Chronic crude garlic-feeding modified adult male rat testicular markers: Mechanisms of action

Reproductive Biology and Endocrinology

Volumn 7, Issue , 2009, Pages

  Hammami, Imen ^a,b,c,d   Amara, Souheila ^b,c,d   Benahmed, Mohamed ^b,c,d   El May, Michèle V ^a   Mauduit, Claire ^e  

^a UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

^b INSERM   (France)

^c UNIVERSITÉ DE LYON   (France)

^d UNIVERSITÉ LYON 1   (France)

^e CENTRE HOSPITALIER LYON SUD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; BETA TUBULIN; CASPASE 3; CASPASE 6; CASPASE INHIBITOR; CELL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GARLIC EXTRACT; GLUTATHIONE TRANSFERASE A2; HYDROXYSTEROID DEHYDROGENASE; MUELLERIAN INHIBITING FACTOR; PROTEIN BIRC2; PROTEIN BIRC3; PROTEIN BIRC5; PROTEIN CYPL 1A; PROTEIN RHOX5; PROTEIN TUBB3; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; STEROID REDUCTASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; 17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 3; 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3; BIRC3 PROTEIN, RAT; CARRIER PROTEIN; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); DIABLO PROTEIN, RAT; INHIBITOR OF APOPTOSIS PROTEIN; MITOCHONDRIAL PROTEIN; PHOSPHOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG MECHANISM; ENZYME INHIBITION; FEEDING; GERM CELL; HORMONE INHIBITION; LEYDIG CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; SERTOLI CELL; SPERMATID; SPERMATOCYTE; TESTOSTERONE SYNTHESIS; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; GARLIC; METABOLISM; PATHOLOGY; TESTIS; WISTAR RAT;

ALLIUM SATIVUM; RATTUS;

17-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CASPASE 3; CASPASE 6; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; GARLIC; INHIBITOR OF APOPTOSIS PROTEINS; MALE; MITOCHONDRIAL PROTEINS; PHOSPHOPROTEINS; RATS; RATS, WISTAR; SERTOLI CELLS; SPERMATIDS; SPERMATOCYTES; TESTIS;

EID: 67651151543     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-7-65     Document Type: Article

References (52)

