Signals that initiate, augment, and provide directionality for human keratinocyte motility

Journal of Investigative Dermatology

Volumn 123, Issue 4, 2004, Pages 622-633

  Li, Wei ^a,b,c   Henry, Ginard ^a   Fan, Jianhua ^a   Bandyopadhyay, Balaji ^a   Pang, Katie ^a   Garner, Warren ^a   Chen, Mei ^a   Woodley, David T ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

ECM; Growth factor; Human keratinocyte; Motility; Signal transduction; Wound healing

Indexed keywords

GROWTH FACTOR; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CELL GROWTH; CELL MOTILITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENE; WOUND HEALING;

EID: 4644331941     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23416.x     Document Type: Article

References (58)

1. Albrecht-Buehler G: The phagokinetic tracks of 3T3 cells. Cell 11:395-404, 1977
2. Ando Y, Jensen PJ: Epidermal growth factor and insulin-like growth factor I enhance keratinocyte migration. J Invest Dermatol 100:633-639, 1993
3. Bladt F, Aippersbach E, Gelkop S, et al: The murine Nek SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol 23:4586-4597, 2003
4. Carter SB: Haptotaxis and the mechanism of cell motility. Nature 2:256-261, 1967
5. Chang L, Karin M: Mammalian MAP kinase signaling cascades. Nature 410:37-40, 2001
6. Chen JD, Helmold M, Kim JP, Wynn KC, Woodley DT: Human keratinocytes make uniquely linear phagokinetic tracks. Dermatology 188:6-12, 1994
7. Chen JD, Kim JP Zhang K, Sarret Y, Wynn KC, Kramer RH, Woodley DT: Epidermal growth factor (EGF) promotes human keratinocyte locomotion on collagen by increasing the alpha 2 integrin subunit. Exp Cell Res 209: 216-223, 1993
8. Chen M, Li W, Fan J, Kasahara N, Woodley D: An efficient gene transduction system for studying gene functions in primary human. Exp Dermatol 28:193-199, 2003
9. Chen M, She H, Kim A, Woodley DT, Li W: Nck-beta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor-BB. Mol Cell Biol 20:7867-7880, 2000
10. Cuevas BD, Abell AN, Witowsky JA, et al: MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. EMBO J 22:3346-3355, 2003
11. Dazy S, Damiola F, Parisey N, Beug H, Gandrillon O: The MEK-1/ERKs signalling pathway is differentially involved in the self-renewal of early and late avian erythroid progenitor cells. Oncogene 22:9205-9216, 2003
12. del Pozo MA, Price LS, Alderson NB, Ren XD, Schwartz MA: Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK. EMBO J 19:2008-2014, 2000
13. Devreotes PN, Zigmond SH: Chemotaxis in eukaryotic cells: A focus on leukocytes and dictyostelium. Annu Rev Cell Biol 4:649-686, 1988
14. Dmitrieva RI, Doris PA: Ouabain is a potent promoter of growth and activator of ERK1/2 in ouabain-resistant rat renal epithelial cells. J Biol Chem 278:28160-28166, 2003
15. Eliceiri BP: Integrin and growth factor receptor crosstalk. Circ Res 89:1104-1110, 2001
16. English JM, Cobb MH: Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci 23:40-45, 2002
17. Galiacy S, Planus E, Lepetit H, et al: Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Exp Cell Res 283:215-229, 2003
18. Giancotti FG, Ruoslahti E: Integrin signaling. Science 285:1028-1032, 1999
19. Haase I, Evans R, Pofahl R, Watt FM: Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways. J Cell Sci 116:3227-3238, 2003
20. Henry G, Li W, Garner W, Woodley DT: Migration of human keratinocytes in plasma and serum and wound re-epithelialisation. Lancet 361:574-576, 2003
21. Hsieh T, Gordon RE, Clemmons DR, Busby WH Jr, Duan C: Regulation of vascular smooth muscle cell responses to insulin-like growth factor (IGF)-I by local IGF binding proteins. J Biol Chem 278:42886-42892, 2003
22. Huttenlocher A, Sandborg R, Horwitz AF: Adhesion in cell migration. Curr Opin Cell Biol 7:607-706, 1995
23. Javelaud D, Laboureau J, Gabison E, Verrecchia F, Mauviel A: Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing. J Biol Chem 278:24624-24628, 2003
24. Jones PL, Crack J, Rabinovitch M: Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth. J Cell Biol 139:279-293, 1997
25. Kelemen BR, Hsiao K, Goueli SA: Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. J Biol Chem 277: 8741-8874, 2002
26. Khwaja A, Downward J: Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells. J Cell Biol 139:1017-1023, 1997
27. Klemke RL, Yebra M, Bayna EM, Cheresh DA: Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol 127:859-866, 1994
28. Lauffenburger DA, Horwitz AF: Cell migration: A physically integrated molecular process. Cell 84:359-369, 1996
29. Li W, Fan J, Chen M, Guan S, Sawcer D, Bokoch GM, Woodley DT: Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB. Mol Biol Cell 15:294-309, 2004
30. Li W, Nadelman C, Gratch NS, Li WQ, Chen M, Kasahara N, Woodley DT: An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen. Exp Cell Res 273:219-228, 2002
31. Li W, Nadelman C, Henry G, et al: The p38-MAPK/SAPK pathway is required for human keratinocyte migration on dermal collagen. J Invest Dermatol 117:1601-1611, 2001
32. Lin TH, Chen Q, Howe A, Juliano RL: Cell anchorage permits efficient signal transduction between ras and its downstream kinases. J Biol Chem 272:8849-8852, 1997
33. Maheshwari G, Wells A, Griffith LG, Lauffenburger DA: Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration. Biophys J 76:2814-2823, 1999
34. Mainiero F, Pepe A, Yeon M, Ren Y, Giancotti FG: The intracellular functions of alpha6beta4 integrin are regulated by EGF. J Cell Biol 134:241-253, 1996
35. McAllister SS, Becker-Hapak M, Pintucci G, Pagano M, Dowdy SF: Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol 23: 216-228, 2003
36. Miranti CK, Brugge JS: Sensing the environment: A historical perspective on integrin signal transduction. Nat Cell Biol 4:E83-E90, 2002
37. Miyamoto S, Teramoto H, Gutkind JS, Yamada KM: Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors. J Cell Biol 135:1633-1642, 1996
38. Moro L, Dolce L, Cabodi S, et al: Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J Biol Chem 277:9405-9414, 2002
39. Moro L, Venturino M, Bozzo C, et al: Integrins induce activation of EGF receptor: Role in MAP kinase induction and adhesion-dependent cell survival. EMBO J 17:6622-6632, 1998
40. Nobes CD, Hall A: Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol 144:1235-1244, 1999
41. O'Toole EA, Marinkovich MP, Hoeffler WK, Furthmayr H, Woodley DT: Laminin-5 inhibits human keratinocyte migration. Exp Cell Res 233:330-339, 1997
42. Plopper GE, McNamee HR Dike LE, Bojanowski K, Ingber DE: Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol Biol Cell 6:1349-1365, 1995
43. Pratt PF, Bokemeyer D, Foschi M, Sorokin A, Dunn MJ: Alterations in subcellular localization of p38 MAPK potentiates endothelin-stimulated COX-2 expression in glomerular mesangial cells. J Biol Chem 278:51928-51936, 2003
44. Pullar CE, Chen J, Isseroff RR: PP2A activation by beta2-adrenergic receptor agonists: Novel regulatory mechanism of keratinocyte migration. J Biol Chem 278:22555-22562, 2003
45. Renshaw MW, Ren XD, Schwartz MA: Growth factor activation of MAP kinase requires cell adhesion. EMBO J 16:5592-5599, 1997
46. Russell AJ, Fincher EF, Millman L, et al: Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. J Cell Sci 116:3543-3556, 2003
47. Sadowski T, Dietrich S, Koschinsky F, Sedlacek R: Matrix metalloproteinase 19 regulates IGF-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth factor binding protein-3. Mol Biol Cell 14:4569-4580, 2003
48. Sarret Y, Woodley DT, Grigsby K, Wynn K, O'Keefe EJ: Human keratinocyte locomotion: The effect of selected cytokines. J Invest Dermatol 98:12-16, 1992
49. Satish L, Yager D, Wells A: Glu-Leu-Arg-negative CXC chemokine Interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair. J Invest Dermatol 120:1110-1117, 2003
50. Schwartz MA, Ginsberg MH: Networks and crosstalk: Integrin signalling spreads. Nat Cell Biol 65-E78, 2002
51. Schwartz MA, Schaller MD, Ginsberg MH: Integrins: Emerging paradigms of signal transduction. Annu Rev Cell Dev Biol 11:549-599, 1995
52. Short SM, Talbott GA, Juliano RL: Integrin-mediated signaling events in human endothelial cells. Mol Biol Cell 9:1969-1980, 1998
53. Tucker GC, Boyer B, Valles AM, Thiery JP: Combined effects of extracellular matrix and growth factors on NBT-II rat bladder carcinoma cell dispersion. J Cell Sci 100:371-380, 1991
54. Ware MF, Wells A, Lauffenburger DA: Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner. J Cell Sci 111:2423-2432, 1998
55. Woodard AS, Garcia-Cardena G, Leong M, Madri JA, Sessa WC, Languino LR: The synergistic activity of alphavbetaS integrin and PDGF receptor increases cell migration. J Cell Sci 111:469-478, 1998
56. Woodley DT: Re-epithelialization. In: Clark RAF (eds). The Molecular and Cellular Biology of Wound Repair, 2nd edn. New York: Plenum Publishing Corp., 1996; p 339-350
57. Woodley DT, Bachmann PM, O'Keefe EJ: Laminin inhibits human keratinocyte migration. J Cell Physiol 136:140-146, 1988
58. Zigmond SH: Mechanisms of sensing chemical gradients by polymorphonuclear leukocytes. Nature 249:450-452, 1974