메뉴 건너뛰기




Volumn 34, Issue 3, 2009, Pages 440-446

Mitochondrial function and dysfunction in exercise and insulin resistance

Author keywords

Fatty acid oxidation; Insulin resistance; Mitochondria; Mitochondrial biogenesis; Obesity; Plasma membrane transport

Indexed keywords

FATTY ACID;

EID: 67651209198     PISSN: 17155312     EISSN: None     Source Type: Journal    
DOI: 10.1139/H09-028     Document Type: Review
Times cited : (22)

References (61)
  • 1
    • 34548448413 scopus 로고    scopus 로고
    • Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity
    • doi:10.1152/ajpendo.00685.2006. PMID:17550999
    • Alkhateeb, H., Chabowski, A., Glatz, J.F., Luiken, J.F., and Bonen, A. 2007. Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity. Am. J. Physiol. Endocrinol. Metab. 293: E783-E793. doi:10.1152/ajpendo.00685.2006. PMID:17550999.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293
    • Alkhateeb, H.1    Chabowski, A.2    Glatz, J.F.3    Luiken, J.F.4    Bonen, A.5
  • 2
    • 33749370466 scopus 로고    scopus 로고
    • Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects
    • doi:10.2337/db06-0062. PMID:16873691
    • Bandyopadhyay, G.K., Yu, J.G., Ofrecio, J., and Olefsky, J.M. 2006. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes, 55: 2277-2285. doi:10.2337/db06-0062. PMID:16873691.
    • (2006) Diabetes , vol.55 , pp. 2277-2285
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 3
    • 20044390768 scopus 로고    scopus 로고
    • Dose-response effect of elevated plasma free fatty acid on insulin signaling
    • doi:10.2337/diabetes.54.6.1640. PMID:15919784
    • Belfort, R., Mandarino, L., Kashyap, S., Wirfel, K., Pratipanawatr, T., Berria, R., et al. 2005. Dose-response effect of elevated plasma free fatty acid on insulin signaling. Diabetes, 54: 1640- 1648. doi:10.2337/diabetes.54.6.1640. PMID:15919784.
    • (2005) Diabetes , vol.54 , pp. 1640-1648
    • Belfort, R.1    Mandarino, L.2    Kashyap, S.3    Wirfel, K.4    Pratipanawatr, T.5    Berria, R.6
  • 4
    • 33646376502 scopus 로고    scopus 로고
    • Inverse relationship between PGC-1a protein expression and triacylglycerol accumulation in rodent skeletal muscle
    • doi:10.1152/japplphysiol.00781.2005. PMID:16223979
    • Benton, C.R., Han, X.X., Febbraio, M., Graham, T.E., and Bonen, A. 2006. Inverse relationship between PGC-1a protein expression and triacylglycerol accumulation in rodent skeletal muscle. J. Appl. Physiol. 100: 377-383. doi:10.1152/japplphysiol.00781.2005. PMID:16223979.
    • (2006) J. Appl. Physiol. , vol.100 , pp. 377-383
    • Benton, C.R.1    Han, X.X.2    Febbraio, M.3    Graham, T.E.4    Bonen, A.5
  • 5
    • 33645082002 scopus 로고    scopus 로고
    • Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation
    • doi:10.1152/ajpendo.00312.2005. PMID:16219667
    • Bezaire, V., Bruce, C.R., Heigenhauser, G.J., Tandon, N.N., Glatz, J.F., Luiken, J.J., et al. 2006. Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation. Am. J. Physiol. Endocrinol. Metab. 290: E509-E515. doi:10.1152/ajpendo.00312.2005. PMID:16219667.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290
    • Bezaire, V.1    Bruce, C.R.2    Heigenhauser, G.J.3    Tandon, N.N.4    Glatz, J.F.5    Luiken, J.J.6
  • 6
    • 0037449380 scopus 로고    scopus 로고
    • Effects of free fatty acids on gluconeogenesis and glycogenolysis
    • doi:10.1016/S00243205(02)02350-0. PMID:12495777
    • Boden, G. 2003. Effects of free fatty acids on gluconeogenesis and glycogenolysis. Life Sci. 72: 977-988. doi:10.1016/S00243205(02)02350-0. PMID:12495777.
    • (2003) Life Sci. , vol.72 , pp. 977-988
    • Boden, G.1
  • 7
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • doi:10.1172/JCI117252. PMID:8200979
    • Boden, G., Chen, X., Ruiz, J., White, J.V., and Rossetti, L. 1994. Mechanisms of fatty acid-induced inhibition of glucose uptake. J. Clin. Invest. 93: 2438-2446. doi:10.1172/JCI117252. PMID:8200979.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 8
    • 2942719049 scopus 로고    scopus 로고
    • Regulation of fatty acid transport by fatty acid translocase/CD36
    • doi:10.1079/PNS2004331. PMID:15294038
    • Bonen, A., Campbell, S.E., Benton, C.R., Chabowski, A., Coort, S.L., Han, X.X., et al. 2004a. Regulation of fatty acid transport by fatty acid translocase/CD36. Proc. Nutr. Soc. 63: 245-249. doi:10.1079/PNS2004331. PMID:15294038.
    • (2004) Proc. Nutr. Soc. , vol.63 , pp. 245-249
    • Bonen, A.1    Campbell, S.E.2    Benton, C.R.3    Chabowski, A.4    Coort, S.L.5    Han, X.X.6
  • 9
    • 4544355465 scopus 로고    scopus 로고
    • Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    • PMID:15132977
    • Bonen, A., Parolin, M.L., Steinberg, G.R., Calles-Escandon, J., Tandon, N.N., Glatz, J.F., et al. 2004b. Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J. 18: 1144-1146. PMID:15132977.
    • (2004) FASEB J. , vol.18 , pp. 1144-1146
    • Bonen, A.1    Parolin, M.L.2    Steinberg, G.R.3    Calles-Escandon, J.4    Tandon, N.N.5    Glatz, J.F.6
  • 10
    • 33847611885 scopus 로고    scopus 로고
    • Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle
    • doi:10.1007/s00125-007-0594-3. PMID:17334651
    • Boushel, R., Gnaiger, E., Schjerling, P., Skovbro, M., Kraunsoe, R., and Dela, F. 2007. Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia, 50: 790-796. doi:10.1007/s00125-007-0594-3. PMID:17334651.
    • (2007) Diabetologia , vol.50 , pp. 790-796
    • Boushel, R.1    Gnaiger, E.2    Schjerling, P.3    Skovbro, M.4    Kraunsoe, R.5    Dela, F.6
  • 11
    • 33644699965 scopus 로고    scopus 로고
    • The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects
    • doi:10.2337/diabetes.54.11.3154. PMID:16249439
    • Bruce, C.R., Mertz, V.A., Heigenhauser, G.J., and Dyck, D.J. 2005. The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects. Diabetes, 54: 3154-3160. doi:10.2337/diabetes.54.11.3154. PMID:16249439.
    • (2005) Diabetes , vol.54 , pp. 3154-3160
    • Bruce, C.R.1    Mertz, V.A.2    Heigenhauser, G.J.3    Dyck, D.J.4
  • 12
    • 4344595619 scopus 로고    scopus 로고
    • A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria
    • doi:10.1074/jbc.M400566200. PMID:15161924
    • Campbell, S.E., Tandon, N.N., Woldegiorgis, G., Luiken, J.J., Glatz, J.F., and Bonen, A. 2004. A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. J. Biol. Chem. 279: 36235-36241. doi:10.1074/jbc.M400566200. PMID:15161924.
    • (2004) J. Biol. Chem. , vol.279 , pp. 36235-36241
    • Campbell, S.E.1    Tandon, N.N.2    Woldegiorgis, G.3    Luiken, J.J.4    Glatz, J.F.5    Bonen, A.6
  • 13
    • 3042739406 scopus 로고    scopus 로고
    • Enhanced sarcolemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats
    • doi:10.2337/diabetes.53.7.1655. PMID:15220187
    • Coort, S.L., Hasselbaink, D.M., Koonen, D.P., Willems, J., Coumans, W.A., Chabowski, A., et al. 2004. Enhanced sarcolemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats. Diabetes, 53: 1655-1663. doi:10.2337/diabetes.53.7.1655. PMID:15220187.
    • (2004) Diabetes , vol.53 , pp. 1655-1663
    • Coort, S.L.1    Hasselbaink, D.M.2    Koonen, D.P.3    Willems, J.4    Coumans, W.A.5    Chabowski, A.6
  • 14
    • 40449094269 scopus 로고    scopus 로고
    • Insulin resistant muscle is exercise resistant: evidence for reduced response of nuclear encoded mitochondrial genes to exercise
    • doi:10.1152/ajpendo.00729.2007. PMID:18182465
    • De Filippis, E., Alvarez, G., Berria, R., Cusi, K., Everman, S., Meyer, C., and Mandarino, L.J. 2008. Insulin resistant muscle is exercise resistant: evidence for reduced response of nuclear encoded mitochondrial genes to exercise. Am. J. Physiol. Endocrinol. Metab. 294: E607-E614. doi:10.1152/ajpendo.00729.2007. PMID:18182465.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294
    • De Filippis, E.1    Alvarez, G.2    Berria, R.3    Cusi, K.4    Everman, S.5    Meyer, C.6    Mandarino, L.J.7
  • 15
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • doi:10.1172/JCI5001. PMID:9916137
    • Dresner, A., Laurent, D., Marcucci, M., Griffin, M.E., Dufour, S., Cline, G.W., et al. 1999. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J. Clin. Invest. 103: 253-259. doi:10.1172/JCI5001. PMID:9916137.
