Probing Akt-Inhibitor Interaction by Chemical Cross-Linking and Mass Spectrometry

Journal of the American Society for Mass Spectrometry

Volumn 20, Issue 8, 2009, Pages 1504-1513

  Huang, Bill X ^a   Kim, Hee Yong ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT ACTIVATION; ANTI-TUMOR AGENTS; CELL SURVIVAL; CHEMICAL CROSS-LINKING; CONFORMATIONAL CHANGE; DRUG DISCOVERY; HUMAN MALIGNANCIES; INTER-DOMAIN; KINASE DOMAINS; NOVEL STRATEGIES; OPEN CONFORMATION; PLASMA MEMBRANES; QUANTITATIVE COMPARISON; REGULATORY DOMAIN; THERAPEUTIC STRATEGY; UNILAMELLAR VESICLE;

ACTIVATION ANALYSIS; AMINES; CONFORMATIONS; CROSSLINKING; DRUG INTERACTIONS; LABELS; MASS SPECTROMETERS; MASS SPECTROMETRY; PLASMAS; SUGAR (SUCROSE);

CELL MEMBRANES;

PHOSPHATIDYLINOSITOL; PROTEIN KINASE B INHIBITOR; THREONINE;

ARTICLE; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS LINKING; DRUG DESIGN; DRUG PROTEIN BINDING; MASS SPECTROMETRY; MOLECULAR INTERACTION; MOLECULAR PROBE; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS;

BINDING SITES; CROSS-LINKING REAGENTS; MASS SPECTROMETRY; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 67650725991     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2009.04.004     Document Type: Article

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