Non-compensating roles between Nckα and NckΒ in PDGF-BB signaling to promote human dermal fibroblast migration

Journal of Investigative Dermatology

Volumn 129, Issue 8, 2009, Pages 1909-1920

  Guan, Shengxi ^a   Fan, Jianhua ^a,b   Han, Arum ^a   Chen, Mei ^a,b   Woodley, David T ^a,b   Li, Wei ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NCK PROTEIN; P21 ACTIVATED KINASE 1; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN CDC42; PROTEIN KINASE B; PROTEIN NCK ALPHA; PROTEIN NCK BETA; PROTEIN SH3; RHO FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; FILOPODIUM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SKIN FIBROBLAST; STRESS FIBER;

EID: 67651112122     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.457     Document Type: Article

References (57)

1. Albrecht-Buehler G (1977) The phagokinetic tracks of 3T3 cells. Cell11:395-404
2. Ansel JC, Tiesman JP, Olerud JE, Krueger JG, Krane JF, Tara DC et al. (1993) Human keratinocytes are a major source of cutaneous platelet-derived growth factor. J Clin Invest 92:671-8
3. Bladt F, Aippersbach E, Gelkop S, Strasser GA, Nash P, Tafuri A et al. (2003) The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol 23:4586-97
4. Blasutig IM, New LA, Thanabalasuriar A, Dayarathna TK, Goudreault M, Quaggin SE et al. (2008) Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization. Mol Cell Biol28:2035-46
5. Cardin E, Latreille M, Khoury C, Greenwood MT, Larose L (2007) Nck-1 selectively modulates eIF2alphaSer51 phosphorylation by a subset of eIF2alpha-kinases. FEBS J 274:5865-75
6. Chen M, She H-Y, Dey A, Li W (1998) Nck family genes, chromosomal location, expression and signaling specificity. J Biol Chem 273: 25171-8
7. Chen M, She H, Kim A, Woodley DT, Li W (2000) Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to plateletderived growth factor bb. Mol Cell Biol 20:7867-80
8. Cowan CA, Henkemeyer M (2001) The SH2/SH3 adaptor Grb4 transduces Bephrin reverse signals. Nature 413:174-9
9. Deuel TF, Kawahara RS, Mustoe TA, Pierce AF (1991) Growth factors and wound healing: platelet-derived growth factor as a model cytokine. Annu Rev Med 42:567-84
10. Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (2002) Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418:790-3
11. Fawcett JP, Georgiou J, Ruston J, Bladt F, Sherman A, Warner N et al.(2007) Nck adaptor proteins control the organization of neuronal circuits important for walking. Proc Natl Acad Sci USA 104: 20973-8
12. Fleischmajer R, Krieg T, Dziadek M, Altchek D, Timpl R (1984) Ultrastructure and composition of connective tissue in hyalinosis cutis et mucosae skin. J Invest Dermatol 82:252-8
13. Garrity PA, Rao Y, Salecker I, McGlade J, Pawson T, Zipursky SL (1996) Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. Cell 85:639-50
14. Gil D, Schamel WW, Montoya M, Sa'nchez-Madrid F, Alarco'n B (2002) Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Cell 109:901-12
15. Goicoechea SM, Tu Y, Hua Y, Chen K, Shen TL, Guan JL et al. (2002) Nck-2 interacts with focal adhesion kinase and modulates cell motility. Int J Biochem Cell Biol 34:791-805
16. Grotendorst GR, Seppä HE, Kleinman HK, Martin GR (1981) Attachment of smooth muscle cells to collagen and their migration toward plateletderived growth factor. Proc Natl Acad Sci USA 78:3669-72
17. Gruenheid S, DeVinney R, Bladt F, Goosney D, Gelkop S, Gish GD et al.(2001) Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells. Nat Cell Biol 3:856-9
18. Guan S, Chen M, Woodley D, Li W (2007) Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level. Mol Cell Biol27:6001-11
19. Gugasyan R, Quilici C, Stacey TTI, Grail D, Verhagen AM, Roberts A, Kitamura T et al. (2002) Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites. J Cell Biol 158:115-25
20. Gupta RW, Mayer BJ (1998) Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by bFGF in Xenopus. Oncogene17:2155-65
21. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279:509-14
22. Heldin P, Laurent TC, Heldin CH (1989) Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts. Biochem J258:919-22
23. Heldin CH, Westermark B (1999) Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79:1283-316
24. Jones N, Blasutig IM, Eremina V, Ruston JM, Bladt F, Li H et al. (2006) Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature 440:818-23
25. Kebache S, Zuo D, Chevet E, Larose L (2002) Modulation of protein translation by Nck-1. Proc Natl Acad Sci USA 99:5406-11
26. Kremer BE, Adang LA, Macara IG (2007) Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. Cell 130:837-50
27. Ku GM, Yablonski D, Manser E, Lim L, Weiss A (2001) A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J 20:457-65
