Protective roles of onion and garlic extracts on cadmium-induced changes in sperm characteristics and testicular oxidative damage in rats

Food and Chemical Toxicology

Volumn 46, Issue 12, 2008, Pages 3604-3611

  Ola Mudathir, Kikelomo F ^a   Suru, Stephen M ^a   Fafunso, Michael A ^a   Obioha, Udoka E ^a   Faremi, Toyin Y ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Cadmium; Garlic; Onion; Oxidative damage; Protection; Sperm characteristics; Testis

Indexed keywords

ALKALINE PHOSPHATASE; ANTIOXIDANT; CADMIUM; CATALASE; GARLIC EXTRACT; GLUTATHIONE; GLUTATHIONE TRANSFERASE; ONION EXTRACT; OXIDIZING AGENT; SUPEROXIDE DISMUTASE;

ARTICLE; CONTROLLED STUDY; DEFENSE MECHANISM; DOSE RESPONSE; EPIDIDYMIS; GARLIC; LIPID PEROXIDATION; MALE; NONHUMAN; ONION; OXIDATIVE STRESS; RAT; SPERMATOZOON MOTILITY; TESTIS INJURY;

ALKALINE PHOSPHATASE; ANIMALS; CADMIUM; CATALASE; GARLIC; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; ONIONS; ORGAN SIZE; OXIDATIVE STRESS; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS; RATS, WISTAR; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; TESTIS;

ALLIUM CEPA; ALLIUM SATIVUM; RATTUS;

EID: 55949134039     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.09.004     Document Type: Article

References (50)

