Zalypsis (PM00104) is a potent inducer of γ-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition

Molecular Cancer Therapeutics

Volumn 8, Issue 7, 2009, Pages 2007-2014

  Guirouilh Barbat, Josée ^a   Antony, Smitha ^a   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H2AX; PM 00104; TETRAHYDROISOQUINOLINE DERIVATIVE; TRABECTEDIN; UNCLASSIFIED DRUG; ZALYPSIS;

ARTICLE; CELL LINE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; DNA FOOTPRINTING; DNA REPLICATION; DNA TRANSCRIPTION; DRUG DNA BINDING; DRUG STRUCTURE; EWING SARCOMA; EXCISION REPAIR; GROWTH INHIBITION; HUMAN; HUMAN CELL; PHARMACODYNAMICS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, ALKYLATING; BONE NEOPLASMS; DIOXOLES; DNA DAMAGE; DNA FOOTPRINTING; DNA REPAIR; DNA REPLICATION; HISTONES; HUMANS; SARCOMA, EWING'S; TETRAHYDROISOQUINOLINES; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 67651158998     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-0336     Document Type: Article

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