    • (1999) J. Clin. Invest. , vol.103 , pp. 253-259
    • Dresner, A.1    Laurent, D.2    Marcucci, M.3    Griffin, M.E.4    Dufour, S.5    Cline, G.W.6
  • 16
    • 10744222588 scopus 로고    scopus 로고
    • Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK
    • doi:10.1101/gad.1152204. PMID:14744933
    • Fan, M., Rhee, J., St-Pierre, J., Handschin, C., Puigserver, P., Lin, J., et al. 2004. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK. Genes Dev. 18: 278-289. doi:10.1101/gad.1152204. PMID:14744933.
    • (2004) Genes Dev. , vol.18 , pp. 278-289
    • Fan, M.1    Rhee, J.2    St-Pierre, J.3    Handschin, C.4    Puigserver, P.5    Lin, J.6
  • 17
    • 34547505089 scopus 로고    scopus 로고
    • Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle
    • doi:10.1073/pnas.0704024104. PMID:17548828
    • Garcia-Roves, P., Huss, J.M., Han, D.H., Hancock, C.R., IglesiasGutierrez, E., Chen, M., and Holloszy, J.O. 2007. Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle. Proc. Natl. Acad. Sci. U.S.A. 104: 10709-10713. doi:10.1073/pnas.0704024104. PMID:17548828.
    • (2007) Proc. Natl. Acad. Sci. U.S.A , vol.104 , pp. 10709-10713
    • Garcia-Roves, P.1    Huss, J.M.2    Han, D.H.3    Hancock, C.R.4    IglesiasGutierrez, E.5    Chen, M.6    Holloszy, J.O.7
  • 18
    • 34547621405 scopus 로고    scopus 로고
    • Metabolic challenges reveal impaired fatty acid metabolism and translocation of FAT/CD36 but not FABPpm in obese zucker rat muscle
    • doi:10.1152/ajpendo.00106.2007. PMID:17519284
    • Han, X.X., Chabowski, A., Tandon, N.N., Calles-Escandon, J., Glatz, J.F., Luiken, J.J., and Bonen, A. 2007. Metabolic challenges reveal impaired fatty acid metabolism and translocation of FAT/CD36 but not FABPpm in obese zucker rat muscle. Am. J. Physiol. Endocrinol. Metab. 293: E566-E575. doi:10.1152/ajpendo.00106.2007. PMID:17519284.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293
    • Han, X.X.1    Chabowski, A.2    Tandon, N.N.3    Calles-Escandon, J.4    Glatz, J.F.5    Luiken, J.J.6    Bonen, A.7
  • 19
    • 33847332202 scopus 로고    scopus 로고
    • Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    • doi:10.1016/j.cmet.2007.01.002. PMID:17339025
    • Holland, W.L., Brozinick, J.T., Wang, L.P., Hawkins, E.D., Sargent, K.M., Liu, Y., et al. 2007. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 5: 167-179. doi:10.1016/j.cmet.2007.01.002. PMID:17339025.
    • (2007) Cell Metab. , vol.5 , pp. 167-179
    • Holland, W.L.1    Brozinick, J.T.2    Wang, L.P.3    Hawkins, E.D.4    Sargent, K.M.5    Liu, Y.6
  • 20
    • 33645892283 scopus 로고    scopus 로고
    • Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise
    • doi:10.1113/jphysiol.2005.102178. PMID:16357012
    • Holloway, G.P., Bezaire, V., Heigenhauser, G.J., Tandon, N.N., Glatz, J.F., Luiken, J.J., et al. 2006. Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise. J. Physiol. 571: 201-210. doi:10.1113/jphysiol.2005.102178. PMID:16357012.
