The neurokinin-1 and neurokinin-2 receptor binding sites of MDL103,392 differ

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 12, 1999, Pages 2867-2876

  Greenfeder, Scott ^a   Cheewatrakoolpong, Boonlert ^a   Billah, Motasim ^a   Egan, Robert W ^a   Keene, Elizabeth ^a   Murgolo, Nicholas J ^a   Anthes, John C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonists; Mutagenesis; Receptors; Tachykinins

Indexed keywords

AMINO ACID; GLUTAMINE; HISTIDINE; ISOLEUCINE; LEUCINE; MDL 103392; MUTANT PROTEIN; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ A; PHENYLALANINE; SUBSTANCE P DERIVATIVE; TACHYKININ RECEPTOR AGONIST; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MODEL; NONHUMAN; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; COS CELLS; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PYRROLES; PYRROLIDINES; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0033381792     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00220-5     Document Type: Article

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