Age-related decline in rod phototransduction sensitivity in rhesus monkeys fed an n-3 fatty acid-deficient diet

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 9, 2009, Pages 4360-4367

  Jeffrey, Brett G ^a   Neuringer, Martha ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAROTENOID; DOCOSAHEXAENOIC ACID; LINOLEIC ACID; OMEGA 3 FATTY ACID; SAFFLOWER OIL; SOYBEAN OIL;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; ESSENTIAL FATTY ACID DEFICIENCY; LOW FAT DIET; N 3 FATTY ACID DEFICIENCY; NONHUMAN; PHOTOACTIVATION; PHOTOSENSITIVITY; PHOTOTRANSDUCTION; PRIORITY JOURNAL; RETINA ROD; RHESUS MONKEY; ANIMAL; MACACA; PHOTOSTIMULATION; PHYSIOLOGY; RETINA CONE; VISION;

AGING; ANIMALS; DOCOSAHEXAENOIC ACIDS; ELECTRORETINOGRAPHY; FATTY ACIDS, OMEGA-3; MACACA MULATTA; PHOTIC STIMULATION; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL ROD PHOTORECEPTOR CELLS; SAFFLOWER OIL; SOYBEAN OIL; VISION, OCULAR;

EID: 67651143802     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3640     Document Type: Article

References (37)