1. Agarwal A., and Saleh R.A. Role of oxidants in male infertility: rationale, significance, and treatment. Urol. Clin. North Am. 29 (2002) 817-827
2. Akinloye O., Arowojolu A.O., Shittu O.B., and Anetor J.I. Cadmium toxicity: a possible cause of male infertility in Nigeria. Reprod. Biol. 6 1 (2006) 17-30
3. +-ATPase in some tissues of rats exposed to a Nigerian-like diet and cadmium. Biol. Trace Elem. Res. 100 1 (2004) 75-86
4. Augusti K.T. Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.). Indian J. Exp. Biol. 34 (1996) 634-640
5. Banerjee S.K., and Maulik S.K. Effect of garlic on cardiovascular disorders: a review. Nutr. J. 1 4 (2002) 1-14
6. Beuge J.A., and Aust S.D. Microsomal lipid peroxidation. Meth. Enzymol. 52 (1978) 302-310
7. Block E. The chemistry of garlic and onions. Sci. Am. 252 (1985) 114-119
8. Casalino E., Calzaretti G., Sblano C., and Landriscina C. Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. Toxicology 179 1-2 (2002) 37-50
9. Denton L., and Ojeifo I.M. Onion production practices and their improvement in Nigeria. Onion Newslett. Trop. 2 (1990) 10-13
10. El-Demerdash F.M., Yousef M.I., Kedwany F.S., and Bahadadi H.H. Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene. Food Chem. Toxicol. 42 (2004) 1563-1571
11. El-Demerdash F.M., Yousef M.I., Abou, and EI-Naga N.I. Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem. Toxicol. 43 (2005) 57-63
12. Evans G., and Maxwell W.M.C. Handling and examination of semen. In: Maxwell W.M.C. (Ed). Salamon's Artificial Insemination of Sheep and Goats (1987), Butterworths, Sidney 93-106
13. Goyer R.A., Liu J., and Waalkes M.P. Cadmium and cancer of prostate and testis. Biometals 17 5 (2004) 555-558
14. Griffiths G., Trueman L., Crowther T., Thomas B., and Smith B. Onions - a global benefit to health. Phytother. Res. 16 (2002) 603-615
15. Grose E.C., Richards J.H., Jaskot R.H., Menache M.G., Graham J.A., and Dauterman W.C. Glutathione peroxidase and glutathione transferase activities in rat lung and liver following cadmium. Toxicology 44 (1987) 171-179
16. Guyonnet D., Belloir C., Suschetet M., Siess M.H., and Lebon A.M. Antimutagenic activity of organosulfur compounds from Allium is associated with phase 2 enzyme induction. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 495 (2001) 135-145
17. Habig W.H., Pabst M.J., and Jakoby W.B. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 22 (1974) 7130-7139
18. Halliwell B., and Gutteridge J.M.C. Free Radical Biology and Medicine. third ed. (1999), Oxford University Press
19. Hansen J.C., and Deguchi Y. Selenium and fertility in animals and man - a review. Acta Vet. Scand. 37 (1996) 19-30
20. Jollow D.J., Michell J.R., Zampaglione N., and Gillete J. Bromobenzene-induced liver necrosis: protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11 (1974) 151-169
21. Kagi J.H. Overview of metallothionein. Meth. Enzymol. 205 (1991) 613-626
22. Kara H., Karatas F., Canatan H., and Servi K. Effects of exogenous metallothionein on acute cadmium toxicity in rats. Biol. Trace Elem. Res. 104 (2005) 223-232
23. Kumari K., and Augusti K.T. Anti-diabetic and antioxidant effects of S-methyl cysteine sulfoxide isolated from onions (Allium cepa L.) as compared to standard drugs in alloxan diabetic rats. Indain J. Exp. Biol. 40 (2002) 1005-1009
24. Lau B.H.S. Detoxifying, radio-protective and phagocyte-enhancing effects of galic. Int. Clin. Nutr. Rev. 9 (1998) 27-31
25. Linder R.E., Strader L.F., and McElroy W.K. Measurement of epididymal sperm motility as a test variable in the rat. Bull. Environ. Contam. Toxicol. 36 (1986) 317-324
26. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
27. Milner J.A. Garlic: its anti-carcinogenic and anti-mutagenic properties. Nutr. Rev. 54 (1996) S82-S86
28. Misra H.P., and Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247 10 (1972) 3170-3175
29. Morales A.I., Vicente-Sanchez C., Jerkic M., Santiago J.M., Sanchez-Gonzalez P.D., Perez-Barriocanal F., and Lopez-Novoa J.M. Effect of quercetin on metallothionein, nitric oxide synhases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Toxicol. Appl. Pharmacol. 210 (2006) 128-135
30. Moskaug J.O., Carlsen H., Myhrstad M.C.W., and Blomhoff R. Polyphenols and glutathione synthesis regulation. Am. J. Clin. Nutr. 81 1 (2005) 277S-283S
31. Murugavel P., and Pari L. Diallyl tetrasulfide modulates the cadmium-induced impairment of membrane bound enzymes in rats. J. Basic Clin. Physiol. Pharmacol. 18 1 (2007) 37-48
32. Nijveldt R.J., Van Nood E., Van Hooran D.E.C., Boelens P.G., Van Norren K., and Leeuwen P.A.M. Flavonoids: a review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr. 74 4 (2001) 418-425
33. Nuutila A.M., Puuponen-Pimia R., Aarni M., and Oksman-Caldentey K. Comparison of antioxidant activities of onion and garlic and extracts by inhibition of lipid peroxidation and radical scavenging activity. Food Chem. 81 (2003) 485-493
34. Ognjanovic B., Zikic R.V., Stajn A., Saicic Z.S., Kostic M.M., and Petrovic V.M. The effects of selenium on the antioxidant defense system in the liver of rats exposed to cadmium. Physiol. Res. 44 5 (1995) 293-300
35. Ognjanovic B.I., Pavlovic S.Z., Maletic S.D., Zikic R.V., Stajn A.S., Radojicic R.M., Saicic Z.S., and Petrovic V.M. Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium. Physiol. Res. 52 (2003) 563-570
36. Rana S.V., Rekha S., and Seema V. Protective effects of few antioxidants on liver function in rats treated with cadmium and mercury. Indian J. Exp. Biol. 34 (1996) 177-179
37. Satarug S., Baker J.R., Urbenjapol S., Haswell-Elkins M., Reilly P.E., Williams D.J., and Moore M.R. A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol. Lett. 137 (2003) 65-83
38. Shaikh Z.A., Vu T.T., and Zaman K. Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol. Appl. Pharmacol. 154 3 (1999) 256-263
39. Sharma R.K., and Argawal A. Role of reactive oxygen species in male infertility. Urology 48 (1996) 835-850
40. +-ATPase, glutathione, and hydroxyl free radicals in cadmium chloride-induced testicular toxicity in mice. Arch. Environ. Contam. Toxicol. 29 (1995) 174-179
41. Sikka S.C. Relative impact of oxidative stress on male reproductive function. Curr. Med. Chem. 8 (2001) 851-862
42. Sinha K.A. Colorimetric assay of catalase. Anal. Biochem. 47 (1971) 389-394
43. Stajner D., and Varga I.S. An evaluation of antioxidant abilities of Allium species. Acta Biologica Szegdiensis 47 1-4 (2003) 103-106
44. Stohs S.J., Bagchi D., Hassoun E., and Bagchi M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J. Environ. Pathol. Toxicol. Oncol. 19 (2000) 201-213
45. Suzuki Y., Morita I., Yamane Y., and Murota S. Preventive effects of zinc on cadmium-induced inhibition of alkaline phosphatase activity in osteoblast-like cells, MC3T3-EI. J. Pharmacobiodyn. 12 (1989) 94-99
46. Teyssier C., Amiot M.J., Mondy N., Auger J., Kahane R., and Siess M.H. Effect of onion consumption by rats on hepatic drug metabolizing enzymes. Food Chem. Toxicol. 39 (2001) 981-987
47. Vernet P., Aitken R.J., and Drevet J.R. Antioxidant strategies in the epididymis. Mol. Cell Endocrinol. 216 1-2 (2004) 31-39
48. Wang B., Schneider S.N., Dragin N., Girijashanker K., Dalton T.P., He L., Miller M.L., Stringer K.F., Soleimani M., Richardson D.D., and Nebert D.W. Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc 39a8-transgenic mouse line. Am. J. Physiol. Cell Physiol. 292 4 (2007) 523-535 C1523
49. World Health Organization, 1992. Environmental Health Criteria 134, Cadmium. International Programme on Chemical Safety (IPCS), Geneva.
50. Yang H.S., Han D.K., Kim J.R., and Sin J.C. Effect of α-tocopherol on cadmium-induced toxicity in rat testis and spermatogenesis. J. Korean Med. Sci. 21 3 (2006) 445-451