N-acetyl cysteine ameliorates ischemic renal failure

American Journal of Physiology - Renal Physiology

Volumn 272, Issue 3 41-3, 1997, Pages

  DiMari, John ^a,c   Megyesi, Judit ^a   Udvarhelyi, Nora ^a   Price, Peter ^a   Davis, Roger ^b   Safirstein, Robert ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c 4200 John Sealy Annex   (United States)

Author keywords

Ischemia reperfusion; Stress activated kinases

Indexed keywords

ACETYLCYSTEINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; IMMEDIATE EARLY GENE; KIDNEY BLOOD VESSEL; KIDNEY FAILURE; KIDNEY ISCHEMIA; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; VASCULAR ENDOTHELIUM;

EID: 0030764921     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1997.272.3.f292     Document Type: Article

References (39)

1. Angel, P., and M. Karin. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072: 129-157, 1991.
2. Aviv, H., and P. Leder. Purification of biologically active globin messenger RNA by chromatography on oligthymidylic acid-cellulose. Proc. Natl. Acad. Sci. USA 69: 1408-1412, 1972.
3. Bardella, L., and R. Comolli. Differential expression of c-jun and c-fos and hsp 70 mRNAs after folic acid and ischemia-reperfusion injury; effect of antioxidant treatment. Exp. Nephrol. 2: 158-165, 1994.
4. Bauskin, A. R., I. Alkalay, and Y. Ben-Neriah. Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum. Cell 66: 685-696, 1991.
5. Bonventre, J. V., V. Sukhatme, M. Bamberber, A. Oulette, and D. Brown. Localization of the protein product of the immediate early gene growth response gene, Egr-1, in the kidney after ischemia and reperfusion. Cell Regul. 2: 251-260, 1991.
6. Bump, E. A., and M. J. Brown. Role of glutathione in the radiation response of mammalian cells in vitro and in vivo. Pharmacol. Ther. 47: 117-136, 1990.
7. Chintala, M. S., P. J. S. Chiu, S. Vemulapalli, R. W. Watkins, and E. Sybertz. Inhibition of endothelial derived relaxing factor aggravates ischemic acute renal failure in anesthetized rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 348: 305-310, 1993.
8. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.Biochemstry 18: 5294-5299, 1979.
9. Cronin, R. E., A. de Torrente, P. D. Miller, R. E. Bulger, T. J. Burke, and R. W. Schrier. Pathogenic mechanisms in early norepinephrine-induced acute renal failure; functional and histological correlates of protection. Kidney Int. 14: 115-125, 1978.
10. Davis, R. J. MAPKs: new JNK expands the group. Trends Biol. Sci. 19: 470-473, 1994.
11. Devary, Y., R. A. Gottlieb, T. Smeal, and M. Karin. The mammalian ultraviolet repsonse is triggered by activation of Src tyrosine kinases. Cell 71: 1081-1091, 1992.
12. Dérijard, B., J. Raingeaud, T. Barrett, I. Wu, J. Han, R. J. Ulevitch, and R. J. Davis. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science Wash. DC 267: 682-685, 1995.
13. Fung, H. L., E. Kowaluk, K. Hough, and M. Kakemi. Mechanism for the pharmacologic interaction of organic nitrates with thiols. Existence of an extracellular pathway for the reversal of nitrate vascular tolerance by N-acetylcysteine. J. Pharmacol. Exp. Ther. 245: 524-530, 1988.
14. Gamelin, L. M., and R. A. Zager. Evidence against oxidant injury as a critical mediator of postischemic acute renal failure. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24): F450-F460, 1988.
15. Gibbons, J. Nonparametric Statistical Inference New York: McGraw Hill, 1971.
16. Goldstone, S. D., and M. F. Lavin. Prolonged expression of c-jun and associated activity of the transcription factor AP-1, during apoptosis in a human leukaemic cell line. Oncogene 9: 2305-2311, 1994.
17. Hibi, M., A. Lin, T. Smeal, A. Minden, and M. Karin. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7: 2135-2148, 1993.
18. Kin, S., T. Sasaki, K. Gu, K. Nakayama, K. Tamura, I. Nakai, and T. Oka. The cytoprotective role of nitric oxide in ischemia-reperfusion injury in the rat kidney. Transplantation Proc. 27: 754-756, 1995.
19. Klemsz, M. J., L. B. Justement, E. Palmer, and J. C. Cambier. Induction of c-fos and c-myc expression during B cell activation by IL-4 and immunoglobulin binding ligands (Abstract). J. Immunol. 143: 1032-1039, 1989.
