Nckβ adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb

Molecular and Cellular Biology

Volumn 20, Issue 21, 2000, Pages 7867-7880

  Chen, M ^a   She, H ^a   Kim, A ^a   Woodley, D T ^a   Li, W ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN NCK BETA; PROTEIN TYROSINE KINASE; RAC PROTEIN; TYROSINE; UNCLASSIFIED DRUG; ACTIN; ISOPROTEIN; NCK PROTEIN; ONCOPROTEIN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET-DERIVED GROWTH FACTOR BB; RAC1 PROTEIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOSKELETON; GENE MUTATION; GENE OVEREXPRESSION; LAMELLIPODIUM; MAMMAL; MEMBRANE STRUCTURE; MOUSE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CELL FRACTIONATION; CELL MEMBRANE; CHEMISTRY; DOG; FIBROBLAST; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOBLOTTING; KIDNEY; METABOLISM; NORTHERN BLOTTING; PHYSIOLOGY; PROTEIN BINDING; PROTEIN PROCESSING; PSEUDOPODIUM; SERODIAGNOSIS; SITE DIRECTED MUTAGENESIS; SRC HOMOLOGY DOMAIN; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ACTINS; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL FRACTIONATION; CELL MEMBRANE; CELLS, CULTURED; DOGS; FIBROBLASTS; HUMANS; IMMUNOBLOTTING; KIDNEY; MICE; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MUTAGENESIS, SITE-DIRECTED; ONCOGENE PROTEINS; PLATELET-DERIVED GROWTH FACTOR; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN ISOPRENYLATION; PSEUDOPODIA; RAC1 GTP-BINDING PROTEIN; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TRANSFECTION; TYROSINE;

EID: 0033623198     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.21.7867-7880.2000     Document Type: Article

References (45)

1. Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation
2. SH2 and SH3-containing adaptor proteins: Redundant or independent mediators of intracellular signal transduction
3. Identification of Grb4/Nck, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
4. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76
5. Nck family genes, chromosomal location, expression and signaling specificity
6. Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein
7. Rho GTPases and the actin cytoskeleton
8. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase
9. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila
10. Chromosome locations of genes encoding human signal transduction adapter proteins Nck, Shc and Grb2
11. Receptor tyrosine kinases and their targets
12. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interaction with cellular proteins
13. The 64-kDa protein that associates with the PDGF receptor subunit via tyrosine 1009 is the SH2-containing phosphotyrosine phosphatase Syp/SHPTP2/PTP1D/SHPTP3
14. The Nck SH2/SH3 adapter protein is present in nucleus and associates with the nuclear SAM68
15. The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors
16. The SH2 and SH3 adapter Nck: A two-gene family and a linker between tyrosine kinases and multiple signaling networks
17. Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck
18. Proteins with SH2 domains: Transducers in the tyrosine kinase signaling pathway
19. Signaling through SH2 and SH3 domains
20. The Nck SH2/SH3 adaptor protein: A regulator of multiple intracellular signal transduction events
21. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
22. Two signaling molecules share a phosphotyrosine-containing binding site in the PDGF receptor
23. Activation of the small GTP-binding proteins rho and rac by growth factor receptors
24. PAK promotes morphological changes by acting upstream of Rac
25. Cloning, sequencing, and overexpression of SH2/SH3 adaptor protein Nck from mouse thymus
26. Protein modules and signaling networks
27. Domain requirements for the Dock adapter protein in growth cone signaling
28. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
29. Nck inhibits NGF and basic FGF induced PC12 cell differentiation via mitogen-activated protein kinase-independent pathway
30. The SH2/SH3 adaptor protein dock interacts with the Ste20-like kinase misshapen in controlling growth cone motility
31. Platelet-derived growth factor (PDGF)-induced actin rearrangement is deregulated in cells expressing a mutant Y778F PDGF beta-receptor
32. SH2/SH3 signaling proteins
33. Human p21-activated kinase (PAK1) regulates actin organization of mammalian cells
34. Activation of the Abl tyrosine kinase in vivo by Src homology 3 domains from the Src homology 2/Src homology 3 adaptor Nck
35. SH2 domains recognize specific phosphopeptide sequences
36. Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase
37. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
38. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
39. Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins
40. Nck-2, a novel src homology2/3-containing adapter protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways
41. Localization of human AF2 and NCK genes and 13 other Notl-linking clones to chromosome 3 by fluorescence in situ hybridization
42. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
43. Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase
44. A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK