Mechanisms of platelet-derived growth factor-induced chemotaxis

International Journal of Cancer

Volumn 91, Issue 6, 2001, Pages 757-762

  Rönnstrand, Lars ^a   Heldin, Carl Henrik ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR;

ACTIN FILAMENT; CELL MIGRATION; EMBRYO DEVELOPMENT; GROWTH REGULATION; LAMELLIPODIUM; LIGAND BINDING; MITOGENICITY; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; SHORT SURVEY; TISSUE SPECIFICITY;

ANIMALS; CHEMOTAXIS; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENES, SRC; GRB10 ADAPTOR PROTEIN; GRB7 ADAPTOR PROTEIN; GTP-BINDING PROTEINS; HELMINTH PROTEINS; HUMANS; ISOENZYMES; MICE; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLATELET-DERIVED GROWTH FACTOR; PROTEIN-TYROSINE KINASES; PROTEINS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 0035869649     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(200002)9999:9999<::AID-IJC1136>3.0.CO;2-J     Document Type: Short Survey

References (66)

1. Cell migration: A physically integrated molecular process
2. Signal transduction via platelet-derived growth factor receptors
3. Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis
4. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins
5. PDGF α- and β-receptors activate unique and common signal transduction pathways
6. A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets
7. Heparan sulfate proteoglycans mediate a potent inhibitory signal for migration of vascular smooth muscle cells
8. Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover
9. Relative platelet-derived growth factor receptor subunit expression determines cell migration to different dimeric forms of PDGF
10. Signaling by distinct classes of phosphoinositide 3-kinases
11. Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol 3′ kinase
12. HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3′-kinase
13. Nerve growth factor functions as a chemoattractant for mast cells through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways
14. IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 receptor, IGF binding proteins, phosphatidylinositol-3 kinase pathway and plasmin system
15. Phosphatidylinositol 3-kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis
16. The PI3K-PDK1 connection: More than just a road to PKB
17. The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C
18. Signaling to Rho GTPases
19. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
20. Involvement of phosphatidylinositide 3′-kinase and Rac in platelet- derived growth factor-induced actin reorganization and chemotaxis
21. Platelet-derived growth factor and fibronectin-stimulated migration are differentially regulated by the Rac and extracellular signal-regulated kinase pathways
22. Tyr-716 in the platelet-derived growth factor β-receptor kinase insert is involved in GRB2 binding and Ras activation
23. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
24. A new function for a phosphotyrosine phosphatase: Linking GRB2-Sos to a receptor tyrosine kinase
25. The chemotactic response to PDGF-BB: Evidence of a role for Ras
26. PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF
27. Mitogen-activated protein kinase activation mediates PDGF-directed migration of RPE cells
28. From receptors to stress-activated MAP kinases
29. Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration
30. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration
31. Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27
32. Proteins regulating Ras and its relatives
33. Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: A conformational mechanism for SH3 domain regulation
34. Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok
35. rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo
36. A role for Cdc42 in macrophage chemotaxis
37. Regulation of chemotaxis by the platelet-derived growth factor receptor-β
38. Role of p120 Ras-GAP in directed cell movement
39. Identification of two C-terminal autophosphorylation sites in the PDGF β-receptor: Involvement in the interaction with phospholipase C-γ
40. Mutation of a Src phosphorylation site in the PDGF β-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis
41. Overactivation of phospholipase C-γ1 renders platelet-derived growth factor β-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis
42. Identification of two juxtamembrane autophosphorylation sites in the PDGF β-receptor: Involvement in the interaction with Src family tyrosine kinases
43. The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding
44. Multiple roles for Src in a PDGF-stimulated cell
45. Src family kinases are required for integrin but not PDGFR signal transduction
46. No requirement for the src family kinases for PDGF signaling in fibroblasts expressing SV40 large T antigen
47. Signaling through focal adhesion kinase
48. Reduced cell motility and enhanced focal adhesion contract formation in cells from FAK-deficient mice
49. FAK integrates growth-factor and integrin signals to promote cell migration
50. The GRB family of SH2 domain proteins
51. Grb7 is a downstream signaling component of platelet-derived growth factor α- and β-receptors
52. Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis
53. Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains
54. Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor
55. SHP-2 binds to Tyr763 and Tyr1009 in the PDGF β-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis
56. Identification of a putative Syp substrate, the PDGF β-receptor
57. Localization and down-regulating role of the protein tyrosine phosphatase PTP2C in membrane ruffles of PDGF-stimulated cells
58. The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors
59. Tyrosine phosphatase SHP-2 is involved in regulation of platelet-derived growth factor-induced migration
60. Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion
61. r phosphotyrosine protein phosphatases
62. PDGF receptor as a specific in vivo target for low M(r) phosphotyrosine protein phosphatase
63. Low molecular weight protein-tyrosine phosphatase tyrosine phosphorylation by c-Src during platelet-derived growth factor-induced mitogenesis correlates with its subcellular targeting
64. The low M(r) protein-tyrosine phosphatase is involved in Rho-mediated cytoskeleton rearrangement after integrin and platelet-derived growth factor stimulation
65. Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts
66. Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: Spatial and temporal modulation of PDGF chemotactic signal transduction