Use of the rabbit with a failing heart to test for torsadogenicity

Pharmacology and Therapeutics

Volumn 119, Issue 2, 2008, Pages 179-185

  Hamlin, Robert L ^a,b   Kijtawornrat, Anusak ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b QTest Laboratories Inc   (United States)

Author keywords

Heart failure; QT; Rabbit; Torsades de pointes; Torsadogens

Indexed keywords

4 (4 FLUOROPHENYL) 2 METHYL 6 (5 PIPERIDINOPENTYLOXY)PYRIMIDINE; AMIODARONE; CISAPRIDE; CLOFILIUM; DOFETILIDE; QUINIDINE; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG SCREENING; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; RABBIT; REVIEW; TORSADE DES POINTES;

ANIMALS; CALCIUM; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGY; HEART FAILURE; HUMANS; PHARMACEUTICAL PREPARATIONS; RABBITS; TORSADES DE POINTES; TOXICITY TESTS; VENTRICULAR REMODELING;

EID: 50049092328     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2008.03.011     Document Type: Review

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