    • (2006) J. Physiol. , vol.571 , pp. 201-210
    • Holloway, G.P.1    Bezaire, V.2    Heigenhauser, G.J.3    Tandon, N.N.4    Glatz, J.F.5    Luiken, J.J.6
  • 21
    • 34447576831 scopus 로고    scopus 로고
    • Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women
    • doi:10.1152/ajpendo.00639.2006. PMID:17311893
    • Holloway, G.P., Thrush, A.B., Heigenhauser, G.J., Tandon, N.N., Dyck, D.J., Bonen, A., and Spriet, L.L. 2007. Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women. Am. J. Physiol. Endocrinol. Metab. 292: E1782-E1789. doi:10.1152/ajpendo.00639.2006. PMID:17311893.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.292
    • Holloway, G.P.1    Thrush, A.B.2    Heigenhauser, G.J.3    Tandon, N.N.4    Dyck, D.J.5    Bonen, A.6    Spriet, L.L.7
  • 22
    • 47549098993 scopus 로고    scopus 로고
    • PGC-1α's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1α and PGC-1β protein
    • doi:10.1152/ajpendo.00726.2007. PMID:18349111
    • Holloway, G.P., Perry, C.G., Thrush, A.B., Heigenhauser, G.J., Dyck, D.J., Bonen, A., and Spriet, L.L. 2008. PGC-1α's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1a and PGC-1β protein. Am. J. Physiol. Endocrinol. Metab. 294: E1060-E1069. doi:10.1152/ajpendo.00726.2007. PMID:18349111.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294
    • Holloway, G.P.1    Perry, C.G.2    Thrush, A.B.3    Heigenhauser, G.J.4    Dyck, D.J.5    Bonen, A.6    Spriet, L.L.7
  • 23
    • 65649133062 scopus 로고    scopus 로고
    • In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation
    • [Epub ahead of print.] PMID:19141681
    • Holloway G.P., Benton C., Mullen K.L., Yoshida Y., Snook L.A., Han X.X., et al. 2009. In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation. Am J Physiol Endocrinol Metab. [Epub ahead of print.] PMID:19141681.
    • (2009) Am J Physiol Endocrinol Metab.
    • Holloway, G.P.1    Benton, C.2    Mullen, K.L.3    Yoshida, Y.4    Snook, L.A.5    Han, X.X.6
  • 24
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • PMID:10600804
    • Kelley, D.E., Goodpaster, B., Wing, R.R., and Simoneau, J.A. 1999. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am. J. Physiol. 277: E1130-E1141. PMID:10600804.
    • (1999) Am. J. Physiol. , vol.277
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 25
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • doi:10.2337/diabetes.51.10. 2944.PMID:12351431
    • Kelley, D.E., He, J., Menshikova, E.V., and Ritov, V.B. 2002. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes, 51: 2944-2950. doi:10.2337/diabetes.51.10. 2944.PMID:12351431.
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 27
    • 35748962960 scopus 로고    scopus 로고
    • Fatty acid oxidation in cardiac and skeletal muscle mitochondria is unaffected by deletion of CD36
    • doi:10.1016/j.abb.2007.08.020. PMID:17904092
    • King, K.L., Stanley, W.C., Rosca, M., Kerner, J., Hoppel, C.L., and Febbraio, M. 2007. Fatty acid oxidation in cardiac and skeletal muscle mitochondria is unaffected by deletion of CD36. Arch. Biochem. Biophys. 467: 234-238. doi:10.1016/j.abb.2007.08.020. PMID:17904092.
    • (2007) Arch. Biochem. Biophys. , vol.467 , pp. 234-238
    • King, K.L.1    Stanley, W.C.2    Rosca, M.3    Kerner, J.4    Hoppel, C.L.5    Febbraio, M.6
  • 28
    • 0035859836 scopus 로고    scopus 로고
    • Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor
    • doi:10.1073/pnas.171184698. PMID:11481440
    • Knutti, D., Kressler, D., and Kralli, A. 2001. Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proc. Natl. Acad. Sci. U.S.A. 98: 9713-9718. doi:10.1073/pnas.171184698. PMID:11481440.
    • (2001) Proc. Natl. Acad. Sci. U.S.A , vol.98 , pp. 9713-9718
    • Knutti, D.1    Kressler, D.2    Kralli, A.3
  • 29
    • 17644394969 scopus 로고    scopus 로고
    • Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism
    • doi:10.1152/ajpcell.00391.2004. PMID:15647392
    • Koves, T.R., Noland, R.C., Bates, A.L., Henes, S.T., Muoio, D.M., and Cortright, R.N. 2005. Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism. Am. J. Physiol. Cell Physiol. 288: C1074-C1082. doi:10.1152/ajpcell.00391.2004. PMID:15647392.
