The antiatherosclerotic effect of Allium sativum

Atherosclerosis

Volumn 144, Issue 1, 1999, Pages 237-249

  Koscielny, J ^a   Klußendorf D ^b   Latza, R ^a   Schmitt, R ^c   Radtke, H ^a   Siegel, G ^b   Kiesewetter, H ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c FRAUNHOFER INSTITUTE FOR BIOMEDICAL ENGINEERING   (Germany)

Author keywords

Arteriosclerosis; B mode ultrasound; Carotid and femoral arteries; Garlic powder; Plaque volume; Randomized, double blind, placebo controlled phase IV clinical trial; Time and age dependent reduction

Indexed keywords

LT 111; PLACEBO; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; B SCAN; CAROTID ARTERY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FEMORAL ARTERY; GARLIC; HUMAN; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PHASE 4 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ALLIUM SATIVUM;

EID: 0344573936     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00060-X     Document Type: Article

References (75)

1. Crouse III JR. B-mode ultrasound in clinical trials. Answers and questions. Circulation 1993;88:319-21.
2. Delcker A, Diener HC. Methoden zur Quantifizierung beginnender arteriosklerotischer Wandveränderungen der Karotiden. Nervenarzt 1995;66:603-9.
3. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 1986;74:1399-406.
4. Frost D, Beischer W. Carotiswandveränderungen bei jungen Typ- 1 -Diabetikern. Ultraschalldiagnostik der frühen Arteriosklerose. Dtsch med Wochenschr 1994;119:1225-30.
5. Lanzer P, Bond MG. Karotisultraschall in der Früherkennung der Atherosklerose. Dt Ärztebl 1992;89:B-2604 - 9.
6. Poli A, Tremoli E, Colombo A, Sirtori M, Pignoli P, Paoletti R. Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients. A new model for the quantitation and follow-up of preclinical atherosclerosis in living human subjects. Atherosclerosis 1988;70:253-61.
7. Baldassarre D, Werba JP, Tremoli E, Poli A, Pazzucconi F, Sirtori CR. Common carotid intima-media thickness measurement. A method to improve accuracy and precision. Stroke 1994;25:1588-92.
8. Blankenhorn DH, Selzer RH, Crawford DW, Barth JD, Liu C-r, Liu C-h, Mack WJ, Alaupovic P. Beneficial effects of colestipolniacin therapy on the common carotid artery. Two- and fouryear reduction of intima-media thickness measured by ultrasound. Circulation 1993;88:20-8.
9. Bonithon-Kopp C, Touboul P-J, Berr C, Leroux C, Mainard F, Courbon D, Ducimetière P. Relation of intima-media thickness to atherosclerotic plaques in carotid arteries. The Vascular Aging (EVA) Study. Arterioscler Thromb Vase Biol 1996;16:310-6.
10. Riley WA, Barnes RW, Applegate WB, Dempsey R, Hartwell T, Davis VG, Bond MG, Furberg CD. Reproducibility of noninvasive ultrasonic measurement of carotid atherosclerosis. The asymptomatic carotid artery plaque study. Stroke 1992;23:1062-8.
11. Salonen JT, Salonen R. Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation 1993;87(Suppl II):II-56-65.
12. Veller MG, Fisher CM, Nicolaides AN, Renton S, Geroulakos G, Stafford NJ, Sarker A, Szendro G, Belcaro G. Measurement of the ultrasonic intima-media complex thickness in normal subjects. J Vase Surg 1993;17:719-25.
13. Wendelhag I, Wiklund O, Wikstrand J. Atherosclerotic changes in the femoral and carotid arteries in familial hypercholesterolemia. Ultrasonographic assessment of intima-media thickness and plaque occurrence. Arterioscler Thromb 1993;13:1404-11.
