Myocardial gene transfer and overexpression of β2-adrenergic receptors potentiates the functional recovery of unloaded failing hearts

Circulation

Volumn 106, Issue 1, 2002, Pages 124-129

  Tevaearai, Hendrik T ^a   Eckhart, Andrea D ^a   Walton, G Brant ^a   Keys, Janelle R ^a   Wilson, Katrina ^a   Koch, Walter J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Gene therapy; Heart failure; Heart assist device; Receptors, adrenergic, beta; Remodeling

Indexed keywords

ADENOVIRUS VECTOR; BETA 2 ADRENERGIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE TRANSFER; HEART ASSIST DEVICE; HEART FAILURE; HEART LEFT VENTRICLE CONTRACTILITY; HEART VENTRICLE REMODELING; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ADENOVIRIDAE; ANIMALS; DENERVATION; GENE THERAPY; GENETIC VECTORS; HEART; HEART FAILURE, CONGESTIVE; HEART TRANSPLANTATION; HEART VENTRICLES; KINETICS; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; RABBITS; RECEPTORS, ADRENERGIC, BETA-2; TRANSGENES; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0036645306     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000020220.79105.FD     Document Type: Article

References (22)

1. Beta-adrenoceptors in cardiac disease
2. 2 adrenergic receptor mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium
3. 2-adrenergic receptor
4. 2-adrenergic receptor overexpression in mouse hearts: Critical role for expression level
5. Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary β2-adrenergic receptor gene delivery
6. 2-adrenergic receptor in the heart: Prospects for molecular ventricular assistance
7. 1-adrenergic receptor transgenic mice
8. Improved left ventricular function after chronic left ventricular unloading
9. Weaning from mechanical support after complete recovery in patients with idiopathic dilated cardiomyopathy
10. Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure
11. Recovery from end-stage ischemic cardiomyopathy during long-term LVAD support
12. Cardiac recovery in dilated cardiomyopathy by unloading with a left ventricular assist device
13. Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure
14. Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure
15. Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer
16. Molecular β-adrenergic signaling abnormalities in failing rabbit hearts after infarction
17. Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure following myocardial infarction
18. Adenovirus-mediated genetic manipulation of the myocardial β-adrenergic signaling system in transplanted hearts
19. Ventricular dysfunction after cardioplegic arrest is improved after myocardial gene transfer of a β-adrenergic receptor kinase inhibitor
20. Pharmacologic support for postoperative low cardiac output
21. Midterm follow-up of patients who underwent removal of a left ventricular assist device after cardiac recovery from end-stage cardiomyopathy
22. Seven membrane spanning receptors and heart function