1. Agarwal KC Therapeutic actions of garlic constituents Med Res Rev 1996, 16:111-124. 10.1002/ (SICI)1098-1128(199601)16:1<111::AID-MED4>3.0.CO;2-5 8788216
2. Tattelman E Health effects of garlic Am Fam Physician 2005, 72:103-106. 16035690
3. Amagase H Petesch BL Matsuura H Kasuga S Itakura Y Intake of garlic and its bioactive components J Nutr 2001, 131:955S-962S. 11238796
4. Mahmoodi M Islami MR Asadi Karam GR Khaksari M Sahebghadam Lotfi A Hajizadeh MR Mirzaee MR Study of the effects of raw garlic consumption on the level of lipids and other blood biochemical factors in hyperlipidemic individuals Pak J Pharm Sci 2006, 19:295-298. 17105707
5. Yeh YY Yeh SM Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis Lipids 1994, 29:189-193. 10.1007/BF02536728 8170288
6. Koscielny J Klussendorf D Latza R Schmitt R Radtke H Siegel G Kiesewetter H The antiatherosclerotic effect of Allium sativum Atherosclerosis 1999, 144:237-249. 10.1016/S0021-9150(99)00060-X 10381297
7. Siegel G Klussendorf D The anti-atheroslerotic effect of Allium sativum: statistics re-evaluated Atherosclerosis 2000, 150:437-438. 10.1016/ S0021-9150(00)00416-0 10917869
8. Galeone C Pelucchi C Levi F Negri E Franceschi S Talamini R Giacosa A La Vecchia C Onion and garlic use and human cancer Am J Clin Nutr 2006, 84:1027-1032. 17093154
9. Shukla Y Kalra N Cancer chemoprevention with garlic and its constituents Cancer Lett 2007, 247:167-181. 10.1016/j.canlet.2006.05.009 16793203
10. Chan KC Yin MC Chao WJ Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats Food Chem Toxicol 2007, 45:502-507. 10.1016/j.fct.2006.10.005 17123684
11. Steiner M Li W Aged garlic extract, a modulator of cardiovascular risk factors: A dose-finding study on the effects of AGE on platelet functions J Nutr 2001, 131:980S-984S. 11238801
12. Silagy CA Neil HA A meta-analysis of the effect of garlic on blood pressure J Hypertens 1994, 12:463-468. 10.1097/00004872-199404000-00017 8064171
13. Ried K Frank OR Stocks NP Fakler P Sullivan T Effect of garlic on blood pressure: A systematic review and meta-analysis BMC Cardiovasc Disord 2008, 8:13. 2442048 18554422 10.1186/1471-2261-8-13
14. Kasuga S Uda N Kyo E Ushijima M Morihara N Itakura Y Pharmacologic activities of aged garlic extract in comparison with other garlic preparations J Nutr 2001, 131:1080S-1084S. 11238821
15. Dixit VP Joshi S Effects of chronic administration of garlic (Allium sativum Linn) on testicular function Indian J Exp Biol 1982, 20:534-536. 7173985
16. Hammami I Nahdi A Mauduit C Benahmed M Amri M Ben Amar A Zekri S El May A El May MV The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding Asian J Androl 2008, 10:593-601. 10.1111/j.1745-7262.2008.00358.x 18097508
17. Chakrabarti K Pal S Bhattacharyya AK Sperm immobilization activity of Allium sativum L. and other plant extracts Asian J Androl 2003, 5:131-135. 12778325
18. Qian YX Shen PJ Xu RY Liu GM Yang HQ Lu YS Sun P Zhang RW Qi LM Lu QH Spermicidal effect in vitro by the active principle of garlic Contraception 1986, 34:295-302. 10.1016/0010-7824(86)90010-7 3791995
19. Hengartner MO The biochemistry of apoptosis Nature 2000, 407:770-776. 10.1038/35037710 11048727
20. Clem RJ Miller LK Control of programmed cell death by the baculovirus genes p35 and iap Mol Cell Biol 1994, 14:5212-5222. 359040 8035800
21. Liston P Fong WG Korneluk RG The inhibitors of apoptosis: There is more to life than Bcl2 Oncogene 2003, 22:8568-8580. 10.1038/sj.onc.1207101 14634619
22. Vaux DL Silke J IAPs, RINGs and ubiquitylation Nat Rev Mol Cell Biol 2005, 6:287-297. 10.1038/nrm1621 15803136
23. Liston P Fong WG Kelly NL Toji S Miyazaki T Conte D Tamai K Craig CG McBurney MW Korneluk RG Identification of XAF1 as an antagonist of XIAP anti-Caspase activity Nat Cell Biol 2001, 3:128-133. 10.1038/35055027 11175744
24. Liu Z Sun C Olejniczak ET Meadows RP Betz SF Oost T Herrmann J Wu JC Fesik SW Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain Nature 2000, 408:1004-1008. 10.1038/35050006 11140637
25. Wu G Chai J Suber TL Wu JW Du C Wang X Shi Y Structural basis of IAP recognition by Smac/DIABLO Nature 2000, 408:1008-1012. 10.1038/35050012 11140638
26. Cande C Cecconi F Dessen P Kroemer G Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci 2002, 115:4727-4734. 10.1242/jcs.00210 12432061
27. Mauduit C Siah A Foch M Chapet O Clippe S Gerard JP Benahmed M Differential expression of growth factors in irradiated mouse testes Int J Radiat Oncol Biol Phys 2001, 50:203-212. 11316565
28. Oi Y Imafuku M Shishido C Kominato Y Nishimura S Iwai K Garlic supplementation increases testicular testosterone and decreases plasma corticosterone in rats fed a high protein diet J Nutr 2001, 131:2150-2156. 11481410
29. Ola-Mudathir KF Suru SM Fafunso MA Obioha UE Faremi TY Protective roles of onion and garlic extracts on cadmium-induced changes in sperm characteristics and testicular oxidative damage in rats Food Chem Toxicol 2008, 46:3604-3611. 10.1016/j.fct.2008.09.004 18824205