    • (2005) Am. J. Physiol. Cell Physiol. , vol.288
    • Koves, T.R.1    Noland, R.C.2    Bates, A.L.3    Henes, S.T.4    Muoio, D.M.5    Cortright, R.N.6
  • 30
    • 37449020075 scopus 로고    scopus 로고
    • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    • doi:10.1016/j.cmet.2007.10.013. PMID:18177724
    • Koves, T.R., Ussher, J.R., Noland, R.C., Slentz, D., Mosedale, M., Ilkayeva, O., et al. 2008. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7: 45-56. doi:10.1016/j.cmet.2007.10.013. PMID:18177724.
    • (2008) Cell Metab. , vol.7 , pp. 45-56
    • Koves, T.R.1    Ussher, J.R.2    Noland, R.C.3    Slentz, D.4    Mosedale, M.5    Ilkayeva, O.6
  • 31
    • 0001635904 scopus 로고
    • The relative value of fat and carbohydrate as sources of muscular energy: with appendices on the correlation between standard metabolism and the respiratory quotient during rest and work
    • PMID:16742941
    • Krogh, A., and Lindhard, J. 1920. The relative value of fat and carbohydrate as sources of muscular energy: with appendices on the correlation between standard metabolism and the respiratory quotient during rest and work. Biochem. J. 14: 290-363. PMID:16742941.
    • (1920) Biochem. J. , vol.14 , pp. 290-363
    • Krogh, A.1    Lindhard, J.2
  • 32
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study
    • doi:10.1007/s001250051123. PMID:10027589
    • Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S.M., Rothman, D.L., et al. 1999. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia, 42: 113-116. doi:10.1007/s001250051123. PMID:10027589.
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1    Falk Petersen, K.2    Dresner, A.3    DiPietro, L.4    Vogel, S.M.5    Rothman, D.L.6
  • 33
    • 0036148471 scopus 로고    scopus 로고
    • Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation
    • doi:10.1210/jc.87.1.226. PMID:11788651
    • Kruszynska, Y.T., Worrall, D.S., Ofrecio, J., Frias, J.P., Macaraeg, G., and Olefsky, J.M. 2002. Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. J. Clin. Endocrinol. Metab. 87: 226-234. doi:10.1210/jc.87.1.226. PMID:11788651.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 226-234
    • Kruszynska, Y.T.1    Worrall, D.S.2    Ofrecio, J.3    Frias, J.P.4    Macaraeg, G.5    Olefsky, J.M.6
  • 34
    • 0033803048 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    • doi:10.1172/JCI10268. PMID:11018072
    • Lehman, J.J., Barger, P.M., Kovacs, A., Saffitz, J.E., Medeiros, D.M., and Kelly, D.P. 2000. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 106: 847-856. doi:10.1172/JCI10268. PMID:11018072.
    • (2000) J. Clin. Invest. , vol.106 , pp. 847-856
    • Lehman, J.J.1    Barger, P.M.2    Kovacs, A.3    Saffitz, J.E.4    Medeiros, D.M.5    Kelly, D.P.6
  • 35
    • 0020624753 scopus 로고
    • Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues Demonstration of the presence of malonyl-CoA in nonhepatic tissues of the rat
    • PMID:6615466
    • McGarry, J.D., Mills, S.E., Long, C.S., and Foster, D.W. 1983. Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Demonstration of the presence of malonyl-CoA in nonhepatic tissues of the rat. Biochem. J. 214: 21-28. PMID:6615466.
    • (1983) Biochem. J. , vol.214 , pp. 21-28
    • McGarry, J.D.1    Mills, S.E.2    Long, C.S.3    Foster, D.W.4
  • 36
    • 34249720640 scopus 로고    scopus 로고
    • Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes
    • doi:10.2337/db06-0981. PMID:17351150
    • Mogensen, M., Sahlin, K., Fernstrom, M., Glintborg, D., Vind, B.F., Beck-Nielsen, H., and Hojlund, K. 2007. Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes, 56: 1592-1599. doi:10.2337/db06-0981. PMID:17351150.
    • (2007) Diabetes , vol.56 , pp. 1592-1599
    • Mogensen, M.1    Sahlin, K.2    Fernstrom, M.3    Glintborg, D.4    Vind, B.F.5    Beck-Nielsen, H.6    Hojlund, K.7
  • 37
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • doi:10.1038/ng1180. PMID:12808457
    • Mootha, V.K., Lindgren, C.M., Eriksson, K.F., Subramanian, A., Sihag, S., Lehar, J., et al. 2003. PGC-1a-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34: 267-273. doi:10.1038/ng1180. PMID:12808457.
