopathy in rabbits: further parasitological, morphological and functional studies. Int. J. Cardiol. 10 (1986) 277-290 (PM:3514479)
84. Teixeira A.R., et al. The immunology of experimental Chagas' disease. IV. Production of lesions in rabbits similar to those of chronic Chagas' disease in man. Am. J. Pathol. 80 (1975) 163-180 (PM:808136)
85. Perdikaris G.S., et al. Successful single-dose teicoplanin prophylaxis against experimental streptococcal, enterococcal, and staphylococcal aortic valve endocarditis. Antimicrob. Agents Chemother. 41 (1997) 1916-1921 (PM:9303384)
86. Faivre V., et al. Cardiac and renal effects of levosimendan, arginine vasopressin, and norepinephrine in lipopolysaccharide-treated rabbits. Anesthesiology 103 (2005) 514-521 (PM:16129976)
87. Fajardo L.F., and Stewart J.R. Pathogenesis of radiation-induced myocardial fibrosis. Lab. Invest. 29 (1973) 244-257 (PM:4724850)
88. Eltringham J.R., et al. Adriamycin cardiomyopathy: enhanced cardiac damage in rabbits with combined drug and cardiac irradiation. Radiology 115 (1975) 471-472 (PM:806934)
89. Zhang Y., et al. Atrioventricular nodal fast pathway modification: mechanism for lack of ventricular rate slowing in atrial fibrillation. Cardiovasc. Res. 61 (2004) 45-55 (PM:14732201)
90. Himel H.D., et al. Translesion stimulus-excitation delay indicates quality of linear lesions produced by radiofrequency ablation in rabbit hearts. Physiol. Meas. 28 (2007) 611-623 (PM:17664616)
91. Saba S., et al. Prevention of adverse electrical and mechanical remodeling with biventricular pacing in a rabbit model of myocardial infarction. Heart Rhythm. 5 (2008) 124-130 (PM:18180026)
92. So P.P., et al. I(Ks) block by HMR 1556 lowers ventricular defibrillation threshold and reverses the repolarization shortening by isoproterenol without rate-dependence in rabbits. J. Cardiovasc. Electrophysiol. 18 (2007) 750-756 (PM:17578345)
93. Efimov I.R., et al. High-resolution fluorescent imaging does not reveal a distinct atrioventricular nodal anterior input channel (fast pathway) in the rabbit heart during sinus rhythm. J. Cardiovasc. Electrophysiol. 8 (1997) 295-306 (PM:9083879)
94. Tevaearai H.T., et al. Myocardial gene transfer and overexpression of beta2-adrenergic receptors potentiates the functional recovery of unloaded failing hearts. Circulation 106 (2002) 124-129 (PM:12093781)
95. White D.C., et al. Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 5428-5433 (PM:10779554)
96. Shah A.S., et al. In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation 103 (2001) 1311-1316 (PM:11238278)
97. Maurice J.P., et al. Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. J. Clin. Invest. 104 (1999) 21-29 (PM:10393695)
98. Munch G., et al. Functional alterations after cardiac sodium-calcium exchanger overexpression in heart failure. Am. J. Physiol. Heart Circ. Physiol. 291 (2006) H488-H495 (PM:16603685)
99. Laugwitz K.L., et al. Blocking caspase-activated apoptosis improves contractility in failing myocardium. Hum. Gene Ther. 12 (2001) 2051-2063 (PM:11747596)
100. Munch G., et al. Cardiac overexpression of the norepinephrine transporter uptake-1 results in marked improvement of heart failure. Circ. Res. 97 (2005) 928-936 (PM:16166553)
101. Li Q., et al. Gene therapy with extracellular superoxide dismutase protects conscious rabbits against myocardial infarction. Circulation 103 (2001) 1893-1898 (PM:11294809)
102. McCue J.D., et al. The real estate of myoblast cardiac transplantation: negative remodeling is associated with location. J. Heart Lung Transplant. 27 (2008) 116-123 (PM:18187097)
103. Chen M., et al. Effects of autologous stem cell transplantation on ventricular electrophysiology in doxorubicin-induced heart failure. Cell Biol. Int. 30 (2006) 576-582 (PM:16731012)
104. Dhein S., et al. Effects of autologous bone marrow stem cell transplantation on beta-adrenoceptor density and electrical activation pattern in a rabbit model of non-ischemic heart failure. J. Cardiothorac. Surg. 1 (2006) 17 (PM:16800896)
105. 2+ reloading in mammalian ventricular myocytes. J. Physiol. 559 (2004) 591-607 (PM:15243136)