The oxygen level determines the fermentation pattern in Kluyveromyces lactis

FEMS Yeast Research

Volumn 9, Issue 5, 2009, Pages 749-756

  Merico, Annamaria ^a   Galafassi, Silvia ^a   Piškur, Jure ^b   Compagno, Concetta ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Ethanol; Fermentation; Hypoxia; Kluyveromyces lactis; Redox

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLYCEROL; HEXOKINASE; OXYGEN; PYRUVATE DECARBOXYLASE;

ANAEROBIC METABOLISM; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; ECOLOGICAL NICHE; ENZYME ACTIVITY; FERMENTATION; FUNGAL GENE; FUNGUS GROWTH; GENE DUPLICATION; GLUCOSE METABOLISM; GLYCOLYSIS; GROWTH RATE; HOMEOSTASIS; HYPOXIA; KLUYVEROMYCES; NONHUMAN; OXIDATION REDUCTION REACTION; PENTOSE PHOSPHATE CYCLE; RAG1 GENE; SACCHAROMYCES CEREVISIAE; YEAST;

ANAEROBIOSIS; BIOMASS; ETHANOL; FERMENTATION; GLUCOSE; GLUCOSEPHOSPHATE DEHYDROGENASE; KLUYVEROMYCES; OXYGEN; SACCHAROMYCES;

KLUYVEROMYCES LACTIS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES KLUYVERI;

EID: 67651148300     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2009.00528.x     Document Type: Article

References (42)