    • (2003) Nat. Genet. , vol.34 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3    Subramanian, A.4    Sihag, S.5    Lehar, J.6
  • 38
    • 31044433308 scopus 로고    scopus 로고
    • Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
    • doi:10.1172/JCI25151. PMID:16284649
    • Morino, K., Petersen, K.F., Dufour, S., Befroy, D., Frattini, J., Shatzkes, N., et al. 2005. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J. Clin. Invest. 115: 3587-3593. doi:10.1172/JCI25151. PMID:16284649.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3587-3593
    • Morino, K.1    Petersen, K.F.2    Dufour, S.3    Befroy, D.4    Frattini, J.5    Shatzkes, N.6
  • 39
    • 0029980385 scopus 로고    scopus 로고
    • Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exercise
    • PMID:8638703
    • Odland, L.M., Heigenhauser, G.J., Lopaschuk, G.D., and Spriet, L.L. 1996. Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exercise. Am. J. Physiol. 270: E541-E544. PMID:8638703.
    • (1996) Am. J. Physiol. , vol.270
    • Odland, L.M.1    Heigenhauser, G.J.2    Lopaschuk, G.D.3    Spriet, L.L.4
  • 40
    • 0031833280 scopus 로고    scopus 로고
    • Skeletal muscle malonyl-CoA content at the onset of exercise at varying power outputs in humans
    • PMID:9611159
    • Odland, L.M., Howlett, R.A., Heigenhauser, G.J., Hultman, E., and Spriet, L.L. 1998. Skeletal muscle malonyl-CoA content at the onset of exercise at varying power outputs in humans. Am. J. Physiol. 274: E1080-E1085. PMID:9611159.
    • (1998) Am. J. Physiol. , vol.274
    • Odland, L.M.1    Howlett, R.A.2    Heigenhauser, G.J.3    Hultman, E.4    Spriet, L.L.5
  • 41
    • 0030969532 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride levels are inversely related to insulin action
    • doi:10.2337/diabetes.46.6.983. PMID:9166669
    • Pan, D.A., Lillioja, S., Kriketos, A.D., Milner, M.R., Baur, L.A., Bogardus, C., et al. 1997. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes, 46: 983-988. doi:10.2337/diabetes.46.6.983. PMID:9166669.
    • (1997) Diabetes , vol.46 , pp. 983-988
    • Pan, D.A.1    Lillioja, S.2    Kriketos, A.D.3    Milner, M.R.4    Baur, L.A.5    Bogardus, C.6
  • 42
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1
    • doi:10.1073/pnas.1032913100. PMID: 12832613
    • Patti, M.E., Butte, A.J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., et al. 2003. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. U.S.A. 100: 8466-8471. doi:10.1073/pnas.1032913100. PMID: 12832613.
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3    Cusi, K.4    Berria, R.5    Kashyap, S.6
  • 43
    • 0032764784 scopus 로고    scopus 로고
    • Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
    • doi:10.2337/diabetes.48.8.1600. PMID:10426379
    • Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., et al. 1999. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes, 48: 1600-1606. doi:10.2337/diabetes.48.8.1600. PMID:10426379.
    • (1999) Diabetes , vol.48 , pp. 1600-1606
    • Perseghin, G.1    Scifo, P.2    De Cobelli, F.3    Pagliato, E.4    Battezzati, A.5    Arcelloni, C.6
  • 44
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • doi:10.1016/S0092-8674(00)81410-5. PMID:9529258
    • Puigserver, P., Wu, Z., Park, C.W., Graves, R., Wright, M., and Spiegelman, B.M. 1998. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell, 92: 829-839. doi:10.1016/S0092-8674(00)81410-5. PMID:9529258.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 45
    • 18244399631 scopus 로고    scopus 로고
    • Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARg coactivator-1
    • doi:10.1016/S1097-2765(01)00390-2. PMID:11741533
    • Puigserver, P., Rhee, J., Lin, J., Wu, Z., Yoon, J.C., Zhang, C.Y., et al. 2001. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARg coactivator-1. Mol. Cell, 8: 971-982. doi:10.1016/S1097-2765(01)00390-2. PMID:11741533.
    • (2001) Mol. Cell , vol.8 , pp. 971-982
    • Puigserver, P.1    Rhee, J.2    Lin, J.3    Wu, Z.4    Yoon, J.C.5    Zhang, C.Y.6
  • 46
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • doi:10.1016/S0140-6736(63)91500-9. PMID:13990765
    • Randle, P.J., Garland, P.B., Hales, C.N., and Newsholme, E.A. 1963. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet, 1: 785-789. doi:10.1016/S0140-6736(63)91500-9. PMID:13990765.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 47
    • 12144275294 scopus 로고    scopus 로고
    • Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
    • doi:10.2337/diabetes.54.1.8. PMID:15616005
    • Ritov, V.B., Menshikova, E.V., He, J., Ferrell, R.E., Goodpaster, B.H., and Kelley, D.E. 2005. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes, 54: 8-14. doi:10.2337/diabetes.54.1.8. PMID:15616005.