14. Bots ML, Hofman A, de Bruyn AM, de Jong PTVM, Grobbee DE. Isolated systolic hypertension and vessel wall thickness of the carotid artery. The Rotterdam elderly study. Arterioscler Thromb 1993; 13:64-9.
15. Salonen R, Salonen JT. Determinants of carotid intima-media thickness: a population-based ultrasonography study in eastern Finnish men. J Intern Med 1991;229:225-31.
16. Belcaro G, Laurora G, Cesarone MR, De Sanctis MT, Incandela L, Barsotti A. Progression of subclinical atherosclerosis in 6 years. Ultrasound evaluation of the average, combined femoral and carotid bifurcation intima-media thickness. VASA 1995:24:227-32.
17. Haapanen A, Koskenvuo M, Kaprio J, Kesäniemi YA, Heikkilä K. Carotid arteriosclerosis in identical twins discordant for cigarette smoking. Circulation 1989;80:10-6.
18. Hodges TC, Detmer PR, Dawson DL, Bergelin RO, Beach KW, Hatsukami TS, Zierler BK, Isaacson JA, Strandness DE Jr. Ultrasound determination of total arterial wall thickness. J Vase Surg 1994:19:745-53.
19. Persson J, Formgren J, Israelsson B, Berglund G. Ultrasound-determined intima-media thickness and atherosclerosis. Direct and indirect validation. Arterioscler Thromb 1994;14:261-4.
20. Salonen R, Tervahauta M, Salonen JT, Pekkanen J, Nissinen A, Karvonen MJ. Ultrasonographic manifestations of common carotid atherosclerosis in elderly eastern Finnish men. Prevalence and associations with cardiovascular diseases and risk factors. Arterioscler Thromb 1994;14:1631-40.
21. Furberg CD, Byington RP, Craven TE. Lessons learned from clinical trials with ultrasound end-points. J Intern Med 1994:236:575-80.
22. Grobbee DE, Bots ML. Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. J Intern Med 1994:236:567-73.
23. Howard G, Burke GL, Evans GW, Crouse III JR, Riley W, Arnett D, de Lacy R, Heiss G. Relations of intimal-medial thickness among sites within the carotid artery as evaluated by B-mode ultrasound. ARIC investigators. Atherosclerosis risk in communities. Stroke 1994;25:1581-7.
24. Howard G, Sharrett AR, Heiss G, Evans GW, Chambless LE, Riley WA, Burke GL. Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. ARIC investigators. Stroke 1993;24:1297-304.
25. Wikstrand J, Wendelhag I. Methodological considerations of ultrasound investigation of intima-media thickness and lumen diameter. J Intern Med 1994;236:555-9.
26. Persson J, Stavenow L, Wikstrand J, Israelsson B, Formgren J, Berglund G. Noninvasive quantification of atherosclerotic lesions. Reproducibility of ultrasonographic measurement of arterial wall thickness and plaque size. Arterioscler Thromb 1992; 12:261-6.
27. Steinke W, Meairs S, Ries S, Hennerici M. Sonographic assessment of carotid artery stenosis. Comparison of power Doppler imaging and color Doppler flow imaging. Stroke 1996;27:91-4.
28. Sutton-Tyrrell K, Wolfson SK Jr., Thompson T, Kelsey SF. Measurement variability in duplex scan assessment of carotid atherosclerosis. Stroke 1992;23:215-20.
29. Marquardt DW. An algorithm for least-squares estimation of nonlinear parameters. J Soc Indust Appl Math 1963;11:431-41.
30. Bergmann S, DRECAN-Team. Association of dietary intervention in populations and CHD risk profile. Proc Int Dresden Lipid Symp 1995;8:97-103.
31. Alexandrov AV, Bladin CF, Maggisano R, Norris JW. Measuring carotid stenosis. Time for a reappraisal. Stroke 1993;24:1292-6.
32. Bladin CF, Alexandrov AV, Murphy J, Maggisano R, Norris JW. Carotid stenosis index. A new method of measuring internal carotid artery stenosis. Stroke 1995;26:230-4.
33. Delcker A, Diener HC. 3D ultrasound measurement of atherosclerotic plaque volume in carotid arteries. Bildgebung 1994;61:116-21.
34. Delcker A, Diener HC. Quantification of atherosclerotic plaques in carotid arteries by three-dimensional ultrasound. Br J Radiol 1994:67:672-8.
35. Massonneau M, Caillard P, de Chassey L, Mouren X, Thebault B, Cloaree M. Short-term evaluation of plaque area measurement reproducibility from computer-assisted sonography. Angiology 1995:46:375-81.
36. Strohschneider T, Oberhoff M, Hanke H, Hannekum A, Karsch KR. Effect of chronic nicotine delivery on the proliferation rate of endothelial and smooth muscle cells in experimentally induced vascular wall plaques. Clin Invest 1994;72:908-12.
37. Wendelhag I, Gustavsson T, Suurkula M, Berglund G, Wikstrand J. Ultrasound measurement of wall thickness in the carotid artery: fundamental principles and description of a computerized analysing system. Clin Physiol 1991;11:565-77.
38. Gamble G, Zorn J, Sanders G, MacMahon S, Sharpe N. Estimation of arterial stiffness, compliance, and distensibility from M-mode ultrasound measurements of the common carotid artery. Stroke 1994;25:11-6.
39. Ögren M, Hedblad B, Isacsson S-O, Janzon L, Jungquist G, Lindell S-E. Non-invasively detected carotid stenosis and ischaemic heart disease in men with leg arteriosclerosis. Lancet 1993:342:1138-41.
40. Rudofsky G, Hirche H. Verlauf präklinischer Arteriosklerose bei Risikopatienten. Natur-GanzheitsMed 1989;3:64-8.
41. Rudofsky G, Hirche H, Druck A, Altenhoff B. Läßt sich die Progression der Arteriosklerose pharmakologisch beeinflussen? VASA (Suppl) 1988:24:67-75.
42. Pellegrino L, Prencipe G. High-resolution ultrasonographic study of atherosclerosis lesions of the carotid arteries in border-line essential arterial hypertension. G Ital Cardiol 1994;24:1199-210.
43. Segrest JP, Anantharamaiah GM. Pathogenesis of atherosclerosis. Curr Opin Cardiol 1994;9:404-10.
44. Bots ML, Witteman JCM, Grobbee DE. Carotid intima-media wall thickness in elderly women with and without atherosclerosis of the abdominal aorta. Atherosclerosis 1993;102:99-105.
45. Byington RP, Furberg CD, Crouse JR III, Espeland MA, Bond MG. Pravastatin, lipids, and atherosclerosis in the carotid arteries (PLAC-II). Am J Cardiol 1995;76:54C-9C.
46. Hennerici M, Kleophas W, Gries FA. Regression of carotid plaques during low density lipoprotein cholesterol elimination. Stroke 1991;22:989-92.
47. Deslypere JP. The treatment of hyperlipidaemia and regression of atherosclerosis. Novartis Satellite Symposium, Taipei 1998;4-6.
48. Deslypere JP. Regression of coronary atherosclerosis: LCAS proves the point. Atherosclerosis 1998; 136:S44.
49. Borhani NO, Mercuri M, Borhani PA, Buckalew VM, Canossa-Terris M, Carr AA, Kappagoda T, Rocco MV, Schnaper HW, Sowers JR, Bond MG. Final outcome results of the multicenter isradipine diuretic atherosclerosis study (MIDAS). A randomized controlled trial. J Am Med Assoc 1996;276:785-91.
50. Weichselbaum CTE. An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma. Am J Clin Path (Tech Sec) 1946;10:40-9.
51. Furberg CD, Adams HP Jr., Applegate WB, Byington RP, Espeland MA, Hartwell T, Hunninghake DB, Lefkowitz DS, Probstfield J, Riley WA, Young B. Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Circulation 1994;90:1679-87.
52. Salonen R, Nyyssönen K, Porkkala E, Rummukainen J, Belder R, Park J-S, Salonen JT. Kuopio Atherosclerosis Prevention Study (KAPS). A population-based primary preventive trial of the effect of LDL lowering on atherosclerotic progression in carotid and femoral arteries. Circulation 1995;92:1758-64.
53. Davignon J. The pleiotropic effects of drugs affecting lipid metabolism. Atherosclerosis 1998;XI:63-77.
54. Paoletti R. Lipid and pleiotropic effects of statins. Novartis Satellite Symposium, Taipei 1998;2.
55. Barrie SA, Wright JV, Pizzorno JE. Effects of garlic oil on platelet aggregation, serum lipids and blood pressure in humans. J Orthomol Med 1987;2:15-21.
56. Blankenhorn DH. Prevention or reversal of atherosclerosis: review of current evidence. Am J Cardiol 1989;63:38H-41H.
57. Kiesewetter H, Jung F, Jung EM, Mrowietz C, Koscielny J, Wenzel E. Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack. Eur J Clin Pharmacol 1993;45:333-6.
58. Kiesewetter H, Jung F, Mrowietz C, Wenzel E. Wirkung von Knoblauch (Allium sativum L.), insbesondere rheologische und hämostaseologische Effekte. Hämostaseologie 1993; 13:43-52.
59. Kiesewetter H, Jung F, Pindur G, Jung EM, Mrowietz C, Wenzel E. Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. Int J Clin Pharmacol Ther Toxicol 1991;29:151-5.
60. Antiplatelet Trialists' Collaboration: Secondary prevention of vascular disease by prolonged antiplatelet treatment. Br Med J 1988:296:320-31.
61. Kannel WB, Castelli WP, Gordon T, McNamara PM. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham Study. Ann Intern Med 1971;74:1-12.
62. The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. J Am Med Assoc 1984:251:365-74.
63. Thiery J, Seidel D. Fish oil feeding results in an enhancement of cholesterol-induced atherosclerosis in rabbits. Atherosclerosis 1987:63:53-6.
64. Arora RC, Arora S, Gupta RK. The long-term use of garlic in ischemic heart disease. Atherosclerosis 1981;40:175-9.
65. Kiesewetter H, Jung F, Jung EM, Blume J, Mrowietz C, Birk A, Koscielny J, Wenzel E. Effects of garlic coated tablets in peripheral arterial occlusive disease. Clin Invest 1993;71:383-6.
66. Foushee DB, Ruffin J, Banerjee U. Garlic as a natural agent for the treatment of hypertension: a preliminary report. Cytobios 1982:34:145-52.
67. Kandziora J. Antihypertensive Wirksamkeit und Verträglichkeit eines Knoblauch-Präparates. Ärztliche Forschung 1988;35:l-8.
68. König F-K, Schneider B. Knoblauch bessert Durchblutungsstörungen. Ärztliche Praxis 1986;38:344-5.
69. Ruffin J, Hunter SA. An evaluation of the side effects of garlic as an antihypertensive agent. Cytobios 1983;37:85-9.
70. Vorberg G, Schneider B. Therapy with garlic: results of a placebo-controlled, double-blind study. Br J Clin Pract (Suppl) 1990:69:7-11.
71. Breithaupt-Grögler K, Ling M, Boudoulas H, Beiz GG. Protective effect of chronic garlic intake on elastic properties of aorta in the elderly. Circulation 1997;96:2649-55.
72. Siegel G. Arteriosklerose-Prophylaxe mit Knoblauch. Ärztl Forsch 1996:43:3-8.
73. Siegel G. Prophylaxe des Schlaganfalls: Bedeutung pflanzlicher Arzneimittel. Der Deutsche Apotheker 1998;50:184-8.
74. + channel opening by garlic in human vascular smooth muscle cell membranes. Phytother Res 1998;12:S149-51.
75. Siegel G, Walter A, Engel S, Walper A, Michel F. Pleiotrope Wirkungen von Knoblauch. Wiener med Wschr 1999 (in press).