28. Lamalice L, Houle F, Huot J (2006) Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. J Biol Chem 281:34009-20
29. Lepistö J, Peltonen J, Vähä-Kreula M, Söderström K, Niinikoski J, Laato M (1996) Selective modulation of collagen gene expression by different isoforms of platelet-derived growth factor in experimental wound healing. Cell Tissue Res 286:449-55
30. Li H, Zhu J, Aoudjit L, Latreille M, Kawachi H, Larose L et al. (2006) Rat nephrin modulates cell morphology via the adaptor protein Nck. Biochem Biophys Res Commun 349:310-6
31. Li W, Fan J, Chen M, Guan S, Sawcer D, Bokoch GM et al. (2004a) Mechanism of human dermal fibroblast migration driven by type I collagen, platelet-derived growth factor-BB. Mol Biol Cell 15:294-309
32. Li W, Fan J, Woodley DT (2001) Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton. Oncogene 20:6403-17
33. Li W, Henry G, Fan J, Bandyopadhyay B, Pang K, Garner W et al. (2004b) Signals that initiate, augment, and provide directionality for human keratinocyte motility. J Invest Dermatol 123:622-33
34. Lu W, Mayer BJ (1999) Mechanism of activation of Pak1 kinase by membrane localization. Oncogene 18:797-806
35. Nguyên DT, Kebache S, Fazel A, Wong HN, Jenna S, Emadali A et al. (2004) Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress. Mol Biol Cell 15:4248-60
36. Nishimura R, Li W, Kashishian A, Mondino A, Zhou M, Cooper J et al. (1993) Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor. Mol Cell Biol13:6889-96
37. Paulsson Y, Hammacher A, Heldin CH, Westermark B (1987) Possible positive autocrine feedback in the prereplicative phase of human fibroblasts. Nature 328:715-7
38. Pramatarova A, Ochalski PG, Chen K, Gropman A, Myers S, Min KT et al.(2003) Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons. Mol Cell Biol 23:7210-7221
39. Pawson T, Nash P (2003) Assembly of cell regulatory systems through protein interaction domains. Science 300:445-52
40. Poitras L, Jean S, Islam N, Moss T (2003) PAK interacts with NCK and MLK2 to regulate the activation of jun N-terminal kinase. FEBS Lett 543:129-35
41. Qin XF, An DS, Chen IS, Baltimore D (2003) Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci USA 100:183-8
42. Rivera GM, Antoku S, Gelkop S, Shin NY, Hanks SK, Pawson T et al. (2006) Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. Proc Natl Acad Sci USA103:9536-41
43. Reuterdahl C, Sundberg C, Rubin K, Funa K, Gerdin B (1993) Tissue localization of beta receptors for platelet-derived growth factor and platelet-derived growth factor B chain during wound repair in humans. J Clin Invest 91:2065-75
44. Robson MC, Phillips LG, Thomason A, Robson LE, Pierce GF (1992) Plateletderived growth factor BB for the treatment of chronic pressure ulcers. Lancet 339:23-5
45. Rönnstrand L, Heldin CH (2001) Mechanisms of platelet-derived growth factor-induced chemotaxis. Int J Cancer 91:757-62
46. Ruusala A, Pawson T, Heldin CH, Aspenström P (2008) Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor. J Biol Chem 283:30034-44
47. Schlessinger J (1994) SH2/SH3 signaling proteins. Curr Opin Genet Dev 4:25-30 Sprugel KH, McPherson JM, Clowes AW, Ross R (1987) Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers. Am J Pathol 129:601-13
48. Steed DL, Goslen JB, Holloway GA, Malone JM, Bunt TJ, Webster MW (1992) Randomized prospective double-blind trial in healing chronic diabetic foot ulcers. CT-102 activated platelet supernatant, topical versus placebo. Diabetes Care 15:1598-604
49. Stoletov KV, Gong C, Terman BI (2004) Nck and Crk mediate distinct VEGF-induced signaling pathways that serve overlapping functions in focal adhesion turnover and integrin activation. Exp Cell Res 295:258-68
50. Terracio L, Rönnstrand L, Tingström A, Rubin K, Claesson-Welsh L, Funa K et al. (1988) Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing. J Cell Biol 107:1947-57
51. Tu Y, Li F, Wu C (1998) Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. Mol Biol Cell9:3367-82
52. Tryggvason K, Pikkarainen T, Patrakka J (2006) Nck links nephrin to actin in kidney podocytes. Cell 125:221-4
53. Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB (2006) Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest 116:1346-59
54. Woodley DT, Bachmann PM, O'Keefe EJ (1988) Laminin inhibits human keratinocyte migration. J Cell Physiol 136:140-6
55. Yablonski D, Kane LP, Qian D, Weiss A. (1998) A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK. EMBO J 17:5647-57
56. Yuan B, Latek R, Hossbach M, Tuschl T, Lewitter F (2004) siRNA Selection Server: an automated siRNA oligonucleotide prediction server. Nucleic Acids Res 32(Web Server issue):W130-4
57. Zhou GL, Zhuo Y, King CC, Fryer BH, Bokoch GM, Field J (2003) Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol 23:8058-69