    • (2005) Diabetes , vol.54 , pp. 8-14
    • Ritov, V.B.1    Menshikova, E.V.2    He, J.3    Ferrell, R.E.4    Goodpaster, B.H.5    Kelley, D.E.6
  • 48
    • 11144305245 scopus 로고    scopus 로고
    • Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise
    • doi:10.1152/ajpendo.00379.2004. PMID:15383373
    • Roepstorff, C., Halberg, N., Hillig, T., Saha, A.K., Ruderman, N.B., Wojtaszewski, J.F., et al. 2005. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. Am. J. Physiol. Endocrinol. Metab. 288: E133-E142. doi:10.1152/ajpendo.00379.2004. PMID:15383373.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.288
    • Roepstorff, C.1    Halberg, N.2    Hillig, T.3    Saha, A.K.4    Ruderman, N.B.5    Wojtaszewski, J.F.6
  • 49
    • 12144286554 scopus 로고    scopus 로고
    • Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner
    • doi:10.1161/01.RES.0000117088.36577.EB. PMID:14726475
    • Russell, L.K., Mansfield, C.M., Lehman, J.J., Kovacs, A., Courtois, M., Saffitz, J.E., et al. 2004. Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ. Res. 94: 525-533. doi:10.1161/01.RES. 0000117088.36577.EB. PMID:14726475.
    • (2004) Circ. Res. , vol.94 , pp. 525-533
    • Russell, L.K.1    Mansfield, C.M.2    Lehman, J.J.3    Kovacs, A.4    Courtois, M.5    Saffitz, J.E.6
  • 50
    • 33745818883 scopus 로고    scopus 로고
    • Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training
    • doi:10.1152/ajpendo.00051.2006. PMID:16670153
    • Schenk, S., and Horowitz, J.F. 2006. Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training. Am. J. Physiol. Endocrinol. Metab. 291: E254-E260. doi:10.1152/ ajpendo.00051.2006. PMID:16670153.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291
    • Schenk, S.1    Horowitz, J.F.2
  • 51
    • 33845947550 scopus 로고    scopus 로고
    • Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI matched control subjects
    • doi:10.1007/s00125-006-0475-1. PMID:17093944
    • Schrauwen-Hinderling, V.B., Kooi, M.E., Hesselink, M.K., Jeneson, J.A., Backes, W.H., van Echteld, C.J., et al. 2007. Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI matched control subjects. Diabetologia, 50: 113-120. doi:10.1007/s00125-006-0475-1. PMID:17093944.
    • (2007) Diabetologia , vol.50 , pp. 113-120
    • Schrauwen-Hinderling, V.B.1    Kooi, M.E.2    Hesselink, M.K.3    Jeneson, J.A.4    Backes, W.H.5    van Echteld, C.J.6
  • 52
    • 27644450194 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma and its coactivator-1 alpha may be associated with features of the metabolic syndrome in adolescents
    • doi:10.1677/jme.1.01837. PMID:16216916
    • Sookoian, S., Garcia, S.I., Porto, P.I., Dieuzeide, G., Gonzalez, C.D., and Pirola, C.J. 2005. Peroxisome proliferator-activated receptor gamma and its coactivator-1 alpha may be associated with features of the metabolic syndrome in adolescents. J. Mol. Endocrinol. 35: 373-380. doi:10.1677/jme.1.01837. PMID:16216916.
    • (2005) J. Mol. Endocrinol. , vol.35 , pp. 373-380
    • Sookoian, S.1    Garcia, S.I.2    Porto, P.I.3    Dieuzeide, G.4    Gonzalez, C.D.5    Pirola, C.J.6
  • 53
    • 31644443192 scopus 로고    scopus 로고
    • Ceramides in insulin resistance and lipotoxicity
    • doi:10.1016/j.plipres.2005.11.002. PMID:16445986
    • Summers, S.A. 2006. Ceramides in insulin resistance and lipotoxicity. Prog. Lipid Res. 45: 42-72. doi:10.1016/j.plipres.2005.11.002. PMID:16445986.