1. Fliesler SJ, Anderson RE. Chemistry and metabolism of lipids in the vertebrate retina. Prog Lipid Res. 1983;22:79 -131.
2. Anderson GJ, Connor WE, Corliss JD, Lin DS. Rapid modulation of the n-3 docosahexaenoic acid levels in the brain and retina of the newly hatched chick. J Lipid Res. 1989;30:433-441.
3. Bourre J-M, Francois M, Youyou A, et al. The effects of dietary_-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. J Nutr. 1989;119:1880-1892.
4. Weisinger HS, Vingrys AJ, Sinclair AJ. Dietary manipulation of long-chain polyunsaturated fatty acids in the retina and brain of guinea pigs. Lipids. 1995;30:471-473.
5. Neuringer M, Connor WE, Lin DS, Barstad L, Luck S. Biochemical and functional effects of prenatal and postnatal omega-3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci U S A. 1986;83:4021-4025.
6. Jeffrey BG, Weisinger HS, Neuringer M, Mitchell DC. The role of docosahexaenoic acid in retinal function. Lipids. 2001;36:859-871.
7. Weisinger HS, Vingrys AJ, Bui BV, Sinclair AJ. Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. Invest Ophthalmol Vis Sci. 1999;40:327-338.
8. Jeffrey BG, Mitchell DC, Gibson RA, Neuringer M. n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys. Invest Ophthalmol Vis Sci. 2002;43:2806-2814.
9. Neuringer M, Sandstrom MM, Johnson EJ, Snodderly DM. Nutritional manipulation of primate retinas. I. Effects of lutein or zeaxanthin supplements on serum and macular pigment of xanthophyll-free monkeys. Invest Ophthalmol Vis Sci. 2004;45:3234-3243.
10. Leung IY, Sandstrom MM, Zucker CL, Neuringer M, Snodderly DM. Nutritional manipulation of primate retinas, II: effects of age, n-3 fatty acids, lutein, and zeaxanthin on retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2004;45:3244-3256.
11. Coleman H, Chew E. Nutritional supplementation in age related macular degeneration. Curr Opin Ophthalmol. 2007;18:220-223.
12. Wyszecki G, Stiles WS. Color Science: Concepts and Methods, Quantitative Data and Formulae. 2nd ed. New York: John Wiley & Sons; 1982.
13. Birch DG, Hood DC, Nusinowitz S, Pepperberg DR. Abnormal activation and inactivation mechanisms of rod transduction in patients with autosomal dominant retinitis pigmentosa and the pro-23-his mutation. Invest Ophthalmol Vis Sci. 1995;36:1603-1614.
14. Robson JG, Saszik SM, Ahmed J, Frishman LJ. Rod and cone contributions to the a-wave of the electroretinogram of the macaque. J Physiol. 2003;547:509-530.
15. Cobbs WH, Pugh EN Jr. Kinetics and components of the flash photocurrent of isolated retinal rods of the larval salamander, Ambystoma tigrinum. J Physiol. 1987;394:529-572.
16. Breton ME, Schueller AW, Lamb TD, Pugh EN Jr. Analysis of ERG a-wave amplification and kinetics in terms of the G-protein cascade of phototransduction. Invest Ophthalmol Vis Sci. 1994;35:295-309.
17. Niu SL, Mitchell DC, Lim SY, et al. Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency. J Biol Chem. 2004;279:31098-31104.
18. Pepperberg DR, Birch DG, Hood DC. Photoresponses of human rods in vivo derived from paired-flash electroretinograms. Vis Neurosci. 1997;14:73-82.
19. Friedburg C, Thomas MM, Lamb TD. Time course of the flash response of dark- and light-adapted human rod photoreceptors derived from the electroretinogram. J Physiol. 2001;534:217-242.
20. Leaf A. Omega-3 fatty acids and prevention of ventricular fibrillation. Prostaglandins Leukotr Essent Fatty Acids. 1995;52:197-198.
21. Vreugdenhil M, Bruehl C, Voskuyl RA, Kang J, Leaf A, Wadman WJ. Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. Proc Natl Acad Sci U S A. 1996;93:12559-12563.
22. Bush RA, Malnoe A, Reme CE, Williams TP. Dietary deficiency of N-3 fatty acids alters rhodopsin content and function in the rat retina. Invest Ophthalmol Vis Sci. 1994;35:91-100.
23. Reme CE, Malnoe A, Jung HH, Wei JQ, Munz K. Effect of dietary fish oil on acute light induced photoreceptor damage in the rat retina. Invest Ophthalmol Vis Sci. 1994;35:78 -90.
24. Feller SE, Gawrisch K. Properties of docosahexaenoic-acid-containing lipids and their influence on the function of rhodopsin. Curr Opin Struct Biol. 2005;15:416-422.
25. Grossfield A, Feller SE, Pitman MC. A role for direct interactions in the modulation of rhodopsin by omega-3 polyunsaturated lipids. Proc Natl Acad Sci U S A. 2006;103:4888-4893.
26. de Turco EB, Jackson FR, Parkins N, Gordon WC. Strong association of unesterified [3H]docosahexaenoic acid and [3H-docosahexaenoyl] phosphatidate to rhodopsin during in vivo labeling of frog retinal rod outer segments. Neurochem Res. 2000;25:695-703.
27. Fu Y, Yau K-W. Phototransduction in mouse rods and cones. Eur J Physiol. 2007;454:805-819.
28. Kawamura S, Tachibanaki S. Rod and cone photoreceptors: Molecular basis of the difference in their physiology. Comp Biochem Physiol A Mol Integr Physiol. 2008;150:369-377.
29. Leung IY, Sandstrom MM, Zucker CL, Neuringer M, Max Snodderly D. Nutritional manipulation of primate retinas. IV. Effects of n-3 fatty acids, lutein, and zeaxanthin on S-cones and rods in the foveal region. Exp Eye Res. 2005;81:513-529.
30. SanGiovanni JP, Chew EY. The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res. 2005;24:87-138.
31. Krinsky NI, Landrum JT, Bone RA. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Ann Rev Nutr. 2003;23:171-201.
32. Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci U S A. 2004;101:8491-8496.
33. Mukherjee PK, Marcheselli VL, Barreiro S, Hu J, Bok D, Bazan NG. Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. Proc Natl Acad Sci U S A. 2007;104:13152-13157.
34. Cideciyan AV, Jacobson SG. An alternative phototransduction model for human rod and cone ERG a-waves: normal parameters and variation with age. Vision Res. 1996;36:2609 -2621.
35. Birch DG, Hood DC, Locke KG, Hoffman DR, Tzekov RT. Quantitative electroretinogram measures of phototransduction in cone and rod photoreceptors: normal aging, progression with disease, and test-retest variability. Arch Ophthalmol. 2002;120:1045-1051.
36. Jackson GR, McGwin G Jr, Phillips JM, Owsley C. Impact of aging and age-related maculopathy on activation of the a-wave of the rod mediated electroretinogram. Invest Ophthalmol Vis Sci. 2004;45:3271-3278.
37. Chong EWT, Kreis AJ, Wong TY, Simpson JA, Guymer RH. Dietary-3 fatty acid and fish intake in the primary prevention of agerelated macular degeneration. A systematic review and meta-analysis. Arch Ophthalmol. 2008;126:826-833.