20. Kyriakis, J. M., P. Banerjee, E. Nikolakaki, T. Dai, E. A. Rubie, M. F. Ahmad, J. Avruch, and J. R. Woodgett. The stress-activated protein kinase subfamily of c-Jun kinases. Nature Lond. 369: 156-160, 1994.
21. McCoy, R. N., K. E. Hill, M. A. Ayon, J. H. Stein, and R. F. Burk. Oxidant stress following renal ischemia: changes in the glutathione redox ratio. Kidney Int. 33: 812-817, 1988.
22. Megyesi, J., J. F. DiMari, N. Udvarhelyi, S. Saggi, P. M. Price, and R. Safirstein. DNA synthesis is dissociated from the immediate-early gene response in the post-ischemic kidney. Kidney Int. 48: 1451-1458, 1995.
23. Moldeus, P., and I. A. Cotgreave. Oxygen radicals in biologic systems. In: Methods of Enzymology, edited by L. Packer. New York: Academic, 1994, p. 482-492.
24. Noiri, E., T. Peresleni, F. Miller, and M. S. Goligorsky. In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. J. Clin. Invest. 97: 2377-2383, 1996.
25. Ouellette, A. J., R. A. Malt, V. P. Sukhatme, and J. V. Bonventre. Expression of two "immediate early" genes, Egr-1 and c-fos, in response to renal ischemia and during compensatory renal hypertropy in mice. J. Clin. Invest. 85: 766-771, 1990.
26. Paller, M. S., and M. Patten. Protective effects of glutathione, glycine, or alanine in an in vitro model of renal anoxia. J. Am. Soc. Nephrol. 2: 1338-1344, 1992.
27. Paller, M. S., and J. R. Ferris. Oxygen free radicals in ischemic acute renal failure in the rat. J. Clin. Invest. 74: 1156-1164, 1984.
28. Pera, M. F., B. C. Zook, and H. C. Harder. Effects of mannitol and furosemide diureses on the nephrotoxicity and physiological disposition of cisdichloro/diammine-platinum (II) in rats. Cancer Res. 39: 1269-1278, 1979.
29. Pombe, C. M., J. V. Bonventre, J. Avruch, J. R. Woodgett, J. M. Kyriakis, and T. Force. The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. J. Biol. Chem. 269: 26546-26551, 1994.
30. Rice, G. C., E. A. Bump, D. C. Shrieve, W. Lee, and M. Kovacs. Quantitative analysis of cellular glutathione by flow cytometry utilizing monochlorobimane: some applications to radiation and drug resistance in vitro and in vivo. Cancer Res. 46: 6105-6110, 1986.
31. Safirstein, R., J. Megyesi, S. J. Saggi, P. M. Price, M. Poon, B. J. Rollins, and M. B. Taubman. Expression of cytokine-like genes JE and KC is increased during renal ischemia. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F1095-F1101, 1991.
32. Safirstein, R., P. M. Price, S. J. Saggi, and R. C. Harris. Changes in gene expression after temporary renal ischemia. Kidney Int. 37: 1515-1521, 1990.
33. Safirstein, R., A. Z. Zelent, and P. M. Price. Reduced renal prepro-epidermal growth factor mRNA and decreased EGF excretion in ARF. Kidney Int. 36: 810-815, 1989.
34. Scaduto, R. C., V. H. Gattone III, W. J. Groytyohann, and L. F. Martin. Effect of an altered glutathione content on renal ischemic injury. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24): F911-F921, 1988.
35. Scaduto, R. C., and V. H. Martin. Elevation of renal glutathione enhances ischemic injury. Renal Physiol. Biochem. 14: 259-270, 1991.
36. Staal, F. J. T., M. Roederer, and L. A. Herzenberg. Intracellular thiols regulate activation of nuclear factor kB and transcription of human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 87: 9943-9947, 1990.
37. Thielemann, L. E., and E. W. Rosenblut. Sulfur-containing amino acids that increase renal glutathione protect the kidney against papillary necrosis induced by 2-bromothylamine. Cell Biochem. Funct. 8: 19-24, 1990.
38. Witzgall, R., D. Brown, and C. Schwarz. Localization of proliferating cell nuclear antigen, vimentin, c-fos, and clusterin in the post-ischemic kidney: evidence for a heterogeneous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J. Clin. Invest. 93: 2175-2188, 1994.
39. Zager, R. A., S. M. Fuerstenberg, P. H. Baehr, D. Myerson, and B. Torok-Storb. An evaluation of antioxidant effects on recovery from postischemic acute renal failure. J. Am. Soc. Nephrol. 4: 1588-1597, 1994.