Distinct kinetics of human DNA ligases I, IIIα, IIIβ, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair

DNA Repair

Volumn 8, Issue 8, 2009, Pages 961-968

  Chen, Xi ^a   Ballin, Jeff D ^a   Della Maria, Julie ^a   Tsai, Miaw Sheue ^b   White, Elizabeth J ^a   Tomkinson, Alan E ^a   Wilson, Gerald M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Assay; Development; DNA ligases; Enzyme kinetics; Fluorescence spectroscopy; Substrate recognition

Indexed keywords

POLYDEOXYRIBONUCLEOTIDE SYNTHASE; XRCC1 PROTEIN; XRCC4 PROTEIN;

ADENYLATION; ARTICLE; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FLUORESCENCE SPECTROSCOPY; HUMAN; PRIORITY JOURNAL;

ADENINE; BIOCATALYSIS; BIOLOGICAL ASSAY; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA LIGASES; DNA REPAIR; DNA-BINDING PROTEINS; ESTERS; FLUORESCENCE; HUMANS; KINETICS; REPRODUCIBILITY OF RESULTS; SUBSTRATE SPECIFICITY;

EID: 67650641974     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2009.06.002     Document Type: Article

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