30. Sadik NA Effects of diallyl sulfide and zinc on testicular steroidogenesis in cadmium-treated male rats J Biochem Mol Toxicol 2008, 22:345-353. 10.1002/jbt.20247 18972399
31. Murugavel P Pari L Diallyl tetrasulfide modulates the cadmium-induced impairment of membrane bound enzymes in rats J Basic Clin Physiol Pharmacol 2007, 18:37-48. 17569245
32. Khalil WK Ahmed KA Park MH Kim YT Park HH Abdel-Wahhab MA The inhibitory effects of garlic and Panax ginseng extract standardized with ginsenoside Rg3 on the genotoxicity, biochemical, and histological changes induced by ethylenediaminetetraacetic acid in male rats Arch Toxicol 2008, 82:183-195. 10.1007/s00204-007-0237-y 17874070
33. Unsal A Eroglu M Avci A Cimentepe E Guven C Derya Balbay M Durak I Protective role of natural antioxidant supplementation on testicular tissue after testicular torsion and detorsion Scand J Urol Nephrol 2006, 40:17-22. 10.1080/00365590500407514 16452050
34. al-Bekairi AM Shah AH Qureshi S Effect of Allium sativum on epididymal spermatozoa, estradiol-treated mice and general toxicity J Ethnopharmacol 1990, 29:117-125. 10.1016/0378-8741(90)90049-Y 2374426
35. Miura M Chen XD Allen MR Bi Y Gronthos S Seo BM Lakhani S Flavell RA Feng XH Robey PG Young M Shi S A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells J Clin Invest 2004, 114:1704-1713. 535063 15599395
36. Omezzine A Chater S Mauduit C Florin A Tabone E Chuzel F Bars R Benahmed M Long-term apoptotic cell death process with increased expression and activation of caspase-3 and -6 in adult rat germ cells exposed in utero to flutamide Endocrinology 2003, 144:648-661. 10.1210/en.2002-220692 12538628
37. Xiao D Choi S Johnson DE Vogel VG Johnson CS Trump DL Lee YJ Singh SV Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2 Oncogene 2004, 23:5594-5606. 10.1038/sj.onc.1207747 15184882
38. Su CC Chen GW Tan TW Lin JG Chung JG Crude extract of garlic induced caspase-3 gene expression leading to apoptosis in human colon cancer cells In Vivo 2006, 20:85-90. 16433033
39. Oommen S Anto RJ Srinivas G Karunagaran D Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells Eur J Pharmacol 2004, 485:97-103. 10.1016/j.ejphar.2003.11.059 14757128
40. Holcik M Lefebvre CA Hicks K Korneluk RG Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes BMC Genomics 2002, 3:5. 65541 11860601 10.1186/1471-2164-3-5
41. Wang Y Suominen JS Parvinen M Rivero-Muller A Kiiveri S Heikinheimo M Robbins I Toppari J The regulated expression of c-IAP1 and c-IAP2 during the rat seminiferous epithelial cycle plays a role in the protection of germ cells from Fas-mediated apoptosis Mol Cell Endocrinol 2005, 245:111-120. 10.1016/j.mce.2005.11.004 16343737
42. Wang Y Suominen JS Hakovirta H Parvinen M Martinand-Mari C Toppari J Robbins I Survivin expression in rat testis is upregulated by stem-cell factor Mol Cell Endocrinol 2004, 218:165-174. 10.1016/j.mce.2003.11.028 15130521
43. Joza N Susin SA Daugas E Stanford WL Cho SK Li CY Sasaki T Elia AJ Cheng HY Ravagnan L Ferri KF Zamzami N Wakeham A Hakem R Yoshida H Kong YY Mak TW Zuniga-Pflucker JC Kroemer G Penninger JM Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death Nature 2001, 410:549-554. 10.1038/35069004 11279485
44. Stocco DM Intramitochondrial cholesterol transfer Biochim Biophys Acta 2000, 1486:184-197. 10856721
45. Bakalska M Atanassova N Koeva Y Nikolov B Davidoff M Induction of male germ cell apoptosis by testosterone withdrawal after ethane dimethanesulfonate treatment in adult rats Endocr Regul 2004, 38:103-110. 15693288
46. Tesarik J Greco E Cohen-Bacrie P Mendoza C Germ cell apoptosis in men with complete and incomplete spermiogenesis failure Mol Hum Reprod 1998, 4:757-762. 10.1093/molehr/4.8.757 9733432
47. Woolveridge I de Boer-Brouwer M Taylor MF Teerds KJ Wu FC Morris ID Apoptosis in the rat spermatogenic epithelium following androgen withdrawal: Changes in apoptosis-related genes Biol Reprod 1999, 60:461-470. 10.1095/biolreprod60.2.461 9916015
48. Campbell JH Efendy JL Smith NJ Campbell GR Molecular basis by which garlic suppresses atherosclerosis J Nutr 2001, 131:1006S-1009S. 11238806
49. O'Shaughnessy PJ Hu L Baker PJ Effect of germ cell depletion on levels of specific mRNA transcripts in mouse Sertoli cells and Leydig cells Reproduction 2008, 135:839-850. 2592074 18390686 10.1530/REP-08-0012
50. Slaughter GR Meistrich ML Means AR Expression of RNAs for calmodulin, actins, and tubulins in rat testis cells Biol Reprod 1989, 40:395-405. 10.1095/biolreprod40.2.395 2720034
51. D'Souza R Gill-Sharma MK Pathak S Kedia N Kumar R Balasinor N Effect of high intratesticular estrogen on the seminiferous epithelium in adult male rats Mol Cell Endocrinol 2005, 241:41-48. 10.1016/j.mce.2005.04.011 15936871
52. Meistrich ML Samuels RC Reduction in sperm levels after testicular irradiation of the mouse: A comparison with man Radiat Res 1985, 102:138-147. 10.2307/3576437 3983368