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NMR analysis was made on a sample of the crude residue dried under high vacuum to eliminate unreacted volatile starting components
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The reported solvent/base combination gave the best results in terms of selectivity
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The reported solvent/base combination gave the best results in terms of selectivity.
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Although the reactions were performed under aqueous basic conditions, we had no evidence of methoxycarbonyl group hydrolysis
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Although the reactions were performed under aqueous basic conditions, we had no evidence of methoxycarbonyl group hydrolysis.
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At the end of the reaction, the unreacted haloamide was mostly transformed into the corresponding hydroxy-amide
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At the end of the reaction, the unreacted haloamide was mostly transformed into the corresponding hydroxy-amide.
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3 in anhydrous DMF at 80 °C proved that the conversion of 4 to 5 took place in 2 h. The same transformation performed in aqueous DMF occurred within about 4 h.
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3 in anhydrous DMF at 80 °C proved that the conversion of 4 to 5 took place in 2 h. The same transformation performed in aqueous DMF occurred within about 4 h.
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