1. +). FEBS J 286 : 13 17.
2. Ansell R, Granath K, Hohmann S, Thevelein JM Adler L (1997) The two isoenzymes for yeast NAD+-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation. EMBO J 16 : 2179 2187.
3. Bakker BM, Bro C, Kötter P, Luttik MA, van Dijken JP Pronk JT (2000) The mitochondrial alcohol dehydrogenase Adh3p is involved in a redox shuttle in Saccharomyces cerevisiae. J Bacteriol 182 : 4730 4737.
4. Bao W-G, Guiard B, Fang Z-A, Donnini C, Gervais M, Lopes Passos FM, Ferrero I, Fukuhara H Bolotin-Fukuhara M (2008) Oxygen-dependent transcriptional regulator Hap1p limits glucose uptake by repressing the expression of the major glucose transporter gene RAG1 in Kluyveromyces lactis. Eukaryot Cell 7 : 1895 1905.
5. Blanco M, Núñez L, Tarrío N, Canto E, Becerra M, González-Siso MI Cerdán ME (2007) An approach to the hypoxic and oxidative stress responses in Kluyveromyces lactis by analysis of mRNA levels. FEMS Yeast Res 7 : 702 714.
6. Camarasa C, Faucet V Dequin S (2007) Role in anaerobiosis of the isoenzymes for Saccharomyces cerevisiae fumarate reductase encoded by OSM1 and FRDS1. Yeast 24 : 391 401.
7. Chen XJ, Wésolowski-Louvel M Fukuhara H (1992) Glucose transport in the yeast Kluyveromyces lactis. II. Transcriptional regulation of the glucose transporter gene RAG1. Mol Gen Genet 233 : 97 105.
8. Choquer M, Boccara M Vidal-Cros A (2003) A semi-quantitative RT-PCR method to readily compare expression levels within Botrytis cinerea multigenic families in vitro and in planta. Curr Genet 43 : 303 309.
9. de Jong-Gubbels P, Vanrolleghem P, Heijnen JJ, van Dijken JP Pronk JT (1995) Regulation of carbon metabolism in chemostat cultures of Saccharomyces cerevisiae grown on mixtures of glucose and ethanol. Yeast 11 : 407 418.
10. Destruelle M, Meneghini R, Frontali L Bianchi MM (1999) Regulation of the expression of the Kluyveromyces lactis PDC1 gene: carbon source-responsive elements and autoregulation. Yeast 15 : 361 370.
11. Fukuhara H (2003) The Kluyver effect revisited. FEMS Yeast Res 3 : 327 331.
12. Goffrini P, Ferrero I Donnini C (2002) Respiration-dependent utilization of sugars in yeasts: a determinant role for sugar transporters. J Bacteriol 184 : 427 432.
13. González E, Fernández MR, Larroy C, Solà L, Pericàs MA, Parés X Biosca JA (2000) Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene. J Biol Chem 275 : 35876 35885.
14. González-Domínguez M, Freire-Picos MA, Ramil E, Guiard B Cerdán ME (2000) Heme-mediated transcriptional control in Kluyveromyces lactis. Curr Genet 38 : 171 177.
15. González-Siso MI, Freire-Picos MA, Ramil E, González- Domínguez M, Rodríguez Torres A Cerdán ME (2000) Respirofermentative metabolism in Kluyveromyces lactis: insights and perspectives. Enzyme Microb Tech 26 : 699 705.
16. Ihmels J, Bergmann S, Gerami-Nejad M, Yanai I, McClellan M, Berman J Barkai N (2005) Rewiring of the yeast transcriptional network through the evolution of motif usage. Science 309 : 938 940.
17. Kellis M, Birren BW Lander ES (2004) Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae. Nature 428 : 617 624.
18. Kiers J, Zeeman AM, Luttik M, Thiele C, Castrillo JI, Steensma HY, van Dijken JP Pronk JT (1998) Regulation of alcoholic fermentation in batch and chemostat cultures of Kluyveromyces lactis CBS 2359. Yeast 14 : 459 469.
19. Kwast KE, Lai LC, Menda N, James DT III., Aref S Burke PV (2002) Genomic analyses of anaerobically induced genes in Saccharomyces cerevisiae: functional roles of Rox1 and other factors in mediating the anoxic response. J Bacteriol 184 : 250 265.
20. Lai LC, Kosorukoff AL, Burke PV Kwast KE (2005) Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media. Mol Cell Biol 25 : 4075 4091.
21. Lai LC, Kosorukoff AL, Burke PV Kwast KE (2006) Metabolic-state-dependent remodeling of the transcriptome in response to anoxia and subsequent reoxygenation in Saccharomyces cerevisiae. Eukaryot Cell 5 : 1468 1489.
22. Lamas-Maceiras M, Nunez L, Rodriguez-Belmonte E, Gonzales-Siso MI Cerdan ME (2007) Functional characterization of KlHAP1: a model to foresee different mechanisms of transcriptional regulation by Hap1p in yeasts. Gene 405 : 96 107.
23. Merico A, Sulo P, Piškur J Compagno C (2007) Fermentative lifestyle in yeasts belonging to the Saccharomyces complex. FEBS J 274 : 976 989.
24. Møller K, Olsson L Piškur J (2001) Ability for anaerobic growth is not sufficient for development of the petite phenotype in Saccharomyces kluyveri. J Bacteriol 183 : 2485 2489.
25. Møller K, Christensen B, Forster J, Piškur J, Nielsen J Olsson L (2002) Aerobic glucose metabolism of Saccharomyces kluyveri: growth, metabolite production, and quantification of metabolic fluxes. Biotechnol Bioeng 77 : 186 193.
26. Neil H, Lemaire M Wésolowski-Louvel M (2004) Regulation of glycolysis in Kluyveromyces lactis: role of KlGCR1 and KlGCR2 in glucose uptake and catabolism. Curr Genet 45 : 129 139.
27. Nissen TL, Hamann CW, Kielland-Brandt MC, Nielsen J Villadsen J (2000) Anaerobic and aerobic batch cultivations of Saccharomyces cerevisiae mutants impaired in glycerol synthesis. Yeast 16 : 463 474.
28. Overkamp KM, Bakker BM, Kötter P, van Tuijl A, de Vries S, van Dijken JP Pronk JT (2000) In vivo analysis of the mechanisms for oxidation of cytosolic NADH by Saccharomyces cerevisiae mitochondria. J Bacteriol 182 : 2823 2830.
29. Piškur J, Rozpêdowska E, Polakova S, Merico A Compagno C (2006) How did Saccharomyces cerevisiae evolve to become a good brewer? Trends Genet 22 : 183 186.
30. Postma E, Verduyn C, Scheffers WA van Dijken JP (1989) Enzymatic analysis of the Crabtree effect in glucose-limited chemostat cultures of Saccharomyces cerevisiae. Appl Environ Microb 55 : 468 477.
31. Rigoulet M, Aguilaniu H, Avéret N, Bunoust O, Camougrand N, Grandier-Vazeille X, Larsson C, Pahlman IL, Manon S Gustafsson L (2004) Organization and regulation of the cytosolic NADH metabolism in the yeast Saccharomyces cerevisiae. Mol Cell Biochem 256-257 : 73 81.
32. Rosenfeld E Beauvoit B (2003) Role of the non-respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae. Yeast 20 : 1115 1144.
33. Sabová L, Zeman I, Supek F Kolarov J (1993) Transcriptional control of AAC3 gene encoding mitochondrial ADP/ATP translocator in Saccharomyces cerevisiae by oxygen, heme and ROX1 factor. Eur J Biochem 213 : 547 553.
34. Saliola M, Scappucci G, De Maria I, Lodi T, Mancini P Falcone C (2007) Deletion of the glucose-6-phosphate dehydrogenase gene KlZWF1 affects both fermentative and respiratory metabolism in Kluyveromyces lactis. Eukaryot Cell 6 : 19 27.
35. Tarrío N, Díaz Prado S, Cerdán ME González Siso MI (2005) The nuclear genes encoding the internal (KlNDI1) and external (KlNDE1) alternative NAD(P)H: ubiquinone oxidoreductases of mitochondria from Kluyveromyces lactis. Biochim Biophys Acta 1707 : 199 210.
36. Tarrío N, Becerra M, Cerdán ME González Siso MI (2006) Reoxidation of cytosolic NADPH in Kluyveromyces lactis. FEMS Yeast Res 6 : 371 380.
37. Verduyn C, Postma E, Scheffers WA van Dijken JP (1992) Effect of benzoic acid on metabolic fluxes in yeast: a continuous-culture study on the regulation of respiration and alcoholic fermentation. Yeast 8 : 501 517.
38. Visser W, Scheffers WA, Batenburg-van der Vegte WH van Dijken JP (1990) Oxygen requirements of yeasts. Appl Environ Microb 56 : 3785 3792.
39. Wésolowski-Louvel M, Breunig KD Fukuhara H (1996) Kluyveromyces lactis. Nonconventional Yeast in Biotechnology (Wolf K, ed), pp. 139 202. Springer-Verlag, Berlin.
40. Wolfe KH Shields DC (1997) Molecular evidence for an ancient duplication of the entire yeast genome. Nature 387 : 708 713.
41. Zitomer RS, Carrico P Deckert J (1997) Regulation of hypoxic gene expression in yeast. Kidney Int 51 : 507 513.
42. Zitomer RS Lowry CV (1992) Regulation of gene expression by oxygen in Saccharomyces cerevisiae. Microbiol Rev 56 : 1 11.