    • (2006) Prog. Lipid Res. , vol.45 , pp. 42-72
    • Summers, S.A.1
  • 54
    • 42949084209 scopus 로고    scopus 로고
    • Muscular diacylglycerol metabolism and insulin resistance
    • doi:10.1016/j.physbeh.2007.12.002. PMID:18207474
    • Timmers S, Schrauwen, P., and de Vogel, J. 2007. Muscular diacylglycerol metabolism and insulin resistance. Physiol Behav. 94: 242-251. doi:10.1016/j.physbeh.2007.12.002. PMID:18207474.
    • (2007) Physiol Behav. , vol.94 , pp. 242-251
    • Timmers S Schrauwen, P.1    de Vogel, J.2
  • 55
    • 0034987436 scopus 로고    scopus 로고
    • Increased fatty acid uptake and altered fatty acid metabolism in insulin-resistant muscle of obese Zucker rats
    • doi:10.2337/diabetes.50.6.1389. PMID:11375340
    • Turcotte, L.P., Swenberger, J.R., Zavitz Tucker, M., and Yee, A.J. 2001. Increased fatty acid uptake and altered fatty acid metabolism in insulin-resistant muscle of obese Zucker rats. Diabetes, 50: 1389-1396. doi:10.2337/diabetes.50.6.1389. PMID:11375340.
    • (2001) Diabetes , vol.50 , pp. 1389-1396
    • Turcotte, L.P.1    Swenberger, J.R.2    Zavitz Tucker, M.3    Yee, A.J.4
  • 56
    • 34547588219 scopus 로고    scopus 로고
    • Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
    • doi:10.2337/db07-0093. PMID:17519422
    • Turner, N., Bruce, C.R., Beale, S.M., Hoehn, K.L., So, T., Rolph, M.S., and Cooney, G.J. 2007. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes, 56: 2085-2092. doi:10.2337/db07-0093. PMID:17519422.
    • (2007) Diabetes , vol.56 , pp. 2085-2092
    • Turner, N.1    Bruce, C.R.2    Beale, S.M.3    Hoehn, K.L.4    So, T.5    Rolph, M.S.6    Cooney, G.J.7
  • 57
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome
    • doi:10.1210/en.2003-0870. PMID:12960011
    • Unger, R.H. 2003. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology, 144: 5159-5165. doi:10.1210/en.2003-0870. PMID:12960011.
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 58
    • 0024998320 scopus 로고
    • Time course of exercise-induced decline in malonyl-CoA in different muscle types
    • PMID:2166437
    • Winder, W.W., Arogyasami, J., Elayan, I.M., and Cartmill, D. 1990. Time course of exercise-induced decline in malonyl-CoA in different muscle types. Am. J. Physiol. 259: E266-E271. PMID:2166437.
    • (1990) Am. J. Physiol. , vol.259
    • Winder, W.W.1    Arogyasami, J.2    Elayan, I.M.3    Cartmill, D.4
  • 59
    • 15444339308 scopus 로고    scopus 로고
    • Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A
    • doi:10.1063/1.365801. PMID:9029219
    • Winder, W.W., Wilson, H.A., Hardie, D.G., Rasmussen, B.B., Hutber, C.A., Call, G.B., et al. 1997. Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A. J. Appl. Physiol. 82: 219-225. doi:10.1063/1.365801. PMID:9029219.
    • (1997) J. Appl. Physiol. , vol.82 , pp. 219-225
    • Winder, W.W.1    Wilson, H.A.2    Hardie, D.G.3    Rasmussen, B.B.4    Hutber, C.A.5    Call, G.B.6
  • 60
    • 33846992686 scopus 로고    scopus 로고
    • Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression
    • doi:10.1074/jbc.M606116200. PMID:17099248
    • Wright, D.C., Han, D.H., Garcia-Roves, P.M., Geiger, P.C., Jones, T.E., and Holloszy, J.O. 2007. Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression. J. Biol. Chem. 282: 194-199. doi:10.1074/jbc.M606116200. PMID:17099248.
    • (2007) J. Biol. Chem. , vol.282 , pp. 194-199
    • Wright, D.C.1    Han, D.H.2    Garcia-Roves, P.M.3    Geiger, P.C.4    Jones, T.E.5    Holloszy, J.O.6
  • 61
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • doi:10.1074/jbc.M200958200. PMID:12006582
    • Yu, C., Chen, Y., Cline, G.W., Zhang, D., Zong, H., Wang, Y., et al. 2002. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277: 50230-50236. doi:10.1074/jbc.M200958200. PMID:12006582.
    • (2002) J. Biol. Chem. , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3    Zhang, D.4    Zong, H.5    Wang, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.