A highly conserved tryptophan residue in the fourth transmembrane domain of the A1 adenosine receptor is essential for ligand binding but not receptor homodimerization

Journal of Neurochemistry

Volumn 110, Issue 4, 2009, Pages 1352-1362

  Suzuki, Tokiko ^a,b   Namba, Kazunori ^c   Yamagishi, Ryosuke ^d   Kaneko, Hiroki ^d   Haga, Tatsuya ^e   Nakata, Hiroyasu ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^d NIHON UNIVERSITY   (Japan)

^e GAKUSHUIN UNIVERSITY   (Japan)

Author keywords

Adenosine receptor; Agonist binding model; G protein coupled receptors; Oligomerization; Site directed mutagenesis

Indexed keywords

ADENOSINE A1 RECEPTOR; G PROTEIN COUPLED RECEPTOR; HOMODIMER; MUTANT PROTEIN; RHODOPSIN; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; BIOTINYLATION; CELL MEMBRANE; CELL SURFACE; COMPLEX FORMATION; DIMERIZATION; GENE MUTATION; GENETIC CONSERVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ADENOSINE; AMINO ACID SEQUENCE; CELL MEMBRANE; CONSERVED SEQUENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, ADENOSINE A1; TRYPTOPHAN;

EID: 67651173221     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06227.x     Document Type: Article

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