Long-term apoptotic cell death process with increased expression and activation of caspase-3 and -6 in adult rat germ cells exposed in Utero to flutamide

Endocrinology

Volumn 144, Issue 2, 2003, Pages 648-661

  Omezzine, Asma ^a   Chater, Sonia ^a   Mauduit, Claire ^a   Florin, Anne ^a   Tabone, Eric ^a   Chuzel, Franck ^b   Bars, Remi ^b   Benahmed, Mohamed ^a  

^a INSERM   (France)

^b BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 6; FLUTAMIDE; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GERM CELL; IMMUNODETECTION; MALE; MOLECULAR MECHANICS; NEWBORN; NICK END LABELING; NONHUMAN; OLIGOSPERMIA; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERMATOGENESIS; TESTIS; WESTERN BLOTTING;

AGE FACTORS; ANDROGEN ANTAGONISTS; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 6; CASPASES; FEMALE; FLUTAMIDE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IN SITU NICK-END LABELING; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RNA, MESSENGER; TESTIS;

EID: 0037322045     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-220692     Document Type: Article

References (35)

1. Kelce WR, Wilson EM 1997 Environmental antiandrogens: developmental effects, molecular mechanisms, and clinical implications. J Mol Med 75:198-207
2. Jost A, Vigier B, Prepin J, Perchellet JP 1973 Studies on sex differentiation in mammals. Recent Prog Horm Res 29:1-41
3. Gray LEJ, Ostby JS, Kelce WR 1994 Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat. Toxicol Appl Pharmacol 129:46-52
4. Gray LEJ, Wolf C, Lambright C, Mann P, Price M, Cooper RL, Ostby J 1999 Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p, p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health 15:94-118
5. Dorfman RJ 1970 Biological activity of the antiandrogens. J Dermatol 82:4-8
6. Peets EA, Henson MF, Neri R 1974 On the mechanism of the anti-androgenic action of flutamide (α-α-α-trifluoro-2-methyl-4′-nitro-m- propionotoluidide) in the rat. Endocrinology 94:532-540
7. Imperato-McGinley J, Sanchez RS, Spencer JR, Yee B, Vaughan ED 1992 Comparison of the effects of the 5α-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: dose-response studies. Endocrinology 131:1149-1156
8. Kassim NM, McDonald SW, Reid O, Bennett NK, Gilmore DP, Payne AP 1997 The effects of pre- and postnatal exposure to the nonsteroidal antiandrogen flutamide on testis descent and morphology in the Albino Swiss rat. J Anat 190:577-588
9. McIntyre BS, Barlow NJ, Foster PM 2001 Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues. Toxicol Sci 62:236-249
10. Raff MC 1996 Size control: the regulation of cell numbers in animal development. Cell 86:173-175
11. Nunez G, Benedict MA, Hu Y, Inohara N 1998 Caspases: the proteases of the apoptotic pathway. Oncogene 17:3237-3245
12. Hengartner MO 2000 The biochemistry of apoptosis. Nature 407:770-776
13. Deveraux QL, Reed JC 1999 IAP family proteins - suppressors of apoptosis. Genes Dev 13:239-252
14. Mauduit C, Siah A, Foch M, Chapet O, Clippe S, Gerard JP, Benahmed M 2001 Differential expression of growth factors in irradiated mouse testes. Int J Radiat Oncol Biol Phys 50:203-212
15. Mauduit C, Goddard I, Besset V, Tabone E, Rey C, Gasnier F, Dacheux F, Benahmed M 2001 Leukemia inhibitory factor antagonizes gonadotropin-induced testosterone synthesis in cultured porcine Leydig cells: sites of action. Endocrinology 142:2509-2520
16. Soini Y, Paakko P 1999 Apoptosis and expression of caspases 3, 6 and 8 in malignant non-Hodgkin's lymphomas. APMIS 107:1043-1050
17. Nicholson DW 1999 Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 6:1028-1042
18. Thornberry NA, Lazebnik Y 1998 Caspases: enemies within. Science 281:1312-1316
19. Thornberry NA 1999 Caspases: a decade of death research. Cell Death Differ 6:1023-1027
20. Stroh C, Schulze-Osthoff K 1998 Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ 5:997-1000
21. Salvesen GS, Duckett CS 2002 IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 3:401-410
22. Kim JM, Ghosh SR, Weil AC, Zirkin BR 2001 Caspase-3 and caspase-activated deoxyribonuclease are associated with testicular germ cell apoptosis resulting from reduced intratesticular testosterone. Endocrinology 142:3809-3816
23. McLachlan JA 2001 Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals. Endocr Rev 22:319-341
24. Wolf CJ, LeBlanc GA, Ostby JS, Gray Jr LE 2000 Characterization of the period of sensitivity of fetal male sexual development to vinclozolin. Toxicol Sci 55:152-161
25. Sinha Hikim AP, Swerdloff RS 1999 Hormonal and genetic control of germ cell apoptosis in the testis. Rev Reprod 4:38-47
26. Fujioka H, Fujisawa M, Tatsumi N, Kanzaki M, Okuda Y, Okada H, Arakawa S, Kamidono S 2001 Sertoli cells inhibited apoptosis of pachytene spermatocytes and round spermatids. Endocr Res 27:75-90
27. Reed JC 1994 Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6
28. Nandi S, Banerjee PP, Zirkin BR 1999 Germ cell apoptosis in the testes of Sprague Dawley rats following testosterone withdrawal by ethane 1, 2-dimethanesulfonate administration: relationship to Fas? Biol Reprod 61:70-75
29. Woolveridge I, de Boer-Brouwer M, Taylor MF, Teerds KJ, Wu FC, Morris ID 1999 Apoptosis in the rat spermatogenic epithelium following androgen withdrawal: changes in apoptosis-related genes. Biol Reprod 60:461-470
30. Wang R, Zhang L, Zhang X, Moreno J, Luo X, Tondravi M, Shi Y 2001 Differential regulation of the expression of CD95 ligand, receptor activator of nuclear factor-κB ligand (RANKL), TNF-related apoptosis-inducing ligand (TRAIL), and TNF-α during T cell activation. J Immunol 166:1983-1990
31. Krajewski S, Krajewska M, Shabaik A, Wang HG, Irie S, Fong L, Reed JC 1994 Immunohistochemical analysis of in vivo patterns of Bcl-X expression. Cancer Res 54:5501-5507
32. Krajewski S, Krajewska M, Shabaik A, Miyashita T, Wang HG, Reed JC 1994 Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol 145:1323-1336
33. Knudson CM, Tung KS, Tourtellotte WG, Brown GA, Korsmeyer SJ 1995 Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270:96-99
34. Rodriguez I, Ody C, Araki K, Garcia I, Vassalli P 1997 An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis. EMBO J 16:2262-2270
35. Yan W, Suominen J, Samson M, Jegou B, Toppari J 2000 Involvement of bcl-2 family proteins in germ cell apoptosis during testicular development in the rat and pro-survival effect of stem cell factor on germ cells in vitro. Mol Cell Endocrinol 165:115-129